Search Result
Results for "
metabolite
" in MedChemExpress (MCE) Product Catalog:
3769
Inhibitors & Agonists
33
Biochemical Assay Reagents
666
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W702068
-
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metabolite D hydrochloride
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Biochemical Assay Reagents
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Others
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7-Hydroxy-1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide (Metabolite D) hydrochloride is a biological molecule.
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-
-
- HY-136336
-
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Drug Metabolite
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Others
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Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib .
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-
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- HY-131669
-
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Dasatinib carboxylic acid
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Drug Metabolite
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Others
Cancer
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Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib (HY-10181). Dasatinib is a potent and orally active dual Bcr-Abl and Src family tyrosine kinase inhibitor .
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-
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- HY-126534A
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LSN3106729 hydrochloride
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Ligands for Target Protein for PROTAC
CDK
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Cancer
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Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .
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-
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- HY-G0002A
-
-
-
- HY-164703
-
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Drug Metabolite
Dopamine Receptor
5-HT Receptor
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Neurological Disease
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Lumateperone metabolite 1 (Formula T) is a metabolite of Lumateperone (HY-17637) . Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator
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-
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- HY-136703
-
|
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HIV Protease
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Infection
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Lopinavir Metabolite M-1, an active metabolite of Lopinavir, inhibits HIV protease with a Ki of 0.7 pM. Lopinavir Metabolite M-1 has antiviral activities in vitro .
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-
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- HY-117229
-
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Drug Metabolite
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Cancer
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Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib .
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-
-
- HY-G0002
-
-
-
- HY-172073
-
-
-
- HY-129336S
-
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LSN3106726-d8
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CDK
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Cancer
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Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].
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-
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- HY-G0001A
-
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Drug Metabolite
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Neurological Disease
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Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.
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-
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- HY-G0001
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-
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- HY-164815
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Tianeptine metabolite MC5
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Drug Metabolite
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Neurological Disease
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S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants .
|
-
-
- HY-129336
-
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LSN3106726
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CDK
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Cancer
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Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer .
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-
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- HY-W704938
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-
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- HY-W128916S
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-
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- HY-144165S
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-
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- HY-120927S
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-
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- HY-143913S
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-
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- HY-W020576R
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Cholinesterase (ChE)
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Neurological Disease
|
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Rivastigmine metabolite (Standard) is the analytical standard of Rivastigmine metabolite. This product is intended for research and analytical applications. Rivastigmine metabolite is an acetylcholinesterase (AChE) inhibitor which is produced in kidney. Rivastigmine metabolite is promising for research of Alzheimer’s Disease .
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- HY-G0023
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Niraparib carboxylic acid metabolite M1; M1 metabolite of niraparib
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Drug Metabolite
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Others
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Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
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- HY-172057
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-
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- HY-120927
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Opioid Receptor
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Neurological Disease
|
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Alvimopan metabolite is a μ opioid receptor antagonist with activity that selectively interacts with μ peripheral receptors. Alvimopan metabolite can be used as a potential inhibitory drug to alleviate the side effects caused by opioids. Alvimopan metabolite was identified as a highly selective μ opioid receptor antagonist during research and development .
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- HY-146963S
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- HY-157074S
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- HY-W777199
-
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Drug Metabolite
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Others
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Tianeptine metabolite MC5 sodium salt is a major active metabolite of tianeptine. Tianeptine and MC5 metabolite are eliminated with bile as glucuronide and glutamine conjugates .
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- HY-G0009
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Desthiazolylmethyloxycarbonyl Ritonavir
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Drug Metabolite
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Infection
|
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Ritonavir metabolite is a metabolite of Ritonavir, which is a HIV protease inhibitor.
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-
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- HY-W035375
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-
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- HY-108251
-
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DAMPA
|
Antifolate
Drug Metabolite
Dihydrofolate reductase (DHFR)
Parasite
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Infection
Inflammation/Immunology
|
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Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid (HY-16637) antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC50 values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation .
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- HY-G0001S
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- HY-G0002S
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- HY-108251R
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-
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- HY-156128
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mAChR
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Neurological Disease
|
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Imidafenacin Metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist Imidafenacin (HY-B0662) .
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- HY-P10916
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Drug Metabolite
Fungal
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Infection
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Micafungin metabolite M1 is an active metabolite of Micafungin (HY-17579), which is metabolized by arylsulfatase and exhibits antifungal activity. Micafungin metabolite M1 can be used for research on deep fungal infections caused by Candida and Aspergillus species .
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- HY-W293109
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-
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- HY-19764
-
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RIP kinase
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Cancer
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GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
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- HY-12769
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Mebeverine metabolite Mebeverine acid
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Drug Metabolite
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Neurological Disease
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Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine .
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- HY-170629
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Drug Metabolite
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Neurological Disease
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3,4-Dimethylmethcathinone metabolite hydrochloride is a metabolite of 3,4-Dimethylmethcathinone. 3,4-Dimethylmethcathinone is a stimulant agent .
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- HY-135601
-
|
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Drug Metabolite
|
Cardiovascular Disease
|
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Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease .
|
-
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- HY-103687
-
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3β-OH-5α-Abi
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Drug Metabolite
|
Cancer
|
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Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal agent, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
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-
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- HY-G0024A
-
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Vildagliptin carboxy acid metabolite TFA
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Cytochrome P450
|
Metabolic Disease
|
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Vildagliptin carboxylic acid metabolite (M20.7) TFA is a potent P450 enzyme activity inhibitor .
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- HY-15980
-
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Parasite
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Infection
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GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.
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-
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- HY-120927A
-
|
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Opioid Receptor
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Neurological Disease
|
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Alvimopan metabolite hydrochloride is a peripherally restricted Opioid Receptor antagonist that inhibits the amplitude of electrically evoked contractions and spontaneous mechanical activity in guinea pig ileum .
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-
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- HY-W724091
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-
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- HY-126303
-
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GS-441524 triphosphate; Remdesivir metabolite
|
DNA/RNA Synthesis
SARS-CoV
RSV
HCV
Drug Metabolite
|
Infection
|
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GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir .
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- HY-103005
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-
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- HY-W709579
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-
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- HY-172029
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Monoamine Transporter
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Neurological Disease
|
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3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT), serotonin transporter (SERT), and the norepinephrine transporter (NET) .
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- HY-117659
-
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Prostaglandin D metabolite
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Prostaglandin Receptor
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Inflammation/Immunology
|
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PGDM (Prostaglandin D Metabolite) is the main urinary metabolite of Prostaglandin D2 and is prone to reversible cyclization. PGDM may serve as a biomarker for the endogenous production of PGD2 or be used to evaluate the severity of acute allergic reactions .
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- HY-W020576
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NAP 226-90
|
Cholinesterase (ChE)
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Neurological Disease
|
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Rivastigmine metabolite (NAP 226-90) is an acetylcholinesterase (AChE) inhibitor which is produced in kidney. Rivastigmine metabolite is promising for research of Alzheimer’s Disease .
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- HY-114553
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5F-PB-22 3-carboxyindole metabolite
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Cannabinoid Receptor
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Neurological Disease
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5-Fluoro PB-22 3-carboxyindole metabolite (5F-PB-22 3-carboxyindole metabolite) is a metabolite of 5-fluoro PB-22. 5-Fluoro PB-22 is a synthetic cannabinoid .
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- HY-103005S
-
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Melatonin Receptor
Drug Metabolite
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Neurological Disease
Endocrinology
|
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Ramelteon metabolite M-II-d3 is the deuterium labeled Ramelteon metabolite M-II. Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist[1][2].
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- HY-154754S
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- HY-154757S
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- HY-126534
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- HY-132504S
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- HY-116074
-
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Drug Metabolite
|
Others
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FUB-PB-22 3-carboxyindole metabolite is the main metabolite of FDU-PB-22 and FUB-PB-22 .
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- HY-108251S
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- HY-W756790
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- HY-151002S
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- HY-131471
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- HY-G0025
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(-)-β-Dihydrotetrabenazine; (-)-β-HTBZ
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Monoamine Transporter
Drug Metabolite
|
Neurological Disease
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Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM) . Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders .
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- HY-W714366
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- HY-12778R
-
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Drug Metabolite
|
Cardiovascular Disease
Endocrinology
Cancer
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Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride) (Standard) is the analytical standard of Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride). This product is intended for research and analytical applications. 0
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- HY-128669
-
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LSN2839567
|
CDK
Drug Metabolite
|
Cancer
|
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Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity .
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- HY-G0003
-
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P88; Hydroxy Iloperidone
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Drug Metabolite
|
Others
|
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Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is a metabolite of Iloperidone, which is an atypical antipsychotic.
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- HY-12770
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- HY-118790
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- HY-126303C
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GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium
|
DNA/RNA Synthesis
SARS-CoV
RSV
HCV
Drug Metabolite
|
Infection
|
|
GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734) .
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- HY-12772
-
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Itraconazole metabolite Hydroxy Itraconazole; R-63373
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Fungal
Drug Metabolite
|
Others
|
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Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
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- HY-G0018
-
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17-Deacetyl norgestimate; 17-Deacylnorgestimate
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Drug Metabolite
|
Endocrinology
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Norgestimate metabolite Norelgestromin (17-Deacetyl norgestimate) is a metabolite of Norgestimate (HY-W013172). Norgestimate metabolite Norelgestromin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-G0012
-
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- HY-172056
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- HY-143967S
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- HY-172055
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- HY-172054
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- HY-G0004
-
-
- HY-12798C
-
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AR-13324 M1 metabolite
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PKC
ROCK
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Cardiovascular Disease
|
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AR-13503 (AR-13324 M1 metabolite) is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research .
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- HY-129697
-
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3-OH Medetomidine; Medetomidine metabolite MIII
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Drug Metabolite
|
Metabolic Disease
|
|
3-Hydroxy Medetomidine (3-OH Medetomidine; Medetomidine metabolite MIII) is a metabolite of the α2-adrenergic receptor agonist medetomidine.
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- HY-G0010
-
-
- HY-157338
-
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ADC Linker
Kinesin
|
Cancer
|
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NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .
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- HY-12771
-
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Mebeverine metabolite O-desmethyl Mebeverine acid
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Drug Metabolite
|
Neurological Disease
|
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O-desmethyl Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
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- HY-12778
-
-
- HY-G0018R
-
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17-Deacetyl norgestimate(Standard); 17-Deacylnorgestimate (Standard)
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Drug Metabolite
|
Others
|
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Norgestimate metabolite Norelgestromin (Standard) is the analytical standard of Norgestimate metabolite Norelgestromin. This product is intended for research and analytical applications.
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-
- HY-165691S
-
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Isotope-Labeled Compounds
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Others
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Chlorothalonil Metabolite R611553- 13C2, 15N2 (sodium salt) is 13C and 15N labeled Chlorothalonil Metabolite R611553 (sodium salt) .
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- HY-137546
-
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Haloperidol metabolite II
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Drug Metabolite
|
|
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Reduced Haloperidol (Haloperidol metabolite II) is an antipsychotic compound with neurotransmitter modulating activity. Reduced Haloperidol is commonly used to inhibit schizophrenia and other psychotic disorders. Reduced Haloperidol helps reduce the occurrence of hallucinations and delusions by inhibiting the activity of dopamine receptors.
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- HY-G0005
-
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Para-Naphthol duloxetine
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Drug Metabolite
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Neurological Disease
|
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Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI).
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- HY-W753270S
-
-
- HY-126534S
-
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LSN3106729-d8
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CDK
Ligands for Target Protein for PROTAC
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Cancer
|
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Abemaciclib metabolite M18-d8 is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader[1][2].
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- HY-G0011
-
-
- HY-167948
-
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EGFR
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Cancer
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Dacomitinib metabolite M1/2 is a potent inhibitor of both wild-type (WT) EGFR and the T790M mutation, demonstrating significant activity against acquired resistance mechanisms in EGFR-mutant non-small-cell lung cancer (NSCLC).
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- HY-128669S
-
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LSN2839567-d6
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CDK
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Cancer
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Abemaciclib metabolite M2-d6 is the deuterium labeled Abemaciclib metabolite M2. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity[1][2].
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- HY-W728206S
-
-
- HY-12798E
-
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(R)-AR-13324 M1 metabolite
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PKC
ROCK
Drug Metabolite
|
Cardiovascular Disease
|
|
(R)-AR-13503 ((R)-AR-13324 M1 metabolite) is the the (R)-enantiomer of AR-13503 (HY-12798C). AR-13503 is the hydrolytic metabolite of AR-13324 mesylate. AR-13324 is a ROCK kinase and PKC inhibitor with anti-angiogenic and retinal health-improving effects, showing potential for use in retinal disease research .
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- HY-12767
-
-
- HY-G0017A
-
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Norimatinib mesylate; Imatinib metabolite N-Desmethyl imatinib mesylate
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Drug Metabolite
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Others
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|
N-Desmethyl imatinib mesylate (Norimatinib mesylate) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .
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- HY-G0017
-
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Norimatinib; Imatinib metabolite N-Desmethyl imatinib
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Drug Metabolite
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Others
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|
N-Desmethyl imatinib (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .
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- HY-W714168S
-
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Isotope-Labeled Compounds
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Others
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(rac)-Metolachlor metabolite CGA 351916-d3 is deuterium labeled 2-((2-Ethyl-6-methylphenyl)(1-methoxypropan-2-yl)amino)-2-oxoacetic acid .
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-
- HY-G0008
-
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Mebeverine metabolite O-desmethyl Mebeverine alcohol
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Adrenergic Receptor
Drug Metabolite
|
Metabolic Disease
|
|
O-Desmethyl Mebeverine alcohol is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
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-
- HY-G0008A
-
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Mebeverine metabolite O-desmethyl Mebeverine alcohol hydrochloride
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Adrenergic Receptor
Drug Metabolite
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Metabolic Disease
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O-Desmethyl Mebeverine alcohol hydrochloride is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
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- HY-123144
-
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Drug Metabolite
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Others
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N-Hydroxymethylsorafenib is a Sorafenib (HY-10201) metabolite, and can be used for research of metabolite of Sorafenib .
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-
- HY-N8491B
-
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Others
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Others
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(-)-Dihydrocarveol is a metabolite that can be extracted from actinomycetes .
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- HY-G0018S
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17-Deacetyl norgestimate-d6; 17-Deacylnorgestimate-d6
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Norgestimate metabolite norelgestromin-d6 is the deuterium labeled Norgestimate metabolite norelgestromin. Norelgestromin is a metabolite of Norgestimate, which is a progestin or synthetic progestogen. Norgestimate metabolite norelgestromin-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W020576S
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-
- HY-G0003S1
-
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P88-d3; Hydroxy Iloperidone-d3
|
Drug Metabolite
|
Others
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|
Iloperidone metabolite Hydroxy Iloperidone-d3 is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone[1].
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- HY-126194
-
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Ro 61-1448
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Drug Metabolite
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Others
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Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite and the glucuronide metabolite of Tolcapone (Ro 40-7592; HY-17406). Tolcapone 3-β-D-glucuronide is pharmacologically inactive .
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- HY-123215
-
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7-Hydroxy pomalidomide; Pomalidomide metabolite M16
|
Ligands for E3 Ligase
|
Cancer
|
|
CC-17369 (7-Hydroxy pomalidomide) is a metabolite of Pomalidomide. CC-17369 is the Pomalidomide -based cereblon (CRBN) ligand used in the recruitment of CRBN protein. CC-17369 can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-B0113S2
-
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Omeprazole sulfone (methoxy-d3); Omeprazole sulphone (methoxy-d3)
|
Isotope-Labeled Compounds
Drug Metabolite
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Infection
Cancer
|
|
Omeprazole metabolite Omeprazole sulfone (methoxy-d3) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
|
-
- HY-12767S1
-
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4-Hydroxyphenyl Carvedilol-d4; 4-Hydroxycarvedilol-d4
|
Isotope-Labeled Compounds
|
Cancer
|
|
Carvedilol metabolite 4-Hydroxyphenyl Carvedilol-d4 is deuterated labeled Carvedilol metabolite 4-Hydroxyphenyl Carvedilol (HY-12767). 4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol.
|
-
- HY-171238
-
-
- HY-135384
-
-
- HY-W717406
-
-
- HY-N12018
-
|
|
Others
|
Neurological Disease
|
|
Isomaltopaeoniflorin is a metabolite of the Chinese herbal formula Shuyu. Shuyu is a depression-like disease inhibitor .
|
-
- HY-165687
-
|
2-(Allophanoylsulfamoyl)-N,N-dimethyl-pyridine-3-carboxamide-d6
|
Isotope-Labeled Compounds
|
Others
|
|
Nicosulfuron metabolite UCSN-d6 (2-(Allophanoylsulfamoyl)-N,N-dimethyl-pyridine-3-carboxamide-d6) is deuterium labeled Nicosulfuron metabolite UCSN .
|
-
- HY-135384R
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
Flavone (Standard) is the analytical standard of Flavone. This product is intended for research and analytical applications. Flavone is an endogenous metabolite.
|
-
- HY-135385
-
-
- HY-100651
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Desmethylnortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .
|
-
- HY-124002
-
-
- HY-N7612
-
|
N-Norgalanthamine
|
Cholinesterase (ChE)
|
Others
|
|
N-Desmethyl Galanthamine is a metabolite of Galanthamine. Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM .
|
-
- HY-126061
-
-
- HY-113457
-
-
- HY-W045271
-
-
- HY-100646A
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
(Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .
|
-
- HY-100646
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
(E)-10-Hydroxynortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .
|
-
- HY-134234
-
|
|
COX
|
Others
|
|
Celecoxib carboxylic acid is a metabolite of celecoxib (HY-14398). Celecoxib is a selective COX-2 inhibitor with an IC50 of 40 nM .
|
-
- HY-133010
-
-
- HY-123198
-
-
- HY-164025
-
-
- HY-111238
-
-
- HY-137932
-
-
- HY-100635
-
-
- HY-157423
-
|
1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine
|
Liposome
|
Others
|
|
16:1 (DELTA 9-Cis) PC is a phospholipid metabolite
.
|
-
- HY-125639
-
|
(rac)-AR-13324 M1 metabolite
|
PKC
ROCK
|
Cardiovascular Disease
|
|
(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice .
|
-
- HY-135212
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound .
|
-
- HY-135389
-
|
|
Drug Metabolite
Antibiotic
|
Infection
|
|
Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .
|
-
- HY-N10215
-
-
- HY-N7686
-
-
- HY-123006
-
-
- HY-138166
-
-
- HY-165684
-
|
Methyl N-(carboxyacetyl)-N-(2,6-dimethylphenyl-d9)-DL-alaninate
|
Isotope-Labeled Compounds
|
Others
|
|
Benalaxyl metabolite M1-d9 (Methyl N-(carboxyacetyl)-N-(2,6-dimethylphenyl-d9)-DL-alaninate) is deuterium labeled Benalaxyl metabolite M1 .
|
-
- HY-148197
-
-
- HY-N7994
-
|
|
Others
|
Cancer
|
|
Hellebrigenol is a metabolite of bufadienolides with antitumor activity .
|
-
- HY-125523
-
-
- HY-N8258
-
-
- HY-114656
-
-
- HY-137532
-
-
- HY-169463
-
-
- HY-W004464
-
-
- HY-N2304
-
-
- HY-113270
-
|
γ-Butyrobetaine; Deoxycarnitine
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Actinine (γ-Butyrobetaine) is an amino acid betaine aminobutyric acid zwitterion. Actinine acts as both a human metabolite and a metabolite of E. coli .
|
-
- HY-134670
-
|
|
Drug Metabolite
|
Others
|
|
a-Hydroxymetoprolol is a metabolite of metoprolol. The adrenoreceptor blocking effect of a-Hydroxymetoprolol on metoprolol is almost zero .
|
-
- HY-137152
-
-
- HY-W739861
-
|
1'-Hydroxytriazolam
|
Endogenous Metabolite
|
Others
|
|
α-Hydroxytriazolam (1'-Hydroxytriazolam) is a major metabolite of ranitidine (HY-B0693) .
|
-
- HY-137851
-
|
|
Drug Metabolite
|
Others
|
|
S-Pyruvylglutathione is a serum metabolite and can be used as a potential marker for sensitivity of gastric cancer to neoadjuvant chemotherapy .
|
-
- HY-W662579
-
-
- HY-113316B
-
-
- HY-116757
-
-
- HY-30216A
-
-
- HY-N7278
-
|
|
Others
|
Others
|
|
Mudanpioside J, a monoterpene glycoside, is a metabolite of cortex moutan .
|
-
- HY-W088846
-
-
- HY-W712534
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
N-Acetyl lenalidomide is a metabolite of Lenalidomide (HY-A0003), which is formed by hydrolysis of Lenalidomide in plasma and urine .
|
-
- HY-133694
-
|
|
Drug Metabolite
|
Others
|
|
2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes .
|
-
- HY-145991
-
|
|
Drug Metabolite
|
Infection
|
|
Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity .
|
-
- HY-136344
-
|
|
Drug Metabolite
|
Others
|
|
Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM .
|
-
- HY-137963
-
-
- HY-129977
-
-
- HY-165686
-
|
N-(Carboxyacetyl)-N-(2,6-dimethylphenyl)-DL-alanine-13C3
|
Isotope-Labeled Compounds
|
Others
|
|
Benalaxyl metabolite M2- 13C3 (N-(Carboxyacetyl)-N-(2,6-dimethylphenyl)-DL-alanine- 13C3) is 13C labeled Benalaxyl metabolite M2 .
|
-
- HY-30216
-
-
- HY-G0017S
-
|
Norimatinib-d8; Imatinib metabolite N-Desmethyl imatinib-d8
|
Drug Metabolite
|
Cancer
|
|
N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
|
-
- HY-155792
-
|
|
Drug Metabolite
|
Others
|
|
Troglitazone glucuronide (Compound M2) is an initial metabolite of troglitazone in the liver .
|
-
- HY-125114
-
-
- HY-136345
-
|
|
Drug Metabolite
|
Others
|
|
(Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM .
|
-
- HY-100623
-
-
- HY-30215R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(S)-Leucic acid (Standard) is the analytical standard of (S)-Leucic acid. This product is intended for research and analytical applications. (S)-Leucic acid is an amino acid metabolite .
|
-
- HY-116029
-
-
- HY-N8268
-
|
3α,12α-Dihydroxynorcholanic acid
|
Others
|
Metabolic Disease
|
|
Nordeoxycholic acid is a 23-carbon bile acid. Nordeoxycholic acid is a norcholic acid metabolite and a steroid human metabolite .
|
-
- HY-N8210
-
|
|
Drug Metabolite
|
Others
|
|
Homoeriodictyol is a flavonoid metabolite of Eriocitrin in plasma and urine. Eriocitrin is a strong antioxidant agent .
|
-
- HY-W491891
-
-
- HY-138128
-
-
- HY-N12900
-
|
Tryptophandehydrobutyrine diketopiperazine
|
Others
|
Others
|
|
TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis .
|
-
- HY-148376
-
|
|
Drug Metabolite
|
Cancer
|
|
Abiraterone N-oxide is a metabolite of Abiraterone (HY-148377). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity .
|
-
- HY-U00050S
-
|
E-10-OH-NT-d3
|
Isotope-Labeled Compounds
Drug Metabolite
|
Neurological Disease
|
|
(E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
|
-
- HY-E70248
-
|
|
Endogenous Metabolite
|
Others
|
|
S-(3-Hydroxydodecanoate)-CoACoenzyme A, a Coenzyme A, is a metabolite that can be found or produced in E. coli (strain K12, MG1655) .
|
-
- HY-129591
-
|
PNU-97333
|
Others
|
Others
|
|
Paraherquamide A (PNU-97333) is a toxic metabolite that can be isolated from Penicillium paraherquei .
|
-
- HY-137020
-
-
- HY-43711
-
|
|
mAChR
|
Neurological Disease
|
|
Nor-benzetimide is a major metabolite of Benzetimide. Benzetimide is a mAChR antagonist with anticholinergic activity .
|
-
- HY-B0191C
-
-
- HY-P1703
-
-
- HY-N10236
-
-
- HY-17528
-
|
Cyhalofop acid
|
Drug Metabolite
|
Others
|
|
Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture .
|
-
- HY-135389R
-
|
|
Drug Metabolite
Antibiotic
|
Infection
|
|
Desmethyl Levofloxacin (Standard) is the analytical standard of Desmethyl Levofloxacin. This product is intended for research and analytical applications. Desmethyl Levofloxacin is a metabolite of Levofloxacin. Levofloxacin, a synthetic fluoroquinolone, is an antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication .
