STX1A - syntaxin 1A Gene

Also Known as STX1; HPC-1; P35-1; SYN1A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6804

About STX1A

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,699,210-73,719,669 (from NCBI)

This gene has 14 transcripts (splice variants), 199 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 28.2), bone marrow (RPKM 2.7) and 3 other tissues.

Summary

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

STX1A Products (2)

mRNA Protein Name
NM_001165903.2 NP_001159375.1 syntaxin-1A isoform 2
NM_004603.4 NP_004594.1 syntaxin-1A isoform 1
Molecular Function GO Annotation Evidence References Source
enables chloride channel inhibitor activity IDA
IDA: Inferred from direct assay
18570918 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
24722188 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
12730201 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10321247 GOA
Biological Process GO Annotation Evidence References Source
involved in protein sumoylation IDA
IDA: Inferred from direct assay
26635000 GOA
involved in secretion by cell IDA
IDA: Inferred from direct assay
12130530 GOA
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
26635000 GOA
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
26635000 GOA
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
12730201 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
12115694 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12730201 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX1A Protein Structure

Syntaxin

Syntaxin: Syntaxin (29 - 131)

SNARE

SNARE: SNARE domain (198 - 259)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

syntaxin-1A

  • neuron-specific antigen HPC-1

STX1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STX1A Q16623 UBE2I Homo sapiens Q7KZS0 32296183
Intra
STX1A Q16623 UBE2I Homo sapiens Q7KZS0 32296183
Intra
STX1A Q16623 UBE2I Homo sapiens Q7KZS0 32296183
Intra
STX1A Q16623 TSGA10IP Homo sapiens Q3SY00 32296183
Intra
STX1A Q16623 RTP2 Homo sapiens Q5QGT7 32296183
Intra
STX1A Q16623 SNAP47 Homo sapiens Q5SQN1 32296183
Intra
STX1A Q16623 NRM Homo sapiens Q8IXM6 32296183
Intra
STX1A Q16623 TMEM199 Homo sapiens Q8N511 32296183
Intra
STX1A Q16623 JAGN1 Homo sapiens Q8N5M9 32296183
Intra
STX1A Q16623 TMEM41A Homo sapiens Q96HV5 32296183
Intra
STX1A Q16623 NINJ2 Homo sapiens Q9NZG7 32296183
Intra
STX1A Q16623 SERP1 Homo sapiens Q9Y6X1 32296183
Intra
STX1A Q16623 PLPP4 Homo sapiens Q5VZY2 32296183
Intra
STX1A Q16623 CYB5B Homo sapiens O43169 32296183
Intra
STX1A Q16623 TMEM128 Homo sapiens Q5BJH2-2 32296183
Intra
STX1A Q16623 ZNF557 Homo sapiens Q8N988-2 32296183
Intra
STX1A Q16623 ZNF479 Homo sapiens Q96JC4 32296183
Intra
STX1A Q16623 ZNF490 Homo sapiens Q9ULM2 32296183
Intra
STX1A Q16623 ZNF696 Homo sapiens Q9H7X3 32296183
Intra
STX1A Q16623 ARL13B Homo sapiens Q3SXY8 32296183
Intra
STX1A Q16623 ARL13B Homo sapiens Q3SXY8 32296183
Intra
STX1A Q16623 ARL13B Homo sapiens Q3SXY8 32296183
Intra
STX1A Q16623 AGTRAP Homo sapiens Q6RW13-2 32296183
Intra
STX1A Q16623 PLPP6 Homo sapiens Q8IY26 32296183
Intra
STX1A Q16623 TCEANC Homo sapiens Q8N8B7-2 32296183
Intra
STX1A Q16623 TMEM254 Homo sapiens Q8TBM7 32296183
Intra
STX1A Q16623 AIG1 Homo sapiens Q9NVV5-2 32296183
Intra
STX1A Q16623 SNORC Homo sapiens Q6UX34 32296183
Intra
STX1A Q16623 GIMAP1 Homo sapiens Q8WWP7 32296183
