RMDN3 - regulator of microtubule dynamics 3 Gene

Also Known as RMD3; RMD-3; FAM82C; FAM82A2; ptpip51

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55177

About RMDN3

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,735,887-40,755,254 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in small intestine (RPKM 16.9), lung (RPKM 14.6) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in cellular calcium ion homeostasis. Located in several cellular components, including intercellular bridge; mitochondrial outer membrane; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

RMDN3 Products (6)

mRNA Protein Name
NM_001304802.2 NP_001291731.1 regulator of microtubule dynamics protein 3 isoform 1
NM_001323894.2 NP_001310823.1 regulator of microtubule dynamics protein 3 isoform 1
NM_001323895.2 NP_001310824.1 regulator of microtubule dynamics protein 3 isoform 2
NM_001323896.2 NP_001310825.1 regulator of microtubule dynamics protein 3 isoform 3
NM_001323897.2 NP_001310826.1 regulator of microtubule dynamics protein 3 isoform 3
NM_018145.3 NP_060615.1 regulator of microtubule dynamics protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
18070910 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18771726 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
22131369 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
22131369 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
29858488 GOA
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
18070910 GOA
located in organelle membrane contact site IDA
IDA: Inferred from direct assay
29858488 GOA
located in spindle microtubule IDA
IDA: Inferred from direct assay
18070910 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of microtubule dynamics protein 3

  • TCPTP-interacting protein 51

RMDN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RMDN3 Q96TC7 VAPA Homo sapiens Q9P0L0
Y2H
21900206
Intra
RMDN3 Q96TC7 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
Intra
RMDN3 Q96TC7 MOSPD2 Homo sapiens Q8NHP6
Confocal
29858488
Intra
RMDN3 Q96TC7 MOSPD2 Homo sapiens Q8NHP6
Anti Tag CoIP
29858488
Intra
RMDN3 Q96TC7 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
Intra
RMDN3 Q96TC7 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
RMDN3 Q96TC7 YWHAB Homo sapiens P31946
CoIP
15324660
Intra
RMDN3 Q96TC7 YWHAB Homo sapiens P31946
PLA
21972092
Intra
RMDN3 Q96TC7 YWHAB Homo sapiens P31946
Pull Down
18771726
Intra
RMDN3 Q96TC7 PELI2 Homo sapiens Q9HAT8
Validated Y2H
32296183
Intra
RMDN3 Q96TC7 VKORC1 Homo sapiens Q9BQB6
Validated Y2H
32296183
Intra
RMDN3 Q96TC7 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 8

  • Amyotrophic Lateral Sclerosis Type 8

  • ALS8

  • Sclerosis, Lateral, Amyotrophic, Type Type 8
Amyotrophic Lateral Sclerosis 16, Juvenile

  • Amyotrophic Lateral Sclerosis Type 16

  • ALS16

  • Amyotrophic Lateral Sclerosis 16

  • Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile
Alzheimer Disease 7

  • Ad7

  • Alzheimer'S Disease 7

  • Alzheimer Disease, Familial, 7

  • Alzheimer Disease-7

  • Alzheimer Disease, Familial 7
Hereditary Spastic Paraplegia

  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12013 RMDN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22777 Rmdn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RMDN3 VGNC VGNC:64651
Macaca mulatta RMDN3 VGNC VGNC:76821
Rattus norvegicus RMDN3 RGD RGD:1308697
Bos taurus RMDN3 VGNC VGNC:33993
Mus musculus RMDN3 MGD MGI:1915059
Canis familiaris RMDN3 VGNC VGNC:45607
Others RMDN3 NCBI