FOSL1 - FOS like 1, AP-1 transcription factor subunit Gene

Also Known as FRA; FRA1; fra-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8061

About FOSL1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,892,049-65,900,545 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 8 paralogues. Biased expression in gall bladder (RPKM 16.7), urinary bladder (RPKM 10.2) and 13 other tissues.

Summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

FOSL1 Products (5)

mRNA	Protein	Name
NM_001300844.2	NP_001287773.1	fos-related antigen 1 isoform 2
NM_001300855.2	NP_001287784.1	fos-related antigen 1 isoform 3
NM_001300856.2	NP_001287785.1	fos-related antigen 1 isoform 4
NM_001300857.2	NP_001287786.1	fos-related antigen 1 isoform 5
NM_005438.5	NP_005429.1	fos-related antigen 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21673316	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription initiation	IDA IDA: Inferred from direct assay	23027619	GOA
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	21673316	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	23661758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOSL1 Protein Structure

bZIP_1

0
100
200
271 a.a.

Protein Preferred Names	Protein Names
fos-related antigen 1	FOS like 1, AP-1 trancription factor subunit

FOSL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOSL1	P15407	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	FOSL1	P15407	BATF3	Homo sapiens	Q9NR55	Validated Y2H	32296183
Intra	FOSL1	P15407	USF1	Homo sapiens	P22415	Y2H Prey Pooling	25416956
Intra	FOSL1	P15407	USF1	Homo sapiens	P22415	Validated Y2H	32296183
Intra	FOSL1	P15407	USF1	Homo sapiens	P22415	Validated Y2H	25416956
Intra	FOSL1	P15407	USF1	Homo sapiens	P22415	Y2H Array	25416956
Intra	FOSL1	P15407	USF1	Homo sapiens	P22415	Anti Tag CoIP	33961781
Intra	FOSL1	P15407	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	FOSL1	P15407	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	FOSL1	P15407	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	FOSL1	P15407	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	FOSL1	P15407	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	FOSL1	P15407	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	FOSL1	P15407	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	FOSL1	P15407	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	FOSL1	P15407	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	FOSL1	P15407	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	FOSL1	P15407	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	FOSL1	P15407	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	FOSL1	P15407	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	FOSL1	P15407	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	FOSL1	P15407	TAB2	Homo sapiens	Q9NYJ8	Validated Y2H	32296183
Intra	FOSL1	P15407	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	FOSL1	P15407	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	FOSL1	P15407	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	FOSL1	P15407	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	FOSL1	P15407	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	FOSL1	P15407	LDOC1	Homo sapiens	O95751	Y2H Pooling	19060904
Intra	FOSL1	P15407	LDOC1	Homo sapiens	O95751	Y2H Array	19060904
Intra	FOSL1	P15407	LDOC1	Homo sapiens	O95751	Y2H Pooling	16189514
Intra	FOSL1	P15407	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	FOSL1	P15407	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	FOSL1	P15407	NME7	Homo sapiens	Q9Y5B8	Y2H Array	25416956
Intra	FOSL1	P15407	NME7	Homo sapiens	Q9Y5B8	Y2H Prey Pooling	25416956
Intra	FOSL1	P15407	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	25416956
Intra	FOSL1	P15407	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	FOSL1	P15407	JUNB	Homo sapiens	P17275	Anti Bait CoIP	24029232
Intra	FOSL1	P15407	JUNB	Homo sapiens	P17275	Anti Tag CoIP	33961781
Intra	FOSL1	P15407	JUNB	Homo sapiens	P17275	Validated Y2H	32296183
Intra	FOSL1	P15407	JUN	Homo sapiens	P05412	Anti Tag CoIP	33961781
Intra	FOSL1	P15407	JUN	Homo sapiens	P05412	Anti Bait CoIP	26258633
Intra	FOSL1	P15407	JUN	Homo sapiens	P05412	PLA	20511396
Intra	FOSL1	P15407	JUN	Homo sapiens	P05412	FRET	23661758
Intra	FOSL1	P15407	JUN	Homo sapiens	P05412	Anti Bait CoIP	24029232

Cross: Cross-species interaction Intra: Intraspecies interaction

FOSL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82282	FRA1 Antibody (YA2027)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Krabbe Disease	Globoid Cell Leukodystrophy Galactosylceramide Beta-Galactosidase Deficiency Galc Deficiency Galactocerebrosidase Deficiency GLD Globoid Cell Leukoencephalopathy Diffuse Globoid Body Sclerosis Gcl Leukodystrophy, Globoid Cell Krabbe'S Leukodystrophy Krabbe Leukodystrophy KRB Beta Galactocerebrosidase Deficiency Krabbe'S Disease Galactosylceramidase Deficiency Disease Galactosylceramide Lipidosis Galactosylcerebrosidase Deficiency Galactosylsphingosine Lipidosis Psychosine Lipidosis Galactosylceramidase Deficiency Infantile Globoid Cell Leukodystrophy Krabbe Brain Sclerosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Trichorhinophalangeal Syndrome, Type I	Trichorhinophalangeal Dysplasia Type I TRPS1 Trichorhinophalangeal Syndrome Type I Trps I Trichorhinophalangeal Syndrome Type 1 Type I Trichorhinophalangeal Syndrome Giedion Syndrome Trp Syndrome Tricho-Rhino-Phalangeal Syndrome 1 Trichorhinophalangeal Syndrome, Type Iii
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162723	FOSL1 degrader 1	Degrader	99.66%	Unkown
HY-202699	SHOC2-RAS PPI-IN-1	Inhibitor	99.50%	Unkown
HY-W019901B	Anhydrous calcium sulfate (97%)	Activator	99.40%	Unkown
HY-RS05034	FOSL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18064	Fosl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24539	Fosl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOSL1	MGD	MGI:107179
Bos taurus	FOSL1	VGNC	VGNC:29075
Rattus norvegicus	FOSL1	RGD	RGD:2627
Macaca mulatta	FOSL1	VGNC	VGNC:72505
Canis familiaris	FOSL1	VGNC	VGNC:40942
Felis catus	FOSL1	VGNC	VGNC:102890
Others	FOSL1	NCBI