STX1A - syntaxin 1A Gene
Also Known as STX1; HPC-1; P35-1; SYN1A
Species: Homo sapiens
About STX1A
This gene has 14 transcripts (splice variants), 199 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 28.2), bone marrow (RPKM 2.7) and 3 other tissues.
Summary
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
STX1A Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001165903.2 | NP_001159375.1 | syntaxin-1A isoform 2 |
| NM_004603.4 | NP_004594.1 | syntaxin-1A isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables chloride channel inhibitor activity |
IDA
IDA: Inferred from direct assay
|
18570918 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
24722188 | GOA |
| enables kinase binding |
IPI
IPI: Inferred from physical interaction
|
12730201 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10321247 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in protein sumoylation |
IDA
IDA: Inferred from direct assay
|
26635000 | GOA |
| involved in secretion by cell |
IDA
IDA: Inferred from direct assay
|
12130530 | GOA |
| involved in synaptic vesicle endocytosis |
IDA
IDA: Inferred from direct assay
|
26635000 | GOA |
| involved in synaptic vesicle exocytosis |
IDA
IDA: Inferred from direct assay
|
26635000 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of SNARE complex |
IDA
IDA: Inferred from direct assay
|
12730201 | GOA |
| located in neuron projection |
IDA
IDA: Inferred from direct assay
|
12115694 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
12730201 | GOA |
STX1A Protein Structure
Syntaxin: Syntaxin (29 - 131)
SNARE: SNARE domain (198 - 259)
- 0
- 100
- 200
- 288 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
syntaxin-1A |
|
STX1A Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
STX1A | Q16623 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
STX1A | Q16623 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
STX1A | Q16623 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TSGA10IP | Homo sapiens | Q3SY00 | 32296183 | |
|
Intra
|
STX1A | Q16623 | RTP2 | Homo sapiens | Q5QGT7 | 32296183 | |
|
Intra
|
STX1A | Q16623 | SNAP47 | Homo sapiens | Q5SQN1 | 32296183 | |
|
Intra
|
STX1A | Q16623 | NRM | Homo sapiens | Q8IXM6 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM199 | Homo sapiens | Q8N511 | 32296183 | |
|
Intra
|
STX1A | Q16623 | JAGN1 | Homo sapiens | Q8N5M9 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM41A | Homo sapiens | Q96HV5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | NINJ2 | Homo sapiens | Q9NZG7 | 32296183 | |
|
Intra
|
STX1A | Q16623 | SERP1 | Homo sapiens | Q9Y6X1 | 32296183 | |
|
Intra
|
STX1A | Q16623 | PLPP4 | Homo sapiens | Q5VZY2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | CYB5B | Homo sapiens | O43169 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM128 | Homo sapiens | Q5BJH2-2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF557 | Homo sapiens | Q8N988-2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF479 | Homo sapiens | Q96JC4 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF490 | Homo sapiens | Q9ULM2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF696 | Homo sapiens | Q9H7X3 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
STX1A | Q16623 | AGTRAP | Homo sapiens | Q6RW13-2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | PLPP6 | Homo sapiens | Q8IY26 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TCEANC | Homo sapiens | Q8N8B7-2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM254 | Homo sapiens | Q8TBM7 | 32296183 | |
|
Intra
|
STX1A | Q16623 | AIG1 | Homo sapiens | Q9NVV5-2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | SNORC | Homo sapiens | Q6UX34 | 32296183 | |
|
Intra
|
STX1A | Q16623 | GIMAP1 | Homo sapiens | Q8WWP7 | 32296183 | |
|
Intra
|
STX1A | Q16623 | CLEC1A | Homo sapiens | Q8NC01 | 32296183 | |
|
Intra
|
STX1A | Q16623 | C4orf3 | Homo sapiens | Q8WVX3-2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | PGAP2 | Homo sapiens | Q9UHJ9-5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ANKRD46 | Homo sapiens | Q86W74-2 | 32296183 | |
|
Intra
|
STX1A | Q16623 | KIFC3 | Homo sapiens | Q9BVG8-5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF441 | Homo sapiens | Q8N8Z8 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM14C | Homo sapiens | Q9P0S9 | 32296183 | |
|
Intra
|
STX1A | Q16623 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
STX1A | Q16623 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
STX1A | Q16623 | STX12 | Homo sapiens | Q86Y82 | 32296183 | |
|
Intra
|
STX1A | Q16623 | RMDN2 | Homo sapiens | Q96LZ7 | 32296183 | |
|
Intra
|
