2. Metabolic Enzyme/Protease Stem Cell/Wnt MAPK/ERK Pathway
  3. Phosphatase Endogenous Metabolite ERK
  4. β-Glycerophosphate disodium salt pentahydrate

β-Glycerophosphate disodium salt pentahydrate 

Cat. No.: HY-D0886 Purity: 99.99%
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β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.

For research use only. We do not sell to patients.

CAS No. : 13408-09-8

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Based on 30 publication(s) in Google Scholar

Other Forms of β-Glycerophosphate disodium salt pentahydrate:

β-Glycerophosphate disodium salt pentahydrate Related Antibodies

Top Publications Citing Use of Products
Cell Imaging/Staining
IF
WB

    β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Jun 21:33:102009.  [Abstract]

    β-Glycerophosphate disodium salt pentahydrate (10 mM; 1 week). DPA@NM@CTZE boosts the mineralization and differentiation capabilities of osteoblasts in a palmitic acid (Pa) environment.

    β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 15:313:122756.  [Abstract]

    Representative images of Alizarin Red staining on 14 and 21 days of BMSCs seeded on porous tantalum scaffolds and cultured in osteogenic induction medium containing 1 M β-glycerophosphate (β-Glycerophosphate disodium salt pentahydrate) and 10 mM ascorbic acid ( L-Ascorbic acid).

    β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: J Mol Histol. 2024 Aug;55(4):503-512.

    β-Glycerophosphate disodium salt pentahydrate (10 mM; 7-21 days). The expression levels of KLF9 (shown by immunofluorescence staining) under different induction conditions.

    β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2023 May 18:20:100667.

    β-Glycerophosphate disodium salt pentahydrate (10 mM; 7 days). Representative ALP staining image of BMSCs cultured on Gyroid, Cylindrical, Cubic pore scaffolds and Control in the osteogenic medium after culturing for 7 days.

    β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: J Mol Histol. 2021 Oct;52(5):1067-1080.  [Abstract]

    β-Glycerophosphate disodium salt pentahydrate (10 mM; 48 h). Western blot showed that the expression of ALP, BMP2, phosphorylation-STAT3 and STAT3 protein in VSMCs treated by different chemical compound.

    View All Endogenous Metabolite Isoform Specific Products:

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    Human Endogenous Metabolite Microbial Metabolite

    View All ERK Isoform Specific Products:

    View All Isoforms
    ERK ERK1 ERK2 ERK5 ERK8

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells[1][2][3][4].

    IC50 & Target

    ERK1

     

    ERK2

     

    In Vitro

    β-Glycerophosphate disodium salt pentahydrate, as a phosphate source of the bone mineral hydroxyapatite, can promote osteogenic differentiation and further induce osteogenic gene expression through phosphorylation of the cytokinase-associated kinase ERK1/2[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    β-Glycerophosphate disodium salt pentahydrate Related Antibodies
    Molecular Weight

    306.11

    Formula

    C3H17Na2O11P
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OCC(OP(O[Na])(O[Na])=O)CO.[5H2O]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 83.33 mg/mL (272.22 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2668 mL 16.3340 mL 32.6680 mL
    5 mM 0.6534 mL 3.2668 mL 6.5336 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (326.68 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.99%

    SDS (394 KB)

    COA (253 KB) HNMR (248 KB) RP-HPLC (243 KB) MS (70 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.2668 mL 16.3340 mL 32.6680 mL 81.6700 mL
    5 mM 0.6534 mL 3.2668 mL 6.5336 mL 16.3340 mL
    10 mM 0.3267 mL 1.6334 mL 3.2668 mL 8.1670 mL
    15 mM 0.2178 mL 1.0889 mL 2.1779 mL 5.4447 mL
    20 mM 0.1633 mL 0.8167 mL 1.6334 mL 4.0835 mL
    25 mM 0.1307 mL 0.6534 mL 1.3067 mL 3.2668 mL
    30 mM 0.1089 mL 0.5445 mL 1.0889 mL 2.7223 mL
    40 mM 0.0817 mL 0.4083 mL 0.8167 mL 2.0417 mL
    50 mM 0.0653 mL 0.3267 mL 0.6534 mL 1.6334 mL
    60 mM 0.0544 mL 0.2722 mL 0.5445 mL 1.3612 mL
    80 mM 0.0408 mL 0.2042 mL 0.4083 mL 1.0209 mL
    100 mM 0.0327 mL 0.1633 mL 0.3267 mL 0.8167 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    β-Glycerophosphate disodium salt pentahydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    β-Glycerophosphate disodium salt13408-09-8PhosphataseEndogenous MetaboliteERKExtracellular signal regulated kinasesBone cellsMineral metabolism Endogenous metaboliteCalcificationInhibitorinhibitorinhibit

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