Search Result
Results for "
metabolite
" in MCE Product Catalog:
1868
Inhibitors & Agonists
7
Biochemical Assay Reagents
414
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
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- HY-136336
-
-
- HY-136703
-
-
- HY-131669
-
|
Dasatinib metabolite M6
Dasatinib carboxylic acid
|
Drug Metabolite
|
Others
|
|
Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor.
|
-
- HY-117229
-
-
- HY-126534A
-
-
- HY-G0002A
-
-
- HY-G0002
-
-
- HY-129336S
-
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Abemaciclib metabolite M20-d8
LSN3106726-d8
|
CDK
|
Cancer
|
|
Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].
|
-
- HY-G0001A
-
-
- HY-G0002S
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-
- HY-G0023
-
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Niraparib metabolite M1
Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib
|
Drug Metabolite
|
Others
|
|
Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
|
-
- HY-W128916S
-
-
- HY-144165S
-
-
- HY-143913S
-
-
- HY-146963S
-
-
- HY-108251
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-
- HY-G0009
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-
- HY-G0001S
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-
- HY-19764
-
|
GSK2983559 active metabolite
|
RIP kinase
|
Cancer
|
|
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
|
-
- HY-103687
-
|
Abiraterone metabolite 1
3β-OH-5α-Abi
|
Drug Metabolite
|
Cancer
|
|
Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal drug, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
|
-
- HY-12769
-
|
Mebeverine acid
Mebeverine metabolite Mebeverine acid
|
Drug Metabolite
|
Neurological Disease
|
|
Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine.
|
-
- HY-126303
-
|
GS-443902
GS-441524 triphosphate; Remdesivir metabolite
|
DNA/RNA Synthesis
SARS-CoV
RSV
HCV
Drug Metabolite
|
Infection
|
|
GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
|
-
- HY-135601
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-
- HY-15980
-
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GNF179 (Metabolite)
|
Parasite
|
Infection
|
|
GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.
|
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- HY-103005
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-
- HY-12798C
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-
- HY-103005S
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-
- HY-132504S
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-
- HY-126534
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-
- HY-129336
-
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Abemaciclib metabolite M20
LSN3106726
|
CDK
|
Cancer
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Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer.
|
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- HY-143668S
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-
- HY-108251S
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-
- HY-124227S
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-
- HY-116485S
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-
- HY-117590S
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- HY-126303C
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GS-443902 trisodium
GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium
|
DNA/RNA Synthesis
SARS-CoV
RSV
HCV
Drug Metabolite
|
Infection
|
|
GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734).
|
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- HY-G0025
-
|
Tetrabenazine Metabolite
(-)-β-Dihydrotetrabenazine; (-)-β-HTBZ
|
Monoamine Transporter
Drug Metabolite
|
Neurological Disease
|
|
Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM). Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders.
|
-
- HY-G0003
-
-
- HY-12770
-
-
- HY-128669
-
-
- HY-138952S
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-
- HY-145011S
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- HY-12772
-
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Hydroxy Itraconazole
Itraconazole metabolite Hydroxy Itraconazole; R-63373
|
Fungal
Drug Metabolite
|
Others
|
|
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
|
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- HY-G0012
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-
- HY-143967S
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- HY-G0004
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-
- HY-G0018
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-
- HY-G0007
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-
- HY-G0010
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-
- HY-12771
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-
- HY-12778
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- HY-G0005
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- HY-126534S
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Abemaciclib metabolite M18-d8
LSN3106729-d8
|
CDK
Ligands for Target Protein for PROTAC
|
Cancer
|
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Abemaciclib metabolite M18-d8 is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].
|
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- HY-G0011
-
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- HY-128669S
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Abemaciclib metabolite M2-d6
LSN2839567-d6
|
CDK
|
Cancer
|
|
Abemaciclib metabolite M2-d6 is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].
|
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- HY-12767
-
-
- HY-G0017A
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N-Desmethyl imatinib mesylate
Norimatinib mesylate; Imatinib metabolite N-Desmethyl imatinib mesylate
|
Drug Metabolite
|
Others
|
|
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR.
|
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- HY-G0017
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N-Desmethyl imatinib
Norimatinib; Imatinib metabolite N-Desmethyl imatinib
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Drug Metabolite
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Others
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N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR.
|
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- HY-B0113S2
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-
- HY-G0008
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- HY-G0008A
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- HY-G0018S
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Norgestimate metabolite norelgestromin-d6
17-Deacetyl norgestimate-d6; 17-Deacylnorgestimate-d6
|
Drug Metabolite
|
|
|
Norgestimate metabolite norelgestromin-d6 is the deuterium labeled Norgestimate metabolite norelgestromin. Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen.
|
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- HY-G0007S
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-
- HY-W045271
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-
- HY-123215
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CC-17369
7-Hydroxy pomalidomide; Pomalidomide metabolite M16
|
Ligands for E3 Ligase
|
Cancer
|
|
CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC.
|
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- HY-30216
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- HY-135384
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- HY-100651
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- HY-135385
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- HY-126061
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- HY-113457
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- HY-N7612
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- HY-100646A
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- HY-100646
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- HY-111238
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- HY-137932
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- HY-N10215
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- HY-N8268
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- HY-116246
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- HY-N7686
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- HY-123006
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- HY-135212
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- HY-135389
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- HY-W004464
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- HY-148197
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- HY-N7994
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- HY-125523
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- HY-N8258
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- HY-137532
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- HY-G0017S
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- HY-N7278
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- HY-109619
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D4-abiraterone
Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite
|
Androgen Receptor
Cytochrome P450
|
Cancer
|
|
D4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor.
|
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- HY-133694
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-
- HY-145991
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-
- HY-125114
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-
- HY-100623
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-
- HY-136344
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- HY-G0007S1
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- HY-N8210
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- HY-B0191C
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- HY-U00050S
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(E)-10-Hydroxynortriptyline-d3
E-10-OH-NT-d3
|
Drug Metabolite
|
Neurological Disease
|
|
(E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
|
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- HY-148376
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- HY-136345
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- HY-41494
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o-Toluic acid
2-Methylbenzoic acid
|
Endogenous Metabolite
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Others
|
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o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
|
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- HY-113437
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-
- HY-113437A
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- HY-W014180
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- HY-129591
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Paraherquamide A
PNU-97333
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Others
|
Others
|
|
Paraherquamide A (PNU-97333) is a toxic metabolite that can be isolated from Penicillium paraherquei.
|
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- HY-43711
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-
- HY-P1703
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-
- HY-N10236
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- HY-17528
-
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Cyhalofop
Cyhalofop acid
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Drug Metabolite
|
Others
|
|
Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
|
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- HY-N10186
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- HY-N6711A
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- HY-A0178
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- HY-139199
-
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4-Hydroxyphenylbutazone
|
Drug Metabolite
|
Others
|
|
4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory drug (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS).
|
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- HY-N10233
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- HY-G0022
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- HY-109591A
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- HY-135580A
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- HY-135580
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- HY-137181
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- HY-113351
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- HY-W011848
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- HY-136347
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- HY-125684
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- HY-N8548
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- HY-N10238
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- HY-136428
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- HY-N7715
-
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Ferulic acid acyl-β-D-glucoside
Ferulic acid glucoside
|
Drug Metabolite
|
Others
|
|
Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid (HY-N0060). Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
|
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- HY-N10980
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- HY-N8552
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- HY-U00050
-
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(E)-10-Hydroxynortriptyline
E-10-OH-NT
|
Drug Metabolite
|
Neurological Disease
|
|
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A). E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.
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- HY-135387
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-
- HY-W012874
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- HY-W001117
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-
- HY-P3282
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MM 419447
|
Guanylate Cyclase
|
Metabolic Disease
|
|
MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).
|
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- HY-Y1771
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-
- HY-125344
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-
- HY-W008452
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-
- HY-70002BS
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-
- HY-148507
-
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GSK1790627
|
MEK
|
Cancer
|
|
GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis.
|
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- HY-145000
-
-
- HY-135956
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-
- HY-N9474
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-
- HY-105713
-
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Sulochrin
|
Bacterial
|
Infection
|
|
Sulochrin is a metabolite produced by Aspergillus terreus var. aureus. I. Sulochrin has antimicrobial activities.
|
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- HY-118427
-
-
- HY-130189
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-
- HY-126370
-
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Geranylgeranyl pyrophosphate
|
Endogenous Metabolite
|
Cancer
|
|
Geranylgeranyl pyrophosphate is a metabolite involved in protein geranylgeranylation. Geranylgeranyl pyrophosphate is the common precursor of diterpenoids, for example, Paclitaxel. Geranylgeranyl pyrophosphate can be used for cancer research.
|
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- HY-126373
-
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SN-38 glucuronide
SN-38G
|
Drug Metabolite
|
Cancer
|
|
SN-38 glucuronide is an inactive metabolite of the cancer drug Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.
|
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- HY-100652A
-
-
- HY-124551
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-
- HY-N10234
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-
- HY-129987
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-
- HY-N1867
-
|
trans-Cinnamyl alcohol
|
PPAR
|
Metabolic Disease
|
|
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite.
|
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- HY-N8549
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- HY-W050000
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- HY-125934
-
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Allocholic acid
|
Others
|
Cancer
|
|
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite.
|
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- HY-135955
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-
- HY-133813A
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-
- HY-N2713
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- HY-100659
-
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Dihydrodiol-Ibrutinib
PCI-45227
|
Btk
|
Cancer
|
|
Dihydrodiol-Ibrutinib (PCI-45227) is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib.
|
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- HY-100655
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-
- HY-100622
-
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Ro 20-0657/000
|
Bacterial
|
Infection
|
|
Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine.
