KASH5 - KASH domain containing 5 Gene

Also Known as CCDC155

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147872

About KASH5

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,388,249-49,417,990 (from NCBI)

This gene has 15 transcripts (splice variants), 91 orthologues and 30 paralogues. Restricted expression toward testis (RPKM 13.2).

Summary

Predicted to enable dynein complex binding activity. Predicted to be involved in several processes, including Cytoskeleton organization; homologous chromosome segregation; and spindle localization. Predicted to act upstream of or within double-strand break repair via homologous recombination; oogenesis; and spermatogenesis. Predicted to be integral component of membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in chromosome; meiotic spindle pole; and nuclear outer membrane. [provided by Alliance of Genome Resources, Apr 2022]

KASH5 Products (1)

mRNA Protein Name
NM_144688.5 NP_653289.3 protein KASH5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KASH5 Protein Structure

EF-hand_9

EF-hand_9: EF-hand domain (38 - 105)

KASH_CCD

KASH_CCD: Coiled-coil region of CCDC155 or KASH (157 - 349)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 562 a.a.
Protein Preferred Names Protein Names

protein KASH5

  • KASH domain-containing protein 5

KASH5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KASH5 Q8N6L0 ADIPOQ Homo sapiens A8K660
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 ADIPOQ Homo sapiens A8K660
Y2H Array
25416956
Intra
KASH5 Q8N6L0 b2r9h7_human Homo sapiens B2R9H7
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 GPR25 Homo sapiens O00155
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 GPR25 Homo sapiens O00155
Y2H Array
25416956
Intra
KASH5 Q8N6L0 UPK2 Homo sapiens O00526
Y2H Array
25416956
Intra
KASH5 Q8N6L0 SLN Homo sapiens O00631
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 SLN Homo sapiens O00631
Y2H Array
25416956
Intra
KASH5 Q8N6L0 SLN Homo sapiens O00631
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 VAMP4 Homo sapiens O75379-2
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 FTCD Homo sapiens O95954
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 VAMP1 Homo sapiens P23763
Y2H Array
25416956
Intra
KASH5 Q8N6L0 CRABP2 Homo sapiens P29373
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 CRABP2 Homo sapiens P29373
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 CLDN8 Homo sapiens P56748
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 CLDN8 Homo sapiens P56748
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 CLDN8 Homo sapiens P56748
Y2H Array
25416956
Intra
KASH5 Q8N6L0 GALNT2 Homo sapiens Q10471
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 GALNT2 Homo sapiens Q10471
Y2H Array
25416956
Intra
KASH5 Q8N6L0 GALNT2 Homo sapiens Q10471
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 BET1 Homo sapiens Q53XK0
Y2H Array
25416956
Intra
KASH5 Q8N6L0 RTP2 Homo sapiens Q5QGT7
Y2H Array
25416956
Intra
KASH5 Q8N6L0 RTP2 Homo sapiens Q5QGT7
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 RIPPLY2 Homo sapiens Q5TAB7
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 RSRC2 Homo sapiens Q7L4I2-2
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 TMEM199 Homo sapiens Q8N511
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TMEM199 Homo sapiens Q8N511
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 TMEM41A Homo sapiens Q96HV5
Y2H Array
25416956
Intra
KASH5 Q8N6L0 SLC41A2 Homo sapiens Q96JW4
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 CIB3 Homo sapiens Q96Q77
Y2H Array
25416956
Intra
KASH5 Q8N6L0 ABHD1 Homo sapiens Q96SE0
Y2H Array
25416956
Intra
KASH5 Q8N6L0 NRIP3 Homo sapiens Q9NQ35
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 NRIP3 Homo sapiens Q9NQ35
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 NRIP3 Homo sapiens Q9NQ35
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TMPRSS4 Homo sapiens Q9NRS4-3
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TMPRSS4 Homo sapiens Q9NRS4
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TMPRSS4 Homo sapiens Q9NRS4
Y2H Array
25416956
Intra
KASH5 Q8N6L0 MARCHF2 Homo sapiens Q9P0N8
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 LARP1 Homo sapiens Q6PKG0
Y2H Array
25416956
Intra
KASH5 Q8N6L0 LARP1 Homo sapiens Q6PKG0
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 LARP1 Homo sapiens Q6PKG0
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 PIGU Homo sapiens Q9H490
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 RNF146 Homo sapiens Q9NTX7-2
Validated Y2H
27107012
Intra
KASH5 Q8N6L0 RNF146 Homo sapiens Q9NTX7-2
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 NRAC Homo sapiens Q8N912
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 PGAP2 Homo sapiens Q9UHJ9-5
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 SLC5A4 Homo sapiens Q9NY91
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 GPATCH4 Homo sapiens Q5T3I0
Y2H Array
25416956
Intra
KASH5 Q8N6L0 GPATCH4 Homo sapiens Q5T3I0
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 PPP1R18 Homo sapiens Q6NYC8
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 OLFM4 Homo sapiens Q6UX06
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 OLFM4 Homo sapiens Q6UX06
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 MS4A1 Homo sapiens P11836