|
-
- HY-135212R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Hydroxy ipronidazole (Standard) is the analytical standard of Hydroxy ipronidazole. This product is intended for research and analytical applications. Hydroxy ipronidazole (Ipronidazole-OH) is a metabolite of nitroimidazole antibiotics, such as ipronidazole (IPZ). Hydroxy ipronidazole may has similar mutagenic potential as the parent compound .
|
-
- HY-N0343A
-
|
p-Formylphenyl-β-D-glucopyranoside; p-Hydroxybenzaldehyde glucoside
|
Others
|
Others
|
|
4-Formylpyrnyl-β-D-glucopyranoside (p-Formylphenyl-β-D-glucopyranoside) is a metabolite of Gastrodin (HY-N0115) in rat plasma. 4-Formylpyrnyl-β-D-glucopyranoside can be used to study the effects of multiple doses and food on the pharmacokinetic behavior of oral Gastrodin and its metabolites .
|
-
- HY-164093
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Isovaleryl-CoA is an intermediate metabolite in the catabolic pathway of leucine. Isovaleryl-CoA is the starting unit for some secondary metabolites and iso-odd fatty acids in several bacteria .
|
-
- HY-126915
-
-
- HY-109619
-
|
Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite
|
Androgen Receptor
Cytochrome P450
|
Cancer
|
|
D4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor.
|
-
- HY-N10186
-
-
- HY-N6711A
-
-
- HY-N8841
-
|
|
Others
|
Others
|
|
Daidzein-7-O-glucuronide (compound 3) is a main metabolite of daidzein. Daidzein-7-O-glucuronide has oral activity .
|
-
- HY-139199
-
|
|
Drug Metabolite
|
Others
|
|
4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS) .
|
-
- HY-126996
-
|
|
Drug Metabolite
Endogenous Metabolite
|
Metabolic Disease
|
|
Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity .
|
-
- HY-N12530
-
-
- HY-W509381
-
-
- HY-N10233
-
-
- HY-119329
-
|
Oxiranecarboxamide; 2,3-Epoxypropanamide
|
Drug Metabolite
|
Others
|
|
Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects .
|
-
- HY-W739521
-
|
|
mAChR
|
Others
|
|
N-Desethyloxybutynin hydrochloride is an active metabolite of Oxybutynin. N-Desethyloxybutynin hydrochloride binds to mAChRs in isolated? human bladder and human parotid gland with pKi values of 8.2 and 8.7, respectively .
|
-
- HY-W587691
-
-
- HY-113861
-
-
- HY-G0022
-
|
13-Dihydroadriamycin hydrochloride
|
Drug Metabolite
|
Cancer
|
|
Doxorubicinol hydrochloride (13-Dihydroadriamycin hydrochloride) is a secondary alcohol metabolite of Doxorubicin .
|
-
- HY-135580A
-
|
|
Drug Metabolite
|
Endocrinology
|
|
Raloxifene Bismethyl Ether hydrochloride is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent .
|
-
- HY-135580
-
|
|
Drug Metabolite
|
Endocrinology
|
|
Raloxifene Bismethyl Ether is a metabolite of Raloxifene and an estrogen receptor inactive compound on which both hydroxyl groups are absent .
|
-
- HY-137181
-
|
|
HSV
|
Infection
|
|
9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent .
|
-
- HY-113351
-
-
- HY-W011848
-
|
2-((Benzyloxy)carbonyl)benzoic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP) .
|
-
- HY-136347
-
-
- HY-138166R
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor) .
|
-
- HY-W587542
-
|
|
Serotonin Transporter
|
Others
|
|
(1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a metabolite of Sertraline. (1S,4S)-N-Desmethyl Sertraline (hydrochloride) is a selective serotonin uptake blocker with antidepressant properties .
|
-
- HY-N9713
-
|
|
Others
|
Others
|
|
Dihydroxyaflavinine (Compound Ⅲ) is an indole metabolite extracted from Aspergillus flavus .
|
-
- HY-W576312
-
-
- HY-125684
-
-
- HY-W714833
-
-
- HY-N8548
-
-
- HY-N10238
-
-
- HY-N14927
-
-
- HY-N7715
-
|
Ferulic acid glucoside
|
Drug Metabolite
|
Others
|
|
Ferulic acid acyl-β-D-glucoside is a metabolite of Ferulic Acid (HY-N0060) . Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively .
|
-
- HY-136428
-
|
|
Drug Metabolite
|
Cancer
|
|
Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound .
|
-
- HY-129903
-
|
|
Drug Metabolite
|
Others
|
|
N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine .
|
-
- HY-134670R
-
|
|
Drug Metabolite
|
Others
|
|
a-Hydroxymetoprolol (Standard) is the analytical standard of a-Hydroxymetoprolol. This product is intended for research and analytical applications. a-Hydroxymetoprolol is a metabolite of metoprolol. The adrenoreceptor blocking effect of a-Hydroxymetoprolol on metoprolol is almost zero .
|
-
- HY-132417S
-
-
- HY-N14928
-
-
- HY-N3264
-
-
- HY-N10980
-
|
|
Others
|
Others
|
|
Ethyl everninate is an atranol-like secondary metabolite that can be isolated from oakmoss .
|
-
- HY-155953
-
|
|
Drug Isomer
|
Cancer
|
|
6-epi-COTC is a diastereoisomer of Streptomyces metabolite with a anti-cancer activitie .
|
-
- HY-78542
-
-
- HY-138627
-
|
|
Drug Metabolite
EGFR
|
Cancer
|
|
AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity .
|
-
- HY-W740380
-
|
|
Drug Metabolite
|
Others
|
|
21-Carboxylic acid triamcinolone acetonide is a metabolite produced in the body after oral administration of [14C]-triamcinolone acetonide .
|
-
- HY-137393
-
-
- HY-N8552
-
-
- HY-U00050
-
|
E-10-OH-NT
|
Drug Metabolite
|
Neurological Disease
|
|
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A) . E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.
|
-
- HY-135387
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
4-Desmethyl Istradefylline is a metabolite of Istradefylline. 4-Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease .
|
-
- HY-41494
-
|
2-Methylbenzoic acid
|
Endogenous Metabolite
|
Others
|
|
O-toluic acid (2-Methylbenzoic acid) is an organic compound that is benzoic acid with a methyl group substituted at the 2-position. O-toluic acid can act as an exogenous metabolite and holds some chemical research value .
|
-
- HY-N14940
-
-
- HY-W016033
-
-
- HY-W001117
-
-
- HY-N14929
-
-
- HY-13936
-
|
1-Methylimidazole-4-acetic acid
|
Endogenous Metabolite
|
Others
|
|
1-Methylimidazoleacetic acid (1-Methylimidazole-4-acetic acid) is a histamine metabolite in urine that can be used in the study of mastocytosis .
|
-
- HY-P3282
-
|
|
Guanylate Cyclase
|
Metabolic Disease
|
|
MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C) .
|
-
- HY-W700643
-
-
- HY-Y1771
-
|
Phthalaldehydic acid
|
Drug Metabolite
|
Infection
|
|
2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain .
|
-
- HY-113118
-
|
5-Acetylamino-6-amino-3-methyluracil
|
Endogenous Metabolite
|
Others
|
|
AAMU (5-Acetylamino-6-amino-3-methyluracil) is the main metabolite of caffeine in the human body .
|
-
- HY-17528R
-
|
|
Drug Metabolite
|
Others
|
|
Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture .
|
-
- HY-125344
-
-
- HY-W746555S
-
|
Metazachlor OA-d9; Metazachlor oxalic acid-d9
|
Isotope-Labeled Compounds
|
Others
|
|
Metazachlor metabolite BH479-4-d9 (Metazachlor OA-d9) is deuterium labeled Metazachlor Oxalic Acid .
|
-
- HY-148507
-
|
|
MEK
|
Cancer
|
|
GSK1790627 is the N-deacetylated metabolite of Trametinib (HY-10999). Trametinib is an orally active MEK inhibitor, and activates autophagy and induces apoptosis .
|
-
- HY-107494
-
|
4-Keto 13-cis-retinoic acid; 4-Oxoisotretinoin; Ro 22-6595
|
Endogenous Metabolite
|
Others
|
|
13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .
|
-
- HY-N12145
-
|
Ao58A; NSC 66645
|
Bacterial
|
Infection
Cancer
|
|
Streptimidone (Ao58A) is a bacterial metabolite found in Streptomyces. Streptimidone has antitumor activity .
|
-
- HY-145000
-
|
|
Drug Metabolite
|
Endocrinology
|
|
N-Desalkyludenafil is a metabolite of Udenafil. Udenafil is a PDE5 inhibitor used for the research of the erectile dysfunction .
|
-
- HY-W012874
-
-
- HY-12388
-
|
Desmethylclomipramine; Norclomipramine
|
Drug Metabolite
|
Neurological Disease
|
|
Desmethylclomipramine (Norclomipramine) is a metabolite of Clomipramine (HY-B0457A) and can be used for neurological research .
|
-
- HY-135956
-
-
- HY-N9474
-
|
5-Diphosphomevalonic acid tetralithium; Mevalonic acid 5-diphosphate tetralithium
|
Endogenous Metabolite
|
Others
|
|
Mevalonic acid 5-pyrophosphate (5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite of the mevalonate pathway .
|
-
- HY-105713
-
|
|
Bacterial
|
Infection
|
|
Sulochrin is a metabolite produced by Aspergillus terreus var. aureus. I. Sulochrin has antimicrobial activities .
|
-
- HY-N12877
-
|
|
Bacterial
|
Infection
|
|
Ophiobolin H is a fungal metabolite that can be isolated from Aspergillus ustus. Ophiobolin H inhibits growth of Bacillus subtilis cultures. Ophiobolin H induces hyperacusia in day-old chicks at rates up to 375 mg/kg .
|
-
- HY-118427
-
|
|
Parasite
Endogenous Metabolite
|
Infection
Cancer
|
|
Asterriquinol D dimethyl ether is a fungal metabolite, which can inhibit mouse myeloma NS-1 cell lines with an IC50 of 28 μg/mL. Asterriquinol D dimethyl ether also inhibits Tritrichomonas foetus .
|
-
- HY-145991R
-
|
|
Drug Metabolite
|
Infection
|
|
Ribavirin carboxylic acid (Standard) is the analytical standard of Ribavirin carboxylic acid. This product is intended for research and analytical applications. Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity .
|
-
- HY-116246
-
-
- HY-N8853
-
|
|
Others
|
Others
|
|
Victoxinine is a metabolite of Bipolaris sp. Victoxinine has minor phytotoxic .
|
-
- HY-N1099
-
|
(+)-Vellosimine; Alkaloid RB 19
|
Others
|
Others
|
|
Vellosimine ((+)-Vellosimine) is an indole alkaloid. Vellosimine acts as a plant metabolite .
|
-
- HY-W337335
-
|
1-P-GPA sodium salt
|
Endogenous Metabolite
|
Metabolic Disease
|
|
1-Palmitoyl-sn-glycerol 3-phosphate (sodium salt) (1-P-GPA (sodium salt)) is an endogenous metabolite. 1-Palmitoyl-sn-glycerol 3-phosphate (sodium salt) can be used in the study of non-alcoholic fatty liver disease .
|
-
- HY-130529
-
|
OH-α-Pyrrolidinovalerophenone TFA
|
Endogenous Metabolite
|
Metabolic Disease
|
|
OH-α-PVP (OH-α-Pyrrolidinovalerophenone ) TFA is a metabolite of α-pyrrolidinovalerophenone. α-pyrrolidinovalerophenone is a synthetic stimulant of the cathinone class .
|
-
- HY-100664
-
-
- HY-70002BS
-
-
- HY-130189
-
|
|
Drug Metabolite
|
Others
|
|
S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay .
|
-
- HY-126370
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Geranylgeranyl pyrophosphate is a metabolite involved in protein geranylgeranylation. Geranylgeranyl pyrophosphate is the common precursor of diterpenoids, for example, Paclitaxel. Geranylgeranyl pyrophosphate can be used for cancer research .
|
-
- HY-30216AR
-
|
|
Endogenous Metabolite
|
Others
|
|
Leucic acid (Standard) is the analytical standard of Leucic acid. This product is intended for research and analytical applications. Leucic acid is an amino acid metabolite .
|
-
- HY-134137
-
-
- HY-W004464R
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
2-(1-Piperazinyl)pyrimidine (Standard) is the analytical standard of 2-(1-Piperazinyl)pyrimidine. This product is intended for research and analytical applications. 2-(1-Piperazinyl)pyrimidine is the major metabolite of Tandospirone (HY-14558) .
|
-
- HY-133694R
-
|
|
Drug Metabolite
|
Others
|
|
2-Aminoflubendazole (Standard) is the analytical standard of 2-Aminoflubendazole. This product is intended for research and analytical applications. 2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes .
|
-
- HY-158623
-
-
- HY-129410
-
|
|
Endogenous Metabolite
|
Others
|
|
ADR-925 is an active chelated iron metabolite with the ability to protect neonatal rat cardiomyocytes from doxorubicin (HY-15142A)-induced damage .
|
-
- HY-100652A
-
|
|
Factor Xa
|
Cardiovascular Disease
|
|
O-Desmethyl apixaban sulfate sodium is a major circulating metabolite of Apixaban in humans. O-Desmethyl apixaban sulfate sodium inhibits factor X (FXa) with a Ki of 58 μM .
|
-
- HY-157586
-
|
Lysophosphatidylethanolamine C18:2; LysoPE(0:0/18:2)
|
Endogenous Metabolite
|
Others
|
|
2-Linoleoyl-sn-glycero-3-phosphoethanolamine (Lysophosphatidylethanolamine C18:2) is a kind of lipid metabolite, that can be used as biomarkers .
|
-
- HY-124551
-
-
- HY-N2317
-
-
- HY-N10234
-
|
|
Acyltransferase
|
Infection
|
|
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 0.8 μM .
|
-
- HY-129987
-
-
- HY-100243A
-
|
(±)-Norcisapride; rel-Ticalopride
|
Drug Metabolite
|
Neurological Disease
|
|
Norcisapride is a metabolite of cisapride (HY-14149). Norcisapride can be converted into UNK under CYP3A4 .
|
-
- HY-N12529
-
-
- HY-41494R
-
|
|
Endogenous Metabolite
|
Others
|
|
o-Toluic acid (Standard) is the analytical standard of o-Toluic acid. This product is intended for research and analytical applications. o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
|
-
- HY-122474
-
|
|
Drug Derivative
|
Cancer
|
|
Acetylaranotin is a metabolite produced by the fungus Arachniotus aureus, exhibiting antitumor activity. Acetylaranotin is utilized in research within the field of oncology for its potential in anti-cancer applications .
|
-
- HY-116026
-
-
- HY-164092
-
-
- HY-157690
-
-
- HY-W050000
-
-
- HY-N15406
-
-
- HY-126370A
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Geranylgeranyl pyrophosphate triammonium is a metabolite involved in protein geranylgeranylation. Geranylgeranyl pyrophosphate triammonium is the common precursor of diterpenoids, for example, Paclitaxel. Geranylgeranyl pyrophosphate triammonium can be used for cancer research .
|
-
- HY-116462
-
|
|
Drug Metabolite
|
Others
|
|
ONO-EI-601 is the major metabolite of human neutrophil elastase inhibitor ONO-5046. ONO-5046 has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19 .
|
-
- HY-109591
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Oleoyl coenzyme A (Oleoyl-CoA) is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A has a role as an Escherichia coli metabolite and a mouse metabolite .
|
-
- HY-N11224
-
-
- HY-W052051
-
|
N-Acetylbenzylamine
|
Endogenous Metabolite
|
Others
|
|
N-Benzylacetamide (N-Acetylbenzylamine), as an endogenous metabolite, is the major component of the plasma metabolic profile of Benznidazole (HY-B1548) .
|
-
- HY-W834359
-
-
- HY-148846
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Mosapride N-Oxide is a major active metabolite of Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
|
-
- HY-133813A
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action .
|
-
- HY-135400
-
|
|
FXR
|
Inflammation/Immunology
|
|
Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist .
|
-
- HY-N2713
-
|
|
Others
|
Others
|
|
10-Carboxylinalool is a metabolite compound isolated from the genus Pseudomonasin in a mineral salt medium .
|
-
- HY-100659
-
|
PCI-45227
|
Btk
|
Cancer
|
|
Dihydrodiol-Ibrutinib (PCI-45227) is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .
|
-
- HY-139199R
-
|
|
Drug Metabolite
|
Others
|
|
4-Hydroxyphenylbutazone (Standard) is the analytical standard of 4-Hydroxyphenylbutazone. This product is intended for research and analytical applications. 4-Hydroxyphenylbutazone is a metabolite of Phenylbutazone. Phenylbutazone, a nonsteroidal anti-inflammatory agent (NSAID), is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS) .
|
-
- HY-100655
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01) . Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively .
|
-
- HY-120956
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Methyl stearidonate is a secondary metabolite that can be isolated from Padina tenuis. Methyl stearidonate can be used for the research of type 2 diabetic .
|
-
- HY-100622
-
|
|
Bacterial
|
Infection
|
|
Ro 20-0657/000 is a metabolite of Trimethoprim. Trimethoprim is a dihydrofolate reductase inhibitor, used as an antibacterial agent in human and veterinary medicine .
|
-
- HY-130441
-
-
- HY-136327
-
|
|
DNA Alkylator/Crosslinker
|
Cancer
|
|
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity .
|
-
- HY-109591A
-
|
Oleoyl-CoA lithium
|
Biochemical Assay Reagents
|
Others
|
|
Oleoyl coenzyme A (Oleoyl-CoA) lithium is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A lithium has a role as an Escherichia coli metabolite and a mouse metabolite .
|
-
- HY-121184
-
-
- HY-N10270
-
-
- HY-17026E
-
|
dFdCTP trisodium
|
Endogenous Metabolite
|
Cancer
|
|
Gemcitabine triphosphate (trisodium) is one of the two nucleoside metabolites of Gemcitabine (HY-17026) in cells. The other is active diphosphate (dFdDTP). Gemcitabine triphosphate can be used as a standard in radio-labeled probe imaging studies, to identify tumors sensitive to Gemcitabine, and to evaluate Gemcitabine uptake and retention by cells .
|
-
- HY-129974
-
-
- HY-130353
-
|
N-desethylamiodarone hydrochloride; LB 33020 hydrochloride
|
Potassium Channel
Autophagy
|
Cardiovascular Disease
|
|
Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM .
|
-
- HY-137989A
-
|
Voriconazole oxynitride hydrochloride
|
Drug Metabolite
|
Infection
|
|
Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .
|
-
- HY-136428R
-
|
|
Drug Metabolite
Antibiotic
|
Cancer
|
|
Desoxycarbadox (Standard) is the analytical standard of Desoxycarbadox. This product is intended for research and analytical applications. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound .
|
-
- HY-129973
-
|
NSC-12971; 4-Chlorophenylurea
|
Factor Xa
|
Others
|
|
4-Chlorophenylurea is metabolite of diflubenzuron (HY-B1973). 4-Chlorophenylurea can be used to form factor Xa inhibitors .
|
-
- HY-133668
-
|
|
Drug Metabolite
|
Cancer
|
|
Monoethyl phthalate is a metabolite of diethyl phthalate. Monoethyl phthalate acts as a urinary biomarker of phthalates exposure indicating the risks of thyroid cancer and benign nodule .
|
-
- HY-E70272
-
-
- HY-N7061
-
|
|
Others
|
Neurological Disease
|
|
Tropine is a secondary metabolite of Solanaceae plants, is an anticholinergic agent . Tropine is a common intermediate in the synthesis of a variety of bioactive alkaloids, including hyoscyamine and scopolamine .
|
-
- HY-118166
-
|
NSC 329491; 1,3,7-Trihydroxyxanthone
|
5-HT Receptor
|
Neurological Disease
|
|
Gentisein (NSC 329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM .
|
-
- HY-136608
-
|
|
nAChR
|
Neurological Disease
|
|
5-AAM-2-CP is a major metabolite of Acetamiprid. Acetamiprid is a neonicotinoid insecticide used worldwide and is a nAChR agonist .
|
-
- HY-136609
-
|
|
nAChR
|
Neurological Disease
|
|
5-AMAM-2-CP is a major metabolite of Acetamiprid. Acetamiprid is a neonicotinoid insecticide used worldwide and is a nAChR agonist .
|
-
- HY-W749636
-
-
- HY-W265757
-
|
|
DNA/RNA Synthesis
|
Cancer
|
|
4-Ethylcatechol is a ring-dihydroxylated metabolite of 4-Ethylphenol that leads to oxidative DNA damage .
|
-
- HY-N8879
-
|
(-)-Wilforol A
|
Others
|
Metabolic Disease
|
|
Wilforol A ((-)-Wilforol A), plant metabolite, is a pentacyclic triterpenoid. Wilforol A can be used for the research of various biochemical studies .
|
-
- HY-125706
-
-
- HY-N10220
-
-
- HY-N12194
-
|
|
Others
|
Infection
|
|
Cytochalasin O (compound 13) is a secondary metabolite of the phytopathogenic fungus P. sp. CIB-109 .
|
-
- HY-W011848R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Monobenzyl phthalate (Standard) is the analytical standard of Monobenzyl phthalate. This product is intended for research and analytical applications. Monobenzyl phthalate (2-((Benzyloxy)carbonyl)benzoic acid) is the urinary metabolite exposuring to phthalates, such as, diethylhexyl phthalate (DEHP) .
|
-
- HY-135588
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Raloxifene 6,4'-Bis-β-D-glucuronide (compound IV) is a metabolite of Raloxifene. Raloxifene is a selective estrogen receptor antagonist for the prevention of osteoporosis .
|
-
- HY-Z8537
-
-
- HY-124353
-
|
11-Dehydro-TXB3
|
Endogenous Metabolite
|
Others
|
|
11-Dehydro thromboxane B3 (11-Dehydro-TXB3) is a urinary metabolite of Thromboxane A3 (TXA3) .
|
-
- HY-W715341
-
|
|
Cholinesterase (ChE)
|
Others
|
|
RO-1-5237 is a metabolite of Pyridostigmine Bromide, which is a cholinergic and can be used for myasthenia gravis research .
|
-
- HY-N0873A
-
|
|
Drug Metabolite
|
Others
|
|
Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma .
|
-
- HY-139114
-
|
|
PPAR
|
Metabolic Disease
|
|
20-Carboxyarachidonic acid, a relatively stable metabolite of 20-HETE, is an endogenous dual activator of PPARalpha and PPARgamma .
|
-
- HY-W008216
-
|
Hydroxy Dimetridazole
|
Drug Metabolite
|
Others
|
|
HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections .
|
-
- HY-N10299
-
-
- HY-136767
-
|
|
Fungal
Antibiotic
|
Infection
|
|
Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin completely inhibits growth of severa dermatophytes on agar medium at a concentration of 75 μg/mL .
|
-
- HY-W290839
-
|
Sulfamethazine-n4-acetyl
|
Endogenous Metabolite
|
Others
|
|
N4-Acetylsulfamethazine is a metabolite of Sulfamethazine (HY-B0035). Sulfamethazine is one of the most frequently used sulfonamides in the poultry farming industry .
|
-
- HY-138538
-
|
|
Antibiotic
|
Others
|
|
2-Nitrobenzaldehyde Semicarbazone is a derivative of Semicarbazide. 2-Nitrobenzaldehyde Semicarbazone can be measured as a metabolite marker to detect the widely banned antibiotic Nitrofurazone .
|
-
- HY-136346
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
|
-
- HY-W013266
-
|
Acetylsulfamethoxazole
|
Bacterial
|
Infection
Metabolic Disease
|
|
N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections .
|
-
- HY-137310
-
|
|
HMG-CoA Reductase (HMGCR)
Drug Metabolite
|
Metabolic Disease
|
|
4-Hydroxy atorvastatin hemicalcium is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin .
|
-
- HY-125505
-
|
|
Factor Xa
|
Cardiovascular Disease
|
|
BI-11634 is a factor Xa inhibitor. BI-11634 is metabolized by CYP3A4 to form one major metabolite and this reaction is inhibited by Quinidine (HY-B1751H) with a Ki of 7 µM .
|
-
- HY-B1984
-
|
4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane
|
Drug Metabolite
|
Others
|
|
p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT .
|
-
- HY-N8406
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
|
-
- HY-W008097
-
-
- HY-121133
-
|
|
Endogenous Metabolite
|
Others
|
|
(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .
|
-
- HY-113114
-
|
|
Endogenous Metabolite
|
Others
|
|
Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase .
|
-
- HY-N13295
-
|
Ethyl α-(β-D-glucopyranosyloxy)-1H-indole-3-propanoate
|
Endogenous Metabolite
|
Others
|
|
Indole-3-lactate-O-β-D-glucopyranoside is an endogenous metabolite that acts as a plant growth regulator .
|
-
- HY-W005178
-
|
|
Endogenous Metabolite
|
Others
|
|
Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome .
|
-
- HY-W725077S
-
|
Methyl N-(2,6-dimethylphenyl)-N-(formyl)-DL-alaninate-d9
|
Isotope-Labeled Compounds
|
Others
|
|
Benalaxyl metabolite F4-d9 (Methyl N-(2,6-dimethylphenyl)-N-(formyl)-DL-alaninate-d9) is deuterium labeled Methyl N-(2,6-dimethylphenyl)-N-formylalaninate .
|
-
- HY-137117
-
|
15-keto Prostaglandin E1
|
Drug Metabolite
|
Others
|
|
15-keto-PGE1 is an inactive Prostaglandin E1 (PGE1) metabolite. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation .
|
-
- HY-123305
-
|
|
Parasite
|
Others
|
|
5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic agents and are widely used for prevention and treatment of parasitic infections in food-producing animals .
|
-
- HY-142122
-
-
- HY-125411
-
|
|
Endogenous Metabolite
|
Others
|
|
Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis .
|
-
- HY-137339
-
|
|
Drug Metabolite
|
Others
|
|
Amitriptyline N-β-D-glucuronide is an ammonium glucuronide and an urinary excretion metabolite of amitriptyline .
|
-
- HY-124320
-
-
- HY-W016203
-
|
Sodium phenylpyruvate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Phenylpyruvic acid sodium is a endogenous metabolite that participates in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase .
|
-
- HY-137396
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
6β-Hydroxy Eplerenone is a metabolite of Eplerenone (HY-B0251). 6β-Hydroxy Eplerenone plays an important role in the research of hypertension, atherosclerosis, chronic systolic heart failure (HF) and cardiovascular (CV) .
|
-
- HY-129903R
-
|
|
Drug Metabolite
|
Others
|
|
N-Desethyl vardenafil (Standard) is the analytical standard of N-Desethyl vardenafil. This product is intended for research and analytical applications. N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine .
|
-
- HY-W269700S
-
|
L-Isoleucyl-L-leucine-13C6,15N
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Ile-(Leu-13C6,15N)-OH (TFA) is 13C- and 15N-labeled L-Isoleucyl-L-leucine (HY-W269700). L-Isoleucyl-L-leucine has a role as a metabolite and can be used to inhibit movement-induced muscle damage and muscle defective condition.
|
-
- HY-161125
-
|
|
Drug Metabolite
|
Others
|
|
(+)-JQ1-OH is the major metabolite of (+)-JQ1(HY-13030). (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy .
|
-
- HY-113442
-
-
- HY-141749A
-
-
- HY-W145584
-
-
- HY-N10293
-
|
|
Fungal
Endogenous Metabolite
|
Infection
|
|
Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM .
|
-
- HY-W013378
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect. Carbamazepine can be used for the research of seizures .
|
-
- HY-131252
-
|
Dihydro E2020
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively .
|
-
- HY-G0017S1
-
|
Norimatinib-d4; Imatinib metabolite N-Desmethyl imatinib-d4
|
Isotope-Labeled Compounds
|
Others
|
|
N-Desmethyl imatinib-d4 is the deuterium-labeled N-Desmethyl imatinib (HY-G0017). N-Desmethyl imatinib-d4 (Norimatinib) is a metabolite of Imatinib (HY-15463). Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR .
|
-
- HY-113405
-
-
- HY-100046
-
|
Desmethyldoxepin hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
|
Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .
|
-
- HY-126373
-
|
SN-38G
|
Drug Metabolite
|
Cancer
|
|
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
|
-
- HY-113083
-
|
APAP-glu
|
Drug Metabolite
Endogenous Metabolite
|
Others
|
|
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
|
-
- HY-Y1771R
-
|
|
Drug Metabolite
|
Infection
|
|
2-Carboxybenzaldehyde (Standard) is the analytical standard of 2-Carboxybenzaldehyde. This product is intended for research and analytical applications. 2-Carboxybenzaldehyde is the major metabolite found in phenanthrene metabolism. Phenanthrene can be degrade by Pseudomonas sp. Lphe-2 strain .
|
-
- HY-130189R
-
|
|
Drug Metabolite
|
Others
|
|
S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay .
|
-
- HY-138107
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Arimistane is a metabolite of 7-oxo-DHEA and can be used as a diagnostic marker of 7-oxo-DHEA administration .Arimistane is a metabolite of 7-oxo-DHEA and can be used as a diagnostic marker of 7-oxo-DHEA administration .
|
-
- HY-113371
-
|
Methylcitric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .
|
-
- HY-125934
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite .
|
-
- HY-B1417
-
|
Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
|
Autophagy
Drug Metabolite
Apoptosis
|
Neurological Disease
Cancer
|
|
Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects .
|
-
- HY-134611
-
|
β-hydroxyethoxyacetic acid; HEAA
|
Drug Metabolite
|
Others
|
|
(2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the main urinary metabolite of 1,4-Dioxane. (2-Hydroxyethoxy)acetic acid is a reliable and sensitive shortterm biomarker in urine .
|
-
- HY-I0508
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers .
|
-
- HY-113622
-
|
Palmarumycin C13; Diepoxin ζ; Antibiotic Sch53514
|
Fungal
Antibiotic
|
Infection
|
|
Cladospirone bisepoxide is a metabolite that isolated from cultures of a fungus. Cladospirone bisepoxide displays selective antibiotic activity against several bacteria and fungi and inhibits germinations of Lepidium sativum at low concentrations .
|
-
- HY-136347R
-
|
|
HMG-CoA Reductase (HMGCR)
Drug Metabolite
|
Cardiovascular Disease
|
|
3α-Hydroxy pravastatin (sodium) (Standard) is the analytical standard of 3α-Hydroxy pravastatin (sodium). This product is intended for research and analytical applications. 3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor .
|
-
- HY-100659S
-
|
PCI-45227-d5
|
Btk
Isotope-Labeled Compounds
|
Cancer
|
|
Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .
|
-
- HY-131479
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry .
|
-
- HY-A0178A
-
-
- HY-B1342A
-
-
- HY-W585876
-
|
|
FXR
|
Metabolic Disease
|
|
Chenodeoxycholic acid 3-glucuronide is a metabolite of Chenodeoxycholic acid that can activate the key nuclear receptor (FXR), with an EC50 of 8 μM, and in HEK293T cells, the EC50 for activating FXR is 11 μM .
|
-
- HY-118620
-
|
Desmethylamitriptyline; Desitriptilina
|
Autophagy
Drug Metabolite
Apoptosis
|
Neurological Disease
Cancer
|
|
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects .
N
|
-
- HY-113437
-
-
- HY-123305S
-
-
- HY-135500
-
|
|
Endothelin Receptor
|
Endocrinology
|
|
ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist .
|
-
- HY-N1563
-
|
4,5-epi-Cryptomeridiol
|
Others
|
Others
|
|
Pterodondiol is a gandular trichome metabolite on the leaves of Laggera pterodonta .
|
-
- HY-B2124
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy .
|
-
- HY-N8846
-
|
|
Fungal
|
Infection
|
|
dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
|
-
- HY-136303
-
|
|
Drug Metabolite
|
Infection
|
|
GS-704277 is an alanine metabolite of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro .
|
-
- HY-12388A
-
|
Desmethylclomipramine hydrochloride; Norclomipramine hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
|
N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant .
|
-
- HY-P2643
-
-
- HY-150012
-
-
- HY-32349S
-
-
- HY-W014180
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
N-Acetyl-L-histidine monohydrate, a histidine derivative, is a prominent biomolecule in brain, retina and lens of poikilothermic vertebrates. N-Acetyl-L-histidine monohydrate has a role as an animal metabolite .
|
-
- HY-153695
-
|
|
Drug Metabolite
Bacterial
|
Infection
|
|
TXA707, the active metabolite of TXA-709, is an FtsZ inhibitor with antibacterial activity. TXA707 is promising for research of S. aureus infections .
|
-
- HY-103005R
-
|
|
Melatonin Receptor
Drug Metabolite
|
Neurological Disease
Endocrinology
|
|
Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .
|
-
- HY-G0003R
-
|
|
Drug Metabolite
|
Others
|
|
Diamfenetide (Standard) is the analytical standard of Diamfenetide. This product is intended for research and analytical applications. Diamfenetide is used for the study of Fasciola hepatica infections in vitro.?Diamfenetide?leads to irreversible paralysis in vitro of immature and adult Fasciola hepatica .
|
-
- HY-G0023R
-
|
|
Drug Metabolite
|
Others
|
|
Berberine (hemisulfate) (Standard) is the analytical standard of Berberine (hemisulfate). This product is intended for research and analytical applications. Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .
|
-
- HY-128669R
-
-
- HY-133111
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM .
|
-
- HY-135335
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes .
|
-
- HY-135407S
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Neurological Disease
|
|
N-Desethyl Oxybutynin-d5 (hydrochloride) is deuterium labeled N-Desethyl Oxybutynin hydrochloride. N-Desethyl Oxybutynin is the the active metabolite Oxybutynin. Oxybutynin is an anticholinergic agent that inhibits voltage-dependent K+ channels[1].
|
-
- HY-117129
-
|
MK-0436
|
Parasite
|
Infection
|
|
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America .
|
-
- HY-W401407
-
|
|
Drug Metabolite
Cytochrome P450
|
Metabolic Disease
|
|
Diosmetin-3-O-glucuronide is a major circulating metabolite of Diosmetin (HY-N0125) in plasma and in urine. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity .
|
-
- HY-113113
-
|
13,14-Dihydroprostaglandin E1
|
Endogenous Metabolite
|
Metabolic Disease
|
|
13,14-Dihydro PGE1 is a metabolite of PGE1 (Prostaglandin E1) which inhibits the ADP-induced platelet aggregation (ID50 = 10.8 ng/mL platelet rich plasma) .
|
-
- HY-113943A
-
|
(±)9-HETE
|
Endogenous Metabolite
|
Others
|
|
9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
|
-
- HY-N8396
-
-
- HY-125060
-
-
- HY-A0178
-
-
- HY-131607
-
|
CBV-TP; (-)-Carbovir triphosphate; (-)-Carbovir 5′-triphosphate
|
HIV
|
Infection
Inflammation/Immunology
|
|
Carbovir triphosphate (CBV-TP) is a phosphorylated metabolite. Carbovir triphosphate can be used for the research of human immunodeficiency virus (HIV) .
|
-
- HY-137658A
-
|
PTP tetrasodium
|
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
CaMK
|
Metabolic Disease
|
|
Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM .
|
-
- HY-126603
-
|
|
Endogenous Metabolite
|
Infection
|
|
Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .
|
-
- HY-138627A
-
|
|
EGFR
Drug Metabolite
|
Cancer
|
|
AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor .
|
-
- HY-113215
-
|
5a-Tetrahydrocortisol
|
Endogenous Metabolite
|
Others
|
|
Allotetrahydrocortisol (5a-Tetrahydrocortisol) is a metabolite of Cortisol. Cortisol is the main glucocorticoid in human. It is produced in adrenal cortex and plays a crucial role in many physiological processes .
|
-
- HY-N10292
-
|
|
Fungal
Endogenous Metabolite
|
Infection
|
|
Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM .
|
-
- HY-W012982
-
|
AOZ
|
Drug Metabolite
|
Metabolic Disease
|
|
3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo .
|
-
- HY-137200
-
|
|
Drug Metabolite
|
Cancer
|
|
N-Desmethyl Bendamustine is a metabolite of Bendamustine (HY-13567). N-Desmethyl Bendamustine has cytotoxic effect in several lymphoma cell lines and peripheral blood lymphocytes .
|
-
- HY-W008216S
-
|
Hydroxy Dimetridazole-d3
|
Drug Metabolite
Isotope-Labeled Compounds
|
Infection
|
|
HMMNI-d3 is deuterium labeled HMMNI. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class agent that combats protozoan infections[1].
|
-
- HY-120109
-
|
|
Endogenous Metabolite
|
Cancer
|
|
13-HODE methyl ester, a racemic mixture of 13(R)-HODE methyl ester and 13(S)-HODE methyl ester, is a 15-lipoxygenase metabolite of Linoleic acid .
|
-
- HY-N10288
-
-
- HY-125643
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes .
|
-
- HY-135154
-
|
|
GABA Receptor
|
Neurological Disease
|
|
epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent .
|
-
- HY-117605
-
|
Desmethylsildenafil; UK-103,320
|
Phosphodiesterase (PDE)
|
Cardiovascular Disease
|
|
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .
|
-
- HY-113005
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glutarylcarnitine is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes.
|
-
- HY-136438
-
-
- HY-165114
-
|
|
Endogenous Metabolite
|
Cancer
|
|
6-Hydroxyramulosin is a fungal metabolite with antiancer effects. 6-Hydroxyramulosin shows cytotoxic effects against A549 and T24, showing IC50 values of 14.2 µg/mL and 15.3 µg/mL, respectively .
|
-
- HY-N7061R
-
|
|
Others
|
Neurological Disease
|
|
Tropine (Standard) is the analytical standard of Tropine. This product is intended for research and analytical applications. Tropine is a secondary metabolite of Solanaceae plants, is an anticholinergic agent . Tropine is a common intermediate in the synthesis of a variety of bioactive alkaloids, including hyoscyamine and scopolamine .
|
-
- HY-125296
-
|
|
GABA Receptor
|
Neurological Disease
|
|
Fipronil sulfone is the major metabolite of Fipronil.Fipronil sulfone selectively inhibits GABA receptor with IC50 of 175 nM (assayed by displacement of 4′-ethynyl-4-n-[2,3-3H2]- propylbicycloorthobenzoate ([3H]EBOB) from the noncompetitive blocker site).
|
-
- HY-100655R
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
O-Desmethyl apixaban (Standard) is the analytical standard of O-Desmethyl apixaban. This product is intended for research and analytical applications. O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01) . Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively .
|
-
- HY-N8349
-
|
|
Parasite
Endogenous Metabolite
|
Infection
Cancer
|
|
19,20-Epoxycytochalasin D, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin D shows potent in vitro antiplasmodial activity and phytotoxicity .
|
-
- HY-N8385
-
|
|
Parasite
Endogenous Metabolite
|
Infection
Cancer
|
|
19,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity .
|
-
- HY-136440
-
|
Metronidazole-OH
|
Bacterial
Parasite
|
Infection
|
|
Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle .
|
-
- HY-W011245
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion .
|
-
- HY-100665
-
|
OPC-14857; DM-14857
|
5-HT Receptor
|
Neurological Disease
|
|
Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole .
|
-
- HY-122191
-
|
|
Others
|
Infection
|
|
AK-Toxin II is a phytotoxic metabolite that can be isolated from culture broth of alternaria alternata Japanese pear pathotype. AK-Toxin II induces characteristic veinal necrosis and rapid K + loss on susceptible pear leaves .
|
-
- HY-113575
-
|
OPC-14857 hydrochloride; DM-14857 hydrochloride
|
5-HT Receptor
|
Neurological Disease
|
|
Dehydroaripiprazole (OPC-14857) hydrochloride is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole hydrochloride. Dehydroaripiprazole hydrochloride has with antipsychotic activity equivalent to Aripiprazole .
|
-
- HY-141465
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyryl-CoA is a metabolite which can be found in mouse or E.coli, et al. 3-Hydroxybutyryl-CoA has a 3-hydroxybutanoyl as the S-acyl component, and is an intermediate in the fermentation of butyric acid, and in the metabolism of lysine and tryptophan .
|
-
- HY-108226
-
|
N-Desmethyl regorafenib N-oxide
|
Drug Metabolite
Raf
VEGFR
c-Kit
|
Cancer
|
|
Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .
|
-
- HY-113157
-
|
|
Drug Metabolite
Endogenous Metabolite
|
Others
|
|
Estrone 3-glucuronide is deuterium labeled Estrone 3-glucuronide. Estrone 3-glucuronide, the dominant metabolite of estradiol, is determined to be the urinary marker for prediction of the fertile window .
|
-
- HY-136560
-
|
|
Drug Metabolite
|
Others
|
|
6-Azathymine acid is a metabolite of Pymetrozine. Pymetrozine is active against plant-sucking insects, such as aphids and whiteflies in vegetables, cotton, field crops and fruits and affects the nervous regulation of feeding behavior .
|
-
- HY-161001
-
|
|
Biochemical Assay Reagents
|
Others
|
|
AMOZ-CHPh-3-acid is hapten against furaltadone metabolite AMOZ. AMOZ-CHPh-3-acid can couple to BSA for immunogens and couple to OVA for coating antigen .
|
-
- HY-W019726
-
|
BAY-b 4759
|
Drug Metabolite
|
Cardiovascular Disease
Cancer
|
|
Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .
|
-
- HY-133154
-
|
CAIR; 4-Carboxy-AIR
|
Endogenous Metabolite
|
Infection
|
|
Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .
|
-
- HY-100750
-
-
- HY-125058
-
|
|
Apoptosis
|
Cancer
|
|
Kinamycin C is a bacterial metabolite containing a diazo group with anticancer activities. Kinamycin C induces a rapid apoptotic response in K562 cells .
|
-
- HY-113005A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glutarylcarnitine lithium is the diagnostic metabolite for malonic aciduria and glutaric aciduria type I monitored in most tandem mass spectrometry newborn screening programmes .
|
-
- HY-135328
-
-
- HY-117703
-
-
- HY-W722289S
-
|
N-(2-(Ethyl-2,2,2-d3)-6-methylphenyl)-2-aminopropanoic acid
|
Isotope-Labeled Compounds
|
Others
|
|
(rac)-Metolachlor metabolite CGA 50267-d3 (N-(2-(Ethyl-2,2,2-d3)-6-methylphenyl)-2-aminopropanoic acid) is deuterium labeled (2-Ethyl-6-methylphenyl)alanine .
|
-
- HY-B1984R
-
|
|
Drug Metabolite
|
Others
|
|
p,p'-DDD (Standard) is the analytical standard of p,p'-DDD. This product is intended for research and analytical applications. p,p'-DDD is a major metabolite of p,p'-DDT. p,p'-DDD occurs in the feces and livers of rats, that are given p,p'-DDT by stomach tube, but not of rats injected intraperitoneally with p,p'-DDT .
|
-
- HY-133675
-
|
MECPP
|
Drug Metabolite
|
Others
|
|
Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
|
-
- HY-135035
-
|
(-)-Decanoylcarnitine
|
Others
|
Metabolic Disease
|
|
Decanoyl-L-carnitine has stimulatory effect on the formation of desaturated fatty acid metabolites from both [1- 14C]-22:4 (n-6) and [1- 14C]-22:5 (n-3) .
|
-
- HY-137414
-
|
20-Hydroxy-PGE2
|
Drug Metabolite
|
Endocrinology
|
|
20-Hydroxy Prostaglandin E2 (20-Hydroxy-PGE2) is a metabolite of Prostaglandin E2 (HY-101952) that can be metabolized by cytochrome P450 .
|
-
- HY-113327
-
|
|
Endogenous Metabolite
|
Cancer
|
|
1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort .
|
-
- HY-N3102A
-
|
(E)-p-Hydroxycinnamyl alcohol
|
Others
|
Inflammation/Immunology
|
|
(E)-p-Coumaryl alcohol is a metabolite of coumarin that has significant cytotoxicity. (E)-p-Coumaryl alcohol can be isolated from Alpinia officinarum and Rhodiola rosea and can be used for inflammation research .
|
-
- HY-113437A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium (compound 3-F7) is a phosphatidic acid and a human endogenous metabolite . It is used in the generation of micelles, liposomes, and artificial membranes.
|
-
- HY-W008216R
-
|
|
Drug Metabolite
|
Others
|
|
HMMNI (Standard) is the analytical standard of HMMNI. This product is intended for research and analytical applications. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class drug that combats protozoan infections .
|
-
- HY-116026R
-
|
|
Drug Metabolite
Cholinesterase (ChE)
|
Neurological Disease
|
|
3-Hydroxycarbofuran (Standard) is the analytical standard of 3-Hydroxycarbofuran. This product is intended for research and analytical applications. 3-Hydroxycarbofuran, a major metabolite of Carbofuran, is a reversible acetylcholinesterase (AChE) inhibitor .
|
-
- HY-136498
-
|
|
Drug Metabolite
|
Infection
|
|
T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM .
|
-
- HY-W158239
-
-
![4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid](//file.medchemexpress.com/product_pic/hy-w158239.gif)
- HY-N10207
-
|
|
Endogenous Metabolite
|
Infection
Cancer
|
|
Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .
|
-
- HY-137956
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
Cancer
|
|
Previridicatumtoxin is a fungal metabolite with antibacterial and anticancer activities. Previridicatumtoxin can be extracted from P. aethiopicum and utilized in research related to cancer as well as infections .
|
-
- HY-139433
-
-
- HY-W010452
-
|
β-Hydroxybutyric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
|
-
- HY-N10194
-
|
|
Parasite
Endogenous Metabolite
|
Infection
|
|
P-orlandin, a fungal metabolite, prevents FREP1 from binding to gametocytes or ookinetes. P-orlandin effectively inhibits P. falciparum infection in mosquitoes .
|
-
- HY-113378
-
|
β-Hydroxybutyric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids .
|
-
- HY-136456
-
|
|
Drug Metabolite
|
Others
|
|
2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ .
|
-
- HY-70002B
-
|
MDV3100 carboxylic acid
|
Drug Metabolite
|
Cancer
|
|
Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is an inactive metabolite of Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist .
|
-
- HY-P2543
-
|
|
Neuropeptide Y Receptor
|
Metabolic Disease
|
|
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor .
|
-
- HY-116441
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
4-Hydroxy-3-methoxyamphetamine hydrochloride is a metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 4-Hydroxy-3-methoxyamphetamine hydrochloride can be used for forensic analysis .
|
-
- HY-113083R
-
|
|
Drug Metabolite
Endogenous Metabolite
|
Others
|
|
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
|
-
- HY-A0181BS
-
|
AMP-13C10,15N5 disodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
Adenosine Receptor
HSV
|
Infection
Metabolic Disease
|
|
Adenosine monophosphate- 13C10, 15N5 (AMP- 13C10, 15N5) disodium is 13C and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction .
|
-
- HY-N8541
-
-
- HY-I0508R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Phthalic acid (Standard) is the analytical standard of Phthalic acid. This product is intended for research and analytical applications. Phthalic acid is the final common metabolite of phthalic acid esters (PAEs). Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA). Phthalic acid has applications in the preparation of phthalate ester plasticizers .
|
-
- HY-133114
-
|
EZM-K
|
Keap1-Nrf2
Autophagy
|
Cardiovascular Disease
Cancer
|
|
Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor .
|
-
- HY-N6679
-
|
|
Antibiotic
|
Cancer
|
|
(R)-10,11-Dehydrocurvularin is a secondary metabolite isolated from Curvularia sp.. (R)-10,11-Dehydrocurvularin displays concentration-dependent cytotoxicity towards human tumor cell lines
with a mean IC50 value of 1.25 µM .
|
-
- HY-136577
-
-
- HY-70002AS
-
|
N-desmethyl MDV 3100-d6
|
Androgen Receptor
|
Cancer
|
|
N-desmethyl Enzalutamide-d6 is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide[1].
|
-
- HY-136457
-
|
|
Drug Metabolite
|
Others
|
|
2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents .
|
-
- HY-W021267
-
|
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema .
|
-
- HY-100635S
-
-
- HY-115249
-
|
|
Bacterial
Parasite
Antibiotic
|
Infection
|
|
Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa .
|
-
- HY-137801
-
|
|
Parasite
|
Infection
|
|
Sesquicillin A is an insecticidal antibiotic, a fungal metabolite isolated from white plantain. Sesquicillin A inhibits the growth of A. salina brine shrimp with the MIC value of 6.25 µg/mL .
|
-
- HY-125559
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication .
|
-
- HY-134242
-
|
6-Thioguanosine monophosphate disodium; 6-Thio-GMP disodium
|
Drug Metabolite
|
Inflammation/Immunology
|
|
6-T-5'-GMP disodium is an analogue of guanosine-5'-O-monophosphate (5'-GMP) and a metabolite of an immunosuppressive drug, azathioprine (HY-B0256) .
|
-
- HY-164805
-
|
|
Endogenous Metabolite
|
Others
|
|
N-Lactylleucine is an endogenous metabolite that can be identified in patients with the intermediate type of maple syrup urine disease .
|
-
- HY-164804
-
-
- HY-103252
-
-
- HY-169837
-
-
- HY-W098348
-
|
|
Parasite
|
Metabolic Disease
|
|
N-Methyltaurine is a taurine-derived metabolite with a minimum effective concentration of 10 μM for maintaining hamster sperm motility. N-Methyltaurine is the dominant osmolyte of Vespermum virulentum .
