VTI1B - vesicle transport through interaction with t-SNAREs 1B Gene

Also Known as VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10490

About VTI1B

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:67,647,085-67,674,632 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 68.1), kidney (RPKM 45.6) and 25 other tissues.

Summary

Enables SNARE binding activity and Chloride Channel Inhibitor activity. Involved in regulation of protein localization to plasma membrane. Located in several cellular components, including endosome membrane; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

VTI1B Products (1)

mRNA Protein Name
NM_006370.3 NP_006361.1 vesicle transport through interaction with t-SNAREs homolog 1B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
24550300 GOA
enables chloride channel inhibitor activity IDA
IDA: Inferred from direct assay
18570918 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
23217709 GOA
involved in regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
18570918 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19224922 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
18033301 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
18033301 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
18033301 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18570918 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
18570918 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
18033301 GOA
located in vesicle IDA
IDA: Inferred from direct assay
18570918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VTI1B Protein Structure

V-SNARE

V-SNARE: Vesicle transport v-SNARE protein N-terminus (18 - 96)

V-SNARE_C

V-SNARE_C: Snare region anchored in the vesicle membrane C-terminus (137 - 202)

  • 0
  • 100
  • 200
  • 232 a.a.
Protein Preferred Names Protein Names

vesicle transport through interaction with t-SNAREs homolog 1B

  • vesicle transport v-SNARE protein Vti1-like 1

VTI1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VTI1B Q9UEU0 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra
VTI1B Q9UEU0 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 LDLRAD1 Homo sapiens Q5T700
Y2H Array
31515488
Intra
VTI1B Q9UEU0 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
25416956
Intra
VTI1B Q9UEU0 LDLRAD1 Homo sapiens Q5T700
Y2H Array
25416956
Intra
VTI1B Q9UEU0 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
VTI1B Q9UEU0 TRIM59 Homo sapiens Q8IWR1
Y2H Array
25416956
Intra
VTI1B Q9UEU0 TRIM59 Homo sapiens Q8IWR1
Y2H Array
32296183
Intra
VTI1B Q9UEU0 TRIM59 Homo sapiens Q8IWR1
Y2H Prey Pooling
25416956
Intra
VTI1B Q9UEU0 TRIM59 Homo sapiens Q8IWR1
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 TRIM59 Homo sapiens Q8IWR1
Y2H Array
31515488
Intra
VTI1B Q9UEU0 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
VTI1B Q9UEU0 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
VTI1B Q9UEU0 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
VTI1B Q9UEU0 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 PTPN5 Homo sapiens P54829
Y2H Array
25416956
Intra
VTI1B Q9UEU0 PTPN5 Homo sapiens P54829
Y2H Prey Pooling
25416956
Intra
VTI1B Q9UEU0 PTPN5 Homo sapiens P54829
Validated Y2H
25416956
Intra
VTI1B Q9UEU0 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
VTI1B Q9UEU0 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 CD46 Homo sapiens P15529-3
Y2H Array
32296183
Intra
VTI1B Q9UEU0 CD46 Homo sapiens P15529-3
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
VTI1B Q9UEU0 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra
VTI1B Q9UEU0 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
VTI1B Q9UEU0 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra
VTI1B Q9UEU0 FCGR1A Homo sapiens P12314
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 FCGR1A Homo sapiens P12314
Y2H Array
32296183
Intra
VTI1B Q9UEU0 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra
VTI1B Q9UEU0 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra
VTI1B Q9UEU0 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
VTI1B Q9UEU0 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
VTI1B Q9UEU0 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 STX8 Homo sapiens Q9UNK0
Y2H Array
32296183
Intra
VTI1B Q9UEU0 STX8 Homo sapiens Q9UNK0
Anti Tag CoIP
33961781
Intra
VTI1B Q9UEU0 STX8 Homo sapiens Q9UNK0
Anti Tag CoIP
28514442
Intra
VTI1B Q9UEU0 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra
VTI1B Q9UEU0 STX8 Homo sapiens Q9UNK0
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 STX8 Homo sapiens Q9UNK0
Anti Tag CoIP
35271311
Intra
VTI1B Q9UEU0 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 STX4 Homo sapiens Q12846
Y2H Array
25416956
Intra
VTI1B Q9UEU0 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
VTI1B Q9UEU0 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
VTI1B Q9UEU0 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
VTI1B Q9UEU0 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
VTI1B Q9UEU0 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
VTI1B Q9UEU0 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
VTI1B Q9UEU0 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
VTI1B Q9UEU0 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 TMEM234 Homo sapiens Q8WY98
Y2H Prey Pooling
32296183
Intra
VTI1B Q9UEU0 TMEM234 Homo sapiens Q8WY98
Y2H Array
32296183
Intra
VTI1B Q9UEU0 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Intra
VTI1B Q9UEU0 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

VTI1B Antibodies

Cat. No. Product Name Application Reactivity
HY-P87146 VTI1B Antibody (YA6839) WB, ICC/IF, IHC-P, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Hemophagocytic Lymphohistiocytosis, Familial, 4

  • Familial Hemophagocytic Lymphohistiocytosis 4

  • FHL4

  • Hplh4

  • Hlh4

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Tetanus

  • Lockjaw

  • Clostridial Tetanus

  • Infection Due To Clostridium Tetani

  • Lock-Jaw
Hermansky-Pudlak Syndrome

  • Hps

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • Hermanski-Pudlak Syndrome

  • Hermansky Pudlak Syndrome

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15723 VTI1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VTI1B MGD MGI:1855688
Macaca mulatta VTI1B VGNC VGNC:99341
Rattus norvegicus VTI1B RGD RGD:2323682
Felis catus VTI1B VGNC VGNC:80781
Bos taurus VTI1B VGNC VGNC:36849
Canis familiaris VTI1B VGNC VGNC:48317
Others VTI1B NCBI