PBXIP1 - PBX homeobox interacting protein 1 Gene

Also Known as HPIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57326

About PBXIP1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,944,080-154,956,099 (from NCBI)

This gene has 6 transcripts (splice variants) and 101 orthologues. Ubiquitous expression in ovary (RPKM 58.0), adrenal (RPKM 56.0) and 25 other tissues.

Summary

The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast Cancer, brain tumors, and lung Cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015]

PBXIP1 Products (3)

mRNA Protein Name
NM_001317734.2 NP_001304663.1 pre-B-cell leukemia transcription factor-interacting protein 1 isoform 2
NM_001317735.2 NP_001304664.1 pre-B-cell leukemia transcription factor-interacting protein 1 isoform 3
NM_020524.4 NP_065385.2 pre-B-cell leukemia transcription factor-interacting protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10825160 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
10825160 GOA
Biological Process GO Annotation Evidence References Source
involved in hemopoiesis IEP
IEP: Inferred from expression pattern
10825160 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10825160 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
10825160 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10825160 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pre-B-cell leukemia transcription factor-interacting protein 1

  • hematopoietic PBX-interacting protein

PBXIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PBXIP1 Q96AQ6 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra
PBXIP1 Q96AQ6 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
PBXIP1 Q96AQ6 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Array
25416956
Intra
PBXIP1 Q96AQ6 MORF4L1 Homo sapiens Q9UBU8-2
Y2H Prey Pooling
25416956
Intra
PBXIP1 Q96AQ6 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
PBXIP1 Q96AQ6 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
PBXIP1 Q96AQ6 CAMLG Homo sapiens P49069
Y2H Array
32296183
Intra
PBXIP1 Q96AQ6 CAMLG Homo sapiens P49069
Y2H Prey Pooling
32296183
Intra
PBXIP1 Q96AQ6 GMCL1 Homo sapiens Q96IK5
Anti Tag CoIP
33961781
Intra
PBXIP1 Q96AQ6 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
PBXIP1 Q96AQ6 GMCL1 Homo sapiens Q96IK5
Validated Y2H
32296183
Intra
PBXIP1 Q96AQ6 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
PBXIP1 Q96AQ6 CCNC Homo sapiens P24863
Anti Tag CoIP
33961781
Intra
PBXIP1 Q96AQ6 CCNC Homo sapiens P24863
Validated Y2H
25416956
Intra
PBXIP1 Q96AQ6 CCNC Homo sapiens P24863
Y2H Prey Pooling
25416956
Intra
PBXIP1 Q96AQ6 CCNC Homo sapiens P24863
Y2H Array
25416956
Intra
PBXIP1 Q96AQ6 MORF4L1 Homo sapiens Q9UBU8
Y2H Array
25416956
Intra
PBXIP1 Q96AQ6 MORF4L1 Homo sapiens Q9UBU8
Y2H Prey Pooling
25416956
Intra
PBXIP1 Q96AQ6 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
31515488
Intra
PBXIP1 Q96AQ6 WASHC3 Homo sapiens Q9Y3C0
Y2H Pooling
19060904
Intra
PBXIP1 Q96AQ6 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
19060904
Intra
PBXIP1 Q96AQ6 DEF6 Homo sapiens Q9H4E7
Validated Y2H
25416956
Intra
PBXIP1 Q96AQ6 DEF6 Homo sapiens Q9H4E7
Y2H Array
25416956
Intra
PBXIP1 Q96AQ6 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Intra
PBXIP1 Q96AQ6 DAXX Homo sapiens Q9UER7
Validated Y2H
25416956
Intra
PBXIP1 Q96AQ6 DAXX Homo sapiens Q9UER7
Y2H Array
25416956
Intra
PBXIP1 Q96AQ6 DAXX Homo sapiens Q9UER7
Y2H Prey Pooling
25416956
Intra
PBXIP1 Q96AQ6 LCA5L Homo sapiens O95447
Y2H Array
32296183
Intra
PBXIP1 Q96AQ6 LCA5L Homo sapiens O95447
Y2H Prey Pooling
32296183
Intra
PBXIP1 Q96AQ6 PPTC7 Homo sapiens Q8NI37
Y2H Array
32296183
Intra
PBXIP1 Q96AQ6 PPTC7 Homo sapiens Q8NI37
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10110 PBXIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PBXIP1 RGD RGD:1305180
Bos taurus PBXIP1 VGNC VGNC:32611
Macaca mulatta PBXIP1 VGNC VGNC:75663
Felis catus PBXIP1 VGNC VGNC:103739
Mus musculus PBXIP1 MGD MGI:2441670
Canis familiaris PBXIP1 VGNC VGNC:44290
Others PBXIP1 NCBI