JUN - Jun proto-oncogene, AP-1 transcription factor subunit Gene
Also Known as AP1; p39; AP-1; cJUN; c-Jun
Species: Homo sapiens
About JUN
This gene has 2 transcripts (splice variants), 226 orthologues, 2 paralogues and is associated with 53 phenotypes.
Summary
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
JUN Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002228.4 | NP_002219.1 | transcription factor Jun |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of RNA polymerase II transcription regulator complex |
IPI
IPI: Inferred from physical interaction
|
20102225 | GOA |
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
31341047 | GOA |
| located in euchromatin |
IDA
IDA: Inferred from direct assay
|
19861239 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
9443941 | GOA |
| part of transcription factor AP-1 complex |
IDA
IDA: Inferred from direct assay
|
10508860 | GOA |
| part of transcription factor AP-1 complex |
IMP
IMP: Inferred from mutant phenotype
|
26514923 | GOA |
| part of transcription factor AP-1 complex |
IPI
IPI: Inferred from physical interaction
|
7816143 | GOA |
JUN Protein Structure
Jun: Jun-like transcription factor (5 - 241)
bZIP_1: bZIP transcription factor (250 - 313)
- 0
- 100
- 200
- 300
- 331 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
transcription factor Jun |
|
|
JUN Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
JUN | P05412 | NFATC2 | Homo sapiens | Q13469-2 | 20557936 | |
|
Intra
|
JUN | P05412 | BATF3 | Homo sapiens | Q9NR55 | 20102225 | |
|
Intra
|
JUN | P05412 | BATF3 | Homo sapiens | Q9NR55 | 35271311 | |
|
Intra
|
JUN | P05412 | BATF3 | Homo sapiens | Q9NR55 | 23661758 | |
|
Intra
|
JUN | P05412 | BATF3 | Homo sapiens | Q9NR55 | 25609649 | |
|
Intra
|
JUN | P05412 | SMAD2 | Homo sapiens | Q15796 | 25609649 | |
|
Intra
|
JUN | P05412 | NEFM | Homo sapiens | P07197 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 31515488 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 35271311 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 20102225 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 23661758 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 20511396 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 20195357 | |
|
Intra
|
JUN | P05412 | ATF2 | Homo sapiens | P15336 | 26496610 | |
|
Intra
|
JUN | P05412 | VRK1 | Homo sapiens | Q99986 | 15378002 | |
|
Intra
|
JUN | P05412 | VRK1 | Homo sapiens | Q99986 | 25609649 | |
|
Intra
|
JUN | P05412 | VRK1 | Homo sapiens | Q99986 | 15378002 | |
|
Intra
|
JUN | P05412 | VRK1 | Homo sapiens | Q99986 | 15378002 | |
|
Cross
|
JUN | P05412 | Maz | Mus musculus | P56671 | 19028685 | |
|
Intra
|
JUN | P05412 | CITED1 | Homo sapiens | Q99966 | 10327051 | |
|
Intra
|
JUN | P05412 | CITED1 | Homo sapiens | Q99966 | 10327051 | |
|
Intra
|
JUN | P05412 | MAPK8 | Homo sapiens | P45983 | 10393177 | |
|
Intra
|
JUN | P05412 | MAPK8 | Homo sapiens | P45983 | 15894542 | |
|
Intra
|
JUN | P05412 | MAPK8 | Homo sapiens | P45983-1 | 16533805 | |
|
Intra
|
JUN | P05412 | HSP90AA1 | Homo sapiens | P07900 | 25609649 | |
|
Intra
|
JUN | P05412 | HSP90AA1 | Homo sapiens | P07900 | 20195357 | |
|
Intra
|
JUN | P05412 | HSP90AA1 | Homo sapiens | P07900 | 20936779 | |
|
