RETREG3 - reticulophagy regulator family member 3 Gene
Also Known as FAM134C
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 162427
Summary
Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Involved in endoplasmic reticulum tubular network organization; positive regulation of neuron projection development; and reticulophagy. Located in endoplasmic reticulum tubular network. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in testis (RPKM 16.0), skin (RPKM 14.1) and 25 other tissues.
RETREG3 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_178126.4 | NP_835227.1 | reticulophagy regulator 3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in endoplasmic reticulum tubular network organization |
IMP
IMP: Inferred from mutant phenotype
|
33826365 | GOA |
| involved in positive regulation of neuron projection development |
IMP
IMP: Inferred from mutant phenotype
|
23939472 | GOA |
| involved in reticulophagy |
IMP
IMP: Inferred from mutant phenotype
|
33826365 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in endoplasmic reticulum tubular network |
IDA
IDA: Inferred from direct assay
|
33826365 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
28246125 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
RETREG3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
RETREG3 | Q86VR2 | VAMP5 | Homo sapiens | O95183 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | NRM | Homo sapiens | Q8IXM6 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | JAGN1 | Homo sapiens | Q8N5M9 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | CSGALNACT2 | Homo sapiens | Q8N6G5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | CCL4L1 | Homo sapiens | Q8NHW4 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | SLC30A3 | Homo sapiens | Q99726 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | VAPA | Homo sapiens | Q9P0L0 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM237 | Homo sapiens | Q96Q45-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | CMTM5 | Homo sapiens | Q96DZ9-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM239 | Homo sapiens | Q8WW34-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | PLPP6 | Homo sapiens | Q8IY26 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | MFF | Homo sapiens | Q9GZY8-5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM254 | Homo sapiens | Q8TBM7 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | C4orf3 | Homo sapiens | Q8WVX3-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | LPAR3 | Homo sapiens | Q9UBY5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | ANKRD46 | Homo sapiens | Q86W74-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | FAXDC2 | Homo sapiens | Q96IV6 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | PKMYT1 | Homo sapiens | Q99640-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM203 | Homo sapiens | Q969S6 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | FIMP | Homo sapiens | Q96LL3 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM243 | Homo sapiens | Q9BU79 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | HTATIP2 | Homo sapiens | Q9BUP3-3 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | CDS1 | Homo sapiens | Q92903 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | REEP6 | Homo sapiens | Q96HR9-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM18 | Homo sapiens | Q96B42-2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | AGPAT4 | Homo sapiens | Q9NRZ5 | 32296183 | |
|
Cross
|
RETREG3 | Q86VR2 | orf9c_sars2 | SARS-CoV-2 | P0DTD3 | 36217030 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM176A | Homo sapiens | Q96HP8 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | CMTM7 | Homo sapiens | Q96FZ5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | UBIAD1 | Homo sapiens | Q9Y5Z9 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM60 | Homo sapiens | Q9H2L4 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | SFT2D1 | Homo sapiens | Q8WV19 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | ACSL5 | Homo sapiens | Q9ULC5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TECR | Homo sapiens | Q9NZ01 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM222 | Homo sapiens | Q9H0R3 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | MCRS1 | Homo sapiens | Q96EZ8 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | ABHD16A | Homo sapiens | O95870 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | DHRSX | Homo sapiens | Q8N5I4 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | DERL1 | Homo sapiens | Q9BUN8 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | STAP1 | Homo sapiens | Q9ULZ2 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | STAP1 | Homo sapiens | Q9ULZ2 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | STAP1 | Homo sapiens | Q9ULZ2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | STAP1 | Homo sapiens | Q9ULZ2 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | GIMAP5 | Homo sapiens | Q96F15 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | OTULINL | Homo sapiens | Q9NUU6 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TBRG4 | Homo sapiens | Q969Z0 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | ERG28 | Homo sapiens | Q9UKR5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | RABAC1 | Homo sapiens | Q9UI14 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | FUNDC2 | Homo sapiens | Q9BWH2 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | ARL6IP1 | Homo sapiens | Q15041 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | ARL6IP1 | Homo sapiens | Q15041 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | SENP2 | Homo sapiens | Q9HC62 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | MAP1LC3A | Homo sapiens | Q9H492 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | MAP1LC3A | Homo sapiens | Q9H492 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | ORMDL3 | Homo sapiens | Q8N138 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | CMTM3 | Homo sapiens | Q96MX0 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | STX8 | Homo sapiens | Q9UNK0 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | GABARAPL1 | Homo sapiens | Q9H0R8 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | GABARAPL1 | Homo sapiens | Q9H0R8 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | GABARAPL1 | Homo sapiens | Q9H0R8 | 25416956 | |
|
Intra
|
RETREG3 | Q86VR2 | GABARAPL1 | Homo sapiens | Q9H0R8 | 26040720 | |
|
Intra
|
RETREG3 | Q86VR2 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
RETREG3 | Q86VR2 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
RETREG3 | Q86VR2 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
RETREG3 | Q86VR2 | SERP2 | Homo sapiens | Q8N6R1 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | YIPF6 | Homo sapiens | Q96EC8 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | YIPF1 | Homo sapiens | Q9Y548 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | IFITM3 | Homo sapiens | Q01628 | 33961781 | |
|
Intra
|
RETREG3 | Q86VR2 | RUSF1 | Homo sapiens | Q96GQ5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | SMCO4 | Homo sapiens | Q9NRQ5 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | TMEM100 | Homo sapiens | Q9NV29 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | SEC22A | Homo sapiens | Q96IW7 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | CCDC167 | Homo sapiens | Q9P0B6 | 32296183 | |
|
Intra
|
RETREG3 | Q86VR2 | MAL2 | Homo sapiens | Q969L2 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS11859 | RETREG1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Compound Screening Libraries
Virtual Screening
Customize Your Library
Drug Screening Service