VAPA - VAMP associated protein A Gene

Homo sapiens

Also known as VAP-A; VAP33; VAMP-A; VAP-33; hVAP-33

Gene ID: 9218 | Gene type: protein coding

About VAPA

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,914,016-9,960,021 (from NCBI)

This gene has 9 transcripts (splice variants), 246 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 26.8), brain (RPKM 22.1) and 25 other tissues.

Summary

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the Cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

VAPA Products(2)

mRNA	Protein	Name
NM_003574.6	NP_003565.4	vesicle-associated membrane protein-associated protein A isoform 1
NM_194434.3	NP_919415.2	vesicle-associated membrane protein-associated protein A isoform 2

VAPA Protein Structure

Motile_Sperm

0
100
200
249 a.a.

Protein Preferred Names

Protein Names

vesicle-associated membrane protein-associated protein A

33 kDa VAMP-associated protein

Related Diseases

Diseases

Alias

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

Infant Botulism

Infant Intestinal Botulism	Infant Intestinal Toxemia Botulism
Infant Intestinal Toxin-Mediated Botulism	Infantile Botulism
Botulism, Infantile

Amyotrophic Lateral Sclerosis 8

Amyotrophic Lateral Sclerosis Type 8	ALS8
Sclerosis, Lateral, Amyotrophic, Type Type 8

Retinal Dystrophy With Leukodystrophy

RDLKD	Acbd5 Deficiency
Dystrophy, Retinal, With Leukodystrophy

Anismus

Mesenteric Lymphadenitis

Mesenteric Adenitis

Intestinal Botulism

Intestinal Colonization Botulism	Intestinal Toxemia Botulism
Intestinal Toxin-Mediated Botulism

Hyperhidrosis, Gustatory

Frey Syndrome	Gustatory Sweating
Auriculotemporal Nerve Syndrome	Gustatory Hyperhidrosis
Frey'S Syndrome	Sweating, Gustatory
HYPRG	Baillarger Syndrome
Hyperhidrosis Gustatory	Auriculotemporal Syndrome

Bronchopneumonia

Lobular Pneumonia	Bronchial Pneumonia
Chest Infection - Bronchopneumonia

Cervical Dystonia

Spasmodic Torticollis

Subacute Leukemia

Choreoacanthocytosis

Chorea-Acanthocytosis	CHAC
Acanthocytosis With Neurologic Disorder	Levine-Critchley Syndrome
Choreaacanthocytosis	Chorea Acanthocytosis
Neuroacanthocytosis	Levine-Critchley Syndrome, Formerly
Neuroacanthocytosis, Formerly	Choreo-Acanthocytosis
Acanthocytosis Chorea	Chorea Acanthocytosis Syndrome

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive	Als6
Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia	Autosomal Recessive Amyotrophic Lateral Sclerosis 6
Sclerosis, Lateral, Amyotrophic, Type Type 6	Amyotrophic Lateral Sclerosis 6

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15602	VAPA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VAPA	VGNC	VGNC:36763
Canis familiaris	VAPA	VGNC	VGNC:48229
Mus musculus	VAPA	MGD	MGI:1353561
Rattus norvegicus	VAPA	RGD	RGD:61803
Felis catus	VAPA	VGNC	VGNC:66917