Intra
|
JUN | P05412 | TUBA1A | Homo sapiens | Q71U36 | 20195357 | |
|
Intra
|
JUN | P05412 | TUBA1A | Homo sapiens | Q71U36 | 25609649 | |
|
Cross
|
JUN | P05412 | jnk-1 | Caenorhabditis elegans | Q8WQG9 | 11738026 | |
|
Cross
|
JUN | P05412 | jnk-1 | Caenorhabditis elegans | Q8WQG9 | 10393177 | |
|
Intra
|
JUN | P05412 | PRRC2A | Homo sapiens | P48634 | 20195357 | |
|
Intra
|
JUN | P05412 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
JUN | P05412 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
JUN | P05412 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
JUN | P05412 | GOPC | Homo sapiens | Q9HD26 | 25609649 | |
|
Intra
|
JUN | P05412 | KPNA2 | Homo sapiens | P52292 | 25609649 | |
|
Intra
|
JUN | P05412 | KPNA2 | Homo sapiens | P52292 | 21988832 | |
|
Intra
|
JUN | P05412 | TUBB | Homo sapiens | P07437 | 20195357 | |
|
Intra
|
JUN | P05412 | TUBB | Homo sapiens | P07437 | 25609649 | |
|
Intra
|
JUN | P05412 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
JUN | P05412 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
JUN | P05412 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
JUN | P05412 | HSPA8 | Homo sapiens | P11142 | 25609649 | |
|
Intra
|
JUN | P05412 | HSPD1 | Homo sapiens | P10809 | 25609649 | |
|
Intra
|
JUN | P05412 | FOSL2 | Homo sapiens | P15408 | 32296183 | |
|
Intra
|
JUN | P05412 | FOSL2 | Homo sapiens | P15408 | 25609649 | |
|
Intra
|
JUN | P05412 | FOSL2 | Homo sapiens | P15408 | 26496610 | |
|
Intra
|
JUN | P05412 | FOSL2 | Homo sapiens | P15408 | 20102225 | |
|
Intra
|
JUN | P05412 | FOSL2 | Homo sapiens | P15408 | 25609649 | |
|
Intra
|
JUN | P05412 | MDM2 | Homo sapiens | Q00987 | 20195357 | |
|
Intra
|
JUN | P05412 | RAC1 | Homo sapiens | P63000 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF4 | Homo sapiens | P18848 | 20936779 | |
|
Intra
|
JUN | P05412 | ATF4 | Homo sapiens | P18848 | 23661758 | |
|
Intra
|
JUN | P05412 | ATF4 | Homo sapiens | P18848 | 25241761 | |
|
Intra
|
JUN | P05412 | CREB3 | Homo sapiens | O43889 | 20195357 | |
|
Intra
|
JUN | P05412 | CREB3 | Homo sapiens | O43889 | 20195357 | |
|
Intra
|
JUN | P05412 | NFATC1 | Homo sapiens | O95644 | 25609649 | |
|
Intra
|
JUN | P05412 | NFATC1 | Homo sapiens | O95644 | 25609649 | |
|
Intra
|
JUN | P05412 | NFATC1 | Homo sapiens | O95644 | 25609649 | |
|
Intra
|
JUN | P05412 | TUBB2A | Homo sapiens | Q13885 | 25609649 | |
|
Intra
|
JUN | P05412 | EIF2S2 | Homo sapiens | P20042 | 32814053 | |
|
Intra
|
JUN | P05412 | EIF2S2 | Homo sapiens | P20042 | 25609649 | |
|
Intra
|
JUN | P05412 | EIF2S2 | Homo sapiens | P20042 | 32814053 | |
|
Intra
|
JUN | P05412 | EIF2S2 | Homo sapiens | P20042 | 32814053 | |
|
Intra
|
JUN | P05412 | ATF3 | Homo sapiens | P18847 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF3 | Homo sapiens | P18847 | 23661758 | |
|
Intra
|
JUN | P05412 | ATF3 | Homo sapiens | P18847 | 10327051 | |
|
Intra
|
JUN | P05412 | ATF3 | Homo sapiens | P18847 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF3 | Homo sapiens | P18847 | 20102225 | |
|
Intra
|
JUN | P05412 | ATF3 | Homo sapiens | P18847 | 35271311 | |
|
Intra
|
JUN | P05412 | MAPK10 | Homo sapiens | P53779 | 21988832 | |
|
Intra
|
JUN | P05412 | CRCT1 | Homo sapiens | Q9UGL9 | 32814053 | |
