1. Metabolic Enzyme/Protease
    Neuronal Signaling
    GPCR/G Protein
  2. Endogenous Metabolite
    Adrenergic Receptor
  3. Norepinephrine

Norepinephrine (Synonyms: Levarterenol; L-Noradrenaline)

Cat. No.: HY-13715 Purity: 98.08%
Handling Instructions

Norepinephrine (Levarterenol; L-Noradrenaline) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

For research use only. We do not sell to patients.

Norepinephrine Chemical Structure

Norepinephrine Chemical Structure

CAS No. : 51-41-2

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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Norepinephrine:

Top Publications Citing Use of Products

    Norepinephrine purchased from MCE. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311.

    Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

    Norepinephrine purchased from MCE. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.
    • Biological Activity

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    Norepinephrine (Levarterenol; L-Noradrenaline) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

    IC50 & Target

    Human Endogenous Metabolite


    In Vitro

    Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1].
    Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment.
    Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
    Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight




    CAS No.



    OC1=CC=C([[email protected]@H](O)CN)C=C1O


    Room temperature in continental US; may vary elsewhere.


    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (29.55 mM; ultrasonic and warming and heat to 60°C)

    H2O : < 0.1 mg/mL (insoluble)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.9109 mL 29.5543 mL 59.1086 mL
    5 mM 1.1822 mL 5.9109 mL 11.8217 mL
    10 mM 0.5911 mL 2.9554 mL 5.9109 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Cell Assay

    Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.


    Purity: 98.08%

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    NorepinephrineLevarterenol L-NoradrenalineEndogenous MetaboliteAdrenergic ReceptorAutophagyBeta ReceptorInhibitorinhibitorinhibit

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