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- HY-136327
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-
- HY-121184
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-
- HY-N10270
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-
- HY-125706
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-
- HY-129974
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-
- HY-130353
-
|
Desethylamiodarone hydrochloride
N-desethylamiodarone hydrochloride; LB 33020 hydrochloride
|
Potassium Channel
Autophagy
|
Cardiovascular Disease
|
|
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
|
-
- HY-133668
-
|
Monoethyl phthalate
|
Drug Metabolite
|
Cancer
|
|
Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule.
|
-
- HY-118166
-
|
Gentisein
NSC 329491; 1,3,7-Trihydroxyxanthone
|
5-HT Receptor
|
Neurological Disease
|
|
Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM.
|
-
- HY-136608
-
-
- HY-136609
-
-
- HY-N8879
-
|
Wilforol A
(-)-Wilforol A
|
Others
|
Metabolic Disease
|
|
Wilforol A ((-)-Wilforol A), plant metabolite, is a pentacyclic triterpenoid. Wilforol A can be used for the research of various biochemical studies.
|
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- HY-N10220
-
-
- HY-135588
-
-
- HY-W010347
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-
- HY-N7061
-
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Tropine
|
Others
|
Neurological Disease
|
|
Tropine is a secondary metabolite of Solanaceae plants, is an anticholinergic agent. Tropine is a common intermediate in the synthesis of a variety of bioactive alkaloids, including hyoscyamine and scopolamine.
|
-
- HY-145930
-
|
Colibactin
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Colibactin is a complex secondary metabolite produced by some genotoxic gut Escherichia coli strains. Colibactin has the potential for the research of colorectal cancer[1].
|
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- HY-N0873A
-
-
- HY-121133
-
-
- HY-113114
-
-
- HY-W008216
-
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HMMNI
Hydroxy Dimetridazole
|
Drug Metabolite
|
Others
|
|
HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections.
|
-
- HY-N10299
-
-
- HY-136767
-
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Cladosporin
|
Fungal
Antibiotic
|
Infection
|
|
Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin completely inhibits growth of severa dermatophytes on agar medium at a concentration of 75 μg/mL.
|
-
- HY-138538
-
|
2-Nitrobenzaldehyde Semicarbazone
|
Others
|
Others
|
|
2-Nitrobenzaldehyde Semicarbazone is a derivative of Semicarbazide. 2-Nitrobenzaldehyde Semicarbazone can be measured as a metabolite marker to detect the widely banned antibiotic Nitrofurazone.
|
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- HY-136346
-
-
- HY-W013266
-
-
- HY-B1984
-
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p,p'-DDD
4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane
|
Drug Metabolite
|
Others
|
|
p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT.
|
-
- HY-N8406
-
|
Monomethylsulochrin
|
Bacterial
Antibiotic
|
Infection
|
|
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL.
|
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- HY-W008097
-
-
- HY-W005178
-
-
- HY-118645
-
-
- HY-123305
-
|
5-Hydroxymebendazole
|
Others
Parasite
|
Others
|
|
5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic drugs and are widely used for prevention and treatment of parasitic infections in food-producing animals.
|
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- HY-142122
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-
- HY-125411
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-
- HY-150012
-
-
- HY-113442
-
-
- HY-W145584
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-
- HY-N10293
-
-
- HY-W013378
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-
- HY-131252
-
-
- HY-113405
-
-
- HY-100046
-
-
- HY-B1551
-
|
Benzonatate
Benzononatine
|
Sodium Channel
|
Neurological Disease
|
|
Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite.
|
-
- HY-113371
-
|
2-Methylcitric acid
Methylcitric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
|
-
- HY-113083
-
-
- HY-Y0293
-
|
L-Tartaric acid
L-(+)-Tartaric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Tartaric acid (L-(+)-Tartaric acid) is an endogenous metabolite. L-Tartaric acid is the primary nonfermentable soluble acid in grapes and the principal acid in wine. L-Tartaric acid can be used as a flavorant and antioxidant for a range of foods and beverages.
|
-
- HY-134611
-
|
(2-Hydroxyethoxy)acetic acid
β-hydroxyethoxyacetic acid; HEAA
|
Drug Metabolite
|
Others
|
|
(2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the main urinary metabolite of 1,4-Dioxane. (2-Hydroxyethoxy)acetic acid is a reliable and sensitive shortterm biomarker in urine.
|
-
- HY-I0508
-
|
Phthalic acid
|
Biochemical Assay Reagents
|
Others
|
|
Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers.
|
-
- HY-113622
-
|
Cladospirone bisepoxide
Palmarumycin C13; Diepoxin ζ; Antibiotic Sch53514
|
Fungal
Antibiotic
|
Infection
|
|
Cladospirone bisepoxide is a metabolite that isolated from cultures of a fungus. Cladospirone bisepoxide displays selective antibiotic activity against several bacteria and fungi and inhibits germinations of Lepidium sativum at low concentrations.
|
-
- HY-118620
-
-
- HY-B1417
-
|
Nortriptyline hydrochloride
Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
|
Autophagy
Drug Metabolite
|
Cancer
Neurological Disease
|
|
Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline hydrochloride is a potent autophagy inhibitor.
|
-
- HY-123305S
-
-
- HY-135500
-
-
- HY-B2124
-
|
10,11-Dihydrocarbamazepine
|
Drug Metabolite
|
Neurological Disease
|
|
10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy.
|
-
- HY-135407S
-
-
- HY-136303
-
|
GS-704277
|
Drug Metabolite
|
Infection
|
|
GS-704277 is an alanine metabolite of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
|
-
- HY-12388A
-
-
- HY-P2643
-
-
- HY-32349S
-
-
- HY-W109973
-
|
L-Tartaric acid diammonium
L-(+)-Tartaric acid diammonium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Tartaric acid (L-(+)-Tartaric acid) diammonium is an endogenous metabolite. L-Tartaric acid diammonium is the primary nonfermentable soluble acid in grapes and the principal acid in wine. L-Tartaric acid diammonium can be used as a flavorant and antioxidant for a range of foods and beverages.
|
-
- HY-133111
-
-
- HY-135335
-
-
- HY-N8396
-
-
- HY-125060
-
-
- HY-113005
-
-
- HY-131607
-
-
- HY-138627A
-
|
AST5902 trimesylate
|
EGFR
Drug Metabolite
|
Cancer
|
|
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.
|
-
- HY-W008216S
-
-
- HY-113215
-
|
Allotetrahydrocortisol
5a-Tetrahydrocortisol
|
Endogenous Metabolite
|
Others
|
|
Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes.
|
-
- HY-N10292
-
|
Chaetosemin J
|
Fungal
Endogenous Metabolite
|
Infection
|
|
Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM.
|
-
- HY-W012982
-
-
- HY-N10288
-
-
- HY-125643
-
-
- HY-135154
-
-
- HY-117605
-
-
- HY-136438
-
-
- HY-N8349
-
-
- HY-N8385
-
-
- HY-136440
-
|
Hydroxymetronidazole
Metronidazole-OH
|
Bacterial
Parasite
|
Infection
|
|
Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle.
|
-
- HY-W011245
-
-
- HY-100665
-
|
Dehydroaripiprazole
OPC-14857; DM-14857
|
5-HT Receptor
|
Neurological Disease
|
|
Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.
|
-
- HY-135035
-
|
Decanoyl-L-carnitine
(-)-Decanoylcarnitine
|
Others
|
Metabolic Disease
|
|
Decanoyl-L-carnitine has stimulatory effect on the formation of desaturated fatty acid metabolites from both [1- 14C]-22:4 (n-6) and [1- 14C]-22:5 (n-3).
|
-
- HY-113157
-
-
- HY-136560
-
|
6-Azathymine acid
|
Drug Metabolite
|
Others
|
|
6-Azathymine acid is a metabolite of Pymetrozine. Pymetrozine is active against plant-sucking insects, such as aphids and whiteflies in vegetables, cotton, field crops and fruits and affects the nervous regulation of feeding behavior.
|
-
- HY-W158239
-
-
- HY-133154
-
-
- HY-133675
-
|
Mono(5-carboxy-2-ethylpentyl) phthalate
MECPP
|
Drug Metabolite
|
Others
|
|
Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
|
-
- HY-W011297
-
|
Methyl arachidonate
Arachidonic acid methyl ester
|
Others
|
Metabolic Disease
|
|
Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite.
|
-
- HY-100750
-
-
- HY-113005A
-
-
- HY-135328
-
-
- HY-113327
-
-
- HY-136498
-
|
T-705RMP
|
Drug Metabolite
|
Infection
|
|
T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM.
|
-
- HY-P2543
-
|
Neuropeptide Y (3-36) (human, rat)
|
Neuropeptide Y Receptor
|
Metabolic Disease
|
|
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor.
|
-
- HY-113224
-
|
Desmosterol
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Desmosterol is a molecule similar to cholesterol. Desmosterol is the immediate precursor of cholesterol in the Bloch pathway of cholesterol biosynthesis. Desmosterol, as an endogenous metabolite, used to study cholesterol metabolism.
|
-
- HY-N10207
-
-
- HY-N10189
-
-
- HY-100635S
-
-
- HY-W010452
-
-
- HY-N10194
-
-
- HY-113378
-
-
- HY-136456
-
|
2-NP-AMOZ
|
Drug Metabolite
|
Others
|
|
2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
|
-
- HY-70002B
-
-
- HY-70002AS
-
|
N-desmethyl Enzalutamide-d6
N-desmethyl MDV 3100-d6
|
Androgen Receptor
|
Cancer
|
|
N-desmethyl Enzalutamide-d6 is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].
