PARD6B - par-6 family cell polarity regulator beta Gene

Also Known as PAR6B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84612

About PARD6B

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:50,731,580-50,753,741 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues and 2 paralogues. Broad expression in kidney (RPKM 9.5), lung (RPKM 3.4) and 17 other tissues.

Summary

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]

PARD6B Products (1)

mRNA Protein Name
NM_032521.3 NP_115910.1 partitioning defective 6 homolog beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11260256 GOA
Biological Process GO Annotation Evidence References Source
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
12545177 GOA
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
12545177 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12545177 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARD6B Protein Structure

PB1

PB1: PB1 domain (16 - 95)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (158 - 238)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

partitioning defective 6 homolog beta

  • PAR-6 beta

PARD6B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PARD6B Q9BYG5 FLJ13057 Homo sapiens Q53SE7
Y2H Prey Pooling
25416956
Intra
PARD6B Q9BYG5 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
PARD6B Q9BYG5 FRMD6 Homo sapiens Q96NE9-2
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 FRMD6 Homo sapiens Q96NE9-2
Y2H Array
32296183
Intra
PARD6B Q9BYG5 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 TRIM35 Homo sapiens Q9UPQ4-2
Validated Y2H
32296183
Intra
PARD6B Q9BYG5 CDCA4 Homo sapiens Q9BXL8
Y2H Array
32296183
Intra
PARD6B Q9BYG5 CDCA4 Homo sapiens Q9BXL8
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 GMCL1 Homo sapiens Q96IK5
Y2H Array
32296183
Intra
PARD6B Q9BYG5 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 RASSF3 Homo sapiens Q86WH2
Y2H Array
32296183
Intra
PARD6B Q9BYG5 RASSF3 Homo sapiens Q86WH2
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
33961781
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Array
32296183
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
28514442
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Prey Pooling
25416956
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
14676191
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Anti Tag CoIP
26496610
Intra
PARD6B Q9BYG5 PRKCI Homo sapiens P41743
Y2H Array
25416956
Intra
PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Pull Down
11260256
Intra
PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
33961781
Intra
PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Y2H Array
32296183
Intra
PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
28514442
Intra
PARD6B Q9BYG5 PRKCZ Homo sapiens Q05513
Anti Tag CoIP
14676191
Intra
PARD6B Q9BYG5 YWHAH Homo sapiens Q04917
Anti Tag CoIP
26496610
Intra
PARD6B Q9BYG5 YWHAH Homo sapiens Q04917
Anti Tag CoIP
14676191
Intra
PARD6B Q9BYG5 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra
PARD6B Q9BYG5 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
PARD6B Q9BYG5 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
PARD6B Q9BYG5 RHOJ Homo sapiens Q9H4E5
Y2H Prey Pooling
25416956
Intra
PARD6B Q9BYG5 RHOJ Homo sapiens Q9H4E5
Validated Y2H
32296183
Intra
PARD6B Q9BYG5 RHOQ Homo sapiens P17081
Y2H Array
32296183
Intra
PARD6B Q9BYG5 RHOQ Homo sapiens P17081
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
PARD6B Q9BYG5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 ZSCAN4 Homo sapiens Q8NAM6
Y2H Array
32296183
Intra
PARD6B Q9BYG5 ZSCAN4 Homo sapiens Q8NAM6
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Array
25416956
Intra
PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
25416956
Intra
PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
PARD6B Q9BYG5 MAGOHB Homo sapiens Q96A72
Y2H Array
32296183
Intra
PARD6B Q9BYG5 MAGOHB Homo sapiens Q96A72
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 RAC3 Homo sapiens P60763
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 RAC3 Homo sapiens P60763
Y2H Array
32296183
Intra
PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Array
32296183
Intra
PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Prey Pooling
25416956
Intra
PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Anti Tag CoIP
14676191
Intra
PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Array
25416956
Intra
PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Prey Pooling
32296183
Intra
PARD6B Q9BYG5 CDC42 Homo sapiens P60953
Y2H Pooling
20936779
Intra
PARD6B Q9BYG5 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
33961781
Intra
PARD6B Q9BYG5 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
26496610
Intra
PARD6B Q9BYG5 PARD3 Homo sapiens Q8TEW0
Anti Tag CoIP
14676191
Cross: Cross-species interaction Intra: Intraspecies interaction

PARD6B Antibodies

Cat. No. Product Name Application Reactivity
HY-P89927 PARD6B Antibody (YA9271) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10039 PARD6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PARD6B VGNC VGNC:107850
Rattus norvegicus PARD6B RGD RGD:1308205
Canis familiaris PARD6B VGNC VGNC:54725
Bos taurus PARD6B VGNC VGNC:32584
Mus musculus PARD6B MGD MGI:2135605
Others PARD6B NCBI