1103522-45-7
1103522-45-7
Chemical Structure
Aprocitentan
Synonym(s): ACT-132577
- CAS No.: 1103522-45-7
- Formula:C16H14Br2N6O4S
- Molecular Weight:546.19
InChIKey: DKULOVKANLVDEA-UHFFFAOYSA-N
SMILES: O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
Biological Activity: Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aprocitentan | 99.55% | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent. | ||||||||||||||||||||
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Aprocitentan (Standard) | ≥98% | Aprocitentan (Standard) is the analytical standard of Aprocitentan. This product is intended for research and analytical applications. Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. | ||||||||||||||||||||
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Aprocitentan-d4 | 98.76% | Aprocitentan-d4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.87
HY-14184SMacitentan-d4 -
Similarity Score 0.85
HY-14184Macitentan -
Similarity Score 0.82
HY-14184AMacitentan n-butyl analogue -
Similarity Score 0.67
HY-14184RMacitentan (Standard) -
Similarity Score 0.67
HY-153463Diosuxentan -
Similarity Score 0.65
HY-124234TA-0201 -
Similarity Score 0.63
HY-135500ACT-373898 -
Similarity Score 0.46
HY-19529Ro 46-2005 -
Similarity Score 0.46
HY-W5582801,2-Bis((5-bromopyridin-2-yl)oxy)ethane -
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