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 MS4A1 Homo sapiens P11836
Y2H Array
25416956
Intra
KASH5 Q8N6L0 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 PDGFRA Homo sapiens P16234
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 ITM2B Homo sapiens Q9Y287
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 ITM2B Homo sapiens Q9Y287
Y2H Array
25416956
Intra
KASH5 Q8N6L0 STBD1 Homo sapiens O95210
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 STBD1 Homo sapiens O95210
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 FIS1 Homo sapiens Q9Y3D6
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 SGTA Homo sapiens O43765
Validated Y2H
27107012
Intra
KASH5 Q8N6L0 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 BAG5 Homo sapiens Q9UL15
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 BAG5 Homo sapiens Q9UL15
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 BAG5 Homo sapiens Q9UL15
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 CXCL9 Homo sapiens Q07325
Y2H Array
25416956
Intra
KASH5 Q8N6L0 CDKL3 Homo sapiens Q8IVW4
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 CDKL3 Homo sapiens Q8IVW4
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 MFSD5 Homo sapiens Q6N075
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 MFSD5 Homo sapiens Q6N075
Y2H Array
25416956
Intra
KASH5 Q8N6L0 DERL1 Homo sapiens Q9BUN8
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 GOSR2 Homo sapiens O14653
Y2H Array
25416956
Intra
KASH5 Q8N6L0 EMD Homo sapiens P50402
Validated Y2H
27107012
Intra
KASH5 Q8N6L0 PLP2 Homo sapiens Q04941
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 PLP2 Homo sapiens Q04941
Y2H Array
25416956
Intra
KASH5 Q8N6L0 GIMAP5 Homo sapiens Q96F15
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 NSG1 Homo sapiens P42857
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 NSG1 Homo sapiens P42857
Y2H Array
25416956
Intra
KASH5 Q8N6L0 FAM90A1 Homo sapiens Q86YD7
Y2H Array
25416956
Intra
KASH5 Q8N6L0 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 BCL2L2 Homo sapiens Q92843
Validated Y2H
27107012
Intra
KASH5 Q8N6L0 BCL2L2 Homo sapiens Q92843
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 BCL2L2 Homo sapiens Q92843
Y2H Array
25416956
Intra
KASH5 Q8N6L0 BCL2L2 Homo sapiens Q92843
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 FRA10AC1 Homo sapiens Q70Z53
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 FRA10AC1 Homo sapiens Q70Z53
Y2H Array
25416956
Intra
KASH5 Q8N6L0 STX5 Homo sapiens Q13190
Y2H Array
25416956
Intra
KASH5 Q8N6L0 STX5 Homo sapiens Q13190
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 SENP2 Homo sapiens Q9HC62
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 FAM161A Homo sapiens Q3B820
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
Intra
KASH5 Q8N6L0 GABARAPL2 Homo sapiens P60520
Y2H Array
25416956
Intra
KASH5 Q8N6L0 GABARAPL2 Homo sapiens P60520
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 RNF146 Homo sapiens Q9NTX7
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 RNF146 Homo sapiens Q9NTX7
Y2H Array
25416956
Intra
KASH5 Q8N6L0 VTI1B Homo sapiens Q9UEU0
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 TMEM11 Homo sapiens P17152
Validated Y2H
27107012
Intra
KASH5 Q8N6L0 LENG1 Homo sapiens Q96BZ8
Y2H Array
25416956
Intra
KASH5 Q8N6L0 LENG1 Homo sapiens Q96BZ8
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 MTX2 Homo sapiens O75431
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 MTX2 Homo sapiens O75431
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra
KASH5 Q8N6L0 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 VAMP4 Homo sapiens O75379
Y2H Array
25416956
Intra
KASH5 Q8N6L0 VAMP4 Homo sapiens O75379
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 TCF25 Homo sapiens Q9BQ70
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 SERP2 Homo sapiens Q8N6R1
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 SERP2 Homo sapiens Q8N6R1
Y2H Array
25416956
Intra
KASH5 Q8N6L0 SERP2 Homo sapiens Q8N6R1
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 MALL Homo sapiens Q13021
Y2H Array
25416956
Intra
KASH5 Q8N6L0 ATF7 Homo sapiens P17544
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 ATF7 Homo sapiens P17544
Y2H Array
25416956
Intra
KASH5 Q8N6L0 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 TRAF3IP3 Homo sapiens Q9Y228
Y2H Array
25416956
Intra
KASH5 Q8N6L0 TRAF3IP3 Homo sapiens Q9Y228
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 DNAJC30 Homo sapiens Q96LL9
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 SMCO4 Homo sapiens Q9NRQ5
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
KASH5 Q8N6L0 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TSHZ3 Homo sapiens Q63HK5
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 TSHZ3 Homo sapiens Q63HK5
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 TSHZ3 Homo sapiens Q63HK5
Y2H Array
25416956
Intra
KASH5 Q8N6L0 CDC73 Homo sapiens Q6P1J9
Y2H Array
25416956
Intra
KASH5 Q8N6L0 MMP14 Homo sapiens P50281
Y2H Prey Pooling
25416956
Intra
KASH5 Q8N6L0 MMP14 Homo sapiens P50281
Validated Y2H
25416956
Intra
KASH5 Q8N6L0 MMP14 Homo sapiens P50281
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Genetic Non-Acquired Premature Ovarian Failure
Muscular Dystrophy, Congenital, Lmna-Related