|
-
- HY-137829
-
|
|
Endogenous Metabolite
|
Others
|
|
5-Methyltetrahydrofolic acid disodium is the metabolite of Folinic acid (Leucovorin) (HY-17556). 5-Methyltetrahydrofolic acid disodium is involved in one-carbon metabolism and the transfer of methyl groups .
|
-
- HY-G0004R
-
-
- HY-133115AS
-
|
|
β-catenin
|
Neurological Disease
|
|
N-Desmethylnefopam-d5 (hydrochloride) is a deuterium labeled N-Desmethylnefopam hydrochloride. N-Desmethylnefopam hydrochloride is the main metabolite of Nefopam. N-Desmethylnefopam hydrochloride is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain[1].
|
-
- HY-W353102
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Endocrinology
|
|
Estradiol 17-(β-D-Glucuronide), a metabolite of estrogen, is well known to cause intrahepatic cholestasis in humans. Estradiol 17-(β-D-Glucuronide) is a high-affinity substrate for oatp organic anion transporter .
|
-
- HY-136444
-
|
|
Drug Derivative
|
Others
|
|
2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (HY-W012982, a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues .
|
-
- HY-122508
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Hydroxyebastine is an Ebastine (HY-B0674) (a histamine H1-receptor antagonist) metabolite. Hydroxyebastine is metabolized to Carebastine (HY-121356) by CYP2J2 and CYP3A4 .
|
-
- HY-B1417R
-
|
|
Autophagy
Drug Metabolite
Apoptosis
|
Neurological Disease
Cancer
|
|
Nortriptyline (hydrochloride) (Standard) is the analytical standard of Nortriptyline (hydrochloride). This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects .
|
-
- HY-N8796
-
|
|
Others
|
Cancer
|
|
2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a dihydrochalcone compound isolated from Iryanthera juruensis Warb. 2',4'-Dihydroxy-4,6'-diMethoxydihydrochalcone is a major cytotoxic metabolite when tested against a panel of cancer cell lines .
|
-
- HY-123305R
-
|
|
Parasite
|
Others
|
|
5-Hydroxymebendazole (Standard) is the analytical standard of 5-Hydroxymebendazole. This product is intended for research and analytical applications. 5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic agents and are widely used for prevention and treatment of parasitic infections in food-producing animals .
|
-
- HY-100656
-
-
- HY-W091541
-
|
4-Hydroxyindole-3-carboxaldehyde
|
PPAR
|
Others
|
|
4-Hydroxy-1H-indole-3-carbaldehyde is a plant metabolite found in Capparis spinosa L.. 4-Hydroxy-1H-indole-3-carbaldehyde can be used in the synthesis of fluorescent probe .
|
-
- HY-113261
-
-
- HY-N10322
-
|
|
Drug Metabolite
|
Others
|
|
2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system .
|
-
- HY-100651R
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
3,5-Di-tert-butyl-4-hydroxybenzaldehyde (Standard) is the analytical standard of 3,5-Di-tert-butyl-4-hydroxybenzaldehyde. This product is intended for research and analytical applications. 3,5-Di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO) is a metabolite of Butylated hydroxytoluene (HY-Y0172) .
|
-
- HY-B1986
-
|
4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
|
Androgen Receptor
Drug Metabolite
|
Endocrinology
|
|
p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM .
|
-
- HY-131993
-
|
RvE4
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Resolvin E4 (RvE4) is an endogenous metabolite that stimulates efferocytosis of apoptotic neutrophils and senescent erythrocytes. Resolvin E4 enhances resolution of hemorrhagic exudates and inflammation in vivo .
|
-
- HY-133798
-
|
|
Cytochrome P450
Drug Metabolite
|
Cancer
|
|
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM .
|
-
- HY-100046R
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Nordoxepin (hydrochloride) (Standard) is the analytical standard of Nordoxepin (hydrochloride). This product is intended for research and analytical applications. Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression .
|
-
- HY-12388AS
-
|
Desmethylclomipramine-d3 (hydrochloride)；Norclomipramine-d3 hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
|
N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine[1]
|
-
- HY-124104
-
|
|
Drug Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC50 of 10 μM for both in zebrafish .
|
-
- HY-W707158
-
|
(±)-Norfenfluramine hydrochloride
|
Drug Metabolite
|
Neurological Disease
|
|
Norfenfluramine hydrochloride ((±)-Norfenfluramine hydrochloride) is the primary metabolite of Fenfluramine, formed through N-dealkylation of Fenfluramine. Norfenfluramine hydrochloride is also a potent anorexiant. Norfenfluramine hydrochloride can regulate serotonergic neurotransmission. In addition, Norfenfluramine hydrochloride exhibits sedative effects after acute administration .
|
-
- HY-118620R
-
|
|
Autophagy
Drug Metabolite
Apoptosis
|
Neurological Disease
Cancer
|
|
Nortriptyline (Standard) is the analytical standard of Nortriptyline. This product is intended for research and analytical applications. Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects .
N
|
-
- HY-10003A
-
-
- HY-N10228
-
|
|
Endogenous Metabolite
|
Infection
|
|
Gliorosein is a fungal metabolite isolated from Gliocladium. Gliorosein is isomeric with the quinol but shows a different ultraviolet absorption spectrum .
|
-
- HY-138538R
-
|
|
Antibiotic
|
Others
|
|
2-Nitrobenzaldehyde Semicarbazone (Standard) is the analytical standard of 2-Nitrobenzaldehyde Semicarbazone. This product is intended for research and analytical applications. 2-Nitrobenzaldehyde Semicarbazone is a derivative of Semicarbazide. 2-Nitrobenzaldehyde Semicarbazone can be measured as a metabolite marker to detect the widely banned antibiotic Nitrofurazone .
|
-
- HY-W017445
-
|
|
Fungal
|
Infection
|
|
Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .
|
-
- HY-141621
-
|
|
Parasite
Drug Metabolite
|
Infection
|
|
ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial .
|
-
- HY-W005255
-
-
- HY-136444S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2-NP-AOZ-d4 is a deuterium labeled 2-NP-AOZ. 2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues[1][2].
|
-
- HY-W717548
-
|
|
Drug Metabolite
|
Others
|
|
Safinamide acid (Compound Imp-E) is the metabolite of Safinamide (HY-70057). Safinamide acid can be formed by hydrolysis of Safinamide intermediate under alkaline or acidic conditions. Safinamide acid is utilized to monitor process-related impurities and degradation products in safinamide samples .
|
-
- HY-142105
-
|
2-Ethyl-2-hydroxybutyric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Ethyl-2-hydroxybutanoic acid (2-Ethyl-2-hydroxybutyric acid) is a hydroxy fatty acid. 2-Ethyl-2-hydroxybutanoic is a metabolite of DEHP (HY-B1945) .
|
-
- HY-134242A
-
|
6-Thioguanosine monophosphate; 6-Thio-GMP
|
Drug Metabolite
|
Inflammation/Immunology
|
|
6-T-5'-GMP (6-Thioguanosine monophosphate) is an analogue of guanosine-5'-O-monophosphate (5'-GMP) and a metabolite of an immunosuppressive drug, Azathioprine (HY-B0256) .
|
-
- HY-W778608
-
|
Quercetin 7-O-β-glucuronide
|
Drug Metabolite
|
Inflammation/Immunology
|
|
Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a metabolite of Quercetin (HY-18085), can be isolated from Madagascarian Uncarina species. Quercetin 7-glucuronide can inhibit LDL oxidation .
|
-
- HY-W008452
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .
|
-
- HY-100638A
-
|
NPC hydrochloride
|
Drug Metabolite
|
Cancer
|
|
RPR132595A (NPC) hydrochloride is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .
|
-
- HY-100638
-
|
NPC
|
Drug Metabolite
|
Cancer
|
|
RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .
|
-
- HY-A0178AR
-
|
|
Endogenous Metabolite
Histamine Receptor
|
Inflammation/Immunology
|
|
Isothipendyl (hydrochloride) (Standard) is the analytical standard of Isothipendyl (hydrochloride). This product is intended for research and analytical applications. Isothipendyl hydrochloride (), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist.othipendyl is a primary metabolite .
|
-
- HY-118634
-
|
R-4G
|
FATP
|
Metabolic Disease
|
|
Trans-Resveratrol-4'-O-D-Glucuronide (R-4G) is a metabolite of resveratrol with anti-fat accumulation property, and can be used for metabolic research .
|
-
- HY-N4067
-
|
isoCDCA
|
Drug Metabolite
|
Inflammation/Immunology
Cancer
|
|
Isochenodeoxycholic acid (isoCDCA) is a human fecal bile acid. Isochenodeoxycholic acid has cytoprotective against ethanol-induced cell injuries in HepG2 cells. Isochenodeoxycholic acid is a major metabolite of orally administered ursodeoxycholic acid (UDCA) .
|
-
- HY-W289054S
-
|
2-((2-(Ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoacetic acid
|
Isotope-Labeled Compounds
|
Others
|
|
(S)-Metolachlor metabolite CGA 50720-d3 (2-((2-(Ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoacetic acid) is deuterium labeled 2-((2-Ethyl-6-methylphenyl)amino)-2-oxoacetic acid .
|
-
- HY-125296R
-
|
|
GABA Receptor
|
Neurological Disease
|
|
Fipronil sulfone (Standard) is the analytical standard of Fipronil sulfone. This product is intended for research and analytical applications. Fipronil sulfone is the major metabolite of Fipronil.Fipronil sulfone selectively inhibits GABA receptor with IC50 of 175 nM (assayed by displacement of 4′-ethynyl-4-n-[2,3-3H2]- propylbicycloorthobenzoate ([3H]EBOB) from the noncompetitive blocker site).
|
-
- HY-W013266R
-
|
|
Drug Metabolite
Bacterial
|
Infection
Metabolic Disease
|
|
N4-Acetylsulfamethoxazole (Standard) is the analytical standard of N4-Acetylsulfamethoxazole. This product is intended for research and analytical applications. N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections .
|
-
- HY-116637
-
-
- HY-162297
-
|
|
Drug Metabolite
|
Others
|
|
4-(Sulfooxy)benzoic acid is a sulfated phenolic acid found in C. elegans. 4-(Sulfooxy)benzoic acid is a metabolite of ethyl para-hydroxybenzoate and several flavonoids .
|
-
- HY-W715341R
-
|
|
Drug Derivative
|
Others
|
|
RO-1-5237 (Standard) is the analytical standard of RO-1-5237. This product is intended for research and analytical applications. RO-1-5237 is a metabolite of Pyridostigmine Bromide, which is a cholinergic and can be used for myasthenia gravis research .
|
-
- HY-N11699
-
|
|
Glutathione S-transferase
|
Inflammation/Immunology
|
|
Bequinostatin A is a benzo[a]naphthacenequinone metabolite that can be isolated from Streptomyces sp. MI384-DF12. Bequinostatin A shows considerable inhibitory activity against human pi class glutathione S-transferase (GST pi) .
|
-
- HY-W008449
-
|
|
Drug Metabolite
Endogenous Metabolite
|
Cancer
|
|
1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .
|
-
- HY-W185208S
-
|
Methyldesphenylchloridazon-d3;
5-Amino-4-chloro-2-methyl-d3-3(2H)-pyridazinone
|
Isotope-Labeled Compounds
|
Others
|
|
Chloridazon metabolite B1-d3 (Methyldesphenylchloridazon-d3) is deuterium labeled 5-Amino-4-chloro-2-methyl-2,3-dihydropyridazin-3-one .
|
-
- HY-136438R
-
|
|
Endogenous Metabolite
Parasite
|
Metabolic Disease
Inflammation/Immunology
|
|
Toltrazuril sulfoxide (Standard) is the analytical standard of Toltrazuril sulfoxide. This product is intended for research and analytical applications. Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites .
|
-
- HY-100064S
-
|
|
EGFR
|
Cancer
|
|
O-Desmethyl gefitinib-d8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
|
-
- HY-W013378R
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Carbamazepine 10,11-epoxide (Standard) is the analytical standard of Carbamazepine 10,11-epoxide. This product is intended for research and analytical applications. Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect. Carbamazepine can be used for the research of seizures .
|
-
- HY-137591
-
|
|
Drug Metabolite
|
Endocrinology
|
|
13,14-Dihydro-15-keto-PGE1 is an inactive metabolite of PGE1. 13, 14-Dihydro-15-Keto-pGE1 inhibited platelet aggregation in ADP-induced human isolated platelet-rich plasma with IC50 14.8 μg/mL .
|
-
- HY-138813
-
|
SU-12662 hydrochloride
|
Drug Metabolite
|
Cancer
|
|
N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
|
-
- HY-100637
-
|
|
Drug Metabolite
Adrenergic Receptor
nAChR
|
Neurological Disease
|
|
Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6. Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonist .
|
-
- HY-B1445
-
|
|
Potassium Channel
|
Metabolic Disease
|
|
Minoxidil sulfate, a potent and ATP-sensitive K + channel opener, is the sulfated metabolite of minoxidil. Minoxidil sulfate is considered as a vasodilator to promote hair growth in vivo .
|
-
- HY-133068
-
|
|
COMT
Endogenous Metabolite
|
Others
|
|
5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate .
|
-
- HY-113516
-
-
- HY-135811
-
|
|
Parasite
Toll-like Receptor (TLR)
Autophagy
|
Infection
|
|
Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .
|
-
- HY-W424792A
-
-
- HY-12956B
-
|
Prostaglandin F2β; PGF2β
|
Endogenous Metabolite
|
Others
|
|
(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin .
|
-
- HY-136440S1
-
|
Metronidazole-OH-d2
|
Isotope-Labeled Compounds
|
Infection
|
|
Hydroxymetronidazole-d2 is the deuterium labeled Hydroxymetronidazole(HY-136440).Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle .
|
-
- HY-113147
-
|
|
Potassium Channel
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2 .
|
-
- HY-133115
-
|
|
β-catenin
|
Neurological Disease
|
|
N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo .
|
-
- HY-136440R
-
|
|
Bacterial
Parasite
|
Infection
|
|
Hydroxymetronidazole (Standard) is the analytical standard of Hydroxymetronidazole. This product is intended for research and analytical applications. Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle .
|
-
- HY-113147A
-
|
|
Potassium Channel
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2 .
|
-
- HY-B0794S
-
|
|
EGFR
IGF-1R
Drug Metabolite
|
Others
|
|
AZ7550-d5 is the deuterium labeled AZ7550 (HY-B0794). AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of IGF1R with an IC50 of 1.6 μM[1][2].
|
-
- HY-B2124R
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
10,11-Dihydrocarbamazepine (Standard) is the analytical standard of 10,11-Dihydrocarbamazepine. This product is intended for research and analytical applications. 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy .
|
-
- HY-W354498
-
|
|
Endogenous Metabolite
|
Cancer
|
|
L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer .
|
-
- HY-113161
-
|
|
Endogenous Metabolite
|
Cancer
|
|
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .
|
-
- HY-77641
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment .
|
-
- HY-Y1125
-
|
Pseudothymine
|
Endogenous Metabolite
|
Metabolic Disease
|
|
6-Methyluracil (Pseudothymine), a metabolite of Uracil, can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation. 6-Methyluracil exhibits antiradiation effect in vivo .
|
-
- HY-N10190
-
|
|
Parasite
Endogenous Metabolite
|
Infection
|
|
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells .
|
-
- HY-113405R
-
|
|
Endogenous Metabolite
|
Endocrinology
|
|
21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol. This product is intended for research and analytical applications. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .
|
-
- HY-125705
-
|
Herqueline A
|
Influenza Virus
|
Infection
Cardiovascular Disease
|
|
Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus .
|
-
- HY-133677
-
|
MEHHP
|
Drug Metabolite
|
Endocrinology
|
|
Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-hydroxyhexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
|
-
- HY-W097565S
-
|
5,7-Dimethoxy[1,2,4]triazolo[1,5-a]pyrimidin-2-amine-d6
|
Isotope-Labeled Compounds
|
Others
|
|
Pyroxsulam Metabolite ADTP-d6 (5,7-Dimethoxy[1,2,4]triazolo[1,5-a]pyrimidin-2-amine-d6) is deuterium labeled 5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine .
|
-
- HY-116601
-
|
|
Cytochrome P450
|
Others
|
|
6-Hydroxywarfarin is a metabolite of (+) -warfarin. 6-Hydroxywarfarin is a weaker vitamin K antagonist. 6-Hydroxywarfarin is metabolized by the cytochrome P450 isomer 2C9 (CYP2C9) .
|
-
- HY-N1443
-
|
|
Endogenous Metabolite
Apoptosis
|
Metabolic Disease
Cancer
|
|
Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer .
|
-
- HY-135811A
-
|
|
Parasite
Toll-like Receptor (TLR)
Autophagy
|
Infection
|
|
Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity .
|
-
- HY-126129
-
|
|
Bacterial
|
Infection
|
|
Desacetylcefotaxime, the in vivo metabolite of Cefotaxime (CTX), possesses significant in vitro antimicrobial activity similar to the parent compound against a variety of aerobic and anaerobic bacteria .
|
-
- HY-129491
-
|
CGP62221; O-Desmethyl PKC412
|
PKC
|
Cancer
|
|
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
|
-
- HY-135035R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Decanoyl-L-carnitine (Standard) is the analytical standard of Decanoyl-L-carnitine. This product is intended for research and analytical applications. Decanoyl-L-carnitine has stimulatory effect on the formation of desaturated fatty acid metabolites from both [1-14C]-22:4 (n-6) and [1-14C]-22:5 (n-3) .
|
-
- HY-W011245R
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
Ranitidine S-oxide (Standard) is the analytical standard of Ranitidine S-oxide. This product is intended for research and analytical applications. Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion .
|
-
- HY-113147B
-
|
|
Endogenous Metabolite
Potassium Channel
|
Cardiovascular Disease
Metabolic Disease
|
|
L-Palmitoylcarnitine TFA, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine TFA inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2 .
|
-
- HY-N1867
-
|
|
PPAR
|
Metabolic Disease
|
|
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .
|
-
- HY-125941
-
|
|
Bacterial
|
Infection
|
|
PNU-101603 is a sulfoxide metabolite of Sutezolid (HY-10392). PNU-101603 alone or combined with SQ109 (HY-14989) shows excellent activity against Mycobacterium tuberculosis (MTB), as well as against agent-susceptible and multidrug-resistant TB .
|
-
- HY-100642
-
|
Ro 40-7591
|
COMT
|
Neurological Disease
|
|
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease .
|
-
- HY-114850A
-
|
Prostaglandin F2β tromethamine; PGF2β tromethamine
|
Endogenous Metabolite
|
Others
|
|
(5R)-Dinoprost tromethamine (Prostaglandin F2β tromethamine) is a metabolite produced by the metabolism of arachidonic acid cyclooxygenase. (5R)-Dinoprost tromethamine induces dose-dependent release of hexosaccharide containing mucin .
|
-
- HY-126967A
-
|
1-P-GPA
|
Endogenous Metabolite
|
Metabolic Disease
|
|
1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) is an endogenous metabolite. 1-Palmitoyl-sn-glycerol 3-phosphate can be used for the research of non‐alcoholic fatty liver disease .
|
-
- HY-W019726R
-
|
|
Drug Metabolite
|
Cardiovascular Disease
Cancer
|
|
Dehydro Nifedipine (Standard) is the analytical standard of Dehydro Nifedipine. This product is intended for research and analytical applications. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .
|
-
- HY-113943
-
|
|
Endogenous Metabolite
|
Others
|
|
9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
|
-
- HY-119809
-
|
|
Apoptosis
Endogenous Metabolite
|
Cancer
|
|
Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer .
|
-
- HY-N10227
-
-
- HY-124414A
-
|
|
Estrogen Receptor/ERR
Drug Metabolite
|
Cancer
|
|
4'-Hydroxytamoxifen TFA is a salt form of a metabolite of Tamoxifen. 4'-Hydroxytamoxifen TFA has a higher affinity for ER than Tamoxifen. 4'-Hydroxytamoxifen TFA induces non-apoptotic cytotoxicity in human endometrial adenocarcinoma cells .
|
-
- HY-100620
-
|
APC
|
Topoisomerase
Cholinesterase (ChE)
|
Cancer
|
|
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE .
|
-
- HY-118828A
-
|
(9S,13R)-12-OPDA
|
Lipoxygenase
|
Others
|
|
9S,13R)-12-Oxo phytodienoic acid is the isomerization of 12-oxo PDA (HY-118828). (9S,13R)-12-Oxo phytodienoic acid is a lipoxygenase metabolite in the leaves of green plants .
|
-
- HY-109054A
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .
|
-
- HY-W010452S1
-
-
- HY-W010452S2
-
-
- HY-117605R
-
|
|
Phosphodiesterase (PDE)
|
Cardiovascular Disease
|
|
N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor .
|
-
- HY-N2304A
-
|
|
Opioid Receptor
|
Inflammation/Immunology
|
|
Methyl-6-alpha-Naltrexol is a metabolite of Methylnaltrexone (MNTX). Methylnaltrexone is a selective mu-opioid receptor antagonist and functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract .
|
-
- HY-131844
-
|
N6-Benzoyladenosine-5'-O-monophosphate
|
Endogenous Metabolite
|
Others
|
|
6-Bnz-5'-AMP is a lipophilic analogue of adenosine-5'-O-monophosphate and a potential metabolite of N 6-Benzoyl-cAMP. 6-Bnz-5'-AMP exhibits some cytokinin activity in tobacco and soybean tissue culture assays .
|
-
- HY-127026S
-
|
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
|
Quinaprilat-d5 is a deuterium-labeled Quinaprilat. Quinaprilat is a nonsulfhydryl ACE inhibitor, the active diacid metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits bradykinin degradation. Quinaprilat primarily acts as a vasodilator, decreasing total peripheral and renal vascular resistance[1].
|
-
- HY-N10192
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .
|
-
- HY-114646
-
|
|
Endogenous Metabolite
|
Cancer
|
|
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter .
|
-
- HY-133787
-
|
|
Drug Metabolite
|
Infection
|
|
Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .
|
-
- HY-77293
-
|
|
Apoptosis
Keap1-Nrf2
|
Cancer
|
|
(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells .
|
-
![(E)-[6]-Dehydroparadol](//file.medchemexpress.com/product_pic/hy-77293.gif)
- HY-119696
-
-
- HY-W012982R
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
3-Amino-2-oxazolidinone (Standard) is the analytical standard of 3-Amino-2-oxazolidinone. This product is intended for research and analytical applications. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo .
|
-
- HY-119904
-
|
|
Cholinesterase (ChE)
|
Infection
|
|
Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity .
|
-
- HY-12753A
-
|
SR35021 hydrochloride
|
Thyroid Hormone Receptor
|
Cardiovascular Disease
|
|
Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .
|
-
- HY-124104S
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Aldicarb sulfoxide-d3 is the deuterium labled Aldicarb sulfoxide (HY-124104). Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC50 of 10 μM for both in zebrafish .
|
-
- HY-W438378
-
|
HMPG piperazine
|
Biochemical Assay Reagents
|
Others
|
|
4-Hydroxy-3-methoxyphenylglycol piperazine (HMPG piperazine) is a salt of HMPG combined with piperazine. HMPG is a metabolite of adrenaline and norepinephrine and is an important marker of catecholamine hormone metabolism in the body. 4-Hydroxy-3-methoxyphenylglycol piperazine is used as a standard in clinical laboratories to accurately measure the HMPG content in urine .
|
-
- HY-135328S
-
-
- HY-148377
-
|
|
Drug Metabolite
|
Cancer
|
|
Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer .
|
-
- HY-125170
-
|
|
STAT
|
Cancer
|
|
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer .
|
-
- HY-W040047
-
|
|
Endogenous Metabolite
|
Endocrinology
|
|
Pregnanediol 3-glucuronide is the major terminal metabolite of progesterone, playing an important role in physiological processes, such as the female menstrual cycle, pregnancy (supports gestation), embryogenesis and maternal immune response of humans and other species .
|
-
- HY-100644
-
|
Trimethoprim 1-N-oxide
|
Drug Metabolite
|
Infection
|
|
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes .
|
-
- HY-115249R
-
|
|
Parasite
Antibiotic
Bacterial
|
Infection
|
|
Metronidazole acetic acid (Standard) is the analytical standard of Metronidazole acetic acid. This product is intended for research and analytical applications. Metronidazole acetic acid is a metabolite of Metronidazole with mutagenic activity in bacteria. Metronidazole is a nitroimidazole antibiotic, amebicide, and antiprotozoal agent used particularly for anaerobic bacteria and protozoa .
