N-Desmethyltamoxifen

Name: N-Desmethyltamoxifen
Brand: MedChemExpress
SKU: HY-129099
Rating: 4.5 (0 reviews)

Cat. No.: HY-129099 Purity: 99.59%: Data Sheet
COA

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N-Desmethyltamoxifen is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

For research use only. We do not sell to patients.

N-Desmethyltamoxifen Chemical Structure

CAS No. : 31750-48-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of N-Desmethyltamoxifen:

N-Desmethyl Tamoxifen-d₅ In-stock
N-Desmethyltamoxifen hydrochloride In-stock

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•Related Screening Libraries:

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•Related Proteins:

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]

PKC	Estrogen Receptor

In Vitro

N-desmethyltamoxifen (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells)^[1].
N-desmethyltamoxifen (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells^[2].
N-desmethyltamoxifen, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	MCF 7 human mammary carcinoma cells
Concentration:	1.5, 2.5, 5, 7.5, 10 μM
Incubation Time:	114 hours
Result:	Inhibits growth of MCF 7 human mammary carcinoma cells

Molecular Weight

357.50

Formula

C₂₅H₂₇NO

CAS No.

31750-48-8

Appearance

Solid

Color

White to off-white

SMILES

CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=CC=C3

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 11.4 mg/mL (31.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7972 mL	13.9860 mL	27.9720 mL
5 mM	0.5594 mL	2.7972 mL	5.5944 mL
10 mM	0.2797 mL	1.3986 mL	2.7972 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.59%

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Data Sheet (274 KB) SDS (584 KB)

COA (249 KB) HNMR (259 KB) LCMS (339 KB)

Handling Instructions (2659 KB)

References

[1]. Vertosick FT Jr, et al. A comparison of the relative chemosensitivity of human gliomas to tamoxifen and n-desmethyltamoxifen in vitro. J Neurooncol. 1994;19(2):97-103. [Content Brief]

[2]. Morad SA, et al. Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics. Biochim Biophys Acta. 2015 Jul;1851(7):919-28. [Content Brief]

[3]. Reddel RR,et al. N-desmethyltamoxifen inhibits growth of MCF 7 human mammary carcinoma cells in vitro. Eur J Cancer Clin Oncol. 1983 Aug;19(8):1179-81. [Content Brief]

[4]. Seong Hwan Kim,et al. Use of Antidepressants in Patients with Breast Cancer Taking Tamoxifen. J Breast Cancer. 2010 Dec;13(4):325-336.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7972 mL	13.9860 mL	27.9720 mL	69.9301 mL
	5 mM	0.5594 mL	2.7972 mL	5.5944 mL	13.9860 mL
	10 mM	0.2797 mL	1.3986 mL	2.7972 mL	6.9930 mL
	15 mM	0.1865 mL	0.9324 mL	1.8648 mL	4.6620 mL
	20 mM	0.1399 mL	0.6993 mL	1.3986 mL	3.4965 mL
	25 mM	0.1119 mL	0.5594 mL	1.1189 mL	2.7972 mL
	30 mM	0.0932 mL	0.4662 mL	0.9324 mL	2.3310 mL