|
-
- HY-126995
-
-
- HY-133114
-
-
- HY-N6679
-
|
(R)-10,11-Dehydrocurvularin
|
Antibiotic
|
Cancer
|
|
(R)-10,11-Dehydrocurvularin is a secondary metabolite isolated from Curvularia sp.. (R)-10,11-Dehydrocurvularin displays concentration-dependent cytotoxicity towards human tumor cell lines with a mean IC50 value of 1.25 µM.
|
-
- HY-136577
-
-
- HY-136457
-
|
2-NP-AHD
|
Drug Metabolite
|
Others
|
|
2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran drugs.
|
-
- HY-W021267
-
-
- HY-115249
-
-
- HY-137801
-
|
Sesquicillin A
|
Parasite
|
Infection
|
|
Sesquicillin A is an insecticidal antibiotic, a fungal metabolite isolated from white plantain. Sesquicillin A inhibits the growth of A. salina brine shrimp with the MIC value of 6.25 µg/mL.
|
-
- HY-133115AS
-
|
N-Desmethylnefopam D5 hydrochloride
|
β-catenin
|
Neurological Disease
|
|
N-Desmethylnefopam-d5 (hydrochloride) is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam hydrochloride is the main metabolite of Nefopam. N-Desmethylnefopam hydrochloride is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain[1].
|
-
- HY-103252
-
-
- HY-12388AS
-
-
- HY-136444
-
|
2-NP-AOZ
|
Others
|
Others
|
|
2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (HY-W012982, a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues.
|
-
- HY-N8796
-
|
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone
|
Others
|
Cancer
|
|
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines.
|
-
- HY-W091541
-
|
4-Hydroxy-1H-indole-3-carbaldehyde
4-Hydroxyindole-3-carboxaldehyde
|
Others
|
Others
|
|
4-Hydroxy-1H-indole-3-carbaldehyde is a plant metabolite found in Capparis spinosa L.. 4-Hydroxy-1H-indole-3-carbaldehyde can be used in the synthesis of fluorescent probe.
|
-
- HY-113261
-
-
- HY-N10322
-
|
2-Hydroxyemodin
|
Drug Metabolite
|
Others
|
|
2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system.
|
-
- HY-B1986
-
|
p,p'-DDE
4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
|
Androgen Receptor
Drug Metabolite
|
Endocrinology
|
|
p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM.
|
-
- HY-136444S
-
|
2-NP-AOZ-d4
|
Isotope-Labeled Compounds
|
Others
|
|
2-NP-AOZ-d4 is a deuterium labeled 2-NP-AOZ. 2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues[1][2].
|
-
- HY-116637
-
|
Tetrahydromagnolol
Magnolignan
|
Cannabinoid Receptor
GPR55
|
Inflammation/Immunology
|
|
Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist.
|
-
- HY-142105
-
-
- HY-10003A
-
-
- HY-N10228
-
-
- HY-W050026S
-
-
- HY-141621
-
-
- HY-W005255
-
-
- HY-100656
-
-
- HY-100638
-
|
RPR132595A
NPC
|
Drug Metabolite
|
Cancer
|
|
RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine.
|
-
- HY-100064S
-
|
O-Desmethyl gefitinib-d8
|
EGFR
|
Cancer
|
|
O-Desmethyl gefitinib-d8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
|
-
- HY-138813
-
|
N-Desethyl Sunitinib hydrochloride
SU-12662 hydrochloride
|
Drug Metabolite
|
Cancer
|
|
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.
|
-
- HY-113147A
-
-
- HY-B0794S
-
|
AZ7550-d5
|
EGFR
IGF-1R
Drug Metabolite
|
Others
|
|
AZ7550-d5 is the deuterium labeled AZ7550 (HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of IGF1R with an IC50 of 1.6 μM[1][2].
|
-
- HY-B1445
-
-
- HY-133068
-
|
5-Hydroxyferulic acid
|
COMT
Endogenous Metabolite
|
Others
|
|
5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate.
|
-
- HY-135811
-
-
- HY-W008449
-
|
1-Methylxanthine
|
Endogenous Metabolite
|
Cancer
|
|
1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
|
-
- HY-133115
-
|
N-Desmethylnefopam
|
β-catenin
|
Neurological Disease
|
|
N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo.
|
-
- HY-117727A
-
|
Leriglitazone hydrochloride
Hydroxypioglitazone hydrochloride
|
PPAR
|
Metabolic Disease
|
|
Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to the PPARγ C-terminal ligand-binding domain (LBD) with a Ki of 1.2 μM，Leriglitazone induces transcriptional efficacy of the PPARγ (LBD) with an EC50 of 680 nM.
|
-
- HY-N10190
-
|
Asperaculane B
|
Parasite
Endogenous Metabolite
|
Infection
|
|
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells.
|
-
- HY-W354498
-
-
- HY-113161
-
-
- HY-77641
-
|
Cinnamoylglycine
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment.
|
-
- HY-Y1125
-
-
- HY-113147B
-
-
- HY-125705
-
-
- HY-N1443
-
-
- HY-N11287A
-
-
- HY-135811A
-
-
- HY-125941
-
|
PNU-101603
|
Bacterial
|
Infection
|
|
PNU-101603 is a sulfoxide metabolite of Sutezolid (HY-10392). PNU-101603 alone or combined with SQ109 (HY-14989) shows excellent activity against Mycobacterium tuberculosis (MTB), as well as against drug-susceptible and multidrug-resistant TB.
|
-
- HY-126129
-
|
Desacetylcefotaxime
|
Bacterial
|
Infection
|
|
Desacetylcefotaxime, the in vivo metabolite of Cefotaxime (CTX), possesses significant in vitro antimicrobial activity similar to the parent compound against a variety of aerobic and anaerobic bacteria.
|
-
- HY-129491
-
|
O-Desmethyl Midostaurin
CGP62221; O-Desmethyl PKC412
|
PKC
|
Cancer
|
|
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
|
-
- HY-A0019
-
|
Paliperidone
9-Hydroxyrisperidone
|
Dopamine Receptor
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.
|
-
- HY-N10227
-
-
- HY-100642
-
|
3-O-Methyltolcapone
Ro 40-7591
|
COMT
|
Neurological Disease
|
|
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease.
|
-
- HY-N8743
-
|
Cyclo(Pro-Leu)
A 65190; Cyclo-(leucyl-prolyl)
|
Endogenous Metabolite
|
Cancer
|
|
Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer.
|
-
- HY-100620
-
|
RPR121056
APC
|
Topoisomerase
Cholinesterase (ChE)
|
Cancer
|
|
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE.
|
-
- HY-W010452S1
-
-
- HY-W010452S2
-
-
- HY-127026S
-
|
Quinaprilat-d5
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Quinaprilat-d5 is a deuterium-labeled Quinaprilat. Quinaprilat is a nonsulfhydryl ACE inhibitor, the active diacid metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits bradykinin degradation. Quinaprilat primarily acts as a vasodilator, decreasing total peripheral and renal vascular resistance[1].
|
-
- HY-135328S
-
-
- HY-12753A
-
|
Debutyldronedarone hydrochloride
SR35021 hydrochloride
|
Thyroid Hormone Receptor
|
Cardiovascular Disease
|
|
Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.
|
-
- HY-N10192
-
|
Aculene D
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations.
|
-
- HY-133787
-
|
Levofloxacin N-oxide
|
Drug Metabolite
|
Infection
|
|
Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria.
|
-
- HY-77293
-
|
(E)-[6]-Dehydroparadol
|
Apoptosis
Keap1-Nrf2
|
Cancer
|
|
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells.
|
-
- HY-114646
-
|
TMC-205
|
Endogenous Metabolite
|
Cancer
|
|
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter.
|
-
- HY-148377
-
|
Abiraterone sulfate N-oxide
|
Others
|
Cancer
|
|
Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer.
|
-
- HY-125170
-
|
Galiellalactone
|
STAT
|
Cancer
|
|
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.
|
-
- HY-W040047
-
|
Pregnanediol 3-glucuronide
|
Endogenous Metabolite
|
Endocrinology
|
|
Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone, playing an important role in physiological processes, such as the female menstrual cycle, pregnancy (supports gestation), embryogenesis and maternal immune response of humans and other species.
|
-
- HY-100644
-
|
Trimethoprim N-oxide
Trimethoprim 1-N-oxide
|
Drug Metabolite
|
Infection
|
|
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes.
|
-
- HY-N2907
-
|
Atranorin
|
Ras
Endogenous Metabolite
|
Cancer
|
|
Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity.
|
-
- HY-N3694
-
|
Deacetylnimbin
Desacetyl nimbin
|
Others
|
Others
|
|
Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata.
|
-
- HY-100641
-
-
- HY-137397
-
|
8-Hydroxyefavirenz
8-OH-EFV
|
Apoptosis
JNK
|
Cancer
|
|
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of Efavirenz (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer.
|
-
- HY-W015851
-
|
(R)-3-Hydroxybutanoic acid sodium
(R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxybutanoic acid sodium ((R)-3-Hydroxybutyric acid) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones.
|
-
- HY-P3107
-
-
- HY-Y1097
-
|
Monomethyl phthalate
2-(Methoxycarbonyl)benzoic acid
|
Endogenous Metabolite
|
Cancer
|
|
Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule.
