775-01-9
Chemical Structure
3,4-Dihydroxymandelic acid
- CAS No.: 775-01-9
- Formula:C8H8O5
- Molecular Weight:184.15
IUPAC Name: 2-(3,4-dihydroxyphenyl)-2-hydroxyacetic acid
InChIKey: RGHMISIYKIHAJW-UHFFFAOYSA-N
SMILES: O=C(O)C(O)C1=CC=C(O)C(O)=C1
Biological Activity: 3,4‑Dihydroxymandelic acid is a metabolite of Norepinephrine (HY-13715) with free radical scavenging and antioxidant activities. 3,4-Dihydroxymandelic acid acts as a chemoattractant for enterohaemorrhagic Escherichia coli (EHEC), regulates virulence gene expression and bacterial adhesion to intestinal epithelial cells in a QseC-dependent manner, and targets EHEC to preferred infection sites. 3,4‑Dihydroxymandelic acid can be used in studies related to oxidative stress and enterohaemorrhagic Escherichia coli infection[1][2].
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3,4-Dihydroxymandelic acid | 98.0% | 3,4‑Dihydroxymandelic acid is a metabolite of Norepinephrine (HY-13715) with free radical scavenging and antioxidant activities. 3,4-Dihydroxymandelic acid acts as a chemoattractant for enterohaemorrhagic Escherichia coli (EHEC), regulates virulence gene expression and bacterial adhesion to intestinal epithelial cells in a QseC-dependent manner, and targets EHEC to preferred infection sites. 3,4‑Dihydroxymandelic acid can be used in studies related to oxidative stress and enterohaemorrhagic Escherichia coli infection. | ||||||||||||||||||||
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3,4-Dihydroxymandelic acid (Standard) | ≥98% | 3,4-Dihydroxymandelic acid (Standard) is the analytical standard of 3,4-Dihydroxymandelic acid (HY-113474). This product is intended for research and analytical applications. 3,4‑Dihydroxymandelic acid is a metabolite of Norepinephrine (HY-13715) with free radical scavenging and antioxidant activities. 3,4-Dihydroxymandelic acid acts as a chemoattractant for enterohaemorrhagic Escherichia coli (EHEC), regulates virulence gene expression and bacterial adhesion to intestinal epithelial cells in a QseC-dependent manner, and targets EHEC to preferred infection sites. 3,4‑Dihydroxymandelic acid can be used in studies related to oxidative stress and enterohaemorrhagic Escherichia coli infection. | ||||||||||||||||||||
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rac 3,4-Dihydroxymandelic Acid-d3 | rac 3,4-Dihydroxymandelic Acid-d3 is the deuterated-labeled 3,4-Dihydroxymandelic acid (HY-113474). 3,4‑Dihydroxymandelic acid is a metabolite of Norepinephrine (HY-13715) with free radical scavenging and antioxidant activities. 3,4-Dihydroxymandelic acid acts as a chemoattractant for enterohaemorrhagic Escherichia coli (EHEC), regulates virulence gene expression and bacterial adhesion to intestinal epithelial cells in a QseC-dependent manner, and targets EHEC to preferred infection sites. 3,4‑Dihydroxymandelic acid can be used in studies related to oxidative stress and enterohaemorrhagic Escherichia coli infection. | |||||||||||||||||||||
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References
- [1]. Sule N, et al. The Norepinephrine Metabolite 3,4-Dihydroxymandelic Acid Is Produced by the Commensal Microbiota and Promotes Chemotaxis and Virulence Gene Expression in Enterohemorrhagic Escherichia coli. Infection and immunity. 2017 Oct;85(10):e00431-17. [Content Brief]
- [2]. Ley JP, et al. 3,4-Dihydroxymandelic acid, a noradrenalin metabolite with powerful antioxidative potential. Journal of agricultural and food chemistry. 2002 Oct 09;50(21):5897-902.
