Palladium(Ⅱ) acetylacetonate
Based on 1 Customer Validation
Palladium(II) acetylacetonate is a metal-organic complex. Palladium(II) acetylacetonate upregulates the expression of GRP78, ATF-4, XBP-1, CHOP, and phosphorylated c-Jun. Palladium(II) acetylacetonate induces Apoptosis. Palladium(II) acetylacetonate has anticancer effects against non-small cell lung cancer, gastric cancer, leukemia, and cervical cancer.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 14024-61-4
- Formula: C10H14O4Pd
- Molecular Weight:304.62
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Grp78 |
Palladium(Ⅱ) acetylacetonate (72 h) shows stronger cytotoxicity than Cisplatin (HY-17394) in H460, BGC-823, HL-60, and Hela cells (IC50 values in H460 cells: 4.56 μM (Palladium(Ⅱ) acetylacetonate) vs. 10.17 μM (Cisplatin))[2].
Palladium(Ⅱ) acetylacetonate (5-20 μM; 16 h) induces apoptosis in H460 cells in a dose-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H460
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:16 h
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Result:Increased the percentage of apoptotic cells from 21% to 64.6%.
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Cell Line:H460
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:3 h, 6 h, 12 h, 24 h
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Result:Up-regulated the expression levels of GRP78, ATF-4, XBP-1, CHOP, and phosphorylated c-Jun.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic BALB/cA nu/nu female mice (18-24g, 6-week-old) bearing H460 tumor xenografts[2]
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Dosage:1 mg/kg, 2 mg/kg
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Administration:Intraperitoneal injection, every 2 days, for 16 days
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Result:Dose-dependently reduced the tumor volume and weight compared with the vehicle control group.
Displayed better antitumor activity than Cisplatin at 2 mg/kg.
Showed no significant difference in body weight change between the vehicle group and the Pd(acac)₂-treated groups.
Chemical Information
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CAS No. 14024-61-4
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Appearance Solid
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Molecular Weight 304.62
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Formula C10H14O4Pd
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Color Light yellow to yellow
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SMILES
CC(/C=C([O-])/C)=O.[Pd+2].[2]
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Synonyms
Palladium(Ⅱ) 2,4-pentanedionate; Pd(acac)2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 2 mg/mL (6.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Handling Instructions (2659 KB)
References
[2]. Wang Y, et al. An oxygen-chelate complex, palladium bis-acetylacetonate, induces apoptosis in H460 cells via endoplasmic reticulum stress pathway rather than interacting with DNA. J Med Chem. 2013 Dec 12;56(23):9601-11. [Content Brief]
[3]. Özkar S, et al. Palladium(0) Nanoparticle Formation, Stabilization, and Mechanistic Studies: Pd(acac)₂ as a Preferred Precursor, [Bu₄N]₂HPO₄ Stabilizer, plus the Stoichiometry, Kinetics, and Minimal, Four-Step Mechanism of the Palladium Nanoparticle Formation and Subsequent Agglomeration Reactions. Langmuir. 2016 Apr 19;32(15):3699-716. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2828 mL | 16.4139 mL | 32.8278 mL | 82.0695 mL |
| 5 mM | 0.6566 mL | 3.2828 mL | 6.5656 mL | 16.4139 mL |
Palladium(Ⅱ) acetylacetonate Related Classifications
HY-W020952 Related Classifications
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