2. MAPK/ERK Pathway NF-κB Immunology/Inflammation Apoptosis
  3. JNK NF-κB Interleukin Related TNF Receptor
  4. Ceramide 3

Ceramide 3  (Synonyms: N-Stearoyl phytosphingosine)

Cat. No.: HY-141582 Purity: 98.0%
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Handling Instructions Technical Support

Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin.

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Ceramide 3

Ceramide 3 Chemical Structure

CAS No. : 34354-88-6

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Based on 1 publication(s) in Google Scholar

Other Forms of Ceramide 3:

Ceramide 3 Related Antibodies

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Description

Ceramide 3 (N-Stearoyl phytosphingosine) is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin[1][2][3].

In Vivo

Ceramide 3 (20-50 mg/kg; p.o.; single administration) dose-dependently inhibits histamine-induced pruritus and skin inflammation in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 5 weeks old, 20-22 g)[1]
Dosage: 20 mg/kg; 50 mg/kg
Administration: p.o.; single dose 1 hour prior to histamine challenge
Result: Reduced histamine-induced scratching behavior frequency (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Inhibited histamine-induced IL-4 protein expression (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Inhibited histamine-induced TNF-α protein expression (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Reduced histamine-induced vascular permeability (statistically significant vs.
histamine-treated group) at 20 mg/kg.
Reduced histamine-induced skin inflammation (epidermal hyperplasia and inflammatory cell infiltration) at 20 mg/kg.
Reduced histamine-induced scratching behavior frequency by 67% at 50 mg/kg.
Inhibited histamine-induced IL-4 protein expression by 75% at 50 mg/kg.
Inhibited histamine-induced TNF-α protein expression by 88% at 50 mg/kg.
Reduced histamine-induced vascular permeability by 51% at 50 mg/kg.
Reduced histamine-induced skin inflammation (epidermal hyperplasia and inflammatory cell infiltration) at 50 mg/kg.
Inhibited histamine-induced activation of transcription factors NF-κB (phospho-p65) and c-jun (phospho-c-jun) at both 20 mg/kg and 50 mg/kg.
Molecular Weight

583.97

Formula

C36H73NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(CCCCCCCCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Methanol : 1 mg/mL (1.71 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7124 mL 8.5621 mL 17.1242 mL
5 mM --- --- ---
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* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 98.0%

SDS (254 KB)

COA (238 KB) HNMR (117 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 1.7124 mL 8.5621 mL 17.1242 mL 42.8104 mL
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Ceramide 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceramide 334354-88-6N-Stearoyl phytosphingosineCeramide3Ceramide-3JNKNF-κBInterleukin RelatedTNF Receptorc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRc-junskin barrier dysfunctionsodium lauryl sulfate-irritated skinguinea pig ileumTNF-αIL-4pruritusmicehistamineInhibitorinhibitorinhibit

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