STX1A | Q16623 | CMTM7 | Homo sapiens | Q96FZ5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | AQP3 | Homo sapiens | Q92482 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM60 | Homo sapiens | Q9H2L4 | 32296183 | |
|
Intra
|
STX1A | Q16623 | FAM3C | Homo sapiens | Q92520 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM222 | Homo sapiens | Q9H0R3 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TXLNA | Homo sapiens | P40222 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TXLNA | Homo sapiens | P40222 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TXLNA | Homo sapiens | P40222 | 24722188 | |
|
Intra
|
STX1A | Q16623 | NAPB | Homo sapiens | Q9H115 | 32296183 | |
|
Intra
|
STX1A | Q16623 | NAPB | Homo sapiens | Q9H115 | 24722188 | |
|
Intra
|
STX1A | Q16623 | NAPB | Homo sapiens | Q9H115 | 32296183 | |
|
Intra
|
STX1A | Q16623 | NAPB | Homo sapiens | Q9H115 | 32296183 | |
|
Intra
|
STX1A | Q16623 | AOC3 | Homo sapiens | Q16853 | 32296183 | |
|
Intra
|
STX1A | Q16623 | APOL2 | Homo sapiens | Q9BQE5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | VSTM4 | Homo sapiens | Q8IW00 | 32296183 | |
|
Intra
|
STX1A | Q16623 | GOSR2 | Homo sapiens | O14653 | 32296183 | |
|
Intra
|
STX1A | Q16623 | GOSR2 | Homo sapiens | O14653 | 32296183 | |
|
Intra
|
STX1A | Q16623 | BLOC1S6 | Homo sapiens | Q9UL45 | 32296183 | |
|
Intra
|
STX1A | Q16623 | SNAP25 | Homo sapiens | P60880 | 16169070 | |
|
Intra
|
STX1A | Q16623 | AARD | Homo sapiens | Q4LEZ3 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF835 | Homo sapiens | Q9Y2P0 | 32296183 | |
|
Intra
|
STX1A | Q16623 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
STX1A | Q16623 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
STX1A | Q16623 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
STX1A | Q16623 | CLN6 | Homo sapiens | Q9NWW5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | GIMAP5 | Homo sapiens | Q96F15 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ERG28 | Homo sapiens | Q9UKR5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | STX1A | Homo sapiens | Q16623 | 32296183 | |
|
Intra
|
STX1A | Q16623 | STX1A | Homo sapiens | Q16623 | 24722188 | |
|
Intra
|
STX1A | Q16623 | STX1A | Homo sapiens | Q16623 | 32296183 | |
|
Intra
|
STX1A | Q16623 | STX1A | Homo sapiens | Q16623 | 32296183 | |
|
Intra
|
STX1A | Q16623 | DDX49 | Homo sapiens | Q9Y6V7 | 32296183 | |
|
Intra
|
STX1A | Q16623 | VTI1B | Homo sapiens | Q9UEU0 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF440 | Homo sapiens | Q8IYI8 | 32296183 | |
|
Intra
|
STX1A | Q16623 | STX8 | Homo sapiens | Q9UNK0 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM120A | Homo sapiens | Q9BXJ8 | 32296183 | |
|
Intra
|
STX1A | Q16623 | SMIM3 | Homo sapiens | Q9BZL3 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ABI3 | Homo sapiens | Q9P2A4 | 32296183 | |
|
Intra
|
STX1A | Q16623 | USE1 | Homo sapiens | Q9NZ43 | 32296183 | |
|
Intra
|
STX1A | Q16623 | RAB3IL1 | Homo sapiens | Q8TBN0 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ZNF707 | Homo sapiens | Q96C28 | 32296183 | |
|
Intra
|
STX1A | Q16623 | SERP2 | Homo sapiens | Q8N6R1 | 32296183 | |
|
Intra
|
STX1A | Q16623 | ETNK2 | Homo sapiens | Q9NVF9 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TRAF3IP3 | Homo sapiens | Q9Y228 | 32296183 | |
|
Intra
|
STX1A | Q16623 | TMEM100 | Homo sapiens | Q9NV29 | 32296183 | |
|
Intra
|
STX1A | Q16623 | BTN2A2 | Homo sapiens | Q8WVV5 | 32296183 | |
|
Intra
|
STX1A | Q16623 | SEC22A | Homo sapiens | Q96IW7 | 32296183 | |
|
Intra
|
STX1A | Q16623 | EBAG9 | Homo sapiens | O00559 | 32296183 | |
|
Intra
|
STX1A | Q16623 | EBAG9 | Homo sapiens | O00559 | 32296183 |
STX1A Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82256 | Syntaxin 1A Antibody (YA2001) | WB, IP, FC | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Autism |
|
|
| Cystic Fibrosis |
|
|
| Williams-Beuren Syndrome |
|
|
| Acute Diarrhea |
|
|
| Foodborne Botulism |
|
|
| Dysentery |
|
|
| Campylobacteriosis |
|
|
| Pheochromocytoma |
|
|
| Shigellosis |
|
|
| Gastrointestinal Tularemia |
|
|
| 3-Methylcrotonyl-Coa Carboxylase 2 Deficiency |
|
|
| Supravalvular Aortic Stenosis |
|
|
| Autism Spectrum Disorder |
|
|
| Schizophrenia |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Early Infantile Epileptic Encephalopathy |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | STX1A | VGNC | VGNC:78043 |
| Felis catus | STX1A | VGNC | VGNC:65810 |
| Canis familiaris | STX1A | VGNC | VGNC:46954 |
| Bos taurus | STX1A | VGNC | VGNC:35436 |
| Rattus norvegicus | STX1A | RGD | RGD:69430 |
| Mus musculus | STX1A | MGD | MGI:109355 |
| Others | STX1A | NCBI |