1. Others GPCR/G Protein
  2. Isotope-Labeled Compounds Endothelin Receptor
  3. Aprocitentan-d4

Aprocitentan-d4  (Synonyms: ACT-132577 d4)

Cat. No.: HY-15895S Purity: 97.39%
COA Handling Instructions

Aprocitentan-d4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

For research use only. We do not sell to patients.

Aprocitentan-d<sub>4</sub> Chemical Structure

Aprocitentan-d4 Chemical Structure

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1 mg USD 450 In-stock
5 mg USD 1450 In-stock
10 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Aprocitentan-d4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

IC50 & Target[1]

ETA

3.4 nM (IC50)

ETA

6.7 (pA2)

ETB

987 nM (IC50)

ETB

5.5 (pA2)

Molecular Weight

550.22

Formula

C16H10D4Br2N6O4S

Appearance

Solid

Color

White to off-white

SMILES

O=S(N)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Aprocitentan-d4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aprocitentan-d4
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