(±)14,15-Epoxyeicosatrienoic acid
Based on 1 Customer Validation
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 197508-62-6
- Formula: C20H32O3
- Molecular Weight:320.47
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Storage:
Solution, -20°C, 2 years
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Chemical Information
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CAS No. 197508-62-6
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Appearance Liquid
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Molecular Weight 320.47
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Formula C20H32O3
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Color Colorless to light yellow
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SMILES
OC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O
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Synonyms
(±)14(15)-EET
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (261 KB)
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SDS (604 KB)
- English - EN (604 KB)
- Français - FR (604 KB)
- Deutsch - DE (604 KB)
- Norwegian - NO (604 KB)
- Español - ES (604 KB)
- Swedish - SV (604 KB)
- Italian - IT (604 KB)
- Korean - KR (604 KB)
- Portuguese - PT (604 KB)
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Handling Instructions (2659 KB)
References
[1]. Mitra R, et al. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). J Biol Chem. 2011 May 20;286(20):17543-59. [Content Brief]
[2]. Zhang DX, et al. Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites. Endocrinology. 2004 Oct;145(10):4532-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(±)14,15-Epoxyeicosatrienoic acid Related Classifications
HY-150084 Related Classifications
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