|
Intra
|
JUN | P05412 | CRCT1 | Homo sapiens | Q9UGL9 | 32814053 | |
|
Intra
|
JUN | P05412 | CRCT1 | Homo sapiens | Q9UGL9 | 32814053 | |
|
Intra
|
JUN | P05412 | MTA1 | Homo sapiens | Q13330 | 25609649 | |
|
Intra
|
JUN | P05412 | STRN4 | Homo sapiens | Q9NRL3 | 20195357 | |
|
Intra
|
JUN | P05412 | STRN4 | Homo sapiens | Q9NRL3 | 20195357 | |
|
Intra
|
JUN | P05412 | BATF2 | Homo sapiens | Q8N1L9 | 23661758 | |
|
Intra
|
JUN | P05412 | FOSL1 | Homo sapiens | P15407 | 23661758 | |
|
Intra
|
JUN | P05412 | FOSL1 | Homo sapiens | P15407 | 20511396 | |
|
Intra
|
JUN | P05412 | FOSL1 | Homo sapiens | P15407 | 24029232 | |
|
Intra
|
JUN | P05412 | BATF | Homo sapiens | Q16520 | 23661758 | |
|
Intra
|
JUN | P05412 | BATF | Homo sapiens | Q16520 | 20102225 | |
|
Intra
|
JUN | P05412 | TCL1A | Homo sapiens | P56279 | 19064921 | |
|
Intra
|
JUN | P05412 | TCL1A | Homo sapiens | P56279 | 19064921 | |
|
Intra
|
JUN | P05412 | ATF7 | Homo sapiens | P17544 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF7 | Homo sapiens | P17544 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF7 | Homo sapiens | P17544 | 20102225 | |
|
Intra
|
JUN | P05412 | ATF7 | Homo sapiens | P17544 | 35271311 | |
|
Intra
|
JUN | P05412 | APP | Homo sapiens | P05067 | 20195357 | |
|
Intra
|
JUN | P05412 | SCARB1 | Homo sapiens | Q8WTV0 | 32814053 | |
|
Intra
|
JUN | P05412 | SCARB1 | Homo sapiens | Q8WTV0 | 32814053 | |
|
Intra
|
JUN | P05412 | SCARB1 | Homo sapiens | Q8WTV0 | 32814053 | |
|
Intra
|
JUN | P05412 | APLP2 | Homo sapiens | Q06481 | 20195357 | |
|
Intra
|
JUN | P05412 | APLP2 | Homo sapiens | Q06481 | 20936779 | |
|
Intra
|
JUN | P05412 | ATF1 | Homo sapiens | P18846 | 25609649 | |
|
Intra
|
JUN | P05412 | ATF1 | Homo sapiens | P18846 | 25609649 | |
|
Intra
|
JUN | P05412 | ETS1 | Homo sapiens | P14921 | 20195357 | |
|
Cross
|
JUN | P05412 | MDV005 | Gallid herpesvirus 2 | Q9DGW5 | 20102225 | |
|
Cross
|
JUN | P05412 | HBZ | Human T-cell leukemia virus 1 | P0C746 | 20102225 |
JUN Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80084 | c-Jun Antibody (YA503) | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
| HY-P80456 | Phospho-c-Jun(Ser63) Antibody (YA214) | WB, ICC/IF, IHC-P | Human |
| HY-P80800 | Phospho-c-Jun (Ser243) Antibody | WB, IHC-P | Human, Mouse, Rat |
| HY-P80801 | Phospho-c-Jun (Ser63) Antibody (YA215) | WB, IHC-P | Human, Mouse, Rat |
| HY-P80801A | Phospho-c-Jun (Ser63) Antibody (YA215)(PBS only) | WB, IHC-P | Human, Mouse, Rat |
| HY-P80802 | Phospho-c-Jun (Ser73) Antibody | WB, IHC-P | Human, Mouse, Rat |
| HY-P82861 | Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) | WB, IP | Human, Mouse, Rat |
| HY-P82861A | Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606)(PBS only) | WB, IP | Human, Mouse, Rat |
| HY-P83960 | c-Jun Antibody (YA3657) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Monkey |
| HY-P83960A | c-Jun Antibody (YA3657)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Monkey |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Fibrosarcoma |
|
|
| Pneumoconiosis |
|
|
| Eye Disease |
|
|
| Bone Cancer |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Hepatitis B |
|
|
| Hypertension, Essential |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Cockayne Syndrome |