|
-
- HY-N2907
-
|
|
Ras
Endogenous Metabolite
|
Cancer
|
|
Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity .
|
-
- HY-N3694
-
|
Desacetyl nimbin
|
Others
|
Others
|
|
Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata .
|
-
- HY-N11287
-
|
|
Endogenous Metabolite
|
Others
|
|
UDP-xylose is a natural product that could be isolated from Cryptococcus laurentii (NRRL Y-1401). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi .
|
-
- HY-127137
-
|
Adenylosuccinate; Aspartyl adenylate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Adenylosuccinic acid (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid has the potential for the study of duchenne muscular dystrophy(DMD) .
|
-
- HY-W424779
-
|
|
Drug Metabolite
|
Infection
|
|
5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine . 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine .
|
-
- HY-100641
-
|
Hydroxytolbutamide
|
Potassium Channel
Autophagy
|
Metabolic Disease
Cancer
|
|
4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic .
|
-
- HY-113261R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
Oleoylcarnitine (Standard) is the analytical standard of Oleoylcarnitine. This product is intended for research and analytical applications. Oleoylcarnitine, the metabolite which accumulates through suppression of fatty acid β-oxidation, can enhance hepatocarcinogenesis via STAT3 activation .
|
-
- HY-119663
-
|
|
Fungal
|
Infection
|
|
Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .
|
-
- HY-P3107
-
|
|
Endogenous Metabolite
|
Inflammation/Immunology
|
|
Homodestcardin, a destruxinbased cyclodepsipeptide, is a immunosuppressant. Homodestcardin, a fungal metabolite, displays pronounced activities against concanavalin A (Con A) activation, with an IC50 value of 0.86 μM .
|
-
- HY-Y1097
-
|
2-(Methoxycarbonyl)benzoic acid
|
Endogenous Metabolite
|
Cancer
|
|
Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .
|
-
- HY-W017187
-
|
|
Apoptosis
|
Cancer
|
|
2-tert-Butyl-1,4-benzoquinone is an electrophilic metabolite of butylated hydroxyanisole and an oxidation product of 2-tert-butylhydroquinone .
|
-
- HY-135265
-
|
Ro 12-5637
|
Monoamine Oxidase
|
Neurological Disease
|
|
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm .
|
-
- HY-W015851
-
|
(R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .
|
-
- HY-N8499
-
|
|
Fungal
|
Infection
|
|
Sporothriolide is a metabolite produced by Nodulisporium sp. A21. Sporothriolide has potently antifungal against R. solani and S. sclerotiorum, with EC50 values of 11.6 μM and 10.7 μM, respectively. Sporothriolide inhibits conidium germination of Magnaporthe oryzae in vitro and in vivo .
|
-
- HY-137321
-
|
Estriol 3-β-D-Glucuronide sodium salt
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Estriol 3-glucuronide (Estriol 3-β-D-Glucuronide) sodium salt is a metabolite of Estriol. Estriol 3-glucuronide sodium salt competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide (4Mu-GlcU). Estriol 3-glucuronide sodium salt is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc) .
|
-
- HY-136901
-
|
FC-101
|
Reactive Oxygen Species
|
Cardiovascular Disease
Cancer
|
|
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .
|
-
- HY-W714705S
-
|
Sodium 2-((2-(ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate
|
Isotope-Labeled Compounds
|
Others
|
|
(S)-Metolachlor metabolite CGA 368208-d3 sodium salt (Sodium 2-((2-(ethyl-2,2,2-d3)-6-methylphenyl)amino)-2-oxoethane-1-sulfonate) is deuterium labeled Sodium 2-((2-ethyl-6-methylphenyl)amino)-2-oxoethane-1-sulfonate .
|
-
- HY-W011417
-
|
|
Endogenous Metabolite
mGluR
Apoptosis
|
Others
|
|
Cinnabarinic acid is a specific orthosteric agonist of mGlu4 by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis .
|
-
- HY-W003467
-
|
|
Proton Pump
Bacterial
|
Infection
Inflammation/Immunology
|
|
Rabeprazole Sulfide is an active metabolite of Rabeprazole. Rabeprazole is a proton pump inhibitor that suppresses gastric acid secretion through an interaction with (H +/K +)-ATPase in gastric parietal cells. Rabeprazole markedly inhibits the motility of H. pylori. Rabeprazole has the potential for various peptic diseases treatment .
|
-
- HY-W017464
-
|
|
Drug Metabolite
Endogenous Metabolite
|
Metabolic Disease
|
|
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .
|
-
- HY-W021267R
-
|
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
3-Demethylcolchicine (Standard) is the analytical standard of 3-Demethylcolchicine. This product is intended for research and analytical applications. 3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema .
|
-
- HY-118614
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .
|
-
- HY-163804
-
|
|
Cytochrome P450
Parasite
|
Others
|
|
Cyprocide-B is activated by Cytochrome P450 and converted to electrophilic metabolites that selectively kill nematodes C. elegans. Cyprocide-B is promising for research of selective nematicide .
|
-
- HY-W050026S
-
|
NSC 203800-d5; Phenylacetyl-L-glutamine-d5
|
Endogenous Metabolite
Isotope-Labeled Compounds
|
Others
|
|
Phenylacetylglutamine-d5 (NSC 203800-d5) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation .
|
-
- HY-136456R
-
|
|
Drug Metabolite
|
Others
|
|
2-NP-AMOZ (Standard) is the analytical standard of 2-NP-AMOZ. This product is intended for research and analytical applications. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ .
|
-
- HY-W686186
-
|
|
Drug Metabolite
P2Y Receptor
|
Cardiovascular Disease
|
|
Prasugrel hydroxy thiolactone (compound M18) is a metabolite of Prasugrel (HY-15284). Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits Adenosine 5'-diphosphate (ADP, HY-W010918)-induced platelet aggregation .
|
-
- HY-129491S
-
|
CGP62221-d5; O-Desmethyl PKC412-d5
|
Isotope-Labeled Compounds
Drug Metabolite
|
Cancer
|
|
O-Desmethyl Midostaurin-d5 is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism[1].
|
-
- HY-136444R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-NP-AOZ (Standard) is the analytical standard of 2-NP-AOZ. This product is intended for research and analytical applications. 2-NP-AOZ is a 2-nitrophenyl derivative of AOZ (HY-W012982, a tissue-bound metabolite of the Furazolidone). 2-NP-AOZ can be used to determination of the AOZ residues .
|
-
- HY-N0656
-
|
|
Bacterial
|
Infection
Cancer
|
|
Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1 .
|
-
- HY-119552
-
|
LL-S490β
|
Endogenous Metabolite
Neurokinin Receptor
|
Neurological Disease
|
|
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ 3H]-SP binding to human astrocytoma cells with a Ki of 170 μM .
|
-
- HY-N2528
-
|
|
Bacterial
|
Infection
Cancer
|
|
Usnic acid sodium, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid sodium has excellent anticancer and antimicrobial properties. Usnic acid sodium significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1 .
|
-
- HY-133675S
-
|
MECPP-d4
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Mono(5-carboxy-2-ethylpentyl) phthalate-d4 (MECPP-d4) is a deuterium labeled Mono(5-carboxy-2-ethylpentyl) phthalate (HY-133675). Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
|
-
- HY-158595
-
|
15(R),19(R)-Hydroxy PGF2α
|
Drug Derivative
|
Others
|
|
15(R),19(R)-Hydroxy prostaglandin F2α (15(R),19(R)-Hydroxy PGF2α) is an analog of 19(R)-Hydroxy-prostaglandin F2α. 19(R)-Hydroxy-prostaglandin F2α (HY-N7857) is an ω-1 hydroxylase metabolite of PGF2α found in human semen .
|
-
- HY-W013035
-
|
MBO321
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Methyl-2-buten-1-ol (MBO321) is an orally active endogenous metabolite found in pine trees and is used as a fragrance ingredient in cosmetics and detergents. 3-Methyl-2-buten-1-ol passes cell barrier. 3-Methyl-2-buten-1-ol reduces body weight in rats .
|
-
- HY-135615A
-
|
N-Desmethylsibutramine hydrochloride
|
Serotonin Transporter
|
Neurological Disease
Metabolic Disease
|
|
Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant .
|
-
- HY-N7387
-
|
3-Dehydrocholic acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Oxocholic acid is an oxo-bile acid metabolite and also a major degradation product from cholic by C. perfringens in the intestine. 3-Oxocholic acid is steroid acid found predominantly in bile of mammals .
|
-
- HY-121385
-
|
Ro 48-5033
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities .
|
-
- HY-135615
-
|
N-Desmethylsibutramine
|
Serotonin Transporter
|
Neurological Disease
Metabolic Disease
|
|
Desmethyl Sibutramine, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine can be used in the research of obesity and appetite suppressant .
|
-
- HY-B1986R
-
|
|
Androgen Receptor
Drug Metabolite
|
Endocrinology
|
|
p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM .
|
-
- HY-18646
-
|
24-Oxo-23,25-dihydroxyvitamin D3
|
Endogenous Metabolite
|
Metabolic Disease
|
|
23,25-Dihydroxy-24-oxovitamin D3 is a major metabolite of 24(R),25-Dihydroxyvitamin D3. 23,25-Dihydroxy-24-oxovitamin D3 can be used for the research of metabolic diseases .
|
-
- HY-136457R
-
|
|
Drug Metabolite
|
Others
|
|
2-NP-AHD (Standard) is the analytical standard of 2-NP-AHD. This product is intended for research and analytical applications. 2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents .
|
-
- HY-18719
-
|
|
Estrogen Receptor/ERR
Potassium Channel
|
Cancer
|
|
Endoxifen Z-isomer is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC50 value of 1.6 μM .
|
-
- HY-N3007R
-
|
|
Others
|
Inflammation/Immunology
|
|
(R)-5-Oxopyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-5-Oxopyrrolidine-2-carboxylic acid. This product is intended for research and analytical applications. (R)-5-Oxopyrrolidine-2-carboxylic acid is an endogenous metabolite.
|
-
- HY-N11287A
-
|
|
Endogenous Metabolite
|
Others
|
|
UDP-xylose disodium is a natural product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi ..
|
-
- HY-109054
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
O-Demethyltramadol is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .
|
-
- HY-121362
-
|
|
Bacterial
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects .
|
-
- HY-A0116A
-
|
Trandolaprilat hydrate; RU 44403 hydrate
|
Angiotensin-converting Enzyme (ACE)
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .
|
-
- HY-A0116
-
-
- HY-B1551
-
|
Benzononatine
|
Sodium Channel
|
Neurological Disease
|
|
Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite .
|
-
- HY-77641R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Cinnamoylglycine (Standard) is the analytical standard of Cinnamoylglycine. This product is intended for research and analytical applications. Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment .
|
-
- HY-135751
-
|
|
Antibiotic
DNA/RNA Synthesis
|
Infection
Cancer
|
|
Holomycin is a secondary metabolite of the dithiolopyrrolone class. Holomycin also is a broad spectrum antibiotic. Holomycin has antitumor activity and can act in vivo on RNA synthesis .
|
-
- HY-W008449R
-
|
|
Drug Metabolite
Endogenous Metabolite
|
Cancer
|
|
1-Methylxanthine (Standard) is the analytical standard of 1-Methylxanthine. This product is intended for research and analytical applications. 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .
|
-
- HY-136457S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2-NP-AHD- 13C3 is the 13C labled 2-NP-AHD (HY-136457) . 2-NP-AHD is a 2-nitrophenyl derivative of AHD (a metabolite of nitrofurans type of antibiotics), can be used as indicator of the illegal usage of nitrofuran agents .
|
-
- HY-118828AS
-
|
(9S,13R)-12-OPDA-d5
|
Isotope-Labeled Compounds
|
Others
|
|
(9S,13R)-12-OPDA-d5 is an isotopic label of (9S,13R)-12-oxyphytodienoic acid. (9S,13R)-12-Oxophytodienoic acid is an isomer of 12-oxoPDA (HY-118828). (9S,13R)-12-Oxo phytodienoic Acid is a lipoxygenase metabolite in green plant leaves .
|
-
- HY-W012982S
-
|
AOZ-d4
|
Drug Metabolite
|
Others
|
|
3-Amino-2-oxazolidinone-d4 is a deuterium labeled 3-Amino-2-oxazolidinone. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as an indicator of furazolidone residues[1][2].
|
-
- HY-D0004
-
|
Azure B chloride
|
Monoamine Oxidase
|
Neurological Disease
|
|
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .
|
-
- HY-N7307
-
|
|
Bacterial
|
Infection
|
|
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .
|
-
- HY-N8812
-
|
|
NO Synthase
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Inflammation/Immunology
|
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19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide, the metabolite of Neoandrographolide, inhibits nitric oxide (NO) production in lipopolysaccharide-activated macrophages .
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-
![19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide](//file.medchemexpress.com/product_pic/hy-n8812.gif)
- HY-114950
-
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Losartan Carboxaldehyde; DuP 167
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COX
|
Cardiovascular Disease
Inflammation/Immunology
|
|
EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions .
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-
- HY-135811R
-
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Parasite
Toll-like Receptor (TLR)
Autophagy
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Infection
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Desethyl chloroquine (Standard) is the analytical standard of Desethyl chloroquine. This product is intended for research and analytical applications. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .
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- HY-127137A
-
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Adenylosuccinate tetraammonium; Aspartyl adenylate tetraammonium
|
Endogenous Metabolite
|
Metabolic Disease
|
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Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is an orally active purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD) .
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-
- HY-136592
-
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COX
|
Inflammation/Immunology
Cancer
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1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis . Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively .
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-
- HY-128554A
-
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Parasite
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Infection
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N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria .
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- HY-128554
-
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Parasite
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Infection
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N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria .
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- HY-W008449S2
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Drug Metabolite
Endogenous Metabolite
Isotope-Labeled Compounds
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Cancer
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1-Methylxanthine-d3 is deuterated labeled 1-Methylxanthine (HY-W008449). 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP) . 1-Methylxanthine enhances the radiosensitivity of tumor cells .
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- HY-W040971
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-
- HY-126129R
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Drug Metabolite
Bacterial
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Infection
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Desacetylcefotaxime (Standard) is the analytical standard of Desacetylcefotaxime. This product is intended for research and analytical applications. Desacetylcefotaxime, the in vivo metabolite of Cefotaxime (CTX), possesses significant in vitro antimicrobial activity similar to the parent compound against a variety of aerobic and anaerobic bacteria .
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- HY-W002112
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Nornicotine
|
Endogenous Metabolite
Drug Metabolite
|
Neurological Disease
|
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(±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .
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- HY-12753AS
-
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SR35021-d7 hydrochloride
|
Thyroid Hormone Receptor
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
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Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic .
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- HY-N12255
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Glyoxalase (GLO)
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Cancer
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COTC is a bacterial metabolite with anticancer activity that is found in S. griseosporeus. COTC inhibits glyoxalase in the presence of glutathione (GSH). COTC also inhibits the proliferation of HeLa cells (IC50 = 18 µg/mL), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model .
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- HY-113161R
-
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|
Endogenous Metabolite
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Cancer
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L-Octanoylcarnitine (Standard) is the analytical standard of L-Octanoylcarnitine. This product is intended for research and analytical applications. L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .
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-
- HY-135895
-
-
- HY-136338
-
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Cimetidine sulphoxide
|
Histamine Receptor
|
Inflammation/Immunology
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Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment .
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-
- HY-133676S
-
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Isotope-Labeled Compounds
Drug Metabolite
|
Others
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Mono(2-ethyl-5-oxohexyl) phthalate-d4 is a deuterium labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono(2-ethyl-5-oxohexyl) phthalate is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
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-
- HY-Y0669R
-
-
- HY-136578
-
-
- HY-136610
-
|
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Cholinesterase (ChE)
|
Neurological Disease
|
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Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function .
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-
- HY-15852
-
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Drug Metabolite
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Others
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THRX-195518 is the major metabolite of Revefenacin (HY-15851), a lung-selective and long-acting muscarinic antagonist. THRX-195518 can be utilized in research related to chronic obstructive pulmonary disease .
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- HY-P1141A
-
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GCGR
|
Metabolic Disease
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GLP-1(9-36)amide TFA is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor .
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-
- HY-100642R
-
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COMT
|
Neurological Disease
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3-O-Methyltolcapone (Standard) is the analytical standard of 3-O-Methyltolcapone. This product is intended for research and analytical applications. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease .
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- HY-Y0469
-
|
|
Drug Metabolite
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Others
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1-Aminohydantoin hydrochloride is a major metabolite of nitrofurantoin in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of AHD before detection .
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-
- HY-N10206
-
|
|
Endogenous Metabolite
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Cancer
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11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .
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-
- HY-149504
-
|
|
Drug Metabolite
mAChR
|
Neurological Disease
|
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3-Hydroxy darifenacin is a metabolite of Darifenacin (HY-A0033). 3-Hydroxy darifenacin is an antagonist of M1-5 muscarinic receptors with Kis values of 17.78, 79.43, 2.24, 36.31 and 6.17 nM, respectively in CHO cells .
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-
- HY-134039
-
|
5-Hydroxyxanthotoxin
|
Drug Metabolite
|
Inflammation/Immunology
|
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5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight .
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-
- HY-134243
-
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6-Thioguanosine 5'-diphosphate
|
Endogenous Metabolite
Ras
|
Inflammation/Immunology
|
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6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation .
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-
- HY-133677S
-
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MEHHP-d4
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
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Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4 (MEHHP-d4) is a deuterium labeled Mono(2-ethyl-5-hydroxyhexyl) phthalate (HY-133677). Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-hydroxyhexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking .
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-
- HY-133152
-
|
DM-3411
|
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
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Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM .
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-
- HY-N6735
-
|
OSI 2040
|
HDAC
Parasite
|
Infection
Cancer
|
|
Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research .
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- HY-160849
-
|
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GABA Receptor
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Others
Metabolic Disease
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|
N-desmethyl Rilmazolam, a triazolobenzodiazepine, serves as an analytical reference standard. N-desmethyl Rilmazolam is an active metabolite derived from rilmazafone (HY-106547). N-desmethyl Rilmazolam is designed for use in research and forensic settings .
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-
- HY-118793
-
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6-Hydroxyadenosine
|
Endogenous Metabolite
|
Others
|
|
Inosine oxime (6-Hydroxyadenosine) is an endogenous metabolite in the course of cell metabolism by cytochrome P450, by oxidative stress or by deviating nucleotide biosynthesis. Inosine oxime has toxic and mutagenic for procaryotic and eucaryotic cells .
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-
- HY-126775
-
|
|
Mitochondrial Metabolism
Endogenous Metabolite
|
Cancer
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Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .
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-
- HY-120607
-
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|
Parasite
|
Infection
Cancer
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|
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines .
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-
- HY-N2907R
-
|
|
Ras
Endogenous Metabolite
|
Cancer
|
|
Atranorin (Standard) is the analytical standard of Atranorin. This product is intended for research and analytical applications. Atranorin is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity .
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-
- HY-Y0694
-
|
Resacetophenone; 1-(2,4-Dihydroxyphenyl)ethanone
|
Endogenous Metabolite
COX
|
Cancer
|
|
2',4'-Dihydroxyacetophenone (Resacetophenone) is acetophenone carrying hydroxy substituents at positions 2' and 4'. 2',4'-Dihydroxyacetophenone involves in a practical CsHCO3-mediated alkylation that efficiently provide 4-alkylated products with excellent regioselectivity, good isolated yields and a broad substrate scope. 2',4'-Dihydroxyacetophenone is a plant metabolite .
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-
- HY-135867D
-
|
|
Endogenous Metabolite
Enterovirus
HCV
Topoisomerase
SARS-CoV
|
Infection
|
|
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .
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-
- HY-133787R
-
|
|
Drug Metabolite
|
Infection
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|
Levofloxacin N-oxide (Standard) is the analytical standard of Levofloxacin N-oxide. This product is intended for research and analytical applications. Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .
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-
- HY-109502S
-
|
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
10-OH-NBP-d4 is deuterium labeled 10-OH-NBP. 10-OH-NBP is a Butylphthalide (3-n-Butylphthalide; NBP; HY-B0647) hydroxylated metabolite and can penetrates the blood-brain barrier (BBB). Butylphthalide exerts neuroprotective effects and has potential for cerebral ischemia research[1].
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-
- HY-12798CR
-
|
AR-13324 M1 metabolite (Standard)
|
PKC
ROCK
|
Cardiovascular Disease
|
|
Fluanisone (Standard) is the analytical standard of Fluanisone. This product is intended for research and analytical applications. Fluanisone has potent sedative effect in vivo. Fluanisone can be used to study schizophrenia .
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-
- HY-W674241
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
4-Ethylphenyl sulfate is a gut microbial metabolite. 4-Ethylphenyl sulfate is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .
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-
- HY-W674241A
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
4-Ethylphenyl sulfate sodium is a gut microbial metabolite. 4-Ethylphenyl sulfate sodium is also a protein-bound uremic toxin, a xenobiotic substrate, and causes endothelial dysfunction .
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-
- HY-161795
-
|
|
Drug Metabolite
|
Cancer
|
|
SP3CHO is an active metabolite generated by the metabolism of SP3N in cell culture by the action of amine oxidase. SP3CHO can induce polyubiquitination of specific proteins by recruiting the SCFFBXO22 E3 ligase complex. SP3CHO can be used in cancer therapy research .
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-
- HY-15895S
-
|
ACT-132577 d4
|
Isotope-Labeled Compounds
Endothelin Receptor
|
Cardiovascular Disease
Endocrinology
|
|
Aprocitentan-d4 is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent .
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-
- HY-126989
-
|
|
Arp2/3 Complex
|
Cancer
|
|
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .
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-
- HY-119904R
-
|
|
Drug Metabolite
|
Infection
|
|
Malaoxon (Standard) is the analytical standard of Malaoxon. This product is intended for research and analytical applications. Malaoxon is a pesticide metabolite. Malaoxon can induce cellular death in cultured human pulmonary cells. Malaoxon can be used for the research of pulmonary toxicity .
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-
- HY-136611
-
|
|
Drug Metabolite
|
Infection
|
|
ω-Hydroxy-DEET is a major metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). ω-Hydroxy-DEET has anti-proliferative effects. DEET is a spatial repellent and an irritant that commonly used to prevent contact with mosquitoes .
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-
- HY-W040971R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Creosol (Standard) is the analytical standard of Creosol. This product is intended for research and analytical applications. Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass .
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-
- HY-142972
-
|
|
Prostaglandin Receptor
|
Cardiovascular Disease
|
|
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels .
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-
- HY-W099579
-
|
Kojic dipalmitate
|
Tyrosinase
|
Endocrinology
|
|
Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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- HY-135731
-
|
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .
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-
- HY-135731A
-
|
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .
|
-
- HY-W011297
-
|
Arachidonic acid methyl ester
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
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-
- HY-N2009
-
|
3,4-Dihydroxy-5-methoxybenzoic acid
|
Apoptosis
Caspase
|
Cancer
|
|
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) is an anthocyanin metabolite and has potent antioxidant capacity. 3-O-methylgallic acid inhibits Caco-2 cell proliferation with an IC50 value of 24.1 μM. 3-O-methylgallic acid also induces cell apoptosis and has anti-cancer effects .
|
-
- HY-148225
-
|
|
Drug Metabolite
|
Cancer
|
|
Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer .
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-
- HY-D0004R
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .
|
-
- HY-133116
-
|
|
Adrenergic Receptor
|
Neurological Disease
|
|
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively) .
|
-
- HY-W019721
-
|
|
Nuclear Factor of activated T Cells (NFAT)
|
Inflammation/Immunology
|
|
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .
|
-
- HY-113161S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
L-Octanoylcarnitine-d3 is the deuterium-labeled L-Octanoylcarnitine (HY-113161). L-Octanoylcarnitine-d3 is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine-d3 can be used for the research of breast cancer .
|
-
- HY-135774
-
|
|
Drug Metabolite
Phosphatase
|
Cardiovascular Disease
|
|
6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting .
|
-
- HY-113572
-
|
|
PI3K
|
Cancer
|
|
PX-866-17OH is the metabolite of PX-866 (Sonolisib, HY-N6775) and a pan-isoform inhibitor of PI3K with IC50s of 14, 57, 131, and 148 nM against PI3Kα, PI3Kβ, PI3Kɣ, and PI3Kδ, respectively .
|
-
- HY-W003445
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes .
|
-
- HY-B0228S10
-
|
(R)-(-)-3-Hydroxybutanoic acid-13C2 sodium; (R)-3-Hydroxybutyric acid-13C2 sodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
(R)-3-Hydroxybutanoic acid- 13C2 (sodium) is the 13C labeled (R)-3-Hydroxybutanoic acid (sodium) (HY-W015851). (R)-3-Hydroxybutanoic acid (sodium) is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2][3].
|
-
- HY-N12108
-
|
|
Phosphatase
|
Infection
Inflammation/Immunology
Cancer
|
|
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .
|
-
- HY-Y1097R
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Monomethyl phthalate (Standard) is the analytical standard of Monomethyl phthalate. This product is intended for research and analytical applications. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .
|
-
- HY-A0116R
-
|
|
Angiotensin-converting Enzyme (ACE)
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Trandolaprilate (Standard) is the analytical standard of Trandolaprilate. This product is intended for research and analytical applications. Trandolaprilate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity .
|
-
- HY-B1551R
-
|
|
Sodium Channel
|
Neurological Disease
|
|
Benzonatate (Standard) is the analytical standard of Benzonatate. This product is intended for research and analytical applications. Benzonatate (Benzononatine) is a peripheral oral antitussive that dampens the activity of cough stretch receptors. Benzonatate has sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite .
|
-
- HY-114950R
-
|
|
COX
|
Cardiovascular Disease
Inflammation/Immunology
|
|
EXP3179 (Standard) is the analytical standard of EXP3179. This product is intended for research and analytical applications. EXP3179 is an important intermediate aldehyde metabolite of Losartan. EXP3179 has no AT1-R–blocking activity, but potently inhibits the expression of endothelial cyclooxygenase (COX)-2. EXP3179 exerts potent anti-inflammatory actions .
|
-
- HY-Z0056S
-
|
pentadeuterobromobenzene
|
Cytochrome P450
|
Endocrinology
|
|
Bromobenzene-d5 is the deuterium labeled Bromobenzene. Bromobenzene is a well-known environmental toxin which causes liver and kidney damage through CYP450-mediated bio-activation to generate reactive metabolites and, consequently, oxidative stress[1].
|
-
- HY-107096
-
|
TP3076
|
Topoisomerase
|
Cancer
|
|
CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein) .
|
-
- HY-135615AR
-
|
|
Serotonin Transporter
|
Neurological Disease
Metabolic Disease
|
|
Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant .
|
-
- HY-100973A
-
|
ADP ribose sodium
|
TRP Channel
Autophagy
|
Metabolic Disease
Endocrinology
Cancer
|
|
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD +) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca 2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy .
|
-
- HY-W587960
-
|
Histidine-betaine
|
Drug Metabolite
Drug Intermediate
|
Metabolic Disease
|
|
Hercynine (Histidine-betaine) is an intermediate (precursor) and a redox metabolite of Ergothioneine (HY-N1914), which is found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees. Hercynine has no effect on scavenging •OH radicals .
|
-
- HY-N8060
-
|
Orotidine monophosphate; Orotidylic acid
|
Endogenous Metabolite
|
Others
|
|
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of?uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase .
|
-
- HY-137397
-
|
8-OH-EFV
|
Apoptosis
JNK
|
Cancer
|
|
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer . 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-128554AR
-
|
|
Parasite
|
Infection
|
|
N-Desethyl amodiaquine dihydrochloride (Standard) is the analytical standard of N-Desethyl amodiaquine dihydrochloride. This product is intended for research and analytical applications. N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria .
|
-
- HY-135331
-
|
|
Androgen Receptor
Cytochrome P450
|
Cancer
|
|
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
|
-
- HY-137941
-
|
|
Histamine Receptor
Caspase
NF-κB
p38 MAPK
|
Inflammation/Immunology
|
|
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers .
|
-
- HY-137941R
-
|
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Roxatidine (Standard) is the analytical standard of Roxatidine. This product is intended for research and analytical applications. Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect .
|
-
- HY-126304
-
|
|
Phosphatase
Endogenous Metabolite
ERK
|
Metabolic Disease
|
|
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .
|
-
- HY-100642S
-
|
Ro 40-7591 d7
|
COMT
|
Neurological Disease
|
|
3-O-Methyltolcapone-d7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
|
-
- HY-124542
-
|
|
Drug Metabolite
Apoptosis
|
Cancer
|
|
5-Hydroxydiclofenac is a major metabolite of Diclofenac (HY-15036). 5-Hydroxydiclofenac is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C189, CYP2C19, and CYP2C8. 5-Hydroxydiclofenac shows apoptotic effects in hepatocytes .
|
-
- HY-107096B
-
|
TP3076 TFA
|
Topoisomerase
|
Cancer
|
|
CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein) .
|
-
- HY-W002112R
-
|
|
Endogenous Metabolite
Drug Metabolite
|
Neurological Disease
|
|
(±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine. This product is intended for research and analytical applications. (±)-Nornicotine is the primary metabolite of nicotine that is formed through demethylation of nicotine in the genus Nicotiana tabacum L. (±)-Nornicotine is a precursor of tobacco-specific nitrosamine N-nitrosonornicotine. (±)-Nornicotine has detrimental effects to human health .
|
-
- HY-118614R
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
β-Nicotyrine (Standard) is the analytical standard of β-Nicotyrine. This product is intended for research and analytical applications. β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .
|
-
- HY-119500
-
|
|
HIV
Bacterial
|
Infection
Inflammation/Immunology
Cancer
|
|
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus . Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects .
|
-
- HY-113116
-
|
D-erythro-Dihydrosphingosine 1-phosphate
|
Endogenous Metabolite
|
Inflammation/Immunology
Cancer
|
|
Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes .
|
-
- HY-Y0469R
-
|
|
Drug Metabolite
|
Others
|
|
1-Aminohydantoin (hydrochloride) (Standard) is the analytical standard of 1-Aminohydantoin (hydrochloride). This product is intended for research and analytical applications. 1-Aminohydantoin hydrochloride is a major metabolite of nitrofurantoin in animal tissues and can be used as a standard for the determination of residues of veterinary agents in meat, milk et.al. 1-Aminohydantoin hydrochloride covalently binds to tissue proteins and is released from the tissues under slightly acidic conditions and derivatized with 2-nitrobenzaldehyde to form nitrophenyl derivatives of AHD before detection .
|
-
- HY-126167
-
|
|
Fungal
Phosphodiesterase (PDE)
|
Infection
|
|
Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM) .
|
-
- HY-124124
-
|
|
Endogenous Metabolite
Drug Metabolite
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway. N-Methylnicotinamide is a potential biomarker in miR-1291-altered pancreatic cell metabolism and tumorigenesis .
|
-
- HY-19827
-
|
(+)-Aeroplysinin-1
|
Bacterial
HIV
Apoptosis
|
Infection
Cancer
|
|
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .
|
-
- HY-D0886
-
|
|
Phosphatase
Endogenous Metabolite
ERK
|
Metabolic Disease
Cancer
|
|
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .
|
-
- HY-138542
-
|
|
Integrin
|
Inflammation/Immunology
|
|
RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity .
|
-
- HY-15899
-
|
|
HIV Protease
HIV
Drug Metabolite
|
Infection
|
|
Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective HIV-1 protease inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects .
|
-
- HY-132588
-
|
ALN-G01
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
|
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) .
|
-
- HY-109545
-
|
Unoprostone isopropyl ester; UF-021
|
Potassium Channel
|
Others
|
|
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca 2+-activated K + (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity .
|
-
- HY-Y1097S
-
|
2-(Methoxycarbonyl)benzoic acid-d4
|
Isotope-Labeled Compounds
|
Cancer
|
|
Monomethyl phthalate-d4 (2-(Methoxycarbonyl)benzoic acid-d4) is the deuterium labeled Monomethyl phthalate. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .
|
-
- HY-131606
-
|
|
HSV
CMV
|
Infection
|
|
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .
|
-
- HY-113483
-
|
20-COOH LTB4
|
Drug Metabolite
Leukotriene Receptor
|
Metabolic Disease
|
|
20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608). 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis) .
|
-
- HY-W424779R
-
|
|
Drug Metabolite
|
Infection
|
|
5-Carboxy-2′-deoxyuridine (Standard) is the analytical standard of 5-Carboxy-2′-deoxyuridine. This product is intended for research and analytical applications. 5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine . 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine .
|
-
- HY-136338R
-
|
|
Histamine Receptor
|
Inflammation/Immunology
|
|
Cimetidine sulfoxide (Standard) is the analytical standard of Cimetidine sulfoxide. This product is intended for research and analytical applications. Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment .
|
-
- HY-113224
-
-
- HY-A0019
-
|
9-Hydroxyrisperidone
|
Drug Metabolite
Dopamine Receptor
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .
|
-
- HY-139576
-
|
DUR-928
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Larsucosterol (DUR-928), a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol as a potent endogenous regulator decreases lipogenesis. Larsucosterol inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .
|
-
- HY-139576A
-
|
DUR-928 sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol sodium as a potent endogenous regulator decreases lipogenesis. Larsucosterol sodium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .
|
-
- HY-135867
-
|
|
Endogenous Metabolite
Enterovirus
HCV
Topoisomerase
SARS-CoV
|
Infection
|
|
NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
|
-
- HY-163113
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .
|
-
- HY-N2406
-
|
3,4-Dihydroxy-benzenepropanoic acid
|
p38 MAPK
Endogenous Metabolite
Reactive Oxygen Species
NO Synthase
|
Inflammation/Immunology
|
|
Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .
|
-
- HY-129099
-
|
|
PKC
Estrogen Receptor/ERR
Drug Metabolite
Endogenous Metabolite
|
Cancer
|
|
N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
|
-
- HY-129099A
-
|
|
PKC
Estrogen Receptor/ERR
Drug Metabolite
Endogenous Metabolite
|
Cancer
|
|
N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation .
|
-
- HY-W654264
-
|
|
Endogenous Metabolite
Integrin
|
Cardiovascular Disease
|
|
2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .
|
-
- HY-148642
-
|
12-hydroxy-NVP; 12-OH-NVP
|
Drug Metabolite
|
Infection
|
|
12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine .
|
-
- HY-76569
-
|
PNU-200577; 5-Hydroxymethyl Tolterodine
|
mAChR
|
Neurological Disease
Cancer
|
|
Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .
|
-
- HY-W099579R
-
|
|
Tyrosinase
|
Endocrinology
|
|
Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
|
-
- HY-129993
-
-
- HY-17366
-
|
|
mAChR
Dopamine Receptor
Drug Metabolite
|
Neurological Disease
|
|
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
|
-
- HY-W778340
-
|
|
Drug Metabolite
Glucocorticoid Receptor
|
Inflammation/Immunology
Cancer
|
|
16α-Hydroxy-11-keto prednisolone (compound M-X) is a metabolite of Budesonide (HY-13580). Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide is a widely used for study of asthma, rhinitis, and inflammatory bowel disease .
|
-
- HY-110159
-
|
(E/Z)-A77 1726
|
Dihydroorotate Dehydrogenase
|
Infection
Inflammation/Immunology
|
|
(E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of
Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA) .
|
-
- HY-131479A
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Threo-dihydrobupropion is a major metabolite of Bupropion, formed via oxidation and reduction exhibit pharmacological activity. Bupropion, a dual dopamine-norepinephrine uptake inhibitor and a nicotine receptor antagonist, is widely used in the management of depression and as a smoking cessation aid .
|
-
- HY-B0652
-
-
- HY-135867F
-
|
|
Endogenous Metabolite
Enterovirus
HCV
Topoisomerase
SARS-CoV
|
Infection
|
|
NHC-diphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC-diphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
|
-
- HY-131606B
-
|
|
Drug Metabolite
|
Infection
|
|
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .
|
-
- HY-139576B
-
|
DUR-928 (trimethylamine)
|
LXR
Endogenous Metabolite
|
Metabolic Disease
|
|
Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .
|
-
- HY-135867E
-
|
|
Endogenous Metabolite
Enterovirus
HCV
Topoisomerase
SARS-CoV
|
Infection
|
|
NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetraammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
|
-
- HY-135867A
-
|
|
Endogenous Metabolite
Enterovirus
HCV
Topoisomerase
|
Infection
|
|
NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetrasodium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
|
-
- HY-136239
-
|
Beclomethasone-17-monopropionate; 17-BMP
|
Glucocorticoid Receptor
Drug Metabolite
|
Inflammation/Immunology
|
|
Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages .
|
-
- HY-W019721R
-
|
|
Nuclear Factor of activated T Cells (NFAT)
|
Inflammation/Immunology
|
|
Cyclosporin D (Standard) is the analytical standard of Cyclosporin D. This product is intended for research and analytical applications. Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A . Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc) .
|
-
- HY-N7378A
-
|
1-Hydroxy-2-piperidinecarboxylic acid potassium; NHP potassium
|
Bacterial
|
Inflammation/Immunology
|
|
N-Hydroxypipecolic acid potassium (1-Hydroxy-2-piperidinecarboxylic acid potassium), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid potassium accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid potassium induces SAR to bacterial and oomycete infection .
|
-
- HY-W009300
-
|
4-OHE1
|
Endogenous Metabolite
|
Neurological Disease
|
|
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .
|
-
- HY-N7378
-
|
1-Hydroxy-2-piperidinecarboxylic acid; NHP
|
Bacterial
|
Inflammation/Immunology
|
|
N-Hydroxypipecolic acid (1-Hydroxy-2-piperidinecarboxylic acid), a plant metabolite and a systemic acquired resistance (SAR) regulator, orchestrates SAR establishment in concert with the immune signal salicylic acid. N-Hydroxypipecolic acid accumulates systemically in the plant foliage in response to pathogen attack. N-Hydroxypipecolic acid induces SAR to bacterial and oomycete infection .
|
-
- HY-131543
-
|
RU 42698
|
Endogenous Metabolite
Glucocorticoid Receptor
|
Metabolic Disease
|
|
22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48% .
|
-
- HY-135581
-
|
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
|
-
- HY-135731AR
-
|
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine (hydrochloride) (Standard) is the analytical standard of 4-Methylamino antipyrine (hydrochloride). This product is intended for research and analytical applications. 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .
|
-
- HY-135731R
-
|
|
COX
Drug Metabolite
|
Inflammation/Immunology
|
|
4-Methylamino antipyrine (Standard) is the analytical standard of 4-Methylamino antipyrine. This product is intended for research and analytical applications. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .
|
-
- HY-135582
-
|
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
|
-
- HY-137546S
-
-
- HY-W754151
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
N-Desmethyl apalutamide-d4 is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration .
|
-
- HY-113377
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2 .
|
-
- HY-113377A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2 .
|
-
- HY-135897
-
-
- HY-125348
-
|
|
Drug Metabolite
|
Cancer
|
|
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .
|
-
- HY-135594
-
|
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
4'-Raloxifene-β-D-glucopyranoside, a metabolite of Raloxifene, is a benzothiophene glucuronidated at the 4' postion. 4'-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 4'-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 4'-Raloxifene-β-D-glucopyranoside, example 5, is extracted from patent US5567820A .
|
-
- HY-147336
-
|
|
Drug Metabolite
|
Infection
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Desmethylazelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. Azelastine is an orally active, selective and high-affinity histamine H1-receptor antagonist. Azelastine can be used in studies of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2 .
|
-
- HY-135334
-
|
|
Drug Metabolite
Btk
Cytochrome P450
|
Cancer
|
|
ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM .
|
-
- HY-17366A
-
|
|
mAChR
Dopamine Receptor
Drug Metabolite
|
Neurological Disease
|
|
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
|
-
- HY-A0019R
-
|
|
Drug Metabolite
Dopamine Receptor
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .
|
-
- HY-116364
-
|
3'-Azido-3'-deoxythymidine-5'-triphosphate
|
HIV
DNA/RNA Synthesis
HBV
Reactive Oxygen Species
Apoptosis
|
Infection
|
|
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway .
|
-
- HY-N6979
-
|
20-Hydroxyecdysone
|
Caspase
Autophagy
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .
|
-
- HY-A0132
-
|
N-Acetyl-2-amino-2-deoxy-D-glucose
|
Endogenous Metabolite
Drug Derivative
Drug Isomer
Interleukin Related
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .
|
-
- HY-133152S
-
|
DM-3411 d8
|
Isotope-Labeled Compounds
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Brexpiprazole S-oxide-d8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].
|
-
- HY-76569R
-
|
|
mAChR
|
Neurological Disease
|
|
Desfesoterodine (Standard) is the analytical standard of Desfesoterodine. This product is intended for research and analytical applications. Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .
|
-
- HY-136576
-
|
|
LPL Receptor
Drug Metabolite
|
Inflammation/Immunology
|
|
RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile .
|
-
- HY-76569S1
-
|
PNU-200577-d14; 5-Hydroxymethyl Tolterodine-d14
|
mAChR
Isotope-Labeled Compounds
|
Neurological Disease
|
|
(R)-Hydroxytolterodine-d14 is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a KB and a pA2 of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .
|
-
- HY-W040705
-
|
N-Methylanthranilic acid
|
Drug Metabolite
|
Others
|
|
2-(Methylamino)benzoic acid is the main metabolite of methyl-N-methylanthranilates (MMA) (HY-76705) and is the compound in which the ester group is converted. MMA can be isolated from citrus fruits and has potential analgesic activity. 2-(Methylamino)benzoic acid was used to detect the metabolic levels of MMA in rat liver .
|
-
- HY-12769S1
-
-
- HY-125919
-
-
- HY-116364A
-
|
3'-Azido-3'-deoxythymidine-5'-triphosphate TEA
|
HIV
DNA/RNA Synthesis
HBV
Reactive Oxygen Species
Apoptosis
|
Infection
|
|
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated apoptosis pathway .
|
-
- HY-116364B
-
|
3'-Azido-3'-deoxythymidine-5'-triphosphate tetraammonium
|
HIV
DNA/RNA Synthesis
HBV
Reactive Oxygen Species
Apoptosis
|
Infection
|
|
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway .
|
-
- HY-N1029
-
|
Mangiferitin
|
Glycosidase
PPAR
|
Infection
Inflammation/Immunology
Cancer
|
|
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM . Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively . Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
|
-
- HY-N0771
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
|
-
- HY-B0652R
-
|
|
Drug Metabolite
Estrogen Receptor/ERR
Progesterone Receptor
Endogenous Metabolite
FKBP
|
Endocrinology
|
|
Etonogestrel (Standard) is the analytical standard of Etonogestrel. This product is intended for research and analytical applications. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .
|
-
- HY-146190
-
|
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Callophycin A, a red seaweed derived metabolite, possessing potent activity against Candida albicans with MIC of 62.5~250 mg/L. Callophycin A significantly reduces fungal burden of vaginal candidiasis induced mice, also decreases inflammatory response and immune molecules .
|
-
- HY-111271
-
|
|
Prostaglandin Receptor
|
Inflammation/Immunology
Endocrinology
|
|
L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite .
|
-
- HY-135582S
-
|
|
Estrogen Receptor/ERR
Isotope-Labeled Compounds
|
Endocrinology
|
|
Raloxifene 4'-glucuronide-d4 is deuterated labeled Raloxifene 4'-glucuronide (HY-135582). Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. . Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .
|
-
- HY-41982
-
|
D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone
|
Endogenous Metabolite
Drug Derivative
|
Cardiovascular Disease
Metabolic Disease
|
|
D-Glucuronic acid lactone (D-Glucurono-6,3-lactone) is an endogenous metabolite, which is a glucuronic acid derivative. D-Glucuronic acid lactone can be used as starting regents in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, requirement for the preparation of 1-O-acyl glucuronide of the anti-inflammatory agent ML-3000 (HY-B1452), synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides. D-Glucuronic acid lactone is promising for research of reversible cerebral vasoconstriction syndrome (RCVS) .
|
-
- HY-109854A
-
|
(R)-Lisophylline
|
STAT
|
Metabolic Disease
Inflammation/Immunology
|
|
(R)-Lisofylline ((R)-Lisophylline) is a (R)-enantiomer of the metabolite of Pentoxifylline with anti-inflammatory properties. (R)-Lisofylline is a lysophosphatidic acid acyltransferase inhibitor with an IC50 of 0.6 µM and interrupts IL-12 signaling-mediated STAT4 activation. (R)-Lisofylline has the potential for type 1 diabetes, autoimmune disorders research .
|
-
- HY-N6979R
-
|
|
Caspase
Autophagy
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .
|
-
- HY-129933
-
-
- HY-116084
-
-
- HY-N6807
-
|
|
Stearoyl-CoA Desaturase (SCD)
Influenza Virus
Bacterial
|
Infection
Cancer
|
|
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .
|
-
- HY-G0006
-
|
Ufiprazole
|
Drug Metabolite
|
Others
|
|
Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole.
|
-
- HY-147333
-
|
|
Drug Metabolite
|
Neurological Disease
|
|
Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety .
|
-
- HY-N0771R
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
|
-
- HY-P2124R
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .
|
-
- HY-108915
-
-
- HY-B1746
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of pyridoxal 5'-phosphate hydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .
|
-
- HY-N6798
-
|
Thermozymocidin; ISP-I
|
HCV
Antibiotic
|
Infection
|
|
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection .
|
-
- HY-120733
-
|
FKI-4905
|
Bacterial
Endogenous Metabolite
|
Infection
Inflammation/Immunology
|
|
Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .
|
-
- HY-148002
-
|
|
Drug Metabolite
|
Others
|
|
1'-Hydroxy Midazolam-β-D-glucuronide is a β-D-glucuronide that acts as a drug metabolite, human urine metabolite, and human serum metabolite .
|
-
- HY-G0007S
-
|
Omeprazole sulfone-d3; Omeprazole sulphone-d3
|
Isotope-Labeled Compounds
Drug Metabolite
|
Infection
Cancer
|
|
Omeprazole metabolite Omeprazole sulfone-d3 is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
|
-
- HY-119983
-
|
DBC
|
Cytochrome P450
|
Cancer
|
|
7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .
|
-
![7H-Dibenzo[c,g]carbazole](//file.medchemexpress.com/product_pic/hy-119983.gif)
- HY-N2353S1
-
-
- HY-113246
-
|
15-keto-PGF2α
|
Prostaglandin Receptor
Endogenous Metabolite
|
Endocrinology
|
|
15-keto-Prostaglandin F2α (15-keto-PGF2α) is a metabolite of Prostaglandin F2α. Prostaglandin F2α. Prostaglandin F2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .
|
-
- HY-108263B
-
|
(R)-CGP52421
|
FLT3
Drug Metabolite
|
Cancer
|
|
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
|
-
- HY-77956S3
-
-
- HY-N2353S2
-
-
- HY-77956S4
-
-
- HY-77956S
-
-
- HY-I0903
-
|
|
Fungal
|
Others
|
|
SCH 51048 is a compound that can produce active metabolites, and its active metabolites have antifungal activity. Through metabolic studies and activity screening of the compound, metabolites and compounds with better activity were discovered.
|
-
- HY-135386
-
-
- HY-W740165
-
|
|
Antibiotic
Drug Metabolite
|
Infection
|
|
Desmethyl Levofloxacin hydrochloride is an antibacterial agent with broad-spectrum antibacterial activity against a variety of pathogens. Desmethyl Levofloxacin hydrochloride effectively fights bacterial infections by inhibiting bacterial DNA synthesis. Studies on Desmethyl Levofloxacin hydrochloride have shown that it has potential in inhibiting respiratory infections .
|
-
- HY-W046349
-
-
- HY-W015466S
-
-
- HY-128753S6
-
-
- HY-W019151S
-
-
- HY-111271B
-
|
|
Prostaglandin Receptor
Drug Isomer
|
Inflammation/Immunology
Endocrinology
|
|
(R)-L 888607 is the isomer of L 888607 (HY-111271), and can be used as an experimental control. L 888607 is a potent, selective, stable and orally active CRTH2 agonist. L 888607 has high affinity for the human CRTH2 receptor with a Ki value of 4 nM. L 888607 can be used for the research of several physiological events and metabolite .
|
-
- HY-N0179
-
|
α-Ecdysone
|
Endogenous Metabolite
Apoptosis
|
Metabolic Disease
|
|
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .
|
-
- HY-W011235
-
|
|
5-HT Receptor
Calcium Channel
Drug Metabolite
|
Cardiovascular Disease
Neurological Disease
|
|
Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity .
|
-
- HY-N2353S
-
|
(±)-Arabinose-1-13C; DL-Arabinose-1-13C
|
Endogenous Metabolite
|
Others
|
|
Arabinose-1- 13C is the 13C labeled Arabinose. Arabinose is an endogenous metabolite[1].
|
-
- HY-W013627S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
trans,trans-2,4-Decadienal-d4 is deuterated labeled Elemicin (HY-N6807). Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .
|
-
- HY-77956S1
-
|
Deoxyribose-13C-1
|
Endogenous Metabolite
|
Others
|
|
Thyminose- 13C-1 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-77956S2
-
|
Deoxyribose-13C-2
|
Endogenous Metabolite
|
Others
|
|
Thyminose- 13C-2 is the 13C labeled Thyminose. Thyminose is an endogenous metabolite[1].
