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AANAT - aralkylamine N-acetyltransferase Gene

Also Known as DSPS; SNAT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 15

About AANAT

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,453,351-76,470,117 (from NCBI)

This gene has 4 transcripts (splice variants) and 257 orthologues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

AANAT Products (2)

mRNA	Protein	Name
NM_001088.3	NP_001079.1	serotonin N-acetyltransferase isoform 2
NM_001166579.2	NP_001160051.1	serotonin N-acetyltransferase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables aralkylamine N-acetyltransferase activity	IDA IDA: Inferred from direct assay	11313340	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-terminal protein amino acid acetylation	IDA IDA: Inferred from direct assay	11313340	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	11313340	GOA
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	12736803	GOA
involved in melatonin biosynthetic process	IDA IDA: Inferred from direct assay	11313340	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11313340	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AANAT Protein Structure

Acetyltransf_1

0
100
207 a.a.

Protein Preferred Names	Protein Names
serotonin N-acetyltransferase	arylalkylamine N-acetyltransferase

AANAT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AANAT	Q16613	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	AANAT	Q16613	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	AANAT	Q16613	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	AANAT	Q16613	GRB10	Homo sapiens	Q13322-4	Y2H Prey Pooling	32296183
Intra	AANAT	Q16613	GRB10	Homo sapiens	Q13322-4	Y2H Array	32296183
Intra	AANAT	Q16613	EIF4E3	Homo sapiens	Q8N5X7-2	Validated Y2H	32296183
Intra	AANAT	Q16613	BHLHE40	Homo sapiens	O14503	Y2H Bait-Prey Pool	25910212
Intra	AANAT	Q16613	BHLHE40	Homo sapiens	O14503	Y2H Array	25910212
Intra	AANAT	Q16613	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	AANAT	Q16613	BHLHE40	Homo sapiens	O14503	Y2H Array	25416956
Intra	AANAT	Q16613	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	25416956
Intra	AANAT	Q16613	BHLHE40	Homo sapiens	O14503	Validated Y2H	25910212
Intra	AANAT	Q16613	MDFI	Homo sapiens	Q99750	Y2H Array	25910212
Intra	AANAT	Q16613	MDFI	Homo sapiens	Q99750	Y2H Bait-Prey Pool	25910212
Intra	AANAT	Q16613	MDFI	Homo sapiens	Q99750	Validated Y2H	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schopf-Schulz-Passarge Syndrome	SSPS Eccrine Tumors With Ectodermal Dysplasia Eccrine Tumors-Ectodermal Dysplasia Keratosis Palmoplantaris-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Palmoplantar Hyperkeratosis-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Palmoplantar Keratoderma-Cystic Eyelids-Hypodontia-Hypotrichosis Syndrome Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia, And Hypotrichosis Keratosis Palmoplantaris With Cystic Eyelids, Hypodontia And Hypotrichosis
Delayed Sleep Phase Disorder	Delayed Sleep Phase Syndrome Delayed Sleep Phase Syndrome, Susceptibility To DSPD Delayed Sleep Phase Disorder, Susceptibility To DSPS Sleep Phase, Delayed, Disorder Sleep Phase Syndrome, Delayed, Susceptibility To
Advanced Sleep Phase Syndrome	Fasps Familial Advanced Sleep-Phase Syndrome Advanced Sleep Phase Syndrome, Familial Familial Advanced Sleep Phase Syndrome Sleep Phase Syndrome, Advanced, Familial Advanced Sleep-Phase Syndrome, Familial
Scoliosis
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157521	AANAT-IN-1	Inhibitor	99.87%	Unkown
HY-179397	AANAT-IN-2	Inhibitor	/	Unkown
HY-RS00025	AANAT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AANAT	VGNC	VGNC:59453
Canis familiaris	AANAT	VGNC	VGNC:37413
Macaca mulatta	AANAT	VGNC	VGNC:69468
Mus musculus	AANAT	MGD	MGI:1328365
Rattus norvegicus	AANAT	RGD	RGD:2006
Others	AANAT	NCBI