2. Gene
  3. RAC3 - Rac family small GTPase 3 Gene

RAC3 - Rac family small GTPase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 5881 | Gene type: protein coding

About RAC3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,031,678-82,034,204 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 10.2), brain (RPKM 6.3) and 22 other tissues.

Summary

The protein encoded by this gene is a GTPase which belongs to the Ras superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

RAC3 Products(2)

mRNA Protein Name
NM_001316307.2 NP_001303236.1 ras-related C3 botulinum toxin substrate 3 isoform 2
NM_005052.3 NP_005043.1 ras-related C3 botulinum toxin substrate 3 isoform 1

RAC3 Protein Structure

Ras

Ras: Ras family (5 - 177)

  • 0
  • 100
  • 192 a.a.
Protein Preferred Names Protein Names

ras-related C3 botulinum toxin substrate 3

p21-Rac3

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Structural Brain Anomalies And Dysmorphic Facies

NEDBAF
Ascaridiasis

Ascariasis
Toxic Megacolon

Megacolon, Toxic

Toxic Dilatation Of Colon

Toxic Functional Megacolon
Deafness, Autosomal Recessive 104

DFNB104

Autosomal Recessive Nonsyndromic Deafness 104

Autosomal Recessive Deafness 104

Deafness, Autosomal Recessive, 104

Deafness, Autosomal Recessive, Type 104
Clostridium Difficile Colitis

Pseudomembranous Colitis

Colitis Pseudomembranous

Enterocolitis, Pseudomembranous

Pseudomembranous Enterocolitis

Clostridium Difficile Infection
Deafness, Autosomal Dominant 1, With Or Without Thrombocytopenia

Konigsmark Syndrome

DFNA1

Autosomal Dominant Nonsyndromic Deafness 1

Lfhl1

Deafness, Autosomal Dominant 1

Autosomal Dominant Deafness 1

Autosomal Dominant Deafness 1, With Or Without Thrombocytopenia

Hereditary Low Frequency Hearing Loss 1

Diaph1-Related Sensorineural Hearing Loss-Thrombocytopenia Syndrome

Diaph1-Related Sensorineural Deafness-Thrombocytopenia Syndrome

Hereditary Low-Frequency Hearing Loss

Hereditary Low-Frequency Sensorineural Hearing Loss

Lfsnhl1

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 1

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 1

Deafness, Autosomal Dominant, Type 1
Osteogenesis Imperfecta, Type Xv

Osteogenesis Imperfecta Type 15

OI15

Osteogenesis Imperfecta Type Xv

Oi, Type Xv

Osteogenesis Imperfecta 15

Oi Type Xv

Oi-Xv
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16659 EHT 1864 Inhibitor 99.85% Unkown
HY-12810 EHop-016 Inhibitor 99.85% Unkown
HY-113801 N-(3-Oxooctanoyl)-DL-homoserine lactone 99.15% Unkown
HY-132404S (rac)-3-O-Methyl DOPA-d3 ≥97.0% Unkown
HY-136345 (Rac)-3′-Hydroxy simvastatin / Unkown
HY-RS11593 RAC3 Human Pre-designed siRNA Set A / Unkown
HY-100841 (Rac)-3-Hydroxyphenylglycine Inhibitor 99.58% Unkown
HY-W154267S (Rac)-3-Aminoisobutyric acid-d3 hydrochloride / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RAC3 VGNC VGNC:76642
Bos taurus RAC3 VGNC VGNC:55865
Felis catus RAC3 VGNC VGNC:99429
Rattus norvegicus RAC3 RGD RGD:1590052
Mus musculus RAC3 MGD MGI:2180784