RAC3 - Rac family small GTPase 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5881

About RAC3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,031,678-82,034,204 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 10.2), brain (RPKM 6.3) and 22 other tissues.

Summary

The protein encoded by this gene is a GTPase which belongs to the Ras superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

RAC3 Products (2)

mRNA	Protein	Name
NM_001316307.2	NP_001303236.1	ras-related C3 botulinum toxin substrate 3 isoform 2
NM_005052.3	NP_005043.1	ras-related C3 botulinum toxin substrate 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	11956649	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	11756406	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11956649	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	29276006	GOA
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11956649	GOA
involved in cell projection assembly	IDA IDA: Inferred from direct assay	11956649	GOA
involved in positive regulation of cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	11756406	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11756406	GOA
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21297961	GOA
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21297961	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell periphery	IDA IDA: Inferred from direct assay	11756406	GOA
located in endomembrane system	IDA IDA: Inferred from direct assay	11956649	GOA
part of filamentous actin	IDA IDA: Inferred from direct assay	16525025	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21297961	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21297961	GOA
located in growth cone	IDA IDA: Inferred from direct assay	16525025	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	16525025	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	16525025	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11756406	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAC3 Protein Structure

Ras

0
100
192 a.a.

Protein Preferred Names	Protein Names
ras-related C3 botulinum toxin substrate 3	p21-Rac3

RAC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAC3	P60763	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	RAC3	P60763	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	RAC3	P60763	NRBP1	Homo sapiens	Q9UHY1	Anti Tag CoIP	11956649
Intra	RAC3	P60763	ESR1	Homo sapiens	P03372	Phage Display	21217774
Intra	RAC3	P60763	ESR1	Homo sapiens	P03372	Y2H	21217774
Intra	RAC3	P60763	ESR1	Homo sapiens	P03372	Pull Down	21217774

Cross: Cross-species interaction Intra: Intraspecies interaction

RAC3 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82057	RAC3 Antibody (YA1802)	WB, IHC-P	Human, Mouse, Rat
HY-P82057A	RAC3 Antibody (YA1802)(PBS only)	WB, IHC-P	Human, Mouse, Rat
HY-P83545	RAC1/2/3 Antibody (YA3290)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Structural Brain Anomalies And Dysmorphic Facies	NEDBAF
Ascaridiasis	Ascariasis
Toxic Megacolon	Megacolon, Toxic Toxic Dilatation Of Colon Toxic Functional Megacolon
Deafness, Autosomal Recessive 104	DFNB104 Autosomal Recessive Nonsyndromic Deafness 104 Autosomal Recessive Deafness 104 Deafness, Autosomal Recessive, 104 Deafness, Autosomal Recessive, Type 104
Clostridium Difficile Colitis	Pseudomembranous Colitis Colitis Pseudomembranous Enterocolitis, Pseudomembranous Pseudomembranous Enterocolitis Clostridium Difficile Infection
Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia	Konigsmark Syndrome DFNA1 Autosomal Dominant Nonsyndromic Deafness 1 Lfhl1 Deafness, Autosomal Dominant 1 Autosomal Dominant Deafness 1 Autosomal Dominant Deafness 1, With Or Without Thrombocytopenia Hereditary Low Frequency Hearing Loss 1 Diaph1-Related Sensorineural Hearing Loss-Thrombocytopenia Syndrome Diaph1-Related Sensorineural Deafness-Thrombocytopenia Syndrome Hereditary Low-Frequency Hearing Loss Hereditary Low-Frequency Sensorineural Hearing Loss Lfsnhl1 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 1 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 1 Deafness, Autosomal Dominant, Type 1
Osteogenesis Imperfecta, Type Xv	Osteogenesis Imperfecta Type 15 OI15 Osteogenesis Imperfecta Type Xv Oi, Type Xv Osteogenesis Imperfecta 15 Oi Type Xv Oi-Xv
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-12810	EHop-016	Inhibitor	99.38%	Unkown
HY-113801	N-(3-Oxooctanoyl)-DL-homoserine lactone		99.69%	Unkown
HY-132404S	(rac)-3-O-Methyl DOPA-d3		97.0%	Unkown
HY-RS09091	NCOA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100841	(Rac)-3-Hydroxyphenylglycine	Control	99.14%	Unkown
HY-136345	(Rac)-3′-Hydroxy simvastatin		99.71%	Unkown
HY-167811	1,2-Dipalmitoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))] hydrochloride		/	Unkown
HY-RS11593	RAC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W653885	rac 3,4-Dihydroxymandelic Acid-d3		/	Unkown
HY-RS20451	Ncoa3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21413	Rac3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27932	Rac3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W779204	rac-3-Hexadecanamido-2-methoxypropan-1-ol phosphocholine hydrate		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAC3	VGNC	VGNC:76642
Bos taurus	RAC3	VGNC	VGNC:55865
Felis catus	RAC3	VGNC	VGNC:99429
Rattus norvegicus	RAC3	RGD	RGD:1590052
Mus musculus	RAC3	MGD	MGI:2180784
Others	RAC3	NCBI