|
|
| Teratocarcinoma |
|
|
| Dilated Cardiomyopathy |
|
|
| Sudden Infant Death Syndrome |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Endometrial Cancer |
|
|
| Breast Adenocarcinoma |
|
|
| Skin Papilloma |
|
|
| Peripheral Nervous System Disease |
|
|
| Vascular Disease |
|
|
| Monocytic Leukemia |
|
|
| Toxic Encephalopathy |
|
|
| Asthma |
|
|
| Pancreatic Cancer |
|
|
| Cardiomyopathy, Familial Hypertrophic, 25 |
|
|
| Colorectal Cancer |
|
|
| Glioblastoma |
|
|
| Hyperglycemia |
|
|
| Bernard-Soulier Syndrome |
|
|
| Cystitis |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Inflammatory Bowel Disease |
|
|
| Esophageal Adenosquamous Carcinoma |
|
|
| B-Cell Lymphoma |
|
|
| Rheumatoid Arthritis |
|
|
| Interstitial Lung Disease 2 |
|
|
| Erythroleukemia |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Ocular Hypertension |
|
|
| Combined Immunodeficiency |
|
|
| Esophageal Cancer |
|
|
| Retinitis Pigmentosa |
|
|
| Immune Deficiency Disease |
|
|
| Skin Disease |
|
|
| Colon Adenocarcinoma |
|
|
| Deafness, Autosomal Dominant 12 |
|
|
| Osteoporosis |
|
|
| Aortic Aneurysm, Familial Thoracic 1 |
|
|
| Status Epilepticus |
|
|
| Cranial Nerve Iii Tumor |
|
|
| Colonic Benign Neoplasm |
|
|
| Osteogenic Sarcoma |
|
|
| Skin Benign Neoplasm |
|
|
| Pyriform Sinus Cancer |
|
|
| Neuroblastoma |
|
|
| Skin Carcinoma |
|
|
| Anaplastic Large Cell Lymphoma |
|
|
| Cataract 7 |
|
|
| Optic Nerve Disease |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Cystic Fibrosis |
|
|
| Sarcoma |
|
|
| Severe Combined Immunodeficiency |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Kunjin Encephalitis |
|
|
| Hepatoblastoma |
|
|
| Hypereosinophilic Syndrome |
|
|
| Pediculus Humanus Corporis Infestation |
|
|
| Hepatocellular Carcinoma |
|
|
| Pheochromocytoma |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Melanoma |
|
|
| Spinocerebellar Ataxia 40 |
|
|
| Fleck Retina, Familial Benign |
|
|
| Respiratory Failure |
|
|
| Liposarcoma |
|
|
| Leukemia, Acute Myeloid |
|
|
| Febrile Seizures, Familial, 10 |
|
|
| Amelogenesis Imperfecta, Type Ig |
|
|
| Microphthalmia, Isolated 1 |
|
|
| Ataxia-Telangiectasia |
|
|
| Influenza |
|
|
| Gastric Cancer |
|
|
| Embryonal Carcinoma |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Amelogenesis Imperfecta |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Developmental And Epileptic Encephalopathy 34 |
|
|
| Basal Cell Carcinoma |
|
|
| Cutis Laxa |
|
|
| Retinoblastoma |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Lung Cancer |
|
|
| Breast Cancer |
|
|
| Benign Shuddering Attacks |
|
|
| Pertussis |
|
|
| Brain Edema |
|
|
| Nervous System Disease |
|
|
| Medulloblastoma |
|
|
| Febrile Seizures, Familial, 11 |
|
|
| Prostate Cancer |
|
|
| Ovarian Cancer |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Cholesteatoma Of Middle Ear |
|
|
| Early Yaws |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | JUN | MGD | MGI:96646 |
| Bos taurus | JUN | VGNC | VGNC:30386 |
| Canis familiaris | JUN | VGNC | VGNC:42197 |
| Macaca mulatta | JUN | VGNC | VGNC:106394 |
| Rattus norvegicus | JUN | RGD | RGD:2943 |
| Felis catus | JUN | VGNC | VGNC:67881 |
| Others | JUN | NCBI |