1. GPCR/G Protein
  2. Endothelin Receptor
  3. Aprocitentan D4

Aprocitentan D4 (Synonyms: ACT-132577 D4)

Cat. No.: HY-15895S
Handling Instructions

Aprocitentan D4 (ACT-132577 D4) is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.

For research use only. We do not sell to patients.

Aprocitentan D4 Chemical Structure

Aprocitentan D4 Chemical Structure

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Description

Aprocitentan D4 (ACT-132577 D4) is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

IC50 & Target[1]

ETA

3.4 nM (IC50)

ETA

6.7 (pA2)

ETB

987 nM (IC50)

ETB

5.5 (pA2)

Molecular Weight

550.22

Formula

C₁₆H₁₀D₄Br₂N₆O₄S

SMILES

O=S(N)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Aprocitentan D4ACT-132577 D4Aprocitentan D 4Aprocitentan D-4Endothelin ReceptorDeuteriumlabeledETAETBpharmacologicallymetaboliteMacitentanInhibitorinhibitorinhibit

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Aprocitentan D4
Cat. No.:
HY-15895S
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