2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. FOXO
  5. FOXO1 Isoform

FOXO1

FOXO1 is a Forkhead box O transcription factor regulated by insulin/PI3K/Akt signaling, and it coordinates gene programs controlling metabolism, apoptosis, cell-cycle arrest, oxidative-stress resistance, and DNA repair[1]. Mechanistically, insulin or growth-factor stimulation phosphorylates FOXO proteins through Akt, drives nuclear export, and suppresses FOXO-dependent transcription[1]. In ovarian granulosa cells, FSH and IGF-1 activate PI3K/AKT signaling downstream through FOXO1, supporting gene expression linked to follicle maturation[2]. In diabetes models, FOXO1 regulates hepatic glucose production, and selective FOXO1 inhibition improved insulin sensitivity and glucose control in db/db mice without weight gain[3]. Compared with related isoforms, mammals contain FOXO1, FOXO3, FOXO4, and FOXO6, but FoxO1-null mice die at embryonic day 10.5 from angiogenesis defects, while FoxO3- and FoxO4-null mice are viable[1]. This isoform distinction supports FOXO1-focused experimental designs when metabolic control, hepatic glucose output, or developmental vascular phenotypes are primary endpoints[1][3]. For experimental applications, compound 10 showed higher FOXO1 selectivity than AS1842856 and served as a superior tool molecule for investigating FOXO1 function in vitro and in vivo[3].

FOXO1 Related Products (3):

Cat. No. Product Name Effect Purity
  • HY-N2440
    Gypenoside A
    		Activator 99.79%
    Gypenoside A is an orally active triterpenoid compound that can be isolated from Gynostemma pentaphyllum. Gypenoside A has anti-inflammatory and antioxidant activities. Gypenoside A also has a certain protective effect on cardiomyocytes and can inhibit apoptosis. Gypenoside A can be used in the research of cardiovascular diseases and inflammation-related diseases.
  • HY-137038
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
    		Inhibitor
    N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC50 of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases.
  • HY-179498
    ROCK2-IN-13
    		Activator
    ROCK2-IN-13 is a selective ROCK2 inhibitor. ROCK2-IN-13 reduces nuclear expression by disrupting the interaction of ROCK2 with transcriptional co activators p300> and PGC 1α, repressing oncogenic transcription. ROCK2-IN-13 activates FOXO1 driven PTEN expression, leading to suppression of the PI3K/Akt pathway, induction of G2/M cell cycle arrest, and promotion of apoptosis. ROCK2-IN-13 ablates the nuclear transcriptional function of ROCK2 that sustains oncogenic signaling and restores the tumor suppressive PTEN/FOXO1 axis. ROCK2-IN-13 can be used for prostate cancer reseach.