1. GPCR/G Protein
  2. Endothelin Receptor
  3. Endothelin 1 (swine, human)

Endothelin 1 (swine, human) 

Cat. No.: HY-P0202 Purity: 96.35%
Handling Instructions

Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.

For research use only. We do not sell to patients.

Endothelin 1 (swine, human) Chemical Structure

Endothelin 1 (swine, human) Chemical Structure

CAS No. : 117399-94-7

Size Price Stock Quantity
500 μg USD 144 In-stock
Estimated Time of Arrival: December 31
1 mg USD 264 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1056 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB[1].

IC50 & Target

ETA and ETB[1]

In Vitro

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2491.90

Formula

C₁₀₉H₁₅₉N₂₅O₃₂S₅

CAS No.

117399-94-7

Sequence

Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

Sequence Shortening

CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

SMILES

[CSCSSLMDKECVYFCHLDIIW(Disulfide bridge: Cys1-Cys15,Cys3-Cys11)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (20.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4013 mL 2.0065 mL 4.0130 mL
5 mM 0.0803 mL 0.4013 mL 0.8026 mL
10 mM 0.0401 mL 0.2007 mL 0.4013 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 96.35%

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Keywords:

Endothelin 1 (swine, human)Endothelin ReceptorInhibitorinhibitorinhibit

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Endothelin 1 (swine, human)
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HY-P0202
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