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TMEM100 - transmembrane protein 100 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55273

About TMEM100

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:55,719,627-55,732,081 (from NCBI)

This gene has 6 transcripts (splice variants), 243 orthologues and 1 paralogue. Biased expression in lung (RPKM 28.4), fat (RPKM 14.1) and 10 other tissues.

Summary

Involved in BMP signaling pathway. Located in several cellular components, including endoplasmic reticulum; perikaryon; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TMEM100 Products (2)

mRNA	Protein	Name
NM_001099640.2	NP_001093110.1	transmembrane protein 100
NM_018286.3	NP_060756.2	transmembrane protein 100

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	22783020	GOA
involved in cellular response to BMP stimulus	IDA IDA: Inferred from direct assay	22783020	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22783020	GOA
located in perikaryon	IDA IDA: Inferred from direct assay	23485812	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22783020	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23485812	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM100 Protein Structure

PIRT

0
100
134 a.a.

Protein Preferred Names	Protein Names
transmembrane protein 100

TMEM100 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM100	Q9NV29	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TMEM100	Q9NV29	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	TMEM100	Q9NV29	IFNGR1	Homo sapiens	P15260	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	IFNGR1	Homo sapiens	P15260	Y2H Array	32296183
Intra	TMEM100	Q9NV29	NUP93	Homo sapiens	Q8N1F7	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	NUP93	Homo sapiens	Q8N1F7	Y2H Array	32296183
Intra	TMEM100	Q9NV29	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	TMEM100	Q9NV29	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	TMEM100	Q9NV29	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	TMEM100	Q9NV29	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	TMEM100	Q9NV29	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TMEM100	Q9NV29	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TMEM100	Q9NV29	SLC30A4	Homo sapiens	O14863	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	SLC30A4	Homo sapiens	O14863	Y2H Array	32296183
Intra	TMEM100	Q9NV29	REEP1	Homo sapiens	Q9H902	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	REEP1	Homo sapiens	Q9H902	Y2H Array	32296183
Intra	TMEM100	Q9NV29	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	TMEM100	Q9NV29	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	TMEM100	Q9NV29	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	TMEM100	Q9NV29	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	TMEM100	Q9NV29	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM100	Q9NV29	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	SLC35A5	Homo sapiens	Q9BS91	Y2H Array	32296183
Intra	TMEM100	Q9NV29	SLC35A5	Homo sapiens	Q9BS91	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	TMEM130	Homo sapiens	Q8N3G9	Y2H Array	32296183
Intra	TMEM100	Q9NV29	TMEM130	Homo sapiens	Q8N3G9	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	TMEM100	Q9NV29	STING1	Homo sapiens	Q86WV6	Y2H Array	32296183
Intra	TMEM100	Q9NV29	STING1	Homo sapiens	Q86WV6	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	CCDC57	Homo sapiens	Q2TAC2	Validated Y2H	25416956
Intra	TMEM100	Q9NV29	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TMEM100	Q9NV29	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	COMT	Homo sapiens	P21964	Y2H Array	32296183
Intra	TMEM100	Q9NV29	COMT	Homo sapiens	P21964	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	CD33	Homo sapiens	P20138	Y2H Array	32296183
Intra	TMEM100	Q9NV29	CD33	Homo sapiens	P20138	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TMEM100	Q9NV29	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	TMEM100	Q9NV29	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	TMEM100	Q9NV29	F11R	Homo sapiens	Q9Y624	Y2H Array	32296183
Intra	TMEM100	Q9NV29	F11R	Homo sapiens	Q9Y624	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	F11R	Homo sapiens	Q9Y624	Validated Y2H	32296183
Intra	TMEM100	Q9NV29	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	TMEM100	Q9NV29	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	TMEM100	Q9NV29	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	TMEM100	Q9NV29	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TMEM100	Q9NV29	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TMEM100	Q9NV29	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Van Den Ende-Gupta Syndrome	VDEGS Blepharophimosis, Arachnodactyly, And Congenital Contractures Marden-Walker-Like Syndrome Marden-Walker-Like Syndrome Without Psychomotor Retardation Marden Walker Like Syndrome Marden-Walker-Like Syndrome Without Psychmotor Retardation Van Den Ende Gupta Syndrome Marden Walker Like Syndrome Without Psychomotor Retardation Blepharophimosis Arachnodactyly And Congenital Contractures
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10356	T100-Mut	Inhibitor	/	Unkown
HY-RS14643	TMEM100 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TMEM100	MGD	MGI:1915138
Felis catus	TMEM100	VGNC	VGNC:66253
Rattus norvegicus	TMEM100	RGD	RGD:1560541
Canis familiaris	TMEM100	VGNC	VGNC:47443
Macaca mulatta	TMEM100	VGNC	VGNC:79521
Bos taurus	TMEM100	VGNC	VGNC:35941
Others	TMEM100	NCBI