2. Others GPCR/G Protein Apoptosis
  3. Isotope-Labeled Compounds Endothelin Receptor Apoptosis
  4. Macitentan-d4

Macitentan-d4  (Synonyms: ACT-064992-d4)

Cat. No.: HY-14184S Purity: 98.03%
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Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

For research use only. We do not sell to patients.

Macitentan-d<sub>4</sub> Chemical Structure

Macitentan-d4 Chemical Structure

CAS No. : 1258428-05-5

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1 mg USD 400 In-stock
5 mg USD 1000 In-stock
10 mg USD 1600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Macitentan-d4:

Macitentan-d4 Related Antibodies

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Description

Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

IC50 & Target

ETA

 

ETB

 

Molecular Weight

592.30

Formula

C19H16D4Br2N6O4S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(NCCC)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (168.83 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6883 mL 8.4417 mL 16.8833 mL
5 mM 0.3377 mL 1.6883 mL 3.3767 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6883 mL 8.4417 mL 16.8833 mL 42.2083 mL
5 mM 0.3377 mL 1.6883 mL 3.3767 mL 8.4417 mL
10 mM 0.1688 mL 0.8442 mL 1.6883 mL 4.2208 mL
15 mM 0.1126 mL 0.5628 mL 1.1256 mL 2.8139 mL
20 mM 0.0844 mL 0.4221 mL 0.8442 mL 2.1104 mL
25 mM 0.0675 mL 0.3377 mL 0.6753 mL 1.6883 mL
30 mM 0.0563 mL 0.2814 mL 0.5628 mL 1.4069 mL
40 mM 0.0422 mL 0.2110 mL 0.4221 mL 1.0552 mL
50 mM 0.0338 mL 0.1688 mL 0.3377 mL 0.8442 mL
60 mM 0.0281 mL 0.1407 mL 0.2814 mL 0.7035 mL
80 mM 0.0211 mL 0.1055 mL 0.2110 mL 0.5276 mL
100 mM 0.0169 mL 0.0844 mL 0.1688 mL 0.4221 mL
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Macitentan-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macitentan-d41258428-05-5ACT-064992-d4Isotope-Labeled CompoundsEndothelin ReceptorApoptosisorallynon-peptideETAETBendothelinidiopathicpulmonaryfibrosisarterialhypertensionInhibitorinhibitorinhibit

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