|
-
- HY-W017187
-
-
- HY-W003467
-
|
Rabeprazole Sulfide
|
Proton Pump
Bacterial
|
Infection
Inflammation/Immunology
|
|
Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H +/K +)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment.
|
-
- HY-135265
-
|
Moclobemide N-Oxide
Ro 12-5637
|
Monoamine Oxidase
|
Neurological Disease
|
|
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm.
|
-
- HY-129491S
-
-
- HY-W017464
-
|
NAPQI
|
Endogenous Metabolite
|
Metabolic Disease
|
|
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.
|
-
- HY-W011417
-
|
Cinnabarinic acid
|
mGluR
Apoptosis
|
Others
|
|
Cinnabarinic acid is a specific orthosteric agonist of mGlu4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis.
|
-
- HY-136901
-
-
- HY-119663
-
|
Averantin
|
Fungal
|
Infection
|
|
Averantin is the minor metabolite of the fungus Cercospora arachidicola. Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway.
|
-
- HY-N0656
-
|
Usnic acid
|
Bacterial
|
Cancer
Infection
|
|
Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1.
|
-
- HY-119552
-
-
- HY-111271
-
-
- HY-18646
-
-
- HY-N7387
-
-
- HY-121385
-
-
- HY-W012982S
-
|
3-Amino-2-oxazolidinone-d4
AOZ-d4
|
Drug Metabolite
|
Others
|
|
3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues[1][2].
|
-
- HY-D0004
-
|
Azure B
Azure B chloride
|
Monoamine Oxidase
|
Neurological Disease
|
|
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects.
|
-
- HY-N7307
-
|
Pachybasin
|
Bacterial
|
Infection
|
|
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively.
|
-
- HY-A0116A
-
-
- HY-A0116
-
-
- HY-121362
-
-
- HY-135751
-
-
- HY-N8812
-
-
- HY-114950
-
|
EXP3179
Losartan Carboxaldehyde; DuP 167
|
COX
|
Inflammation/Immunology
Cardiovascular Disease
|
|
EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions.
|
-
- HY-127137A
-
|
Adenylosuccinic acid tetraammonium
Adenylosuccinate tetraammonium; Aspartyl adenylate tetraammonium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is an orally active purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD).
|
-
- HY-15895S
-
-
- HY-136592
-
-
- HY-128554A
-
|
N-Desethyl amodiaquine dihydrochloride
|
Parasite
|
Infection
|
|
N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria.
|
-
- HY-128554
-
|
N-Desethyl amodiaquine
|
Parasite
|
Infection
|
|
N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria.
|
-
- HY-135895
-
-
- HY-136338
-
|
Cimetidine sulfoxide
Cimetidine sulphoxide
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment.
|
-
- HY-Y0469
-
|
1-Aminohydantoin hydrochloride
|
Drug Metabolite
|
Others
|
|
1-Aminohydantoin hydrochloride is a major metabolite of nitrofurantoin in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of AHD before detection.
|
-
- HY-136578
-
-
- HY-137941
-
|
Roxatidine
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect.
|
-
- HY-134039
-
|
5-Hydroxy-8-methoxypsoralen
5-Hydroxyxanthotoxin
|
Others
|
Inflammation/Immunology
|
|
5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
|
-
- HY-136610
-
-
- HY-P1141A
-
|
GLP-1(9-36)amide TFA
|
GCGR
|
Metabolic Disease
|
|
GLP-1(9-36)amide TFA is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor.
|
-
- HY-N10206
-
|
11-epi-Chaetomugilin I
|
Endogenous Metabolite
|
Cancer
|
|
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line.
|
-
- HY-109502S
-
|
10-OH-NBP-d4
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
10-OH-NBP-d4 is deuterium labeled 10-OH-NBP. 10-OH-NBP is a Butylphthalide (3-n-Butylphthalide; NBP; HY-B0647) hydroxylated metabolite and can penetrates the blood-brain barrier (BBB). Butylphthalide exerts neuroprotective effects and has potential for cerebral ischemia research[1].
|
-
- HY-133152
-
|
Brexpiprazole S-oxide
DM-3411
|
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.
|
-
- HY-118793
-
|
Inosine oxime
6-Hydroxyadenosine
|
Endogenous Metabolite
|
Others
|
|
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells.
|
-
- HY-120607
-
|
Chevalone C
|
Parasite
|
Cancer
Infection
|
|
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines.
|
-
- HY-135867D
-
|
NHC-diphosphate
|
Endogenous Metabolite
Enterovirus
HCV
Topoisomerase
SARS-CoV
|
Infection
|
|
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV).
|
-
- HY-N2009
-
|
3-O-Methylgallic acid
3,4-Dihydroxy-5-methoxybenzoic acid
|
Apoptosis
|
Cancer
|
|
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) is an anthocyanin metabolite and has potent antioxidant capacity. 3-O-methylgallic acid inhibits Caco-2 cell proliferation with an IC50 value of 24.1 μM. 3-O-methylgallic acid also induces cell apoptosis and has anti-cancer effects.
|
-
- HY-126989
-
|
19-O-Acetylchaetoglobosin A
|
Arp2/3 Complex
|
Cancer
|
|
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells.
|
-
- HY-136611
-
|
ω-Hydroxy-DEET
|
Drug Metabolite
|
Infection
|
|
ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes.
|
-
- HY-142972
-
|
19(S)-HETE
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels.
|
-
- HY-148225
-
|
Fulvestrant 3-β-D-Glucuronide
|
Others
|
Cancer
|
|
Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer.
|
-
- HY-135731
-
|
4-Methylamino antipyrine
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties.
|
-
- HY-133116
-
|
4-Hydroxyatomoxetine
|
Adrenergic Receptor
|
Neurological Disease
|
|
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).
|
-
- HY-135731A
-
|
4-Methylamino antipyrine hydrochloride
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.
|
-
- HY-135774
-
|
6-Hydroxybenzbromarone
|
Drug Metabolite
Phosphatase
|
Cardiovascular Disease
|
|
6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.
|
-
- HY-W003445
-
|
4-Bromo-3-hydroxybenzoic acid
|
Endogenous Metabolite
|
Neurological Disease
|
|
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes.
|
-
- HY-B0228S10
-
-
- HY-135331
-
|
N-Desmethyl-Apalutamide
|
Androgen Receptor
Cytochrome P450
|
Cancer
|
|
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration.
|
-
- HY-107096
-
|
CH-0793076
TP3076
|
Topoisomerase
|
Cancer
|
|
CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein).
|
-
- HY-W019721
-
|
Cyclosporin D
|
Nuclear Factor of activated T Cells (NFAT)
|
Inflammation/Immunology
|
|
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).
|
-
- HY-100973A
-
-
- HY-N2023A
-
|
Thalifendine chloride
|
Parasite
Drug Metabolite
|
Infection
|
|
Thalifendine chloride is a metabolite of Berberine (HY-N0716), with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activities against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively.
|
-
- HY-100642S
-
|
3-O-Methyltolcapone-d7
Ro 40-7591 d7
|
COMT
|
Neurological Disease
|
|
3-O-Methyltolcapone-d7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
|
-
- HY-N8060
-
|
Orotidine 5′-monophosphate
Orotidine monophosphate; Orotidylic acid
|
Endogenous Metabolite
|
Others
|
|
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase.
|
-
- HY-W016321
-
|
N-Benzylaniline
N-Phenylbenzylamine; Benzylaniline
|
Others
|
Others
|
|
N-Benzylaniline (N-Phenylbenzylamine) is an N-alkylated derivative of aniline. N-benzyl aniline also is a major metabolite of the antihistamine antazoline and other N-substituted benzyl anilines. N-Benzylaniline can be used for the research of various biochemical studies.
|
-
- HY-119696
-
|
MTIC
|
Drug Metabolite
|
Cancer
Neurological Disease
|
|
MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane.
|
-
- HY-15899
-
|
Des(benzylpyridyl) Atazanavir
|
HIV Protease
HIV
Drug Metabolite
|
Infection
|
|
Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective HIV-1 protease inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects.
|
-
- HY-132588
-
|
Lumasiran
ALN-G01
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
|
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
|
-
- HY-107096B
-
|
CH-0793076 TFA
TP3076 TFA
|
Topoisomerase
|
Cancer
|
|
CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein).
|
-
- HY-113116
-
-
- HY-19827
-
|
Aeroplysinin 1
(+)-Aeroplysinin-1
|
Bacterial
HIV
Apoptosis
|
Cancer
Infection
|
|
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells.
|
-
- HY-138542
-
-
- HY-119500
-
-
- HY-109545
-
|
Isopropyl unoprostone
Unoprostone isopropyl ester; UF-021
|
Potassium Channel
|
Others
|
|
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca 2+-activated K + (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity.
|
-
- HY-139576
-
|
Larsucosterol
DUR-928
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Larsucosterol (DUR-928), a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol as a potent endogenous regulator decreases lipogenesis. Larsucosterol inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1.
|
-
- HY-131606
-
|
Cidofovir diphosphate
|
Others
|
Infection
|
|
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively.
|
-
- HY-139576A
-
|
Larsucosterol sodium
DUR-928 sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol sodium as a potent endogenous regulator decreases lipogenesis. Larsucosterol sodium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1.
|
-
- HY-113483
-
|
20-Carboxy-Leukotriene B4
20-COOH LTB4
|
Drug Metabolite
|
Metabolic Disease
|
|
20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis).
