β-Glycerophosphate disodium salt pentahydrate
Based on 31 publication(s) in Google Scholar
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 13408-09-8
- Formula: C3H17Na2O11P
- Molecular Weight:306.11
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) β-Glycerophosphate disodium salt pentahydrate
More- Adv Mater. 2026 Apr;38(19):e23197. [Abstract]
- Adv Mater. 2025 Feb;37(7):e2415543. [Abstract]
- Bone Res. 2025 Mar 3;13(1):30. [Abstract]
- J Adv Res. 2026 Feb 11:S2090-1232(26)00141-4. [Abstract]
- Biomaterials. 2025 Feb:313:122756. [Abstract]
- Chem Eng J. 2026 Jun 8;543:178189.
- J Pharm Anal. 2025 Mar;15(3):101118. [Abstract]
- Mater Today Bio. 2025 Jun 21:33:102009. [Abstract]
- Mater Today Bio. 2023 May 18:20:100667. [Abstract]
- Virtual Phys Prototyp. 2026 Mar 1;21.
- Mater Today Adv. 2026 Feb 10.
- Free Radic Biol Med. 2025 Nov 23:243:351-366. [Abstract]
- Fundam Res. 2025 Jul 17.
- Redox Rep. 2024 Dec;29(1):2428147. [Abstract]
- J Ethnopharmacol. 2025 Jan 31:340:119128. [Abstract]
- Biochem Pharmacol. 2026 Feb:244:117586. [Abstract]
- Biomolecules. 2025 Nov 19;15(11):1623. [Abstract]
- Sci Rep. 2025 Mar 15;15(1):8950. [Abstract]
- Ann N Y Acad Sci. 2026 Mar;1557(1):e70228. [Abstract]
- J Biomed Mater Res A. 2026 Feb;114(2):e70031. [Abstract]
- Cell Transplant. 2025 Jan-Dec:34:9636897251376125. [Abstract]
- J Dent Sci. 2022 Jul;17(3):1281-1291. [Abstract]
- IUBMB Life. 2024 Oct;76(10):832-844. [Abstract]
- J Mol Histol. 2024 Aug;55(4):503-512. [Abstract]
- J Mol Histol. 2021 Oct;52(5):1067-1080. [Abstract]
- Arch Oral Biol. 2025 Aug 13:179:106374. [Abstract]
- Biol Pharm Bull. 2025;48(6):895-907. [Abstract]
- SSRN. 2026 Mar 20.
- Res Sq. 2025 Oct 27.
- Res Sq. 2025 Jul 21.
- Research Square Print. 2022 Aug.
Customer Validation & Images
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Cell Imaging/Staining
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Cell Imaging/Staining
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IF
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Cell Imaging/Staining
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WB
All Endogenous Metabolite Isoforms
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Biological Activity
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ERK1 |
ERK2 |
β-Glycerophosphate disodium salt pentahydrate, as a phosphate source of the bone mineral hydroxyapatite, can promote osteogenic differentiation and further induce osteogenic gene expression through phosphorylation of the cytokinase-associated kinase ERK1/2[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 13408-09-8
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Appearance Solid
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Molecular Weight 306.11
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Formula C3H17Na2O11P
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Color White to off-white
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SMILES
OCC(OP(O[Na])(O[Na])=O)CO.[5H2O]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (31)
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Journal Impact Factor
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Most Recent
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Adv Mater
A Biologically Lubricating Allicin-Based Nanoplatform for Remodeling the Inflammation-Senescence Axis in the Treatment of Periodontitis. [Abstract]2026 Apr;38(19):e23197. PMID: 41787647 -
Adv Mater
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis. [Abstract]2025 Feb;37(7):e2415543. PMID: 39726077 -
Bone Res
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]2025 Mar 3;13(1):30. PMID: 40025004 -
J Adv Res
2026 Feb 11:S2090-1232(26)00141-4. PMID: 41687771 -
Biomaterials
Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study. [Abstract]2025 Feb:313:122756. PMID: 39182327
β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: Biomaterials. 2025 Feb:313:122756. [Abstract]
Representative images of Alizarin Red staining on 14 and 21 days of BMSCs seeded on porous tantalum scaffolds and cultured in osteogenic induction medium containing 1 M β-glycerophosphate (β-Glycerophosphate disodium salt pentahydrate) and 10 mM ascorbic acid ( L-Ascorbic acid).
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J Pharm Anal
Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer. [Abstract]2025 Mar;15(3):101118. PMID: 40161444 -
Mater Today Bio
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis. [Abstract]2025 Jun 21:33:102009. PMID: 40673132
β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Jun 21:33:102009. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 1 week). DPA@NM@CTZE boosts the mineralization and differentiation capabilities of osteoblasts in a palmitic acid (Pa) environment.
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Mater Today Bio
The design of strut/TPMS-based pore geometries in bioceramic scaffolds guiding osteogenesis and angiogenesis in bone regeneration. [Abstract]2023 May 18:20:100667. PMID: 37273795
β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2023 May 18:20:100667. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 7 days). Representative ALP staining image of BMSCs cultured on Gyroid, Cylindrical, Cubic pore scaffolds and Control in the osteogenic medium after culturing for 7 days.