Intra
STX1A Q16623 CLEC1A Homo sapiens Q8NC01 32296183
Intra
STX1A Q16623 C4orf3 Homo sapiens Q8WVX3-2 32296183
Intra
STX1A Q16623 PGAP2 Homo sapiens Q9UHJ9-5 32296183
Intra
STX1A Q16623 ANKRD46 Homo sapiens Q86W74-2 32296183
Intra
STX1A Q16623 KIFC3 Homo sapiens Q9BVG8-5 32296183
Intra
STX1A Q16623 ZNF441 Homo sapiens Q8N8Z8 32296183
Intra
STX1A Q16623 TMEM14C Homo sapiens Q9P0S9 32296183
Intra
STX1A Q16623 RNF4 Homo sapiens P78317 32296183
Intra
STX1A Q16623 RNF4 Homo sapiens P78317 32296183
Intra
STX1A Q16623 STX12 Homo sapiens Q86Y82 32296183
Intra
STX1A Q16623 RMDN2 Homo sapiens Q96LZ7 32296183
Intra
STX1A Q16623 CMTM7 Homo sapiens Q96FZ5 32296183
Intra
STX1A Q16623 AQP3 Homo sapiens Q92482 32296183
Intra
STX1A Q16623 TMEM60 Homo sapiens Q9H2L4 32296183
Intra
STX1A Q16623 FAM3C Homo sapiens Q92520 32296183
Intra
STX1A Q16623 TMEM222 Homo sapiens Q9H0R3 32296183
Intra
STX1A Q16623 TXLNA Homo sapiens P40222 32296183
Intra
STX1A Q16623 TXLNA Homo sapiens P40222 32296183
Intra
STX1A Q16623 TXLNA Homo sapiens P40222 24722188
Intra
STX1A Q16623 NAPB Homo sapiens Q9H115 32296183
Intra
STX1A Q16623 NAPB Homo sapiens Q9H115 24722188
Intra
STX1A Q16623 NAPB Homo sapiens Q9H115 32296183
Intra
STX1A Q16623 NAPB Homo sapiens Q9H115 32296183
Intra
STX1A Q16623 AOC3 Homo sapiens Q16853 32296183
Intra
STX1A Q16623 APOL2 Homo sapiens Q9BQE5 32296183
Intra
STX1A Q16623 VSTM4 Homo sapiens Q8IW00 32296183
Intra
STX1A Q16623 GOSR2 Homo sapiens O14653 32296183
Intra
STX1A Q16623 GOSR2 Homo sapiens O14653 32296183
Intra
STX1A Q16623 BLOC1S6 Homo sapiens Q9UL45 32296183
Intra
STX1A Q16623 SNAP25 Homo sapiens P60880 16169070
Intra
STX1A Q16623 AARD Homo sapiens Q4LEZ3 32296183
Intra
STX1A Q16623 ZNF835 Homo sapiens Q9Y2P0 32296183
Intra
STX1A Q16623 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
STX1A Q16623 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
STX1A Q16623 MMGT1 Homo sapiens Q8N4V1 32296183
Intra
STX1A Q16623 CLN6 Homo sapiens Q9NWW5 32296183
Intra
STX1A Q16623 GIMAP5 Homo sapiens Q96F15 32296183
Intra
STX1A Q16623 ERG28 Homo sapiens Q9UKR5 32296183
Intra
STX1A Q16623 STX1A Homo sapiens Q16623 32296183
Intra
STX1A Q16623 STX1A Homo sapiens Q16623 24722188
Intra
STX1A Q16623 STX1A Homo sapiens Q16623 32296183
Intra
STX1A Q16623 STX1A Homo sapiens Q16623 32296183
Intra
STX1A Q16623 DDX49 Homo sapiens Q9Y6V7 32296183
Intra
STX1A Q16623 VTI1B Homo sapiens Q9UEU0 32296183
Intra
STX1A Q16623 ZNF440 Homo sapiens Q8IYI8 32296183
Intra
STX1A Q16623 STX8 Homo sapiens Q9UNK0 32296183
Intra
STX1A Q16623 TMEM120A Homo sapiens Q9BXJ8 32296183
Intra
STX1A Q16623 SMIM3 Homo sapiens Q9BZL3 32296183
Intra
STX1A Q16623 ABI3 Homo sapiens Q9P2A4 32296183
Intra
STX1A Q16623 USE1 Homo sapiens Q9NZ43 32296183
Intra
STX1A Q16623 RAB3IL1 Homo sapiens Q8TBN0 32296183
Intra
STX1A Q16623 ZNF707 Homo sapiens Q96C28 32296183
Intra
STX1A Q16623 SERP2 Homo sapiens Q8N6R1 32296183
Intra
STX1A Q16623 ETNK2 Homo sapiens Q9NVF9 32296183
Intra
STX1A Q16623 TRAF3IP3 Homo sapiens Q9Y228 32296183
Intra
STX1A Q16623 TMEM100 Homo sapiens Q9NV29 32296183
Intra
STX1A Q16623 BTN2A2 Homo sapiens Q8WVV5 32296183
Intra
STX1A Q16623 SEC22A Homo sapiens Q96IW7 32296183
Intra
STX1A Q16623 EBAG9 Homo sapiens O00559 32296183
Intra
STX1A Q16623 EBAG9 Homo sapiens O00559 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

