1. GPCR/G Protein
    Neuronal Signaling
    Autophagy
  2. Adrenergic Receptor
    Autophagy
  3. Norepinephrine hydrochloride

Norepinephrine hydrochloride (Synonyms: Levarterenol (hydrochloride); L-Noradrenaline (hydrochloride))

Cat. No.: HY-13715A
Handling Instructions

Norepinephrine hydrochloride (Levarterenol hydrochloride) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

For research use only. We do not sell to patients.

Norepinephrine hydrochloride Chemical Structure

Norepinephrine hydrochloride Chemical Structure

CAS No. : 329-56-6

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Top Publications Citing Use of Products

    Norepinephrine hydrochloride purchased from MCE. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311.

    Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

    Norepinephrine hydrochloride purchased from MCE. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.
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    Description

    Norepinephrine hydrochloride (Levarterenol hydrochloride) is a β1-selective adrenergic receptor agonist with EC50 of 5.37 μM.

    IC50 & Target

    EC50: 5.37 μM (β1-selective adrenergic receptor)[1]

    In Vitro

    Norepinephrine (NE) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist. Norepinephrine(NE) also has direct activity at the β2-adrenoceptor in higher concentrations[1]. Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 µM) with or without CGP (10 nM) co-treatment. Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect. Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[2].

    Clinical Trial
    Molecular Weight

    205.64

    Formula

    C₈H₁₂ClNO₃

    CAS No.

    329-56-6

    SMILES

    OC1=CC=C([[email protected]@H](O)CN)C=C1O.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    Cell Assay
    [2]

    Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
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