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Phenylephrine

(Synonyms: (R)-(-)-Phenylephrine; L-Phenylephrine)
35 Cited Publications
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Based on 35 publication(s) in Google Scholar

(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant.

For research use only. We do not sell to patients.

  • Purity: 99.98%
  • CAS No.: 59-42-7
  • Formula: C9H13NO2
  • Molecular Weight:167.21
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Phenylephrine Chemical Structure
    Phenylephrine Chemical Structure
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
  • Experimental Validation Results for Phenylephrine
CAS No.: 59-42-7
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  • Phenylephrine Chemical Structure
    Phenylephrine Chemical Structure
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    Phenylephrine purchased from MedChemExpress. Usage Cited in: Trends Biotechnol. 2025 Apr;43(4):918-945. [Abstract]

    Customer Validation
     Cross-sections of samples fabricated change of double- and triple-layered arterial models following Phenylephrine (4 μM) and Acetylcholine treatment.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]

    Customer Validation
     si-NC or si-FGF21 were infected with adenovirus encoding LC3 for 24 h, then subjected to Phenylephrine (100 μM) stimulation for 24 h. These cells were stained using MitoTracker Red dye, scale bar = 20 µm.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]

    Customer Validation
     Neonatal rat cardiomyocytes were infected with si-NC or si-PINK1, and then treated with control or 100 μM Phenylephrine for 24 h, followed by vehicle or FGF21 protein. LC3 and PINK1, FGF21 protein levels.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: Mater Des. 2025 Aug.

    Customer Validation
     AC16 and NRVMs were treated with DMSO or Phenylephrine hydrochloride (PE; 100 μM) for 48 h to induce cardiac hypertrophy. Upper panel: the expression of MYH7, BNP and METTL3 were detected by immunoblotting. Lower panel: The densities of the signals were plotted as the mean ± SD from 3 independent experiments.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Aug 8;242(Pt 1):117218. [Abstract]

    Customer Validation
     RT-qPCR was used to analyze the expression levels of ANP, BNP, β-MHC in H9c2 cells Phenylephrine stimulation.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jul 16;15(1):5985. [Abstract]

    Customer Validation
     Contraction of isolated aortic rings from indicated groups in response to the Phenylephrine (10 nM-100 μM) treatment.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Feb 20:212:477-492. [Abstract]

    Customer Validation
     Rhodamine phalloidin staining was used to analyze the cytoskeleton of cardiomyocytes (red). Neonatal rat cardiomyocytes were pretreated with the different concentration of BRE or DMSO vehicle for 2 h, and then stimulated with 10 μM Phenylephrine hydrochloride (PE) for 48 h.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Feb 20:212:477-492. [Abstract]

    Customer Validation
     The levels of hypertrophic marker (β-MHC) and fibrosis indice (COL-1) were detected by Western blot analysis in cardiomyocytes. Cells （H9C2 and Neonatal rat cardiomyocytes，NRCMS） were pretreated with the different concentration of BRE or DMSO vehicle for 2 h, and then stimulated with 10 μM Phenylephrine hydrochloride (PE) for 48 h.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Feb 20:212:477-492. [Abstract]

    Customer Validation
     Intracellular and mitochondrial ROS accumulation were observed and quantitative through DCFH-DA and mitoSOX indicators through confocal laser scanning microscopy (green: DCFH-DA, red: mitoSOX, blue: hoechst 33342). Neonatal rat cardiomyocytes (NRCMs) were pretreated with the different concentration of BRE or DMSO vehicle for 2 h, and then stimulated with 10 μM Phenylephrine hydrochloride (PE) for 48 h.

  • 1/16

    Phenylephrine purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Feb 20:212:477-492. [Abstract]

    Customer Validation
     The expression of MFN-1 and MFN-2 were analyzed by Western blot in NRCM cardiomyocytes. Neonatal rat cardiomyocytes (NRCMs) were pretreated with the different concentration of BRE or DMSO vehicle for 2 h, and then stimulated with 10 μM Phenylephrine hydrochloride (PE) for 48 h.

  • Phenylephrine