4238-41-9
Chemical Structure
N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride
Synonym(s): TLCK hydrochloride
- CAS. Nr.: 4238-41-9
- Formula:C14H22Cl2N2O3S
- Molecular Weight:369.31
IUPAC Name: N-(7-amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide hydrochloride
InChIKey: YFCUZWYIPBUQBD-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C)C=C1)(NC(C(CCl)=O)CCCCN)=O.Cl
Biological Activity: N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC50 of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases[1].
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N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride | N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride (TLCK hydrochloride) is a Serine protease inhibitor with an IC50 of 12.0 μM against Caspase-3, 54.5 μM against Caspase-6, and 19.3 μM against Caspase-7. It inhibits thrombin-induced nuclear translocation of FOXO1. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride can be used in research related to leukemia and cardiovascular diseases. | |||||||||||||||||||||
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