1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Phenylephrine

Phenylephrine (Synonyms: (R)-(-)-Phenylephrine; L-Phenylephrine)

Cat. No.: HY-B0769 Purity: ≥98.0%
Handling Instructions

(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.

For research use only. We do not sell to patients.

Phenylephrine Chemical Structure

Phenylephrine Chemical Structure

CAS No. : 59-42-7

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Based on 2 publication(s) in Google Scholar

Other Forms of Phenylephrine:

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Description

(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.

In Vitro

(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist with pKi values of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes[4]. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

167.21

Formula

C₉H₁₃NO₂

CAS No.
SMILES

O[[email protected]](C1=CC(O)=CC=C1)CNC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (29.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9805 mL 29.9025 mL 59.8050 mL
5 mM 1.1961 mL 5.9805 mL 11.9610 mL
10 mM 0.5981 mL 2.9903 mL 5.9805 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[5]

Rats: A total of 170 male Wistar rats are randomLy allocated into 17 groups (n=10) using random number tables. Short-term (40 minutes) mechanical ventilation with high tidal volume is performed to induce lung injury, impair active Na+ transport and lung liquid clearance in the rats. Unventilated rats serves as controls. To demonstrate the effect of phenylephrine on alveolar fluid clearance, phenylephrine at different concentrations (10, 1, 0.1, 0.01, and 0.001 μM) is injected into the alveolar space of the HVT ventilated rats[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: ≥98.0%

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Keywords:

Phenylephrine(R)-(-)-Phenylephrine L-PhenylephrineAdrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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Phenylephrine
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