Abemaciclib metabolite M20
Based on 6 publication(s) in Google Scholar
Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer.
For research use only. We do not sell to patients.
- Purity: 95.92%
- CAS No.: 2138499-06-4
- Formula: C27H32F2N8O
- Molecular Weight:522.59
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Abemaciclib metabolite M20
More- Pharmacol Res. 2022 Apr:178:105954. [Abstract]
- Pharmaceuticals (Basel). 2026 May 19;19(5):795. [Abstract]
- J Pharm Biomed Anal. 2025 Jan 15:253:116531. [Abstract]
- J Pharm Biomed Anal. 2023 Feb 20:225:115211. [Abstract]
- J Pharm Biomed Anal. 2021 Sep 5:203:114225. [Abstract]
- Indonesian Journal of Pharmaceutics. 2025.
Biological Activity
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CDK4 |
CDK6 |
Abemaciclib metabolite M20 (200 nM and 500 nM, 6-8 days) induces senescence in breast cancer cells[2]. Abemaciclib metabolite M20 inhibits the growth and cell cycle progression of non-small cell lung cancer (NSCLC) cells, colorectal cancer (CRC) cells, and breast cancer cells in a concentration-dependent manner[2]. Abemaciclib metabolite has an IC50 value for CDK4 and CDK6 in the range of 1-3 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2138499-06-4
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Appearance Solid
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Molecular Weight 522.59
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Formula C27H32F2N8O
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Color Light yellow to yellow
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SMILES
OCC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C
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Synonyms
LSN3106726
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (6)
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Journal Impact Factor
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Most Recent
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Pharmacol Res
ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites. [Abstract]2022 Apr:178:105954. PMID: 34700018 -
Pharmaceuticals (Basel)
Development and Application of an UPLC-MS/MS Method for Simultaneous Quantification of Abemaciclib and Tamoxifen with Their Active Metabolites in Rat Plasma: Application to a Pharmacokinetic Study. [Abstract]2026 May 19;19(5):795. PMID: 42198468 -
J Pharm Biomed Anal
Assay for the quantification of abemaciclib, its metabolites, and olaparib in human plasma by liquid chromatography-tandem mass spectrometry. [Abstract]2025 Jan 15:253:116531. PMID: 39454543 -
J Pharm Biomed Anal
Therapeutic drug monitoring in breast cancer therapy - LC-MS/MS method for quantification of the CDK4/6 inhibitors abemaciclib, palbociclib, ribociclib, and major metabolites abemaciclib M20 and M2 in human serum. [Abstract]2023 Feb 20:225:115211. PMID: 36603395 -
J Pharm Biomed Anal
Simultaneous quantification of abemaciclib and its active metabolites in human and mouse plasma by UHPLC-MS/MS. [Abstract]2021 Sep 5:203:114225. PMID: 34242947 -
Solvent & Solubility
DMSO : 5 mg/mL (9.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9135 mL | 9.5677 mL | 19.1355 mL | 47.8386 mL |
| 5 mM | 0.3827 mL | 1.9135 mL | 3.8271 mL | 9.5677 mL |
Abemaciclib metabolite M20 Related Classifications
HY-129336 Related Classifications
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