|
-
- HY-129099
-
|
N-Desmethyltamoxifen
|
PKC
Estrogen Receptor/ERR
Drug Metabolite
Endogenous Metabolite
|
Cancer
|
|
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.
|
-
- HY-129099A
-
-
- HY-148642
-
|
12-Hydroxynevirapine
12-hydroxy-NVP; 12-OH-NVP
|
Drug Metabolite
|
Infection
|
|
12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine.
|
-
- HY-76569
-
|
Desfesoterodine
PNU-200577; 5-Hydroxymethyl Tolterodine
|
mAChR
|
Neurological Disease
|
|
Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively. Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053). Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats.
|
-
- HY-135581
-
|
Raloxifene 6-glucuronide
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression.
|
-
- HY-17366
-
|
Clozapine N-oxide
|
mAChR
Dopamine Receptor
Drug Metabolite
|
Neurological Disease
|
|
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
|
-
- HY-135582
-
|
Raloxifene 4'-glucuronide
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression.
|
-
- HY-135867
-
-
- HY-139576B
-
|
Larsucosterol (trimethylamine)
DUR-928 (trimethylamine)
|
LXR
Endogenous Metabolite
|
Metabolic Disease
|
|
Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1.
|
-
- HY-110159
-
-
- HY-N7378A
-
|
N-Hydroxypipecolic acid potassium
1-Hydroxy-2-piperidinecarboxylic acid potassium; NHP potassium
|
Bacterial
|
Inflammation/Immunology
|
|
N-Hydroxypipecolic acid potassium (1-Hydroxy-2-piperidinecarboxylic acid potassium), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid potassium accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid potassium induces SAR to bacterial and oomycete infection.
|
-
- HY-N7378
-
|
N-Hydroxypipecolic acid
1-Hydroxy-2-piperidinecarboxylic acid; NHP
|
Bacterial
|
Inflammation/Immunology
|
|
N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection.
|
-
- HY-129993
-
-
- HY-131606B
-
|
Cidofovir diphosphate tri(triethylamine)
|
Drug Metabolite
|
Infection
|
|
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively.
|
-
- HY-136239
-
|
Beclomethasone 17-propionate
Beclomethasone-17-monopropionate; 17-BMP
|
Glucocorticoid Receptor
Drug Metabolite
|
Inflammation/Immunology
|
|
Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages.
|
-
- HY-W009300
-
|
4-Hydroxyestrone
4-OHE1
|
Endogenous Metabolite
|
Neurological Disease
|
|
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity.
|
-
- HY-135867F
-
-
- HY-135867E
-
-
- HY-135867A
-
-
- HY-125348
-
|
6α-Hydroxy paclitaxel
|
Drug Metabolite
|
Cancer
|
|
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer.
|
-
- HY-147336
-
-
- HY-113377
-
|
L-Glyceric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2.
|
-
- HY-113377A
-
|
L-Glyceric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2.
|
-
- HY-12769S1
-
-
- HY-135594
-
|
4'-Raloxifene-β-D-glucopyranoside
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
4'-Raloxifene-β-D-glucopyranoside, a metabolite of Raloxifene, is a benzothiophene glucuronidated at the 4' postion. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 4'-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 4'-Raloxifene-β-D-glucopyranoside, example 5, is extracted from patent US5567820A.
|
-
- HY-135897
-
-
- HY-133152S
-
|
Brexpiprazole S-oxide-d8
DM-3411 d8
|
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Brexpiprazole S-oxide-d8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].
|
-
- HY-135334
-
|
ACP-5862
|
Drug Metabolite
Btk
Cytochrome P450
|
Cancer
|
|
ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM.
|
-
- HY-17366A
-
|
Clozapine N-oxide dihydrochloride
|
mAChR
Dopamine Receptor
Drug Metabolite
|
Neurological Disease
|
|
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
|
-
- HY-136576
-
|
RP101075
|
LPL Receptor
Drug Metabolite
|
Inflammation/Immunology
|
|
RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile.
|
-
- HY-116364
-
|
AZT triphosphate
3'-Azido-3'-deoxythymidine-5'-triphosphate
|
HIV
DNA/RNA Synthesis
HBV
Reactive Oxygen Species
Apoptosis
|
Infection
|
|
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway.
|
-
- HY-N6979
-
|
Crustecdysone
20-Hydroxyecdysone
|
Caspase
Autophagy
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).
|
-
- HY-125919
-
-
- HY-116364A
-
|
AZT triphosphate TEA
3'-Azido-3'-deoxythymidine-5'-triphosphate TEA
|
HIV
DNA/RNA Synthesis
HBV
Reactive Oxygen Species
Apoptosis
|
Infection
|
|
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated apoptosis pathway.
|
-
- HY-116364B
-
|
AZT triphosphate tetraammonium
3'-Azido-3'-deoxythymidine-5'-triphosphate tetraammonium
|
HIV
DNA/RNA Synthesis
HBV
Reactive Oxygen Species
Apoptosis
|
Infection
|
|
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway.
|
-
- HY-N1029
-
|
Norathyriol
Mangiferitin
|
Glucosidase
PPAR
|
Cancer
Infection
Inflammation/Immunology
|
|
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
|
-
- HY-146190
-
|
Callophycin A
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules.
|
-
- HY-P3989
-
|
Apratoxin A
(-)-Apratoxin A
|
HSP
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Apratoxin A, a cyanobacterial metabolite, mediates antiproliferative activity through the induction of G1 cell cycle arrest and an apoptotic cascade. Apratoxin A associates with Hsp70/Hsc70 to promote the degradation of Hsp90 client proteins. Apratoxin A can specifically bind the Sec61 complex.
|
-
- HY-109854A
-
|
(R)-Lisofylline
(R)-Lisophylline
|
STAT
|
Metabolic Disease
Inflammation/Immunology
|
|
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research.
|
-
- HY-116084
-
-
- HY-147333
-
|
Trimipramine N-oxide
|
Drug Metabolite
|
Neurological Disease
|
|
Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety.
|
-
- HY-N6798
-
|
Myriocin
Thermozymocidin; ISP-I
|
HCV
Antibiotic
|
Infection
|
|
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 µg/mL for inhibiting HCV infection.
|
-
- HY-129319
-
-
- HY-108915
-
-
- HY-117713
-
-
- HY-B1746
-
-
- HY-120733
-
|
Calpinactam
FKI-4905
|
Bacterial
Endogenous Metabolite
|
Infection
Inflammation/Immunology
|
|
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively.
|
-
- HY-W053787
-
-
- HY-135386
-
-
- HY-W007671
-
-
- HY-N6217
-
-
- HY-12771S2
-
-
- HY-113246
-
-
- HY-108263B
-
|
(R)-3-Hydroxy Midostaurin
(R)-CGP52421
|
FLT3
Drug Metabolite
|
Cancer
|
|
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML).
|
-
- HY-W092109
-
-
- HY-N10382
-
-
- HY-N2353S1
-
-
- HY-W011235
-
|
Norfluoxetine hydrochloride
|
5-HT Receptor
Calcium Channel
Drug Metabolite
|
Neurological Disease
|
|
Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity.
|
-
- HY-N0179
-
|
Ecdysone
α-Ecdysone
|
Endogenous Metabolite
Apoptosis
|
Metabolic Disease
|
|
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979).
|
-
- HY-G0006
-
-
- HY-77956S3
-
-
- HY-133872
-
-
- HY-N2353S2
-
-
- HY-77956S4
-
-
- HY-77956S
-
-
- HY-W015466S
-
-
- HY-128753S6
-
-
- HY-W019151S
-
-
- HY-126488
-
-
- HY-130214
-
-
- HY-108263A
-
|
(S)-3-Hydroxy Midostaurin
(S)-CGP52421
|
FLT3
Drug Metabolite
|
Cancer
|
|
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML).
|
-
- HY-113289
-
|
Brassicasterol
|
Androgen Receptor
HSV
Bacterial
Drug Metabolite
|
Cancer
Infection
|
|
Brassicasterol, a metabolite of Ergosterol, plays a role in the inhibitory effect on bladder carcinogenesis promotion via androgen signaling. Brassicasterol shows dual anti-infective properties against HSV-1 (IC50=1.2 µM) and Mycobacterium tuberculosis, and cardiovascular protective effect. Brassicasterol exerts an anti-cancer effect by dual-targeting AKT and androgen receptor signaling in prostate cancer.
