MDFI - MyoD family inhibitor Gene

Homo sapiens

Also known as I-MF; I-mfa

Gene ID: 4188 | Gene type: protein coding

About MDFI

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,637,018-41,654,244 (from NCBI)

This gene has 9 transcripts (splice variants), 192 orthologues and 2 paralogues. Biased expression in fat (RPKM 11.0), placenta (RPKM 3.0) and 12 other tissues.

Summary

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]

MDFI Products(4)

mRNA	Protein	Name
NM_001300804.2	NP_001287733.1	myoD family inhibitor isoform 1
NM_001300805.2	NP_001287734.1	myoD family inhibitor isoform 2
NM_001300806.2	NP_001287735.1	myoD family inhibitor isoform 1
NM_005586.4	NP_005577.1	myoD family inhibitor isoform 1

MDFI Protein Structure

MDFI

0
100
200
246 a.a.

Protein Preferred Names

Protein Names

myoD family inhibitor

inhibitor of MyoD family a

Related Diseases

Diseases

Alias

Erythema Infectiosum

Fifth Disease	Slapped Cheek Syndrome
Parvovirus B19 Infection

Viral Exanthem

Viral Rash Nos	Virus Exanthema
Nonspecific Exanthematous Viral Infection	Nonspecific Viral Exanthem
Nonspecific Viral Rash	Viral Enanthema Nos
Viral Disease Characterised By Exanthem	Viral Exanthemata
Viral Exanthem, Unspecified	Viral Exanthema Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08256	MDFI Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MDFI	VGNC	VGNC:74689
Felis catus	MDFI	VGNC	VGNC:68219
Bos taurus	MDFI	VGNC	VGNC:31329
Mus musculus	MDFI	MGD	MGI:107687
Rattus norvegicus	MDFI	RGD	RGD:1560271
Canis familiaris	MDFI	VGNC	VGNC:43099