|
-
- HY-128741S
-
-
- HY-N0059S4
-
-
- HY-128753S7
-
-
- HY-N0059S
-
-
- HY-N0059S6
-
-
- HY-N0059S5
-
-
- HY-N2325S
-
-
- HY-110252
-
|
|
Endogenous Metabolite
|
Others
|
|
Salvinorin B is the metabolite produced by Salvia divinorum. Salvinorin B is also the main metabolite of Salvinorin A in rhesus monkey blood .
|
-
- HY-N11562
-
|
|
Others
|
Others
|
|
Aristololactam II, a metabolite of Aristolochic acid II (AAII), is an excretion product found in the urine, which is considered to be detoxification metabolite of AAII .
|
-
- HY-164746
-
|
|
Drug Metabolite
|
Metabolic Disease
|
|
4′-Hydroxy Nitazene is the universal metabolite of the nitazene analogs. 4′-Hydroxy Nitazene is a metabolite of isotonitazene .
|
-
- HY-D0185S1
-
-
- HY-12765
-
|
E-3174; EXP-3174
|
Drug Metabolite
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .
|
-
- HY-108263A
-
|
(S)-CGP52421
|
FLT3
Drug Metabolite
|
Cancer
|
|
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
|
-
- HY-109591S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Oleoyl coenzyme A- 13C18 (lithium) is the 13C labeled Oleoyl Coenzyme A lithium[1]. Oleoyl coenzyme A (Oleoyl-CoA) is a thioester of oleic acid and coenzyme A. Oleoyl coenzyme A has a role as an Escherichia coli metabolite and a mouse metabolite[2][3].
|
-
- HY-100635R
-
|
|
Drug Metabolite
|
Cardiovascular Disease
Endocrinology
|
|
Oleic acid (Standard) is the analytical standard of Oleic acid. This product is intended for research and analytical applications. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na+/K+ ATPase activator .
|
-
- HY-128753S3
-
-
- HY-128741S2
-
-
- HY-128753S5
-
-
- HY-N0059S1
-
-
- HY-128741S1
-
-
- HY-108549
-
|
Omuralide; β-Clastolactacystin
|
Proteasome
|
Cancer
|
|
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
|
-
- HY-N0059S2
-
-
- HY-D0185S
-
-
- HY-N0059S3
-
-
- HY-128753S4
-
-
- HY-33212S
-
-
- HY-12771S2
-
-
- HY-G0006R
-
|
|
Drug Metabolite
|
Others
|
|
Omeprazole sulfide (Standard) is the analytical standard of Omeprazole sulfide. This product is intended for research and analytical applications. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole.
|
-
- HY-W015466
-
-
- HY-126358
-
-
- HY-W018059
-
-
- HY-W017370
-
-
- HY-W014410
-
-
- HY-W016812
-
-
- HY-113295
-
-
- HY-N2501
-
-
- HY-128421
-
-
- HY-125909
-
-
- HY-Y1366
-
-
- HY-N2353
-
-
- HY-W010435
-
-
- HY-126357
-
-
- HY-N1423B
-
-
- HY-N2424
-
-
- HY-Y1009
-
-
- HY-125671
-
-
- HY-Y1173
-
|
Sodium 1-hydroxy-2-ethanesulfonate; Sodium 2-hydroxy-1-ethanesulfonate; Sodium 2-hydroxyethanesulfonate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Isethionic acid sodium salt is an endogenous metabolite.
|
-
- HY-128734
-
-
- HY-113373
-
-
- HY-W019151
-
-
- HY-128393
-
-
- HY-W018653
-
-
- HY-128740
-
-
- HY-128739
-
-
- HY-128733
-
-
- HY-W027555
-
-
- HY-W017158
-
-
- HY-W067716
-
-
- HY-W010396
-
-
- HY-W017469
-
-
- HY-Y0519
-
-
- HY-W012595
-
-
- HY-Y0267
-
-
- HY-113219
-
-
- HY-157129
-
|
|
AMPK
|
Cardiovascular Disease
|
|
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC50 value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .
|
-
- HY-113289
-
|
|
Akt
Androgen Receptor
Bacterial
Drug Metabolite
HSV
|
Infection
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Brassicasterol is a metabolite of Ergosterol and has cardiovascular protective effects. Brassicasterol exerts anticancer effects in prostate cancer through dual targeting of AKT and androgen receptor signaling pathways. Brassicasterol inhibits HSV-1 (IC50=1.2 μM) and Mycobacterium tuberculosis. Brassicasterol also inhibits sterol δ 24-reductase, slowing the progression of atherosclerosis. Brassicasterol is also a cerebrospinal fluid biomarker for Alzheimer's disease .
|
-
- HY-172080
-
-
- HY-141776S
-
|
Ufiprazole-d3
|
Drug Metabolite
|
Others
|
|
Omeprazole sulfide-d3 is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
|
-
- HY-G0007S1
-
-
- HY-W739812
-
|
Finasteride carboxylic acid
|
Aldose Reductase
|
Cancer
|
|
Carboxy finasteride is a metabolite of the 5α-reductase inhibitor Finasteride (HY-13635). Finasteride is biotransformed by cytochrome P450 (CYP3A4) and is successively oxidized to Hydroxy finasteride and Carboxy finasteride. Carboxy finasteride is the major metabolite in urine, while Hydroxy finasteride is the major metabolite in plasma .
|
-
- HY-128417S1
-
-
- HY-137391
-
|
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
2-Bromoestradiol is a estrogen 2-hydroxylase inhibitor. 2-Bromoestradiol decreases irreversible binding of radiolabeled estradiol metabolite(s) to microsomal proteins .
|
-
- HY-W053787S
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
1-Methylhistamine-d3 (dihydrochloride) is the deuterium labeled 1-Methylhistamine (dihydrochloride)[1]. 1-Methylhistamine dihydrochloride is a histamine metabolite[2].
|
-
- HY-W006449
-
|
|
Bacterial
Antibiotic
|
Others
|
|
PNU-105368 is a compound with antibacterial activity and a metabolite of linezolid. It exists mainly in the form of the original form and two metabolites in the human body and is excreted through the kidneys and feces.
|
-
- HY-W060470
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
1-Methyl-4-imidazoleacetic acid hydrochloride is a stable metabolite of Histamine (HY-B1204) that is produced by the oxidation of the primary metabolite, N-methylhistamine .
|
-
- HY-128741
-
-
- HY-Y0488A
-
-
- HY-W040430
-
-
- HY-112540A
-
-
- HY-B1777A
-
-
- HY-W009516
-
-
- HY-Y0057
-
-
- HY-B1827
-
-
- HY-78446
-
-
- HY-125910
-
-
- HY-W007346
-
-
- HY-N0059
-
-
- HY-Y1177
-
-
- HY-129319
-
-
- HY-128753
-
-
- HY-30215
-
-
- HY-128745
-
-
- HY-128735
-
-
- HY-B1476
-
-
- HY-114557
-
-
- HY-W015213
-
-
- HY-W017613
-
-
- HY-N6612A
-
-
- HY-136832
-
-
- HY-113369
-
-
- HY-D0885D
-
-
- HY-170703
-
-
- HY-W013826
-
-
- HY-WAA0142
-
-
- HY-135032
-
-
- HY-W007704
-
-
- HY-W015342
-
-
- HY-126354
-
-
- HY-113093
-
-
- HY-W012480
-
-
- HY-Y1644
-
-
- HY-131314
-
|
|
Drug Metabolite
|
Others
|
|
Ibuprofen carboxylic acid is the metabolite of Ibuprofen (HY-78131), that has high concentrations in wastewater and water environments, and disappears fast during biodegradation, compared to the other ibuprofen metabolite .
|
-
- HY-D0272
-
|
|
Estrogen Receptor/ERR
|
Metabolic Disease
|
|
2,3,4-Trihydroxybenzophenone is a hydroxylated benzophenone UV filter with estrogenic activity. 2,3,4-Trihydroxybenzophenone is also a redox mediator, which has a role as a quorum sensing inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, a human urinary metabolite, a rat metabolite and a drug metabolite .
|
-
- HY-12765R
-
|
|
Drug Metabolite
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure [4].
|
-
- HY-W015883S4
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Fumaric acid-d4 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
|
-
- HY-W015883S3
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
|
-
- HY-W004078
-
-
- HY-Y0136
-
-
- HY-Y0442
-
-
- HY-W012657
-
-
- HY-137306
-
-
- HY-W002065
-
-
- HY-W011393
-
-
- HY-150333
-
-
- HY-W017194
-
-
- HY-W010549
-
-
- HY-101416
-
-
- HY-Y1809
-
-
- HY-W005028
-
-
- HY-W040040
-
-
- HY-75954
-
-
- HY-109569
-
-
- HY-33212
-
-
- HY-W001996
-
-
- HY-W011727
-
-
- HY-W017077
-
-
- HY-W015924
-
-
- HY-W004049
-
-
- HY-116132
-
-
- HY-Y0191
-
-
- HY-135204
-
-
- HY-Y1819
-
-
- HY-W004066
-
-
- HY-W040088
-
-
- HY-Y0289
-
-
- HY-128743
-
-
- HY-W012941
-
-
- HY-W016647
-
-
- HY-21075
-
-
- HY-W040948
-
-
- HY-W015302
-
-
- HY-W012658
-
-
- HY-W038287
-
-
- HY-W012790
-
-
- HY-W018197
-
-
- HY-B1673
-
-
- HY-W001083
-
-
- HY-W014796
-
-
- HY-W042193
-
-
- HY-Y1297
-
-
- HY-W011249
-
-
- HY-W012340
-
-
- HY-W747583
-
-
- HY-117713
-
-
- HY-169793
-
-
- HY-Y0624
-
-
- HY-101409A
-
-
- HY-101406
-
-
- HY-150339
-
-
- HY-W014225
-
-
- HY-138223
-
|
|
Fungal
|
Infection
|
|
6-Prenylindole is an antifungal agent that can be isolated from Streptomyces .
|
-
- HY-116787
-
|
5-OHTBZ
|
Drug Metabolite
|
Others
|
|
5-Hydroxythiabendazole (5-OHTBZ) is a biomarker of Thiabendazole (HY-B0263) exposure .
|
-
- HY-116787R
-
|
|
Drug Metabolite
|
Others
|
|
5-Hydroxythiabendazole (Standard) is the analytical standard of 5-Hydroxythiabendazole. This product is intended for research and analytical applications. 5-Hydroxythiabendazole (5-OHTBZ) is a biomarker of Thiabendazole (HY-B0263) exposure .
|
-
- HY-N12843
-
|
Nardosinone acid
|
Drug Metabolite
|
Others
|
|
2-Deoxokanshone M (Nardosinone acid) is a degradation product of Nardosinone (HY-N0380) and has potent vasodilatory activity .
|
-
- HY-133010R
-
|
|
Drug Metabolite
|
Cancer
|
|
Cyclanilide (Standard) is the analytical standard of Cyclanilide. This product is intended for research and analytical applications. Cyclanilide (RPA90946) serves as a plant growth regulator that is applied to cotton during various growth stages.
|
-
- HY-N12842
-
-
- HY-W010476S
-
-
- HY-N7080
-
|
Hydroferulic acid
|
Others
|
Metabolic Disease
|
|
Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid .
|
-
- HY-169449
-
-
- HY-B1342
-
-
- HY-W019704
-
-
- HY-Y1667
-
-
- HY-W006371
-
-
- HY-W015823
-
-
- HY-N0894
-
|
Hexahydrobisdemethoxycurcumin
|
Reactive Oxygen Species
|
Others
|
|
Octahydrocurcumin is a hydrogenated derivative of curcumin and a metabolite of curcumin.
|
-
- HY-W016480
-
-
- HY-116831
-
-
- HY-113353
-
-
- HY-119640
-
-
- HY-W004874
-
-
- HY-W007828
-
-
- HY-114547
-
-
- HY-112537B
-
-
- HY-W062542
-
-
- HY-101403A
-
-
- HY-W049735
-
-
- HY-W011982
-
-
- HY-W018501
-
-
- HY-128749
-
-
- HY-W013674
-
-
- HY-34439
-
-
- HY-W009338
-
-
- HY-W059917
-
-
- HY-W015618
-
-
- HY-113210
-
-
- HY-Y0106
-
-
- HY-B1180
-
-
- HY-W019358
-
-
- HY-76228
-
-
- HY-W034065
-
-
- HY-W053787
-
-
- HY-W007347
-
-
- HY-W007539
-
-
- HY-113474
-
-
- HY-W779002
-
|
|
Isotope-Labeled Compounds
|
|
|
alpha-D-glucose-13C2-1 is a 13C labeled alpha-D-glucose. alpha-D-glucose is an endogenous metabolite[1].
|
-
- HY-32343
-
|
(24R)-24,25-Dihydroxyvitamin D3
|
Endogenous Metabolite
VD/VDR
|
Metabolic Disease
Inflammation/Immunology
|
|
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC50 value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .
|
-
- HY-168756
-
|
|
Fungal
|
Infection
|
|
Byssochlamic acid is a secondary metabolite produced by fungal metabolism .
|
-
- HY-124245
-
-
- HY-W010973
-
-
- HY-113239
-
-
- HY-W008270
-
-
- HY-W019670
-
-
- HY-126169
-
-
- HY-113268
-
-
- HY-W050026
-
|
NSC 203800; Phenylacetyl-L-glutamine
|
Endogenous Metabolite
|
Others
|
|
Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.
|
-
- HY-118840
-
-
- HY-W004360
-
-
- HY-N10235
-
-
- HY-W103882
-
|
Modafinil acid
|
Drug Metabolite
|
Others
|
|
2-Benzhydrylsulfinylacetic acid (Modafinil acid) is the metabolite of modafinil .
|
-
- HY-123068
-
-
- HY-Y0781
-
|
Acetylformic acid
|
Endogenous Metabolite
|
Others
|
|
Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
|
-
- HY-W014930
-
-
- HY-N14390
-
-
- HY-N14306
-
|
|
Bacterial
|
Infection
|
|
Aspersitin is a metabolite of Aspergillus parasiticus with antibacterial activity .
|
-
- HY-113418
-
-
- HY-N10282
-
-
- HY-W002011
-
-
- HY-128752
-
-
- HY-W010594
-
-
- HY-W007671
-
-
- HY-N15193
-
-
- HY-W010476
-
-
- HY-125596
-
|
|
Parasite
|
Infection
|
|
Lachnumon is a fungal metabolite with nematicidal and antimicrobial activities .
|
-
- HY-113220
-
-
- HY-N14348
-
-
- HY-170039
-
-
- HY-W353006
-
-
- HY-101723
-
-
- HY-123128
-
|
|
Phytohormone
|
Others
|
|
Raphanatin is a metabolite of radish seed and is active as a cytokinin .
|
-
- HY-N6217
-
-
- HY-12781
-
|
Desbutyl-benflumetol
|
Drug Metabolite
|
Infection
|
|
Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity .
|
-
- HY-113266
-
-
- HY-B0708
-
-
- HY-158547
-
-
- HY-128459
-
|
|
Drug Metabolite
|
Others
|
|
N-Demethylerythromycin A is a metabolite of Erythromycin A. Erythromycin A is an antibiotic .
|
-
- HY-23497
-
-
- HY-128737
-
-
- HY-70002A
-
|
N-desmethyl MDV 3100
|
Androgen Receptor
|
Cancer
|
|
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .
|
-
- HY-114687
-
|
|
Endogenous Metabolite
|
Cardiovascular Disease
Others
|
|
5,7-Dihydroxy-11-ketotetranorprostanoic acid is a urinary metabolite of prostaglandin F2α and precursor to tetranor-PGF metabolites, exhibits hardly activity in blood pressure assay and smooth muscle stiumulation assay .
|
-
- HY-30004S
-
-
- HY-N7564
-
-
- HY-W092109
-
-
- HY-E70240
-
-
- HY-W008794
-
|
(±)-Normetanephrine hydrochloride; DL-Normetanephrine hydrochloride; (Rac)-Normetanephrine hydrochloride
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE) .
|
-
- HY-W046906
-
-
- HY-N10382
-
-
- HY-W008766
-
-
- HY-W400424
-
-
- HY-N10257
-
-
- HY-113367
-
-
- HY-113110A
-
-
- HY-113227
-
-
- HY-150123
-
-
- HY-W015060
-
-
- HY-W017524
-
-
- HY-N8325
-
-
- HY-113286
-
-
- HY-170041
-
-
- HY-137938
-
|
|
Bacterial
|
Infection
|
|
Radicinol is a metabolite of cochliobolus lunata, and absolute stereochemistry of radicinin .
|
-
- HY-W010448
-
-
- HY-N14879
-
-
- HY-79334
-
-
- HY-169507
-
-
- HY-W010736
-
-
- HY-170040
-
-
- HY-137215
-
-
- HY-128738
-
-
- HY-N13089
-
|
|
Others
|
Others
|
|
Pyrethrolone is a metabolite of Cytochrome P450 oxidation of Jasmolone .
|
-
- HY-168367
-
-
- HY-W016750
-
-
- HY-W340326
-
-
- HY-170709
-
-
- HY-B1103
-
-
- HY-116909
-
|
|
Drug Metabolite
|
Others
|
|
O-Methylsterigmatocystin is a metabolite in Aspergillus flavus and Aspergillus parasiticus .
|
-
- HY-W278566
-
-
- HY-123036
-
|
|
Bacterial
|
Infection
|
|
Renierone is an antibacterial metabolite found in the sponge Reniera sp. .
|
-
- HY-128736
-
-
- HY-G0007
-
-
- HY-W008315
-
-
- HY-128736C
-
-
- HY-150334
-
-
- HY-N10080
-
-
- HY-W001080
-
-
- HY-W010155
-
-
- HY-N14391
-
-
- HY-116687
-
-
- HY-W009713
-
-
- HY-N14931
-
-
- HY-168354
-
|
N-Desmethylfludiazepam
|
Drug Metabolite
|
Others
|
|
Desmethylflutiazepam (N-Desmethylfludiazepam) is a metabolite of various benzodiazepine compounds .
|
-
- HY-119223
-
-
- HY-N12204
-
|
|
Others
|
Others
|
|
Triptonoterpenol (compound 6) is a secondary metabolite of Tripterygium wilfordii .
|
-
- HY-129398
-
-
- HY-Y0181
-
-
- HY-N13993
-
-
- HY-W015883S2
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Fumaric acid- 13C2,d2 is the deuterium and 13C labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
|
-
- HY-113233
-
-
- HY-N1424
-
-
- HY-N9403
-
|
|
Others
|
Others
|
|
Prosaikogenin H is an intestinal metabolite of saikosaponin with a weak hemolytic activity .
|
-
- HY-111095B
-
-
- HY-W335576
-
-
- HY-W009216
-
-
- HY-W007888
-
-
- HY-W017490
-
-
- HY-W017523
-
-
- HY-U00199
-
-
- HY-W008188
-
-
- HY-118844
-
-
- HY-W010514
-
-
- HY-W040154
-
-
- HY-W018339
-
-
- HY-45826
-
-
- HY-W039157
-
-
- HY-W014130A
-
-
- HY-W016103
-
-
- HY-133092
-
-
- HY-130319
-
-
- HY-W060074
-
-
- HY-107032
-
-
- HY-126355
-
-
- HY-W019700
-
-
- HY-N8352
-
-
- HY-N0684A
-
-
- HY-172007
-
-
- HY-169768
-
-
- HY-W701936
-
-
- HY-N14914
-
-
- HY-139268
-
|
|
Drug Metabolite
|
Others
|
|
(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid .
|
-
- HY-113277
-
-
- HY-101397
-
-
- HY-136871
-
-
- HY-15130
-
-
- HY-W010224
-
-
- HY-N9395
-
|
|
Others
|
Others
|
|
Dihydroarteannuin B, a natural Dihydroarteannuin, is an microbial metabolite of Arteannuin B .
|
-
- HY-W342243
-
-
- HY-139267
-
|
|
Drug Metabolite
|
Others
|
|
(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid .
|
-
- HY-14798
-
-
- HY-101131
-
|
DNS-glutathione
|
Biochemical Assay Reagents
|
Others
|
|
Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites.
|
-
- HY-N8606
-
-
- HY-23195
-
-
- HY-W016734
-
-
- HY-113283
-
-
- HY-14572
-
|
SN 27858
|
DNA Alkylator/Crosslinker
Drug Metabolite
|
Cancer
|
|
PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .
|
-
- HY-113457S
-
|
11-Ketoetiocholanolone-d5
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Endocrinology
|
|
11-Oxo etiocholanolone-d5 is the deuterium labeled 11-Oxo etiocholanolone. 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a metabolite of Etiocholanolone. Etiocholanolone is the excreted metabolite of testosterone and has anticonvulsant activity[1][2][3].
|
-
- HY-117679
-
|
|
Endogenous Metabolite
|
Cancer
|
|
LY 135114 free base is a metabolite with antitumor activity. LY 135114 free base is a metabolite of LY 195448, a phenylethanolamine compound with antitumor activity. LY 135114 free base has shown potential biological activity in research and may be used for cancer inhibition .
|
-
- HY-153408
-
-
- HY-125074
-
|
|
Antibiotic
|
Infection
|
|
PNU 142300 is an inactive metabolite of the oxazolidinone antibiotic Linezolid (HY-10394).
|
-
- HY-N7718
-
-
- HY-114876
-
|
Norflunitrazepam; Ro 05-4435
|
Drug Metabolite
|
Neurological Disease
|
|
Desmethylflunitrazepam (Norflunitrazepam) is a compound from the benzodiazepine family and is an active metabolite of Flunitrazepam .
|
-
- HY-W587524
-
-
- HY-128744
-
-
- HY-110406
-
-
- HY-12784
-
-
- HY-133902
-
|
|
Others
|
Others
|
|
Neoglucobrassicin is an endogenous metabolite that can be isolated from the seeds of the plant Sinapis alba L.
|
-
- HY-145154
-
-
- HY-128754S1
-
-
- HY-126857
-
|
Hydroxyomeprazole
|
Drug Metabolite
|
Others
|
|
5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).
|
-
- HY-116290
-
-
- HY-107826
-
-
- HY-W001132S
-
-
- HY-W095705A
-
-
- HY-W741611
-
-
- HY-167831
-
|
|
Fungal
|
Infection
|
|
Vermistatin is a metabolite of the fungal strain Guignardia that has cytotoxic and antifungal activity .
|
-
- HY-155164
-
-
- HY-169828
-
|
CGP-85903; ZK-228354
|
Drug Metabolite
|
Others
|
|
Ketopynalin (CGP-85903) is a metabolite of Vatalanib (HY-10203) .
|
-
- HY-N3697
-
|
Deacetyldemethylpseudolaric acid B
|
Others
|
Others
|
|
Demethoxydeacetoxypseudolaric acid B is a metabolite of the glucoside of pseudolaric acid C2 (PC2) .
|
-
- HY-114744
-
-
- HY-127142
-
-
- HY-W009390A
-
-
- HY-111741
-
|
|
Fungal
|
Infection
|
|
M700F048 is a major plant metabolite of fungicide Fluxapyroxad .
|
-
- HY-N7221
-
|
|
Fungal
|
Infection
|
|
Janthitrem G is a microbial metabolite that can be isolated from cultures of Penicillium .
|
-
- HY-W015326
-
-
- HY-W251779
-
-
- HY-W013061
-
-
- HY-W007566
-
-
- HY-168794
-
-
- HY-168795
-
-
- HY-W002773
-
-
- HY-66047
-
-
- HY-W739772
-
-
- HY-Y0035
-
-
- HY-W739930
-
|
|
Antibiotic
|
Infection
|
|
Desmethyl ofloxacin hydrochloride is a metabolite of the fluoroquinolone antibiotic Ofloxacin (HY-B0125).
|
-
- HY-W004412
-
-
- HY-119328
-
-
- HY-Y0546S
-
-
- HY-113232
-
-
- HY-133871
-
-
- HY-145531
-
-
- HY-128754S
-
-
- HY-12784A
-
-
- HY-118163
-
-
- HY-100978
-
|
DL-Hexanoylcarnitine chloride
|
Endogenous Metabolite
|
Metabolic Disease
|
|
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways .
|
-
- HY-100085
-
|
21-desDFZ
|
Drug Metabolite
|
Inflammation/Immunology
|
|
21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .
|
-
- HY-126747
-
-
- HY-133728
-
-
- HY-W587485
-
|
|
Drug Metabolite
|
Others
|
|
N-acetyl-S-(trichlorovinyl)-L-cysteine is a metabolite of the volatile organic compound (VOC) .