|
-
- HY-N2353S
-
-
- HY-12765
-
|
Losartan Carboxylic Acid
E-3174; EXP-3174
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
|
-
- HY-77956S1
-
-
- HY-77956S2
-
-
- HY-128741S
-
-
- HY-N0059S4
-
-
- HY-128753S7
-
-
- HY-N0059S
-
-
- HY-N0059S6
-
-
- HY-N0059S5
-
-
- HY-N2325S
-
-
- HY-D0185S1
-
-
- HY-N10261
-
-
- HY-B1804
-
-
- HY-128753S3
-
-
- HY-113381
-
-
- HY-128741S2
-
-
- HY-128753S5
-
-
- HY-N0059S1
-
-
- HY-128741S1
-
-
- HY-N0059S2
-
-
- HY-D0185S
-
-
- HY-N0059S3
-
-
- HY-128753S4
-
-
- HY-33212S
-
-
- HY-W015466
-
-
- HY-W018059
-
-
- HY-W017370
-
-
- HY-W014410
-
-
- HY-113295
-
-
- HY-N2501
-
-
- HY-128421
-
-
- HY-125909
-
-
- HY-Y1366
-
-
- HY-N2353
-
-
- HY-W010435
-
-
- HY-107825
-
-
- HY-77956
-
-
- HY-126357
-
-
- HY-W027446
-
-
- HY-N1423B
-
-
- HY-N2424
-
-
- HY-128754
-
-
- HY-Y1009
-
-
- HY-125671
-
-
- HY-Y1173
-
-
- HY-Y0546
-
-
- HY-128734
-
-
- HY-113373
-
-
- HY-W012161
-
-
- HY-W019151
-
-
- HY-128393
-
-
- HY-B0722
-
-
- HY-W040971
-
-
- HY-W018653
-
-
- HY-W007319
-
-
- HY-128740
-
-
- HY-N5034
-
-
- HY-128739
-
-
- HY-128733
-
-
- HY-W027555
-
-
- HY-Y0504
-
-
- HY-W017158
-
-
- HY-W067716
-
-
- HY-125731
-
-
- HY-W010396
-
-
- HY-34431
-
-
- HY-W017469
-
-
- HY-Y0519
-
-
- HY-W012595
-
-
- HY-108213
-
-
- HY-W001132
-
-
- HY-Y0267
-
-
- HY-113219
-
-
- HY-W012999
-
|
Tiglic acid
|
Endogenous Metabolite
|
Others
|
|
Tiglic acid is a monocarboxylic unsaturated organic acid found in croton oil and in several other natural products. Tiglic aci has a role as a plant metabolite.
|
-
- HY-129623
-
-
- HY-D0217
-
-
- HY-141776S
-
|
Omeprazole sulfide-d3
Ufiprazole-d3
|
Drug Metabolite
|
Others
|
|
Omeprazole sulfide-d3 is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
|
-
- HY-128741
-
-
- HY-Y1298
-
-
- HY-N2325
-
-
- HY-78093A
-
-
- HY-112540A
-
-
- HY-128730
-
-
- HY-B1777A
-
-
- HY-W009516
-
-
- HY-Y0057
-
-
- HY-B1827
-
-
- HY-78446
-
-
- HY-125910
-
-
- HY-W007346
-
-
- HY-N0059
-
-
- HY-W012860
-
-
- HY-Y1177
-
-
- HY-124124
-
-
- HY-128753
-
-
- HY-30215
-
-
- HY-128745
-
-
- HY-128735
-
-
- HY-B1476
-
-
- HY-114557
-
-
- HY-50290A
-
-
- HY-W015213
-
-
- HY-W017613
-
-
- HY-124009A
-
-
- HY-N6612A
-
-
- HY-Y0399
-
-
- HY-113369
-
-
- HY-D0885D
-
-
- HY-Y1297
-
-
- HY-WAA0142
-
-
- HY-W007704
-
-
- HY-W015342
-
-
- HY-126354
-
-
- HY-W048838
-
-
- HY-113093
-
-
- HY-W012480
-
-
- HY-Y1644
-
-
- HY-W014233
-
-
- HY-128417S1
-
-
- HY-Y0669
-
-
- HY-N10470
-
-
- HY-W004078
-
-
- HY-Y0136
-
-
- HY-Y0442
-
-
- HY-W012657
-
-
- HY-W002065
-
-
- HY-W011393
-
-
- HY-W017194
-
-
- HY-W010549
-
-
- HY-W011978
-
-
- HY-101416
-
-
- HY-Y1809
-
-
- HY-W005028
-
-
- HY-W040040
-
-
- HY-75954
-
-
- HY-109569
-
-
- HY-33212
-
-
- HY-W001996
-
-
- HY-W011727
-
-
- HY-W017077
-
-
- HY-W015924
-
-
- HY-W004049
-
-
- HY-Y0191
-
-
- HY-Y1819
-
-
- HY-128742
-
-
- HY-W004066
-
-
- HY-W040088
-
-
- HY-Y0289
-
-
- HY-128743
-
-
- HY-W012941
-
-
- HY-W016647
-
-
- HY-21075
-
-
- HY-W040948
-
-
- HY-W015302
-
-
- HY-W012658
-
-
- HY-W038287
-
-
- HY-W012790
-
-
- HY-W018197
-
-
- HY-41982
-
-
- HY-B1673
-
-
- HY-W001083
-
-
- HY-W015786
-
-
- HY-59291
-
-
- HY-W014796
-
-
- HY-W042193
-
-
- HY-W011249
-
-
- HY-W012340
-
-
- HY-Y0624
-
-
- HY-101409A
-
-
- HY-101406
-
-
- HY-D0185
-
-
- HY-W014225
-
-
- HY-W017113
-
-
- HY-W018678
-
|
8-Aminooctanoic acid
|
Others
|
Metabolic Disease
|
|
8-Aminooctanoic acid is an omega-amino fatty acid that is octanoic acid which carries an amino group at position 8. 8-aminooctanoic acid has a role as a human metabolite.
|
-
- HY-W007035
-
-
- HY-B1804S1
-
|
Tricaprilin-d50
Trioctanoin-d50; Glyceryl trioctanoate-d50
|
Endogenous Metabolite
|
|
|
Tricaprilin-d50 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].
|
-
- HY-B1804S2
-
|
Tricaprilin-d15
Trioctanoin-d15; Glyceryl trioctanoate-d15
|
Endogenous Metabolite
|
|
|
Tricaprilin-d15 is the deuterium labeled Tricaprilin. Tricaprilin (Trioctanoin) is used in study for patients with mild to moderate Alzheimer's disease and has a role as an anticonvulsant and a plant metabolite[1][2].
|
-
- HY-W010476S
-
-
- HY-W019704
-
-
- HY-Y1667
-
-
- HY-128417
-
-
- HY-W006371
-
-
- HY-W015823
-
-
- HY-N0894
-
-
- HY-W016480
-
-
- HY-113353
-
-
- HY-128746
-
-
- HY-113110
-
-
- HY-W004874
-
-
- HY-W007828
-
-
- HY-112537B
-
-
- HY-116132
-
-
- HY-W062542
-
-
- HY-W049735
-
-
- HY-W011982
-
-
- HY-34516
-
-
- HY-W018501
-
-
- HY-128749
-
-
- HY-W013674
-
-
- HY-34439
-
-
- HY-W009338
-
-
- HY-W015618
-
-
- HY-113210
-
-
- HY-W008807
-
-
- HY-Y0106
-
-
- HY-B1180
-
-
- HY-W019358
-
-
- HY-76228
-
-
- HY-W034065
-
-
- HY-W015780
-
-
- HY-W007347
-
-
- HY-W007539
-
-
- HY-113474
-
-
- HY-W019724
-
-
- HY-W010973
-
-
- HY-113239
-
-
- HY-W008270
-
-
- HY-W019670
-
-
- HY-113268
-
-
- HY-W050026
-
-
- HY-118840
-
-
- HY-119640
-
-
- HY-W004360
-
-
- HY-Y0781
-
-
- HY-W014930
-
-
- HY-113418
-
-
- HY-W002011
-
-
- HY-128752
-
-
- HY-W010594
-
-
- HY-W059917
-
-
- HY-W010476
-
-
- HY-113220
-
-
- HY-W001171
-
-
- HY-101723
-
-
- HY-W015273A
-
-
- HY-128731
-
-
- HY-113266
-
-
- HY-B0708
-
-
- HY-23497
-
-
- HY-128737
-
-
- HY-10555
-
|
AMG-221
|
11β-HSD
|
Metabolic Disease
|
|
AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC50 of 10.1 nM in cell-based assays. AMG-221 can be used for the research of type 2 diabetes.
|
-
- HY-135410
-
|
ABZ-amine
Amino albendazole
|
Drug Metabolite
|
Infection
|
|
ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
|
-
- HY-14572
-
|
PR-104A
SN 27858
|
DNA Alkylator/Crosslinker
Drug Metabolite
|
Cancer
|
|
PR-104A (SN 27858) is the alcohol metabolite of phosphate prodrug PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL).
|
-
- HY-N7080
-
|
Dihydroferulic acid
Hydroferulic acid
|
Others
|
Metabolic Disease
|
|
Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid.
|
-
- HY-113514
-
-
- HY-W046906
-
-
- HY-W008766
-
-
- HY-113367
-
-
- HY-W013100
-
-
- HY-113227
-
-
- HY-W015060
-
-
- HY-W017524
-
-
- HY-113286
-
-
- HY-W010448
-
-
- HY-79334
-
-
- HY-N10235
-
-
- HY-W010736
-
-
- HY-123068
-
-
- HY-128738
-
-
- HY-113407A
-
-
- HY-W016750
-
-
- HY-B1103
-
-
- HY-N10282
-
-
- HY-W008315
-
-
- HY-W050044
-
-
- HY-75087
-
-
- HY-W001080
-
-
- HY-126304
-
-
- HY-W010155
-
-
- HY-12781
-
-
- HY-Y0181
-
-
- HY-W014589
-
-
- HY-Y0669S
-
|
Pipecolic acid-d9
|
Endogenous Metabolite
Bacterial
|
|
|
Pipecolic acid-d9 is the deuterium labeled Pipecolic acid. Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites. Pipecolic acid can be used as a diagnostic marker of Pyridoxine-dependent epilepsy[1][2].
|
-
- HY-133781
-
|
cis-Clopidogrel-MP derivative
Clopidogrel-MP-AM
|
Drug Metabolite
|
Others
|
|
cis-Clopidogrel-MP derivative (Clopidogrel-MP-AM) is a 3’-methoxyacetophenone derivative of Clopidogrel active metabolite. Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor.
