ATF7 - activating transcription factor 7 Gene

Also Known as ATFA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11016

About ATF7

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,507,856-53,626,382 (from NCBI)

This gene has 12 transcripts (splice variants), 280 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 9.8), fat (RPKM 9.2) and 25 other tissues.

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of colorectal Cancer. [provided by Alliance of Genome Resources, Apr 2022]

ATF7 Products (10)

mRNA Protein Name
NM_001130060.2 NP_001123532.1 cyclic AMP-dependent transcription factor ATF-7 isoform 3
NM_001206682.2 NP_001193611.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4
NM_001206683.1 NP_001193612.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4
NM_001366555.2 NP_001353484.1 cyclic AMP-dependent transcription factor ATF-7 isoform 5
NM_001366556.2 NP_001353485.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2
NM_001366558.2 NP_001353487.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2
NM_001366561.2 NP_001353490.1 cyclic AMP-dependent transcription factor ATF-7 isoform 8
NM_001366562.2 NP_001353491.1 cyclic AMP-dependent transcription factor ATF-7 isoform 4
NM_001366563.2 NP_001353492.1 cyclic AMP-dependent transcription factor ATF-7 isoform 9
NM_006856.3 NP_006847.1 cyclic AMP-dependent transcription factor ATF-7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8288576 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8288576 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables mitogen-activated protein kinase binding IDA
IDA: Inferred from direct assay
10376527 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10376527 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
17264123 GOA
enables transcription coactivator binding IDA
IDA: Inferred from direct assay
17264123 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8288576 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17264123 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8288576 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IPI
IPI: Inferred from physical interaction
20102225 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
17264123 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATF7 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (343 - 402)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-7

  • transcription factor ATF-A

ATF7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATF7 P17544 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
ATF7 P17544 BACH1 Homo sapiens O14867
Peptide Array
20102225
Intra
ATF7 P17544 JUND Homo sapiens P17535
Peptide Array
20102225
Intra
ATF7 P17544 OCIAD1 Homo sapiens Q9NX40
Display Tech
20195357
Intra
ATF7 P17544 FOSL2 Homo sapiens P15408
Peptide Array
20102225
Intra
ATF7 P17544 ATF3 Homo sapiens P18847
Peptide Array
20102225
Intra
ATF7 P17544 CEBPG Homo sapiens P53567
Peptide Array
20102225
Intra
ATF7 P17544 DDIT3 Homo sapiens P35638
Peptide Array
20102225
Intra
ATF7 P17544 JUNB Homo sapiens P17275
Peptide Array
20102225
Intra
ATF7 P17544 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra
ATF7 P17544 JUN Homo sapiens P05412
Peptide Array
20102225
Intra
ATF7 P17544 FOS Homo sapiens P01100
Peptide Array
20102225
Intra
ATF7 P17544 TMEM239 Homo sapiens Q8WW34
Validated Y2H
25416956
Intra
ATF7 P17544 TMEM239 Homo sapiens Q8WW34
Y2H Array
25416956
Cross
ATF7 P17544 MDV005 Gallid herpesvirus 2 Q9DGW5
Peptide Array
20102225
Cross
ATF7 P17544 HBZ Human T-cell leukemia virus 1 P0C746
Peptide Array
20102225
Cross: Cross-species interaction Intra: Intraspecies interaction

ATF7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811029 ATF7 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82906 ATF7 Antibody (YA2651) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Penicilliosis
Tinea Favosa

  • Favus
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19118 Atf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01136 ATF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01137 ATF7IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20138 Atf7ip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22108 Atf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26641 Atf7ip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28630 Atf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATF7 MGD MGI:2443472
Rattus norvegicus ATF7 RGD RGD:1304940
Others ATF7 NCBI