1. Signaling Pathways
  2. GPCR/G Protein
  3. Endothelin Receptor
  4. ETA Isoform

ETA

 
Cat. No. Product Name Effect Purity
  • HY-P0202
    Endothelin 1 (swine, human)
    Activator 99.04%
    Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor.
  • HY-14184
    Macitentan
    Antagonist 99.95%
    Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist.
  • HY-120295
    A-192621
    Antagonist 99.85%
    A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ETB) receptor antagonist with an IC50 of 4.5 nM and a Ki of 8.8 nM.
  • HY-B0323
    Sulfisoxazole
    Antagonist 99.95%
    Sulfisoxazole (Sulfafurazole) is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively.
  • HY-10088
    Zibotentan
    Antagonist 98.19%
    Zibotentan (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM.
  • HY-106994A
    Nebentan potassium
    Antagonist 99.53%
    Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013).
  • HY-103460
    IRL 2500
    Antagonist ≥99.0%
    IRL 2500 is a potent Endothelin receptor antagonist.
  • HY-15895
    Aprocitentan
    Antagonist 98.13%
    Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan.
  • HY-106994
    Nebentan
    Antagonist 99.67%
    Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013).
  • HY-17351
    Tezosentan
    Antagonist 98.79%
    Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively.
  • HY-135283
    ABT-546
    Antagonist
    ABT-546 (A-216546) is a potent, highly selective and active endothelin ETA receptor antagonist with a Ki of 0.46 nM for [125I]endothelin-1 binding to cloned human endothelin ETA.
  • HY-P2496
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled
    Activator
    Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488.
  • HY-19263
    BMS-193884
    Antagonist
    BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor.
  • HY-P1112A
    Sarafotoxin S6a TFA
    Agonist
    Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204).
  • HY-B0323A
    Sulfisoxazole diethanolamine
    Antagonist
    Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively.
  • HY-15895S
    Aprocitentan-d4
    Antagonist
    Aprocitentan D4 (ACT-132577 D4) is a deuterium labeled Aprocitentan.
  • HY-19431
    Ro 46-8443
    Antagonist 99.24%
    Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist.
  • HY-P1112
    Sarafotoxin S6a
    Agonist
    Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204).
  • HY-19274
    ZD-1611
    Antagonist
    ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke.
Cat. No. Product Name / Synonyms Species Source