1. Acids and Aldehydes
  2. Vanillylmandelic acid

Vanillylmandelic acid 

Cat. No.: HY-113121 Purity: 99.75%
Handling Instructions

Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM.

For research use only. We do not sell to patients.

Vanillylmandelic acid Chemical Structure

Vanillylmandelic acid Chemical Structure

CAS No. : 55-10-7

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].

In Vitro

Vanillylmandelic acid has antioxidant activity, the IC50 value is determined as the amount of VMA required to reduce 50% of the starting concentration of free radical is 33*10-6 M in the UV-Vis decolourisation DPPH assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vanillylmandelic acid (intra-arterial injection over 1 min; 1, 10 and 100 mg/kg; the 60 min-observation period) produces a significant difference between vanillylmandelic acid groups and controls. Vanillylmandelic acid decreases the heart rate by 17.5%, 17.9% and 18.9% after 1, 10 and 100 mg/kg, respectively. Mean blood pressure is decreased by 13.5% in control animals as compared to 37%, 23% and 26% after 1, 10 and 100 mg/kg, respectively, in wistar rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

198.17

Formula

C₉H₁₀O₅

CAS No.

55-10-7

SMILES

O=C(O)C(O)C1=CC=C(O)C(OC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1261.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0462 mL 25.2309 mL 50.4617 mL
5 mM 1.0092 mL 5.0462 mL 10.0923 mL
10 mM 0.5046 mL 2.5231 mL 5.0462 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.50 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (10.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Vanillylmandelic acidOthersantioxidantDPPHInhibitorinhibitorinhibit

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Product Name:
Vanillylmandelic acid
Cat. No.:
HY-113121
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