MOSPD2 - motile sperm domain containing 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 158747

About MOSPD2

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:14,873,421-14,922,327 (from NCBI)

This gene has 6 transcripts (splice variants) and 227 orthologues. Ubiquitous expression in thyroid (RPKM 8.4), brain (RPKM 7.3) and 25 other tissues.

Summary

Involved in positive regulation of monocyte chemotaxis and positive regulation of neutrophil chemotaxis. Located in endoplasmic reticulum and endoplasmic reticulum-endosome membrane contact site. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MOSPD2 Products (3)

mRNA	Protein	Name
NM_001177475.2	NP_001170946.1	motile sperm domain-containing protein 2 isoform 2
NM_001330241.2	NP_001317170.1	motile sperm domain-containing protein 2 isoform 3
NM_152581.4	NP_689794.1	motile sperm domain-containing protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables FFAT motif binding	IDA IDA: Inferred from direct assay	33124732	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29858488	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lipid droplet formation	IDA IDA: Inferred from direct assay	35389430	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	28137892	GOA
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	28137892	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	33124732	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	29858488	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	35389430	GOA
located in endoplasmic reticulum-endosome membrane contact site	IDA IDA: Inferred from direct assay	29858488	GOA
located in organelle membrane contact site	IDA IDA: Inferred from direct assay	29858488	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	28137892	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOSPD2 Protein Structure

CRAL_TRIO

Motile_Sperm

0
100
200
300
400
518 a.a.

Protein Preferred Names	Protein Names
motile sperm domain-containing protein 2

MOSPD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MOSPD2	Q8NHP6	RMDN3	Homo sapiens	Q96TC7	Anti Tag CoIP	29858488
Intra	MOSPD2	Q8NHP6	BTN1A1	Homo sapiens	Q13410	Y2H Array	32296183
Intra	MOSPD2	Q8NHP6	BTN1A1	Homo sapiens	Q13410	Y2H Prey Pooling	32296183
Intra	MOSPD2	Q8NHP6	OSBPL1A	Homo sapiens	Q9BXW6	Anti Tag CoIP	29858488
Intra	MOSPD2	Q8NHP6	STARD3	Homo sapiens	Q14849	Anti Tag CoIP	29858488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fanconi Anemia, Complementation Group B	Fanconi Anemia Complementation Group B FANCB Facb Fa2 Fanconi Pancytopenia Type 2 Fanconi Pancytopenia, Type 2
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08601	MOSPD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MOSPD2	VGNC	VGNC:63566
Mus musculus	MOSPD2	MGD	MGI:1924013
Rattus norvegicus	MOSPD2	RGD	RGD:1563952
Macaca mulatta	MOSPD2	VGNC	VGNC:74847
Canis familiaris	MOSPD2	VGNC	VGNC:43325
Others	MOSPD2	NCBI