|
-
- HY-W750822
-
|
|
Drug Metabolite
|
Others
|
|
7-APB hydrochloride is a benzofuran. 7-APB hydrochloride is a metabolite of 7-MAPB.
|
-
- HY-W740674
-
-
- HY-131622
-
-
- HY-130395
-
-
- HY-N14051
-
|
|
Bacterial
|
Infection
|
|
Arizonin C1 is a microbial metabolite with anti-Gram-positive bacterial activities .
|
-
- HY-B1342S1
-
-
- HY-W743525
-
-
- HY-W002304
-
-
- HY-N14042
-
|
|
Bacterial
|
Infection
|
|
Arizonin B2 is a microbial metabolite with anti-Gram-positive bacterial activities .
|
-
- HY-160542
-
|
|
Endogenous Metabolite
|
Others
|
|
Clenhexyl hydrochloride is a urinary metabolite useful for quantitative screening in doping control screening programs .
|
-
- HY-W011195
-
-
- HY-123001
-
-
- HY-W004661
-
-
- HY-W006492
-
-
- HY-W011910
-
-
- HY-111490
-
-
- HY-W741491
-
|
6-Demethylgriseofulvin; 6-Desmethylgriseofulvin
|
Drug Metabolite
|
Others
|
|
6-O-Demethyl griseofulvin is a metabolite of Griseofulvin (HY-17583) .
|
-
- HY-100050
-
-
- HY-116290A
-
-
- HY-133872
-
-
![[(3R)-3-Hydroxydodecanoyl]-L-carnitine](//file.medchemexpress.com/product_pic/hy-133872.gif)
- HY-W036553
-
-
- HY-N10479
-
-
- HY-N14818
-
|
|
Fungal
|
Infection
|
|
O-Acetylbenzeneamidinocarboxylic acid is a fungal metabolite that shows inhibitory to variety of plant pathogenic fungi .
|
-
- HY-138151
-
-
- HY-W728879
-
-
- HY-13320
-
-
- HY-W048404
-
|
|
Proteasome
|
Cancer
|
|
Bortezomib impurity A is a metabolite of the 20S proteasome inhibitor Bortezomib (HY-10227).
|
-
- HY-125731S1
-
-
- HY-150345
-
-
- HY-N14052
-
|
|
Bacterial
|
Infection
|
|
Arizonin C3 is a microbial metabolite with anti-Gram-positive bacterial activities .
|
-
- HY-I0177
-
|
|
Drug Metabolite
|
Others
|
|
Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor) .
|
-
- HY-W010861
-
-
- HY-136445
-
|
Desethylterbuthylazine
|
Drug Metabolite
|
Others
|
|
Terbuthylazine-desethyl (Desethylterbuthylazine) is a chloro dealkylated metabolite of Terbuthylazine (a triazine herbicide) .
|
-
- HY-126986
-
-
- HY-N14041
-
|
|
Bacterial
|
Infection
|
|
Arizonin A2 is a microbial metabolite with anti-Gram-positive bacterial activities .
|
-
- HY-113340
-
-
- HY-113299
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma .
|
-
- HY-12374
-
-
- HY-Z18056
-
|
|
Drug Metabolite
|
Others
|
|
Norpropranolol hydrochloride is the active metabolite of Propranolol (HY-B0573B) .
|
-
- HY-135252
-
-
- HY-Z2338
-
-
- HY-114852
-
-
- HY-128733S
-
-
- HY-137236
-
-
- HY-125731S
-
-
- HY-170042A
-
-
- HY-122494A
-
-
- HY-N7390
-
-
- HY-125723
-
-
- HY-N2584
-
|
|
Others
|
Cancer
|
|
(2S)-Isoxanthohumol is a microbial biotransformed metabolite of the hop prenylflavanone Isoxanthohumol .
|
-
- HY-B1342S
-
-
- HY-129515
-
|
|
Fungal
|
Others
|
|
Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride .
|
-
- HY-100052
-
|
6-Hydroxybentazone
|
Drug Metabolite
|
Others
|
|
6-Hydroxybentazon is a phase I metabolite of bentazone, and bentazone is a chemical for use in herbicides.
|
-
- HY-W011175
-
-
- HY-113252
-
-
- HY-79593
-
-
- HY-169464
-
-
- HY-W041019
-
-
- HY-N6828
-
|
|
Others
|
Metabolic Disease
|
|
Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .
|
-
- HY-N8483
-
-
- HY-154846
-
|
|
COX
|
Others
|
|
4'-Aarboxylic acid imrecoxib is a metabolite of Imrecoxib, a selective COX-II inhibitor .
|
-
- HY-126745
-
-
- HY-Z2337
-
|
|
Drug Intermediate
|
Others
|
|
Rabeprazole sulfone is a metabolite of the proton pump inhibitor Rabeprazole and is an impurity reference for Rabeprazole .
|
-
- HY-135061
-
-
- HY-P0206A
-
-
- HY-W031230
-
-
- HY-10555
-
|
|
11β-HSD
|
Metabolic Disease
|
|
AMG-221 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with a Ki of 12.8 nM in vitro biochemical scintillation proximity assay (SPA) and an IC50 of 10.1 nM in cell-based assays . AMG-221 can be used for the research of type 2 diabetes .
|
-
- HY-N8210R
-
|
|
Drug Metabolite
|
Others
|
|
Benzofenap (Standard) is the analytical standard of Benzofenap. This product is intended for research and analytical applications. Benzofenap is a herbicide .
|
-
- HY-117727A
-
|
MIN-102 hydrochloride; Hydroxypioglitazone hydrochloride
|
PPAR
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
|
Leriglitazone (MIN-102; Hydroxypioglitazone) hydrochloride is an orally active and a BBB-penatrable PPARγ agonist with an EC50 of 9 μM. Leriglitazone hydrochloride, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone hydrochloride can be used in the study of neuroinflammatory and neurodegenerative diseases .
|
-
- HY-133246A
-
|
Daclatasvir Impurity A TFA
|
HCV
|
Infection
|
|
Monodes(N-carboxymethyl)valine Daclatasvir TFA (Daclatasvir Impurity A TFA) is the TFA salt form of Monodes(N-carboxymethyl)valine Daclatasvir (HY-133246). Monodes(N-carboxymethyl)valine Daclatasvir TFA is the main degradation product of Daclatasvir (HY-10466). Daclatasvir is a potent HCV NS5A protein inhibitor .
|
-
- HY-135410
-
|
Amino albendazole
|
Drug Metabolite
|
Infection
|
|
ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .
|
-
- HY-E70262
-
|
|
Oxidative Phosphorylation
Endogenous Metabolite
|
Metabolic Disease
|
|
Acetoyl-CoA (triammonium) is a triammonium derivative of Acetoyl-CoA (HY-114293), Acetyl-CoA is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis .
|
-
- HY-W050000R
-
|
|
Drug Metabolite
Potassium Channel
Phosphodiesterase (PDE)
Autophagy
|
Cardiovascular Disease
|
|
Tanshinone IIA sulfonate (sodium) (Standard) is the analytical standard of Tanshinone IIA sulfonate (sodium). This product is intended for research and analytical applications. Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.
|
-
- HY-135410R
-
|
|
Drug Metabolite
|
Infection
|
|
ABZ-amine (Standard) is the analytical standard of ABZ-amine. This product is intended for research and analytical applications. ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .
|
-
- HY-113371A
-
|
Methylcitric acid trisodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .
|
-
- HY-W704772
-
-
- HY-W072459
-
-
- HY-139391
-
|
|
Drug Metabolite
|
Others
|
|
(±)10(11)-DiHDPA is a fatty acid diol and a metabolite of epoxidized fatty acids (EpFAs) .
|
-
- HY-169044
-
-
- HY-164998
-
-
- HY-118025
-
|
(±)-SR-121683
|
Drug Metabolite
|
Others
|
|
(±)-2-Oxo clopidogrel is a metabolite of the antiplatelet agent Clopidogrel (HY-15283) .
|
-
- HY-W264038
-
-
- HY-43533
-
|
|
EGFR
|
Cancer
|
|
Tarlox-TKI, the active metabolite of Tarloxotinib, is an irreversible pan-ErbB TKI (Tarlox-TKI) .
|
-
- HY-113517
-
-
- HY-131396
-
-
- HY-131146
-
|
3-Amino-5-morpholinomethyl-2-oxazolidone
|
Antibiotic
|
Infection
|
|
AMOZ, a tissue bound metabolite of Furaltadone, Furaltadone is a synthetic nitrofuran antibiotic widely used
|
-
- HY-Y0546S2
-
-
- HY-12770S
-
-
- HY-12769S
-
-
- HY-129899
-
-
- HY-W016812S
-
-
- HY-114750
-
|
|
Drug Metabolite
|
Others
|
|
Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent .
|
-
- HY-W001132S4
-
-
- HY-W727031
-
-
- HY-N14014
-
-
- HY-119675
-
|
|
Bacterial
|
Infection
Cancer
|
|
Albonoursin, a microbial secondary metabolite, is an antibacterial peptide. Albonoursin displays antibacterial and antitumor activities .
|
-
- HY-114658
-
-
- HY-12539
-
|
Metvine; Vincanine methyl chloride
|
Endogenous Metabolite
|
Others
|
|
Fluorocurarine chloride (Metvine; Vincanine methyl chloride) is a plant metabolite that can be isolated from Catharanthus roseus .
|
-
- HY-113085
-
-
- HY-103638A
-
-
- HY-N11918
-
|
|
Others
|
Others
|
|
Jervinone is a metabolite of the Veratrum alkaloid, which can be isolated from the mold Cunninghamella echinulata .
|
-
- HY-136458
-
|
3-Amino-5-nitro-o-toluamide
|
Parasite
|
Infection
|
|
3-ANOT is a metabolite of Dinitolmide (a nitroamide coccidiostat commonly used in poultry production) .
|
-
- HY-B0331A
-
-
- HY-104026
-
-
- HY-126488
-
-
- HY-W702986
-
|
|
HIV Protease
|
Infection
|
|
Hydroxy darunavir is a metabolite of the HIV-1 protease inhibitor Darunavir (HY-17040).
|
-
- HY-129883
-
-
- HY-172010
-
-
- HY-12781S
-
-
- HY-N8067
-
|
Terbufos oxon sulfoxide
|
Drug Metabolite
|
Others
|
|
Terbufoxon sulfoxide (Terbufos oxon sulfoxide) is a metabolite of the insecticide Terbufos in the pepper leaf matrix .
|
-
- HY-118221
-
-
- HY-17616
-
|
LEO 43204
|
Drug Metabolite
|
Others
|
|
Ingenol disoxate (LEO 43204) is a drug metabolite, that exhibits potential in ameliorating actinic keratosis .
|
-
- HY-130214
-
-
- HY-120201
-
|
|
Drug Metabolite
|
Others
|
|
7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
|
-
- HY-118247
-
|
|
Drug Metabolite
|
Others
|
|
Ro 14-6113 is an inactive phenolic metabolite of the "carotenoid" Ro 15-0778, a form of vitamin A.
|
-
- HY-147085
-
-
- HY-B0016
-
-
- HY-118399
-
-
- HY-Y0546S1
-
-
- HY-137386
-
-
- HY-W015224
-
-
- HY-113379
-
|
|
Endogenous Metabolite
|
Others
|
|
2, 3-Diaminopropionic acid is a metabolite of b-oxalyl-L-a, b-diaminopropionic acid a neurotoxic amino acid (ODAP).
|
-
- HY-N3929
-
|
|
Others
|
Others
|
|
Gardenine is a metabolite produced from Gardenoside (HY-N1478) by K. pneumonia .
|
-
- HY-W040971S
-
-
- HY-156054
-
-
- HY-N10040
-
|
|
Others
|
Others
|
|
Poststerone is a nature product. Poststerone is a metabolite of insect metamorphosing substances from Cyathula capata .
|
-
- HY-118608
-
-
- HY-W001132S1
-
-
- HY-G0012S
-
-
- HY-134558
-
|
|
Apoptosis
|
Others
|
|
5-Methoxyflavanone is a 5-Methoxyflavone metabolite when fermented with Beauveria bassiana .
|
-
- HY-400648
-
|
|
Drug Metabolite
|
Cancer
|
|
Folic acid methyl ester is a methyl ester metabolite of folic acid that can be used in the study of neuropsychiatric conditions, such as depression [1] .
|
-
- HY-113150
-
-
- HY-W001132S3
-
-
- HY-113495
-
-
- HY-W016415
-
-
- HY-10002
-
-
- HY-101407
-
-
- HY-15876R
-
|
|
Drug Metabolite
P2Y Receptor
|
Cardiovascular Disease
|
|
Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture .
|
-
- HY-N6039
-
-
- HY-W700165
-
-
- HY-125563
-
-
- HY-Y0202
-
|
Catecholcarboxylic acid; NSC 27435
|
Endogenous Metabolite
|
Others
|
|
Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.
|
-
- HY-W017511
-
-
![5,6-Dimethyl-1H-benzo[d]imidazole](//file.medchemexpress.com/product_pic/hy-w017511.gif)
- HY-114861
-
-
- HY-N3454
-
|
|
Others
|
Others
|
|
Isotaxiresinol is a lignan, which can be isolated from Taxus yunnanensis and has the function of plant metabolites .
|
-
- HY-W013014
-
-
- HY-122439
-
-
- HY-W741106
-
|
|
Drug Metabolite
|
Others
|
|
5-Hydroxybuspirone is a metabolite of the anti-anxiety agent Buspirone (HY-B1115A) .
|
-
- HY-W094755
-
|
3-Nitropyrene
|
DNA Stain
|
Others
|
|
1-Nitropyrene is a DNA probe whose metabolites can form nucleic acid adducts with DNA .
|
-
- HY-W400496
-
|
|
HDAC
|
Cancer
|
|
Valproic acid β-D-glucuronide is the major urinary metabolite of Valproic acid (HY-10585) .
|
-
- HY-W011152
-
|
dCMP disodium
|
Endogenous Metabolite
|
Others
|
|
2'-Deoxycytidine-5'-monophosphoric acid disodium (dCMP disodium) is an endogenous metabolite .
|
-
- HY-128733R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Phenyl acetate (Standard) is the analytical standard of Phenyl acetate. This product is intended for research and analytical applications. Phenyl acetate is an endogenous metabolite.
|
-
- HY-15992
-
|
|
VEGFR
|
Cancer
|
|
BIBF 1202 is the carboxylate metabolite of BIBF 1120 which inhibits VEGFR2 kinase with an IC50 of 62 nM.
|
-
- HY-124124S
-
-
- HY-118020A
-
-
- HY-W585920
-
|
|
FXR
|
Metabolic Disease
|
|
Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of Chenodeoxycholic Acid (HY-76847) .
|
-
- HY-W012595R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Benzylideneacetone (Standard) is the analytical standard of Benzylideneacetone. This product is intended for research and analytical applications. Benzylideneacetone is an endogenous metabolite.
|
-
- HY-W019151R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Meconine (Standard) is the analytical standard of Meconine. This product is intended for research and analytical applications. Meconine is an endogenous metabolite.
|
-
- HY-168396
-
|
|
Fungal
Drug Derivative
|
Others
|
|
Glioroseinol is a fungal metabolite that can be found in Gliocladium, and is a derivative of Gliorosein (HY-N10228) .
|
-
- HY-W274501
-
-
- HY-N11541
-
|
Didemethylasperxanthone
|
Others
|
Others
|
|
Norrubrofusarin (Didemethylasperxanthone) is a natural product that can be obtained by demethylation of the metabolite (Compound III) of Aspergillus nige .
|
-
- HY-34431R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Purine (Standard) is the analytical standard of Purine. This product is intended for research and analytical applications. Purine is an endogenous metabolite.
|
-
- HY-120894
-
-
- HY-W017370R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Carveol (Standard) is the analytical standard of Carveol. This product is intended for research and analytical applications. Carveol is an endogenous metabolite.
|
-
- HY-Y0519R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Pyrimidine (Standard) is the analytical standard of Pyrimidine. This product is intended for research and analytical applications. Pyrimidine is an endogenous metabolite.
|
-
- HY-B1342R
-
|
Vitamin A1 (Standard); all-trans-Retinol (Standard)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Vitamin A (Standard) is the analytical standard of Vitamin A. This product is intended for research and analytical applications. Retinol is an endogenous metabolite.
|
-
- HY-Y1314S
-
-
- HY-W010396R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Pantolactone (Standard) is the analytical standard of Pantolactone. This product is intended for research and analytical applications. Pantolactone is an endogenous metabolite.
|
-
- HY-131629
-
-
- HY-W010435R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Sulcatone (Standard) is the analytical standard of Sulcatone. This product is intended for research and analytical applications. Sulcatone is an endogenous metabolite.
|
-
- HY-Y0504S2
-
|
Hegzadesil-15N; Trimethylamine hydrochloric acid-15N; Trimethylamine monohydrochloride-15N
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Trimethylammonium chloride- 15N is the 15N labeled Trimethylammonium chloride[1]. Trimethylammonium chloride is an endogenous metabolite.
|
-
- HY-N2353R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Arabinose (Standard) is the analytical standard of Arabinose. This product is intended for research and analytical applications. Arabinose is an endogenous metabolite.
|
-
- HY-W700665
-
|
O-Desmethyl indomethacin
|
Drug Metabolite
|
Others
|
|
5-Hydroxy indomethacin (O-Desmethyl indomethacin) is a metabolite of Indomethacin (HY-14397) .
|
-
- HY-W012480S1
-
-
- HY-168791
-
-
- HY-B1777AS
-
-
- HY-118093
-
|
|
Drug Metabolite
|
Others
|
|
N-benzoyl-L-aspartic acid, a major metabolite of benzyl glucosinolate, can be used for modification of peptides or proteins .
|
-
- HY-W107263
-
-
- HY-135174
-
|
|
Endogenous Metabolite
|
Infection
|
|
L-Cysteine-glutathione disulfide is a metabolite in plasma that can be used in biomarker studies for tuberculosis cure .
|
-
- HY-W010381
-
|
Pyrotartaric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
|
2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy.
|
-
- HY-128739R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Isomaltulose (hydrate) (Standard) is the analytical standard of Isomaltulose (hydrate). This product is intended for research and analytical applications. Isomaltulose hydrate is an endogenous metabolite.
|
-
- HY-113219R
-
|
|
Endogenous Metabolite
Fungal
|
Infection
|
|
Hydroxyphenyllactic acid (Standard) is the analytical standard of Hydroxyphenyllactic acid. This product is intended for research and analytical applications. Hydroxyphenyllactic acid is an antifungal metabolite.
|
-
- HY-N2424R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Flavone (Standard) is the analytical standard of Flavone. This product is intended for research and analytical applications. Flavone is an endogenous metabolite.
|
-
- HY-W015346
-
-
- HY-W012480S
-
-
- HY-W585982
-
-
- HY-W495759
-
-
- HY-W016482
-
-
- HY-76210
-
-
- HY-100645
-
|
Trimethoprim 3-N-oxide
|
Drug Metabolite
|
Others
|
|
Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim .
|
-
- HY-117484
-
|
|
Endogenous Metabolite
|
Others
|
|
Rubrosterone is a metabolite of insect metamorphosing substances, that can be isolated from Achyranthes rubrofuca and A. fmaiei (Amaranthaceae) .
|
-
- HY-113295R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Salicyluric acid (Standard) is the analytical standard of Salicyluric acid. This product is intended for research and analytical applications. Salicyluric acid is an endogenous metabolite.
|
-
- HY-W053507
-
|
3-Methylbenzeneacetic acid
|
Drug Metabolite
|
Others
|
|
m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid .
|
-
- HY-W711166
-
|
|
Drug Intermediate
|
Others
|
|
4-(2-Acetoxyacetyl)phenyl acetate is a synthetic intermediate that has been used in the synthesis of phenethylamine metabolites.
|
-
- HY-Y0399S
-
-
- HY-128393R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Trilinolein (Standard) is the analytical standard of Trilinolein. This product is intended for research and analytical applications. Trilinolein is an endogenous metabolite.
|
-
- HY-135394
-
|
|
Drug Metabolite
Antibiotic
|
Infection
|
|
3-Desacetyl Cefotaxime lactone is the active metabolite of Cefotaxime. Cefotaxime sodium salt is a third-generation cephalosporin antibiotic.
|
-
- HY-Y0267R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Phenoxyacetic acid (Standard) is the analytical standard of Phenoxyacetic acid. This product is intended for research and analytical applications. Phenoxyacetic acid is an endogenous metabolite.
|
-
- HY-W041470
-
-
- HY-113247
-
-
- HY-W653803
-
-
- HY-W683681
-
-
- HY-U00039
-
-
- HY-137564
-
|
|
Antibiotic
|
Infection
|
|
Desacetylcephalothin sodium is a metabolite of Cephalothin (HY-B1275A). Desacetylcephalothin sodium exhibits a weak antimicrobial activity .
|
-
- HY-W144308
-
|
TCHQ; Tetrachloroquinol
|
Drug Metabolite
Reactive Oxygen Species
|
Others
|
|
Tetrachlorohydroquinone (TCHQ) is a metabolite of pentachlorophenol. Tetrachlorohydroquinone increases DNA lesions and induce oxidative stress in rodents .
|
-
- HY-114914
-
-
- HY-W700684
-
|
R 21345
|
Drug Metabolite
|
Others
|
|
N-Didesmethyl Loperamide is a metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function.
|
-
- HY-W014410R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Mucic acid (Standard) is the analytical standard of Mucic acid. This product is intended for research and analytical applications. Mucic acid is an endogenous metabolite.
|
-
- HY-N13889
-
|
|
Fungal
|
Infection
|
|
Altiloxin A, a fungal metabolite, is a drimane-type sesquiterpenoid. Altiloxin A shows phytotoxic activity on the lettuce seedlings .
|
-
- HY-W013423
-
|
|
Cytochrome P450
|
Cancer
|
|
5-Methylchrysene can be activated by several isoenzymes of cytochrome P450 into mutagenic metabolites .
|
-
- HY-126995
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glycohyodeoxycholic acid is a major metabolite of Hyodeoxycholic acid in humans. Glycohyodeoxycholic acid has preventative effects on gallstone formation .
|
-
- HY-170738
-
-
- HY-P2200
-
|
BMY-29304
|
HIV
Antibiotic
|
Infection
Inflammation/Immunology
|
|
Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .
|
-
- HY-113437AS
-
-
- HY-137263
-
|
|
Antibiotic
|
Infection
|
|
Propionylmaridomycin is a macrolide antibiotic with antibacterial activity. Propionylmaridomycin is rapidly absorbed from the gastrointestinal tract and rapidly distributed to tissues. Propionylmaridomycin radioactivity levels in the liver, kidneys, and lungs were significantly higher than in plasma, while distribution to the brain was less. Propionylmaridomycin is excreted primarily through the feces, and the high fecal recovery rate is due to unabsorbed compounds and biliary excretion of compounds and their metabolites. Propionylmaridomycin exhibits the highest antibacterial activity in the lungs. Propionylmaridomycin is completely converted to several metabolites in rats, of which 4''-depropionyl-9-propionylmaridomycin was identified as the major metabolite .
|
-
- HY-113126A
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Hydroxyisobutyric acid sodium is an important interorgan metabolite, an intermediate in the pathways of l-valine and thymine and a good gluconeogenic substrate.
|
-
- HY-112175
-
-
- HY-12778S
-
-
- HY-156558
-
-
- HY-117253
-
|
|
Drug Metabolite
|
Cancer
|
|
PHA-782584 is a metabolite of sunitinib. Sunitinib is an oral multitargeted tyrosine kinase inhibitor with antitumor activities .
|
-
- HY-145535
-
|
C24 3'-sulfo Galactosylceramide (d18:1/24:0)
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Tetracosanoyl-sulfatide is an endogenous metabolite present in Urine that can be used for the research of Mild Metachromatic Leukodystrophy .
|
-
- HY-N1939
-
|
Icarisid I
|
Others
|
Others
|
|
Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.
|
-
- HY-Y0267S
-
-
![4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid](http://file.medchemexpress.com/product_pic/hy-w158239.gif)
![(E)-[6]-Dehydroparadol](http://file.medchemexpress.com/product_pic/hy-77293.gif)
![19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide](http://file.medchemexpress.com/product_pic/hy-n8812.gif)
![7H-Dibenzo[c,g]carbazole](http://file.medchemexpress.com/product_pic/hy-119983.gif)
![[(3R)-3-Hydroxydodecanoyl]-L-carnitine](http://file.medchemexpress.com/product_pic/hy-133872.gif)
![5,6-Dimethyl-1H-benzo[d]imidazole](http://file.medchemexpress.com/product_pic/hy-w017511.gif)
