186497-07-4
186497-07-4
Chemical Structure
Zibotentan
Synonym(s): ZD4054
- CAS No.: 186497-07-4
- Formula:C19H16N6O4S
- Molecular Weight:424.43
IUPAC Name: 2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulfonamide
InChIKey: FJHHZXWJVIEFGJ-UHFFFAOYSA-N
SMILES: O=S(NC1=NC=C(C)N=C1OC)(C2=CC=CN=C2C3=CC=C(C4=NN=CO4)C=C3)=O
Biological Activity: Zibotentan (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer (CRPC) research[1][2].
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Zibotentan | 99.17% | Zibotentan (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer (CRPC) research. | ||||||||||||||||||||
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Zibotentan (Standard) | ≥98% | Zibotentan (Standard) is the analytical standard of Zibotentan. This product is intended for research and analytical applications. Zibotentan (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer (CRPC) research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.72
HY-19274ZD-1611 -
Similarity Score 0.52
HY-19263BMS-193884 -
Similarity Score 0.48
HY-15195RAvosentan (Standard) -
Similarity Score 0.48
HY-78323ETA antagonist 2 -
Similarity Score 0.48
HY-111508PI3K/mTOR Inhibitor-2 -
Similarity Score 0.47
HY-109511AZD-1678 -
Similarity Score 0.47
HY-78096O-Deshydroxyethyl bosentan -
Similarity Score 0.46
HY-128221SGK1-IN-5 -
Similarity Score 0.46
HY-10297Omipalisib -
Explore the MedChemAI to find more analogs
References
- [1]. C D Morris, et al. Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence. Br J Cancer. 2005 Jun 20;92(12):2148-52. [Content Brief]
- [2]. Laura Rosanò, et al. Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells. Clin Cancer Res. 2011 Apr 15;17(8):2350-60. [Content Brief]