|
-
- HY-30004S
-
-
- HY-70002A
-
|
N-desmethyl Enzalutamide
N-desmethyl MDV 3100
|
Androgen Receptor
|
Cancer
|
|
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide.
|
-
- HY-W011184
-
-
- HY-N1424
-
-
- HY-111095B
-
-
- HY-W008794
-
-
- HY-N10257
-
-
- HY-113110A
-
-
- HY-W009216
-
-
- HY-W007888
-
-
- HY-W017490
-
-
- HY-W017523
-
-
- HY-W008188
-
-
- HY-137938
-
-
- HY-W010611
-
-
- HY-W010514
-
-
- HY-W040154
-
-
- HY-W018339
-
-
- HY-W039157
-
-
- HY-W014130A
-
-
- HY-W016103
-
-
- HY-111741
-
-
- HY-30004
-
-
- HY-126355
-
-
- HY-113277
-
-
- HY-101397
-
-
- HY-15130
-
-
- HY-W010224
-
-
- HY-W009713
-
-
- HY-B1945
-
-
- HY-14798
-
-
- HY-101131
-
|
Dansyl glutathione
DNS-glutathione
|
Others
|
Others
|
|
Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites.
|
-
- HY-129398
-
-
- HY-23195
-
-
- HY-W016734
-
-
- HY-113283
-
-
- HY-N9403
-
-
- HY-B1342S1
-
-
- HY-103382
-
-
- HY-145154
-
-
- HY-128754S1
-
-
- HY-107826
-
-
- HY-W001132S
-
-
- HY-B1342S2
-
-
- HY-W009390A
-
-
- HY-W015326
-
-
- HY-W013061
-
-
- HY-18569A
-
-
- HY-W060074
-
-
- HY-66047
-
-
- HY-N0684A
-
-
- HY-W015883
-
-
- HY-A0181
-
-
- HY-Y0035
-
-
- HY-B1342S
-
-
- HY-N9395
-
-
- HY-Y0546S
-
-
- HY-113232
-
-
- HY-128754S
-
-
- HY-113457S
-
|
11-Oxo etiocholanolone-d5
11-Ketoetiocholanolone-d5
|
Endogenous Metabolite
|
|
|
11-Oxo etiocholanolone-d5 is the deuterium labeled 11-Oxo etiocholanolone. 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a metabolite of Etiocholanolone. Etiocholanolone is the excreted metabolite of testosterone and has anticonvulsant activity[1][2][3].
|
-
- HY-P2200
-
|
Siamycin I
BMY-29304
|
HIV
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research.
|
-
- HY-W002304
-
-
- HY-W011195
-
-
- HY-W004661
-
-
- HY-128744
-
-
- HY-107785
-
-
- HY-W006492
-
-
- HY-W011910
-
-
- HY-12784
-
-
- HY-111490
-
-
- HY-118844
-
-
- HY-W036553
-
-
- HY-13930
-
|
Miquelianin
Quercetin 3-O-glucuronide; Quercetin 3-glucuronide
|
Endogenous Metabolite
|
Cancer
|
|
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.
|
-
- HY-13320
-
-
- HY-N3697
-
-
- HY-125731S1
-
-
- HY-W010861
-
-
- HY-W007566
-
-
- HY-32349
-
-
- HY-128733S
-
-
- HY-W002773
-
-
- HY-125731S
-
-
- HY-100052
-
-
- HY-W011175
-
-
- HY-113252
-
-
- HY-79593
-
-
- HY-W041019
-
-
- HY-125850
-
-
- HY-119328
-
-
- HY-133871
-
-
- HY-12784A
-
-
- HY-W015450
-
|
D-Ala-D-Ala
|
Endogenous Metabolite
|
Others
|
|
D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite.
|
-
- HY-43470
-
-
- HY-N7404
-
-
- HY-138094
-
|
N-(2-Hydroxyethyl)oxamic acid
|
Drug Metabolite
|
Infection
|
|
N-(2-hydroxyethyl)-oxamic acid is formed when Metronidazole is reduced either chemically or by the action of the intestinal bacteria. Metronidazole, a nitroimidazole antibiotic, has activity against various protozoans and most Gram-negative and Gram-positive anaerobic bacteria.
|
-
- HY-N10200
-
-
- HY-W012572
-
-
- HY-130395
-
-
- HY-W040268
-
-
- HY-W014423
-
-
- HY-128426
-
-
- HY-12770S
-
-
- HY-12769S
-
-
- HY-W007686
-
-
- HY-I0177
-
-
- HY-113085
-
-
- HY-103638A
-
-
- HY-136445
-
-
- HY-126986
-
-
- HY-113340
-
-
- HY-B0331A
-
-
- HY-104026
-
-
- HY-113299
-
-
- HY-Y1117
-
|
Melamine
|
Drug Metabolite
|
Others
|
|
Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials.
|
-
- HY-128736
-
-
- HY-12781S
-
-
- HY-117821
-
-
- HY-B0016
-
-
- HY-N7390
-
-
- HY-W015224
-
-
- HY-N2584
-
-
- HY-129515
-
-
- HY-113379
-
-
- HY-W012997
-
-
- HY-N6828
-
-
- HY-G0012S
-
-
- HY-10002
-
-
- HY-101407
-
-
- HY-113371A
-
|
2-Methylcitric acid trisodium
Methylcitric acid trisodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.
|
-
- HY-Y0202
-
-
- HY-W017511
-
-
- HY-W013014
-
-
- HY-43533
-
|
Tarlox-TKI
|
EGFR
|
Cancer
|
|
Tarlox-TKI, the active metabolite of Tarloxotinib, is an irreversible pan-ErbB TKI (Tarlox-TKI).
|
-
- HY-113517
-
-
- HY-135400
-
-
- HY-15992
-
|
BIBF 1202
|
VEGFR
|
Cancer
|
|
BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.
|
-
- HY-124124S
-
-
- HY-118020A
-
|
Loliolid
|
Others
|
Metabolic Disease
|
|
Loliolide, a Carotenoid Metabolite, is a potential endogenous inducer of herbivore resistance. Loliolide also inhibits the seedling growth.
|
-
- HY-131146
-
|
AMOZ
3-Amino-5-morpholinomethyl-2-oxazolidone
|
Antibiotic
|
Infection
|
|
AMOZ, a tissue bound metabolite of Furaltadone, Furaltadone is a synthetic nitrofuran antibiotic widely used
|
-
- HY-W013035
-
-
- HY-114750
-
-
- HY-N3059
-
-
- HY-Y1314S
-
-
- HY-136458
-
|
3-ANOT
3-Amino-5-nitro-o-toluamide
|
Parasite
|
Infection
|
|
3-ANOT is a metabolite of Dinitolmide (a nitroamide coccidiostat commonly used in poultry production).
|
-
- HY-W012480S1
-
-
- HY-B1777AS
-
-
- HY-W010381
-
-
- HY-W015346
-
-
- HY-W012480S
-
-
- HY-147085
-
-
- HY-W016482
-
-
- HY-118399
-
-
- HY-76210
-
-
- HY-Y0399S
-
-
- HY-135394
-
-
- HY-W041470
-
-
- HY-118608
-
-
- HY-113247
-
-
- HY-U00039
-
-
- HY-113150
-
-
- HY-113495
-
-
- HY-135235
-
|
Cysteine thiol probe
|
Others
|
Others
|
|
Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites.
|
-
- HY-113437AS
-
-
- HY-N6039
-
-
- HY-Y0694
-
-
- HY-112175
-
-
- HY-12778S
-
-
- HY-N1939
-
|
Icariside I
Icarisid I
|
Others
|
Others
|
|
Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.
|
-
- HY-113357
-
-
- HY-G0011S
-
-
- HY-P1488
-
-
- HY-Y1362
-
-
- HY-113126
-
-
- HY-W014504
-
-
- HY-118093
-
-
- HY-A0058
-
-
- HY-G0010S
-
-
- HY-W037619
-
-
- HY-P1484
-
-
- HY-W016498
-
-
- HY-100645
-
-
- HY-G0016S
-
-
- HY-100646AS
-
-
- HY-W016798
-
-
- HY-16232
-
|
GLUFOSFAMIDE
D 19575; Glucosylifosfamide mustard
|
Others
|
Cancer
|
|
Glufosfamide is a novel alkylating agent in which the active metabolite of isophosphoramide mustard is glycosidically linked to β-D-glucose.
|
-
- HY-N7916
-
|
(-)-Menthone
|
Others
|
Others
|
|
(-)-Menthone is a monoterpene component of the essential oil of maturing peppermint. (+)-Neomenthyl-β-d-glucoside is a metabolite of (-)-Menthone.
|
-
- HY-126356
-
-
- HY-G0016S1
-
-
- HY-117253
-
|
PHA-782584
|
Drug Metabolite
|
Cancer
|
|
PHA-782584 is a metabolite of sunitinib. Sunitinib is an oral multitargeted tyrosine kinase inhibitor with antitumor activities.
|
-
- HY-145535
-
-
- HY-135399
-
-
- HY-120154
-
-
- HY-131591
-
-
- HY-N4188
-
-
- HY-122277
-
-
- HY-76801
-
-
- HY-B0794A
-
-
- HY-118100
-
|
Cyclo(Tyr-Val)
Cyclo(L-Tyr-L-Val)
|
Drug Metabolite
|
Others
|
|
Cyclo(Tyr-Val) (Cyclo(L-Tyr-L-Val)) is a diketopiperazine secondary fungal metabolite originally isolated from N. gilva.
