OSBPL1A - oxysterol binding protein like 1A Gene

Also Known as ORP1; ORP-1; OSBPL1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114876

About OSBPL1A

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:24,162,045-24,397,824 (from NCBI)

This gene has 16 transcripts (splice variants), 312 orthologues and 11 paralogues. Ubiquitous expression in brain (RPKM 18.5), fat (RPKM 17.7) and 24 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]

OSBPL1A Products (3)

mRNA	Protein	Name
NM_001242508.1	NP_001229437.1	oxysterol-binding protein-related protein 1 isoform 3
NM_018030.4	NP_060500.3	oxysterol-binding protein-related protein 1 isoform 1
NM_080597.4	NP_542164.2	oxysterol-binding protein-related protein 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cholesterol binding	IDA IDA: Inferred from direct assay	17428193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16176980	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endosome	IDA IDA: Inferred from direct assay	29858488	GOA
located in late endosome	IDA IDA: Inferred from direct assay	16176980	GOA
located in organelle membrane contact site	IDA IDA: Inferred from direct assay	29858488	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL1A Protein Structure

Ank_2

Ank_5

Oxysterol_BP

0
200
400
600
800
950 a.a.

Protein Preferred Names	Protein Names
oxysterol-binding protein-related protein 1	OSBP-related protein 1

OSBPL1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OSBPL1A	Q9BXW6	RAB7A	Homo sapiens	P51149	GMS	30721249
Intra	OSBPL1A	Q9BXW6	RAB7A	Homo sapiens	P51149	ITC	30721249
Intra	OSBPL1A	Q9BXW6	RAB7A	Homo sapiens	P51149	X-Ray Diffraction	30721249
Intra	OSBPL1A	Q9BXW6	VAPA	Homo sapiens	Q9P0L0	SPR	29858488
Intra	OSBPL1A	Q9BXW6	VAPA	Homo sapiens	Q9P0L0	Pull Down	29858488
Intra	OSBPL1A	Q9BXW6	VAPB	Homo sapiens	O95292	Pull Down	29858488
Intra	OSBPL1A	Q9BXW6	VAPB	Homo sapiens	O95292	SPR	29858488
Intra	OSBPL1A	Q9BXW6	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	OSBPL1A	Q9BXW6	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	OSBPL1A	Q9BXW6	MOSPD2	Homo sapiens	Q8NHP6	SPR	29858488
Intra	OSBPL1A	Q9BXW6	MOSPD2	Homo sapiens	Q8NHP6	Confocal	29858488
Intra	OSBPL1A	Q9BXW6	MOSPD2	Homo sapiens	Q8NHP6	Anti Tag CoIP	29858488
Intra	OSBPL1A	Q9BXW6	MOSPD2	Homo sapiens	Q8NHP6	Pull Down	29858488

Cross: Cross-species interaction Intra: Intraspecies interaction

OSBPL1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81732	ORP1 Antibody (YA1477)	WB, ICC/IF, FC	Human, Mouse, Rat
HY-P81732A	ORP1 Antibody (YA1477)(PBS only)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Splenic Manifestation Of Leukemia	Splenic Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09839	OSBPL1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OSBPL1A	VGNC	VGNC:75632
Bos taurus	OSBPL1A	VGNC	VGNC:32460
Felis catus	OSBPL1A	VGNC	VGNC:107713
Mus musculus	OSBPL1A	MGD	MGI:1927551
Rattus norvegicus	OSBPL1A	RGD	RGD:628888
Canis familiaris	OSBPL1A	VGNC	VGNC:44153
Others	OSBPL1A	NCBI