1. Metabolic Enzyme/Protease
    Neuronal Signaling
    GPCR/G Protein
    Autophagy
  2. Endogenous Metabolite
    Adrenergic Receptor
    Autophagy
  3. Norepinephrine

Norepinephrine (Synonyms: Levarterenol; L-Noradrenaline)

Cat. No.: HY-13715 Purity: 98.08%
Handling Instructions

Norepinephrine (Levarterenol) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

For research use only. We do not sell to patients.

Norepinephrine Chemical Structure

Norepinephrine Chemical Structure

CAS No. : 51-41-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 60 Get quote
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 7 publication(s) in Google Scholar

Other Forms of Norepinephrine:

Top Publications Citing Use of Products

    Norepinephrine purchased from MCE. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311.

    Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

    Norepinephrine purchased from MCE. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Norepinephrine (Levarterenol) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2].

    Clinical Trial
    Molecular Weight

    169.18

    Formula

    C₈H₁₁NO₃

    CAS No.

    51-41-2

    SMILES

    OC1=CC=C([[email protected]@H](O)CN)C=C1O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 5 mg/mL (29.55 mM; Need ultrasonic)

    DMSO : 5 mg/mL (29.55 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.9109 mL 29.5543 mL 59.1086 mL
    5 mM 1.1822 mL 5.9109 mL 11.8217 mL
    10 mM 0.5911 mL 2.9554 mL 5.9109 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Cell Assay
    [2]

    Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Norepinephrine
    Cat. No.:
    HY-13715
    Quantity: