Trimipramine N-oxide
Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety.
For research use only. We do not sell to patients.
- CAS No.: 14171-70-1
- Formula: C20H26N2O
- Molecular Weight:310.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 3.59 nM (hSERT), 9.35 nM (hOCT1), 9.4 nM (hDAT), 11.7 nM (hNAT), 27.4 (hOCT2)[1]
Trimipramine N-oxide (0-30 μM; 48 h) inhibits hNAT, hSERT, hDAT, hOCT1 and hOCT2 in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:0-30 μM
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Incubation Time:48 hours
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Result:Dose-dependently inhibited hNAT, hSERT, hDAT, hOCT1 and hOCT2 with IC50s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM in HEK293 cells, respectively.
Chemical Information
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CAS No. 14171-70-1
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Molecular Weight 310.43
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Formula C20H26N2O
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SMILES
[O-][N+](C)(CC(CN1C2=C(CCC3=C1C=CC=C3)C=CC=C2)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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