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Cat. No.: HY-G0014B

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Quetiapine sulfoxide hydrochloride

(Synonyms: Quetiapine S-oxide hydrochloride)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.

For research use only. We do not sell to patients.

CAS No.: 2448341-72-6
Formula: C₂₁H₂₆ClN₃O₃S
Molecular Weight:435.97

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Quetiapine sulfoxide hydrochloride Chemical Structure

CAS No.: 2448341-72-6

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Biological Activity
- Description
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
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Biological Activity

Description

Quetiapine sulfoxide hydrochloride (Quetiapine S-oxide hydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic^[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist^[2].

In Vivo

The C_max value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUC_last value is estimated for Quetiapine sulfoxide (1,286±458 ng•h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2448341-72-6
Appearance Solid
Molecular Weight 435.97
Formula C₂₁H₂₆ClN₃O₃S
Color Light yellow to yellow
SMILES

OCCOCCN(CC1)CCN1C2=NC(C=CC=C3)=C3S(C4=C2C=CC=C4)=O.Cl[H]
Synonyms

Quetiapine S-oxide hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Drug Metab Dispos

Quetiapine competitively inhibits aldehyde oxidase-mediated reduction. [Abstract]

2025 Nov;53(11):100169. PMID: 41100927

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. [Content Brief]

[2]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Quetiapine sulfoxide hydrochloride

1 Cited Publications

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Biological Activity
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Publications (1)
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Quetiapine sulfoxide hydrochloride

Publications Citing Use of MedChemExpress (MCE) Quetiapine sulfoxide hydrochloride

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Quetiapine sulfoxide hydrochloride Related Classifications

HY-G0014B Related Classifications