2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Endogenous Metabolite
  4. γ-Aminobutyric acid

γ-Aminobutyric acid  (Synonyms: 4-Aminobutyric acid)

Cat. No.: HY-N0067 Purity: 99.71%
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γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system.

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γ-Aminobutyric acid Chemical Structure

γ-Aminobutyric acid Chemical Structure

CAS No. : 56-12-2

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in Water USD 61 In-stock
Solid
100 mg USD 55 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of γ-Aminobutyric acid:

γ-Aminobutyric acid Related Antibodies

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Description

γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system[1][2].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM[3].
? Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation[4].
? γ-Aminobutyric acid activates GABA A receptors, causing cell cycle arrest in S phase and limiting growth[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Aminobutyric acid Related Antibodies

Cell Migration Assay [4]

Cell Line: Cortical plate (cp) neurons
Concentration: 1-5 μM
Incubation Time: 18 hours
Result: Promoted motility via G-protein activation and arrested attractantinduced migration via GABAA receptor-mediated depolarization.
In Vivo

γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice[6].
? γ-Aminobutyric acid (1, 2, 4?mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogens free (SPF) Bagg’s albino (Balb/c) mice (18–20 g, 8 weeks old)[6]
Dosage: 33.95, 102.25, 306.75 mg/kg
Administration: Oral gavage; single dose; 20 mL/kg administration; measured in an hour
Result: Prolonged the sleep duration, increased sleep rate, and shorten the sleep latency more effectively.
Animal Model: Sprague-Dawley rat indued by DEHP (HY-B1945) (500 mg/kg)[7]
Dosage: 1, 2, 4 mg/kg
Administration: Oral gavage; combined administration; for 30 consecutive days
Result: Reduced the levels of nitric oxide and nitric oxide synthase in rats treated with DEHP.
Molecular Weight

103.12

Formula

C4H9NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCN
Structure Classification
Initial Source

mammalian central nervous system
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (484.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.6974 mL 48.4872 mL 96.9744 mL
5 mM 1.9395 mL 9.6974 mL 19.3949 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (969.74 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.71%

COA (242 KB) HNMR (113 KB) RP-HPLC (141 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.6974 mL 48.4872 mL 96.9744 mL 242.4360 mL
5 mM 1.9395 mL 9.6974 mL 19.3949 mL 48.4872 mL
10 mM 0.9697 mL 4.8487 mL 9.6974 mL 24.2436 mL
15 mM 0.6465 mL 3.2325 mL 6.4650 mL 16.1624 mL
20 mM 0.4849 mL 2.4244 mL 4.8487 mL 12.1218 mL
25 mM 0.3879 mL 1.9395 mL 3.8790 mL 9.6974 mL
30 mM 0.3232 mL 1.6162 mL 3.2325 mL 8.0812 mL
40 mM 0.2424 mL 1.2122 mL 2.4244 mL 6.0609 mL
50 mM 0.1939 mL 0.9697 mL 1.9395 mL 4.8487 mL
60 mM 0.1616 mL 0.8081 mL 1.6162 mL 4.0406 mL
80 mM 0.1212 mL 0.6061 mL 1.2122 mL 3.0304 mL
100 mM 0.0970 mL 0.4849 mL 0.9697 mL 2.4244 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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γ-Aminobutyric acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Aminobutyric acid56-12-24-Aminobutyric acidGABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAGADpolyamineneurotransmittercentral nervous systemCNSionotropicmetabotropicdevelopmentchemotaxiscortexG-proteindepolarizationneuronmigrationInhibitorinhibitorinhibit

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