GMCL1 - germ cell-less 1, spermatogenesis associated Gene

Also Known as GCL; GCL1; BTBD13; SPATA29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64395

Summary

This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]
Ubiquitous expression in testis (RPKM 10.7), duodenum (RPKM 7.8) and 25 other tissues.

GMCL1 Products (1)

mRNA Protein Name
NM_178439.5 NP_848526.1 germ cell-less protein-like 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
27107012 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21145461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMCL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GMCL1 Q96IK5 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
GMCL1 Q96IK5 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 FAM167A Homo sapiens Q96KS9
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 FAM167A Homo sapiens Q96KS9
Y2H Array
31515488
Intra
GMCL1 Q96IK5 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra
GMCL1 Q96IK5 APOL6 Homo sapiens Q9BWW8
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 ZIM2 Homo sapiens Q9NZV7
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 GAGE10 Homo sapiens A6NGK3
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 GAGE10 Homo sapiens A6NGK3
Y2H Array
32296183
Intra
GMCL1 Q96IK5 GAGE10 Homo sapiens A6NGK3
MAPPIT
32296183
Intra
GMCL1 Q96IK5 GAGE2B Homo sapiens Q13066
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 GAGE2B Homo sapiens Q13066
Y2H Array
32296183
Intra
GMCL1 Q96IK5 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 MYO5B Homo sapiens Q9ULV0-2
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 MID1 Homo sapiens O15344
Y2H Array
32296183
Intra
GMCL1 Q96IK5 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
GMCL1 Q96IK5 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 XAGE3 Homo sapiens Q8WTP9
Y2H Array
31515488
Intra
GMCL1 Q96IK5 ZMYM2 Homo sapiens Q9UBW7
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 ZMYM2 Homo sapiens Q9UBW7
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 ZMYM2 Homo sapiens Q9UBW7
Y2H Array
32296183
Intra
GMCL1 Q96IK5 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 PRPF18 Homo sapiens Q99633
Y2H Array
32296183
Intra
GMCL1 Q96IK5 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 BYSL Homo sapiens Q13895
Validated Y2H
27107012
Intra
GMCL1 Q96IK5 ZSWIM3 Homo sapiens Q96MP5
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 CHIC2 Homo sapiens Q9UKJ5
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 BEGAIN Homo sapiens Q9BUH8
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 BEGAIN Homo sapiens Q9BUH8
Y2H Prey Pooling
32296183
Intra
GMCL1 Q96IK5 BEGAIN Homo sapiens Q9BUH8
Y2H Array
32296183
Intra
GMCL1 Q96IK5 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 XAGE2 Homo sapiens Q96GT9
MAPPIT
32296183
Intra
GMCL1 Q96IK5 DAXX Homo sapiens Q9UER7
Validated Y2H
32296183
Intra
GMCL1 Q96IK5 UBE2I Homo sapiens P63279
Validated Y2H
27107012
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (29)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-125877 PROTAC Mcl1 degrader-1 Inhibitor 98.13% Unkown
HY-132307 Mcl-1 inhibitor 6 98.77% Unkown
HY-155472 Mcl-1 inhibitor 17 Inhibitor 99.41% Unkown
HY-16695 MIM1 Inhibitor 98.0% Unkown
HY-RS08230 MCL1 Human Pre-designed siRNA Set A / Unkown
HY-130261 Mcl-1 antagonist 1 Antagonist / Unkown
HY-133015 Mcl-1 inhibitor 3 Inhibitor / Unkown
HY-145825 Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-145825A (E)-Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-145826 Mcl-1 inhibitor 8 Inhibitor / Unkown
HY-148203 Mcl-1 inhibitor 9 Inhibitor / Unkown
HY-148899 Mcl-1 inhibitor 10 Inhibitor / Unkown
HY-153423 Mcl-1 inhibitor 12 Inhibitor / Unkown
HY-153423A Mcl-1 inhibitor 13 Inhibitor / Unkown
HY-154961 Mcl-1 inhibitor 14 / Unkown
HY-154962 Mcl-1 inhibitor 15 Inhibitor / Unkown
HY-155012 Mcl-1 inhibitor 16 Inhibitor / Unkown
HY-159588 Mcl-1 inhibitor 20 Inhibitor / Unkown
HY-163293 Mcl-1 inhibitor 18 Inhibitor / Unkown
HY-170762 Mcl-1 inhibitor 21 Inducer / Unkown
HY-170762A (+)-Mcl-1 inhibitor 21 Inducer / Unkown
HY-170762B (-)-Mcl-1 inhibitor 21 Inducer / Unkown
HY-170763 Mcl-1 inhibitor 22 Inducer / Unkown
HY-170763A (+)-Mcl-1 inhibitor 22 Inducer / Unkown
HY-170763B (-)-Mcl-1 inhibitor 22 / Unkown
HY-184160 Mcl1 Degrader-1 / Unkown
HY-RS05514 GMCL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08231 Mcl1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08232 Mcl1 Rat Pre-designed siRNA Set A / Unkown