Vanillylmandelic acid-d3
Based on 1 Customer Validation
Vanillylmandelic acid-d3 is the deuterium labeled Vanillylmandelic acid. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 74495-70-8
- Formula: C9H7D3O5
- Molecular Weight:201.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 74495-70-8
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Unlabeled Cas 55-10-7
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Appearance Solid
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Molecular Weight 201.19
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Formula C9H7D3O5
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Color Light brown to brown
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SMILES
OC(C(C1=CC(OC([2H])([2H])[2H])=C(C=C1)O)O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (621.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Michalis K Kolentinis, et al.Cardiovascular effects of vanillylmandelic acid in rats. Eur J Pharmacol. 2013 Mar 5;703(1-3):46-52. [Content Brief]
[3]. Dušan Dimić, et al. Experimental and theoretical elucidation of structural and antioxidant properties of vanillylmandelic acid and its carboxylate anion. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jun 5;198:61-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9704 mL | 24.8519 mL | 49.7038 mL | 124.2594 mL |
| 5 mM | 0.9941 mL | 4.9704 mL | 9.9408 mL | 24.8519 mL | |
| 10 mM | 0.4970 mL | 2.4852 mL | 4.9704 mL | 12.4259 mL | |
| 15 mM | 0.3314 mL | 1.6568 mL | 3.3136 mL | 8.2840 mL | |
| 20 mM | 0.2485 mL | 1.2426 mL | 2.4852 mL | 6.2130 mL | |
| 25 mM | 0.1988 mL | 0.9941 mL | 1.9882 mL | 4.9704 mL | |
| 30 mM | 0.1657 mL | 0.8284 mL | 1.6568 mL | 4.1420 mL | |
| 40 mM | 0.1243 mL | 0.6213 mL | 1.2426 mL | 3.1065 mL | |
| 50 mM | 0.0994 mL | 0.4970 mL | 0.9941 mL | 2.4852 mL | |
| 60 mM | 0.0828 mL | 0.4142 mL | 0.8284 mL | 2.0710 mL | |
| 80 mM | 0.0621 mL | 0.3106 mL | 0.6213 mL | 1.5532 mL | |
| 100 mM | 0.0497 mL | 0.2485 mL | 0.4970 mL | 1.2426 mL |
Vanillylmandelic acid-d3 Related Classifications
HY-113121S Related Classifications
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