1. Acids and Aldehydes
  2. Vanillylmandelic acid

Vanillylmandelic acid 

Cat. No.: HY-113121
Handling Instructions

Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM.

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Vanillylmandelic acid Chemical Structure

Vanillylmandelic acid Chemical Structure

CAS No. : 55-10-7

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Description

Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].

In Vitro

Vanillylmandelic acid has antioxidant activity, the IC50 value is determined as the amount of VMA required to reduce 50% of the starting concentration of free radical is 33*10-6 M in the UV-Vis decolourisation DPPH assay[1].

In Vivo

Vanillylmandelic acid (intra-arterial injection over 1 min; 1, 10 and 100 mg/kg; the 60 min-observation period) produces a significant difference between vanillylmandelic acid groups and controls. Vanillylmandelic acid decreases the heart rate by 17.5%, 17.9% and 18.9% after 1, 10 and 100 mg/kg, respectively. Mean blood pressure is decreased by 13.5% in control animals as compared to 37%, 23% and 26% after 1, 10 and 100 mg/kg, respectively, in wistar rats[1].

Molecular Weight

198.17

Formula

C₉H₁₀O₅

CAS No.

55-10-7

SMILES

O=C(O)C(O)C1=CC=C(O)C(OC)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Vanillylmandelic acidOthersantioxidantDPPHInhibitorinhibitorinhibit

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Vanillylmandelic acid
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