Quetiapine sulfoxide dihydrochloride (Synonyms: Quetiapine S-oxide dihydrochloride)

Cat. No.: HY-G0014A Purity: 99.27%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.

For research use only. We do not sell to patients.

Quetiapine sulfoxide dihydrochloride Chemical Structure

CAS No. : 329218-11-3

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 177	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 177	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Quetiapine sulfoxide dihydrochloride:

Quetiapine In-stock
Quetiapine hemifumarate In-stock
Quetiapine sulfoxide Get quote
Quetiapine sulfoxide hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic^[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist^[2].

In Vivo

The C_max value (mean±SD) is estimated for Quetiapine sulfoxide (77.3±32.4 ng/mL). The AUC_last value is estimated for Quetiapine sulfoxide (1,286±458 ng•h/mL). For Quetiapine sulfoxide, metabolic ratio decreases with time, from 119% on average 2 hours after dosing to 30% on average 72 hours after dosing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

472.43

Formula

C₂₁H₂₇Cl₂N₃O₃S

CAS No.

329218-11-3

Appearance

Solid

Color

White to yellow

SMILES

OCCOCCN(CC1)CCN1C2=NC(C=CC=C3)=C3S(C4=C2C=CC=C4)=O.Cl[H].Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (529.18 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1167 mL	10.5836 mL	21.1672 mL
5 mM	0.4233 mL	2.1167 mL	4.2334 mL
10 mM	0.2117 mL	1.0584 mL	2.1167 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (105.84 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.27%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (255 KB) RP-HPLC (243 KB)

Handling Instructions (2659 KB)

References

[1]. Remmerie B, et al. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole. Clin Pharmacol Drug Dev. 2016 Nov;5(6):528-537. [Content Brief]

[2]. Cross AJ, et al. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.1167 mL	10.5836 mL	21.1672 mL	52.9179 mL
	5 mM	0.4233 mL	2.1167 mL	4.2334 mL	10.5836 mL
	10 mM	0.2117 mL	1.0584 mL	2.1167 mL	5.2918 mL
	15 mM	0.1411 mL	0.7056 mL	1.4111 mL	3.5279 mL
	20 mM	0.1058 mL	0.5292 mL	1.0584 mL	2.6459 mL
	25 mM	0.0847 mL	0.4233 mL	0.8467 mL	2.1167 mL
	30 mM	0.0706 mL	0.3528 mL	0.7056 mL	1.7639 mL
	40 mM	0.0529 mL	0.2646 mL	0.5292 mL	1.3229 mL
	50 mM	0.0423 mL	0.2117 mL	0.4233 mL	1.0584 mL
	60 mM	0.0353 mL	0.1764 mL	0.3528 mL	0.8820 mL
	80 mM	0.0265 mL	0.1323 mL	0.2646 mL	0.6615 mL
	100 mM	0.0212 mL	0.1058 mL	0.2117 mL	0.5292 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Quetiapine sulfoxide dihydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quetiapine sulfoxide329218-11-3Quetiapine S-oxideDrug MetaboliteInhibitorinhibitorinhibit

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