STX1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P82256 Syntaxin 1A Antibody (YA2001) WB, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Autism
  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic

Cystic Fibrosis
  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis

Williams-Beuren Syndrome
  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws

Acute Diarrhea
Foodborne Botulism
  • Botulism

  • Botulism Poisoning

  • Intoxication With Clostridium Botulinum Toxin

  • Wound Botulism

  • Food Poisoning Due To Clostridium Botulinum

  • Infection Due To Clostridium Botulinum

  • Infant Botulism

  • Intoxication Botulism

  • Botulism, Infantile

  • Clostridium Botulinum Poisoning

  • Botulism Nos

Dysentery
  • Infectious Diarrhea

Campylobacteriosis
  • Campylobacter Infections

  • Campylobacter Infection

  • Enteric Campylobacteriosis

Pheochromocytoma
  • Pheochromocytoma, Susceptibility To

  • Phaeochromocytoma

  • Adrenal Gland Chromaffin Paraganglioma

  • Adrenal Gland Chromaffinoma

  • Adrenal Gland Paraganglioma

  • Adrenal Gland Pheochromocytoma

  • Chromaffin Paraganglioma Of The Adrenal Gland

  • Intraadrenal Paraganglioma

  • PCC

  • Chromaffin Cell Tumor

  • Medullary Chromaffinoma

  • Medullary Paraganglioma

  • Pheochromoblastoma

  • Pheochromocytomas

  • Chromaffin Cell Neoplasm

  • Pheochromocytoma, Malignant

Shigellosis
  • Dysentery, Bacillary

  • Bacillary Dysentery

  • Shigella Boydii Infectious Disease

  • Shigella Flexneri Infectious Disease

  • Shigella Gastroenteritis

  • Shigella Sonnei Infectious Disease

  • Shigella Infections

Gastrointestinal Tularemia
  • Enteric Tularemia

  • Intestinal Tularaemia

3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
  • MCC2D

  • Mcc2 Deficiency

  • 3-Methylcrotonyl Coa Carboxylase 2 Deficiency

  • 3-Methylcrotonylglycinuria Ii

  • Methylcrotonylglycinuria, Type Ii

  • 3-Methylcrotonoyl-Coa Carboxylase 2 Deficiency

  • 3-Methylcrotonylglycinuria Type Ii

  • Mcgii

  • Methylcrotonylglycinuria Type Ii

Supravalvular Aortic Stenosis
  • SVAS

  • Supravalvar Aortic Stenosis

  • Supravalvar Aortic Stenosis, Eisenberg Type

  • Aortic Supravalvular Stenosis

  • Aortic Stenosis, Supravalvular

  • Supra-Valvular Aortic Stenosis

  • Stenosis, Aortic Supravalvular

  • Stenosis, Supravalvular Aortic

  • Supravalvular Stenosis, Aortic

  • Aortic Stenosis Supravalvular

Autism Spectrum Disorder
  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Attention Deficit-Hyperactivity Disorder
  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity

Early Infantile Epileptic Encephalopathy
  • Early Infantile Epileptic Encephalopathy With Burst-Suppression

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • Eiee

  • Early Infantile Epileptic Encephalopathy With Suppression-Bursts

  • Ohtahara Syndrome

  • Encephalopathy, Epileptic, Early Infantile

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta STX1A VGNC VGNC:78043
Felis catus STX1A VGNC VGNC:65810
Canis familiaris STX1A VGNC VGNC:46954
Bos taurus STX1A VGNC VGNC:35436
Rattus norvegicus STX1A RGD RGD:69430
Mus musculus STX1A MGD MGI:109355
Others STX1A NCBI