  • Congenital Muscular Dystrophy

  • Congenital Muscular Dystrophy Due To Lmna Mutation

  • MDCL

  • L-Cmd

  • Lmna-Related Congenital Muscular Dystrophy

  • Muscular Dystrophy, Congenital

  • Congenital Muscular Dystrophy Lmna-Related

  • Lmna-Related Cmd

  • Cmd

  • Mdc

  • Muscular Dystrophy Congenital Lmna-Related

  • Dystrophy, Muscular, Congenital, Lmna-Related

  • Dystrophy, Muscular, Congenital

  • Hereditary Muscular Dystrophy

  • Congenital Hereditary Muscular Dystrophy

  • Congenital Progressive Muscular Dystrophy

  • Hereditary Progressive Muscular Dystrophy
Emery-Dreifuss Muscular Dystrophy

  • Edmd

  • Emery-Dreifuss Syndrome

  • Muscular Dystrophy, Emery-Dreifuss

  • Humeroperoneal Neuromuscular Disease

  • Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures

  • Scapuloperoneal Syndrome, X-Linked

  • Benign Scapuloperoneal Muscular Dystrophy With Early Contractures

  • Muscular Dystrophy, Emery-Dreifuss Type

  • Muscular Dystrophy Emery-Dreifuss

  • Dystrophy, Muscular, Emery-Dreifuss

  • Emd - [Emery-Dreifuss Muscular Dystrophy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07072 KASH5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KASH5 VGNC VGNC:38805
Mus musculus KASH5 MGD MGI:2687329
Bos taurus KASH5 VGNC VGNC:26860
Rattus norvegicus KASH5 RGD RGD:1561972
Macaca mulatta KASH5 VGNC VGNC:70871
Felis catus KASH5 VGNC VGNC:60471
Others KASH5 NCBI