rac 3,4-Dihydroxymandelic Acid-d3
Based on 1 Customer Validation
rac 3,4-Dihydroxymandelic Acid-d3 is the deuterated-labeled 3,4-Dihydroxymandelic acid (HY-113474). 3,4‑Dihydroxymandelic acid is a metabolite of Norepinephrine (HY-13715) with free radical scavenging and antioxidant activities. 3,4-Dihydroxymandelic acid acts as a chemoattractant for enterohaemorrhagic Escherichia coli (EHEC), regulates virulence gene expression and bacterial adhesion to intestinal epithelial cells in a QseC-dependent manner, and targets EHEC to preferred infection sites. 3,4‑Dihydroxymandelic acid can be used in studies related to oxidative stress and enterohaemorrhagic Escherichia coli infection.
For research use only. We do not sell to patients.
- Formula: C8H5D3O5
- Molecular Weight:187.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 775-01-9
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Molecular Weight 187.16
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Formula C8H5D3O5
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SMILES
OC1=C(C([2H])=C(C([2H])=C1O)C(C(O)=O)O)[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 83.33 mg/mL (445.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.3430 mL | 26.7151 mL | 53.4302 mL | 133.5755 mL |
| 5 mM | 1.0686 mL | 5.3430 mL | 10.6860 mL | 26.7151 mL | |
| 10 mM | 0.5343 mL | 2.6715 mL | 5.3430 mL | 13.3576 mL | |
| 15 mM | 0.3562 mL | 1.7810 mL | 3.5620 mL | 8.9050 mL | |
| 20 mM | 0.2672 mL | 1.3358 mL | 2.6715 mL | 6.6788 mL | |
| 25 mM | 0.2137 mL | 1.0686 mL | 2.1372 mL | 5.3430 mL | |
| 30 mM | 0.1781 mL | 0.8905 mL | 1.7810 mL | 4.4525 mL | |
| 40 mM | 0.1336 mL | 0.6679 mL | 1.3358 mL | 3.3394 mL | |
| 50 mM | 0.1069 mL | 0.5343 mL | 1.0686 mL | 2.6715 mL | |
| 60 mM | 0.0891 mL | 0.4453 mL | 0.8905 mL | 2.2263 mL | |
| 80 mM | 0.0668 mL | 0.3339 mL | 0.6679 mL | 1.6697 mL | |
| 100 mM | 0.0534 mL | 0.2672 mL | 0.5343 mL | 1.3358 mL |
rac 3,4-Dihydroxymandelic Acid-d3 Related Classifications
HY-W653885 Related Classifications
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Keywords
- rac 3,4-Dihydroxymandelic Acid-d3
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Drug Metabolite
- Bacterial
- α-tocopherol
- intestinal epithelial cells
- commensal microbiota
- C57BL/6 mice
- HeLa S3 cells
- QseC
- Enterohemorrhagic Escherichia coli
- human dermal fibroblasts
- noradrenaline
- EHEC O157:H7 strain 86-24
- Inhibitor
- inhibitor
- inhibit