PELI2 - pellino E3 ubiquitin protein ligase family member 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57161

About PELI2

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:56,118,411-56,301,524 (from NCBI)

This gene has 4 transcripts (splice variants), 209 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein Ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

PELI2 Products (1)

mRNA Protein Name
NM_021255.3 NP_067078.1 E3 ubiquitin-protein ligase pellino homolog 2
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12860405 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
12804775 GOA
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
12804775 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELI2 Protein Structure

Pellino

Pellino: Pellino (5 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase pellino homolog 2

  • RING-type E3 ubiquitin transferase pellino homolog 2

PELI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PELI2 Q9HAT8 SP4 Homo sapiens Q02446 32296183
Intra
PELI2 Q9HAT8 SP4 Homo sapiens Q02446 32296183
Intra
PELI2 Q9HAT8 RMDN3 Homo sapiens Q96TC7 32296183
Intra
PELI2 Q9HAT8 RMDN3 Homo sapiens Q96TC7 32296183
Intra
PELI2 Q9HAT8 REL Homo sapiens Q04864-2 32296183
Intra
PELI2 Q9HAT8 REL Homo sapiens Q04864-2 32296183
Intra
PELI2 Q9HAT8 CLEC17A Homo sapiens Q6ZS10 32296183
Intra
PELI2 Q9HAT8 CLEC17A Homo sapiens Q6ZS10 32296183
Intra
PELI2 Q9HAT8 OR7D2 Homo sapiens Q96RA2 32296183
Intra
PELI2 Q9HAT8 OR7D2 Homo sapiens Q96RA2 32296183
Intra
PELI2 Q9HAT8 PCGF2 Homo sapiens P35227 32296183
Intra
PELI2 Q9HAT8 PCGF2 Homo sapiens P35227 32296183
Intra
PELI2 Q9HAT8 TP63 Homo sapiens Q9H3D4 32296183
Intra
PELI2 Q9HAT8 TP63 Homo sapiens Q9H3D4 32296183
Intra
PELI2 Q9HAT8 HYAL2 Homo sapiens Q12891 32296183
Intra
PELI2 Q9HAT8 HYAL2 Homo sapiens Q12891 32296183
Intra
PELI2 Q9HAT8 LZTFL1 Homo sapiens Q9NQ48 32296183
Intra
PELI2 Q9HAT8 LZTFL1 Homo sapiens Q9NQ48 32296183
Intra
PELI2 Q9HAT8 LZTFL1 Homo sapiens Q9NQ48 32296183
Intra
PELI2 Q9HAT8 MEOX1 Homo sapiens P50221 32296183
Intra
PELI2 Q9HAT8 MEOX1 Homo sapiens P50221 32296183
Intra
PELI2 Q9HAT8 NUP62 Homo sapiens P37198 32296183
Intra
PELI2 Q9HAT8 NUP62 Homo sapiens P37198 32296183
Intra
PELI2 Q9HAT8 IRAK1 Homo sapiens P51617 16884718
Intra
PELI2 Q9HAT8 IRAK1 Homo sapiens P51617 12860405
Intra
PELI2 Q9HAT8 IRAK1 Homo sapiens P51617 12860405
Intra
PELI2 Q9HAT8 RABEP1 Homo sapiens Q15276 32296183
Intra
PELI2 Q9HAT8 RABEP1 Homo sapiens Q15276 32296183
Intra
PELI2 Q9HAT8 IRAK4 Homo sapiens Q9NWZ3 12860405
Intra
PELI2 Q9HAT8 IRAK4 Homo sapiens Q9NWZ3
Y2H
12860405
Intra
PELI2 Q9HAT8 MDFI Homo sapiens Q99750 32296183
Intra
PELI2 Q9HAT8 MDFI Homo sapiens Q99750 32296183
Intra
PELI2 Q9HAT8 SEPTIN3 Homo sapiens Q9UH03 32296183
Intra
PELI2 Q9HAT8 SEPTIN3 Homo sapiens Q9UH03 32296183
Intra
PELI2 Q9HAT8 SEPTIN3 Homo sapiens Q9UH03 32296183
Intra
PELI2 Q9HAT8 TRIM32 Homo sapiens Q13049 32296183
Intra
PELI2 Q9HAT8 TRIM32 Homo sapiens Q13049 32296183
Intra
PELI2 Q9HAT8 TMEM79 Homo sapiens Q9BSE2 32296183
Intra
PELI2 Q9HAT8 TMEM79 Homo sapiens Q9BSE2 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus PELI2 MGD MGI:1891445
Macaca mulatta PELI2 VGNC VGNC:75939
Rattus norvegicus PELI2 RGD RGD:1565884
Bos taurus PELI2 VGNC VGNC:32741
Felis catus PELI2 VGNC VGNC:68784
Canis familiaris PELI2 VGNC VGNC:44415
Others PELI2 NCBI