|
-
- HY-W015954
-
-
- HY-W011727S
-
-
- HY-113168
-
|
Butyrylcarnitine
|
Endogenous Metabolite
|
Others
|
|
Butyrylcarnitine is a metabolite in plasma, acts as a biomarker to improve the diagnosis and prognosis of heart failure, and is indicative of anomalous lipid and energy metabolism.
|
-
- HY-103252S
-
-
- HY-W016509
-
-
- HY-130046
-
-
- HY-W019833
-
-
- HY-101411
-
-
- HY-Y0781S
-
-
- HY-B0794
-
-
- HY-137565
-
-
- HY-W012814
-
-
- HY-P1490
-
-
- HY-W053507
-
|
m-Tolylacetic acid
3-Methylbenzeneacetic acid
|
Drug Metabolite
|
Others
|
|
m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid.
|
-
- HY-145671
-
-
- HY-128750
-
-
- HY-W019773
-
-
- HY-B0794B
-
-
- HY-W012722
-
-
- HY-B0815S
-
|
Chlorpyrifos-d10
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Chlorpyrifos-d10 is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.
|
-
- HY-113336
-
-
- HY-N7143
-
-
- HY-D0063
-
-
- HY-125538
-
-
- HY-133770
-
-
- HY-32350
-
-
- HY-128732
-
-
- HY-13256
-
-
- HY-126126
-
-
- HY-N1178
-
-
- HY-100662
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-
- HY-N8469
-
-
- HY-N10301
-
-
- HY-113200
-
-
- HY-122489
-
-
- HY-W004066S
-
-
- HY-Y0289S1
-
-
- HY-W141810
-
-
- HY-W004066S1
-
-
- HY-W010255
-
-
- HY-B1945S
-
-
- HY-W008794S
-
|
Normetanephrine-d3 hydrochloride
(±)-Normetanephrine-d3 (hydrochloride); DL-Normetanephrine-d3 (hydrochloride); (Rac)-Normetanephrine-d3 (hydrochloride)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Normetanephrine-d3 (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE)[1].
|
-
- HY-N6918
-
-
- HY-N7023
-
|
7-Prenyloxycoumarin
7-O-Prenylumbelliferone
|
Fungal
|
Infection
|
|
7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense.
|
-
- HY-103638
-
-
- HY-N10604
-
-
- HY-113270A
-
-
- HY-B1178
-
|
Cotinine
(-)-Cotinine; (S)-Cotinine; NIH-10498
|
Endogenous Metabolite
|
Cancer
|
|
Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke
|
-
- HY-142908
-
-
- HY-108869
-
-
- HY-118517
-
|
α-Hydroxytamoxifen
(E)-α-Hydroxy tamoxifen; α-OHTAM
|
Drug Metabolite
|
Cancer
|
|
α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts.
|
-
- HY-113366
-
|
Prostaglandin J2
PGJ2
|
Prostaglandin Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with Kis of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD).
|
-
- HY-133781S
-
|
cis-Clopidogrel-MP derivative-13C,d3
Clopidogrel-MP-AM-13C,d3
|
Isotope-Labeled Compounds
|
Others
|
|
cis-Clopidogrel-MP derivative- 13C,d3 is a 13C and deuterium labele cis-Clopidogrel-MP derivative. cis-Clopidogrel-MP derivative is a 3’-methoxyacetophenone derivative of Clopidogrel active metabolite[1]. Clopidogrel is a well-known and orally active platelet inhibitor that targets P2Y12 receptor[2].
|
-
- HY-113371S
-
|
2-Methylcitric acid-d3
Methylcitric acid-d3
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid-d3 is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].
|
-
- HY-W004305
-
-
- HY-13938
-
|
Iretol
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Iretol (2,4,6-trihydroxyanisole) is a a degradation product of a glucoside obtained from Iris Jorentina. Iretol is an intermediate in the synthesis of natural isoflavones, such as Tectorigenin, Irigenin and Caviunin.
|
-
- HY-N8888
-
|
10,11-Dihydro-24-hydroxyaflavinine
|
Others
|
Others
|
|
10,11-Dihydro-24-hydroxyaflavinine (10,23,24,25-tetrahydro-24-hydroxyaflavinine), an aflavinine analog, is a natural product that can be isolated from Ascostromata of Eupenicillium crustaceum.
|
-
- HY-N9253
-
-
- HY-111815A
-
-
- HY-111815
-
-
- HY-N7354
-
-
- HY-125598
-
|
Secologanin
|
Others
|
Others
|
|
Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine. Secologanin synthase (cytochrome P450 isoform CYP72A1) catalyzes the oxidative cleavage of loganin into Secologanin.
|
-
- HY-N10184
-
|
Paecilaminol
FKI-0550
|
Others
|
Infection
|
|
Paecilaminol (FKI-0550) is potent NADH-fumarate reductase inhibitor. Paecilaminol exhibits an IC50 value of 5.1 μM against Ascaris suum NADH-fumarate reductase.
|
-
- HY-133588
-
-
- HY-122317
-
-
- HY-N4075
-
-
- HY-W016812
-
-
- HY-Y0289S
-
-
- HY-12785
-
|
Albendazole sulfoxide
Ricobendazole; Albendazole oxide
|
Parasite
|
Infection
|
|
Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
|
-
- HY-N7495
-
-
- HY-N0384
-
-
- HY-117153
-
-
- HY-W004206
-
-
- HY-Y0801
-
-
- HY-113407
-
-
- HY-P1469
-
-
- HY-N6658
-
-
- HY-W015924S
-
-
- HY-B0806
-
|
Proguanil
|
Parasite
Antifolate
|
Infection
|
|
Proguanil, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor.
|
-
- HY-B0806A
-
-
- HY-128828
-
-
- HY-W008253
-
-
- HY-113293
-
-
- HY-20696
-
-
- HY-113105
-
-
- HY-33914
-
-
- HY-W015874
-
-
- HY-B0459
-
-
- HY-W012926
-
-
- HY-N0797
-
-
- HY-107494A
-
-
- HY-W014225S
-
-
- HY-148375
-
-
- HY-133794
-
-
- HY-W010066
-
-
- HY-108213A
-
-
- HY-W011704A
-
-
- HY-132405S
-
-
- HY-N11425
-
|
Benzydamine N-Oxide
|
Others
|
Others
|
|
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity.
|
-
- HY-113527
-
-
- HY-135772
-
-
- HY-N6683
-
-
- HY-132675S
-
-
- HY-N6662
-
|
(+)-Longifolene
|
Endogenous Metabolite
|
Others
|
|
(+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolen is converted to primary, secondary or tertiary alcohols in rabbits, among which the primary alcohol is predominant.
|
-
- HY-113318
-
-
- HY-12784AS
-
-
- HY-W010248
-
-
- HY-113434
-
-
- HY-W011239
-
|
Fenbendazole sulfone
Oxfendazole sulfone; FBZ-SO2
|
Parasite
|
Infection
|
|
Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent.
|
-
- HY-126708
-
|
Luisol A
|
ADC Cytotoxin
Antibiotic
|
Infection
|
|
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, anthraquinone antibiotic analog, is an ADC Cytotoxin.
|
-
- HY-13256A
-
|
Desmethyl Erlotinib
OSI-420 free base; CP-373420
|
Drug Metabolite
|
Cancer
|
|
Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor.
|
-
- HY-113353S
-
-
- HY-N7148A
-
-
- HY-136596
-
|
Apalutamide-COOH
|
Drug Metabolite
|
Cancer
|
|
Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
|
-
- HY-107850
-
-
- HY-124265
-
-
- HY-W251393
-
-
- HY-N6735
-
|
Apicidin
OSI 2040
|
HDAC
Parasite
|
Cancer
Infection
|
|
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity.
|
-
- HY-W016562
-
|
Hippuric acid
2-Benzamidoacetic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
|
-
- HY-105014
-
-
- HY-13609
-
-
- HY-N5004
-
-
- HY-135391
-
-
- HY-N10255
-
|
Trypacidin
|
Parasite
|
Infection
|
|
Trypacidin is the conidia-bound metabolite with antiprotozoal activity. Trypacidin has a protective function against phagocytes both in the environment and during the infection process.
|
-
- HY-113367S1
-
-
- HY-N9502
-
|
Linalool oxide
|
Others
|
Neurological Disease
|
|
Linalool oxide is a secondary metabolite in elongating wheat plants with antinociceptive and anticonvulsant effects. Linalool oxide shows anxiolytic activity.
|
-
- HY-W008437
-
-
- HY-15830
-
-
- HY-E70043
-
-
- HY-137316
-
-
- HY-128417S
-
-
- HY-32351
-
-
- HY-N9314
-
-
- HY-144773
-
-
- HY-N10493
-
-
- HY-113317
-
-
- HY-16445B
-
-
- HY-W015883S
-
-
- HY-B1348
-
|
Dimethadione
|
Drug Metabolite
|
Neurological Disease
|
|
Dimethadione is the primary metabolite of trimethadione. Dimethadione causes depression of neuromuscular transmission. Dimethadione primarily decreases transmitter release from the nerve terminal.
|
-
- HY-N9484
-
|
Menthofuran
|
Drug Metabolite
|
Others
|
|
Menthofuran is a proximate toxic metabolite of (R)-(+)-Pulegone. Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase.
|
-
- HY-113451
-
-
- HY-113231
-
-
- HY-108491
-