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Free Radic Biol Med
Gut microbial metabolite alleviates osteoporosis by attenuating AKT-NFATc1 signaling pathway and ROS production. [Abstract]2025 Nov 23:243:351-366. PMID: 41290102 -
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Redox Rep
Inhibition of SLC40A1 represses osteoblast formation via inducing iron accumulation and activating the PERK/ATF4/CHOP pathway mediated oxidative stress. [Abstract]2024 Dec;29(1):2428147. PMID: 39607819 -
J Ethnopharmacol
Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice. [Abstract]2025 Jan 31:340:119128. PMID: 39617084 -
Biochem Pharmacol
Glucocorticoid impairs angiogenesis-dependent osteogenesis by downregulating EphB4 in endothelial cells. [Abstract]2026 Feb:244:117586. PMID: 41344513 -
Biomolecules
Mitochondrial Imaging and Transcriptome Analysis of Bone Mesenchymal Stem Cells During Osteogenesis Under Different Culture Conditions. [Abstract]2025 Nov 19;15(11):1623. PMID: 41301543 -
Sci Rep
Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis. [Abstract]2025 Mar 15;15(1):8950. PMID: 40089548 -
Ann N Y Acad Sci
Differential Effects of DLX3 Mutations Drive Phenotypic Variability in Tricho-Dento-Osseous Syndrome via Direct Activation of WNT10A. [Abstract]2026 Mar;1557(1):e70228. PMID: 41774401 -
J Biomed Mater Res A
Injectable Butyl Glycidyl Ether-Modified Methylcellulose Thermosensitive Hydrogel for Topical Delivery of Vancomycin Hydrochloride in the Treatment of Osteomyelitis. [Abstract]2026 Feb;114(2):e70031. PMID: 41586469 -
Cell Transplant
Adipose-derived stem cells inhibit dendritic cell migration by secreting tumor necrosis factor-α-stimulated gene 6 to improve the allogeneic skin transplantation survival rate in mice. [Abstract]2025 Jan-Dec:34:9636897251376125. PMID: 41108126 -
J Dent Sci
MicroRNA-34a and microRNA-146a target CELF3 and suppress the osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch. [Abstract]2022 Jul;17(3):1281-1291. PMID: 35784124 -
IUBMB Life
Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice. [Abstract]2024 Oct;76(10):832-844. PMID: 39012196 -
J Mol Histol
2024 Aug;55(4):503-512. PMID: 38801643
β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: J Mol Histol. 2024 Aug;55(4):503-512. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 7-21 days). The expression levels of KLF9 (shown by immunofluorescence staining) under different induction conditions.
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J Mol Histol
Globular adiponectin inhibits osteoblastic differentiation of vascular smooth muscle cells through the PI3K/AKT and Wnt/β-catenin pathway. [Abstract]2021 Oct;52(5):1067-1080. PMID: 34398360
β-Glycerophosphate disodium salt pentahydrate purchased from MedChemExpress. Usage Cited in: J Mol Histol. 2021 Oct;52(5):1067-1080. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 48 h). Western blot showed that the expression of ALP, BMP2, phosphorylation-STAT3 and STAT3 protein in VSMCs treated by different chemical compound.
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Arch Oral Biol
GDC-0449 suppresses odontogenic keratocyst aggressiveness in fibroblasts by upregulating SPARC via Hedgehog pathway inhibition. [Abstract]2025 Aug 13:179:106374. PMID: 40840062 -
Biol Pharm Bull
Anti-osteoporosis Activity of Sodium Glucuronate in Preosteo-blast MC3T3-E1 Cells and an Ovariectomized Rat Model. [Abstract]2025;48(6):895-907. PMID: 40571633 -
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Solvent & Solubility
H2O : 83.33 mg/mL (272.22 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (326.68 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Belfield A, et al. Inhibition of the nucleotidase effect of alkaline phosphatase by beta-glycerophosphate. Nature. 1968 Jul 6;219(5149):73-5. [Content Brief]
[3]. Chung CH, et al. Mechanism of action of beta-glycerophosphate on bone cell mineralization. Calcif Tissue Int. 1992;51(4):305-311. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.2668 mL | 16.3340 mL | 32.6680 mL | 81.6700 mL |
| 5 mM | 0.6534 mL | 3.2668 mL | 6.5336 mL | 16.3340 mL | |
| 10 mM | 0.3267 mL | 1.6334 mL | 3.2668 mL | 8.1670 mL | |
| 15 mM | 0.2178 mL | 1.0889 mL | 2.1779 mL | 5.4447 mL | |
| 20 mM | 0.1633 mL | 0.8167 mL | 1.6334 mL | 4.0835 mL | |
| 25 mM | 0.1307 mL | 0.6534 mL | 1.3067 mL | 3.2668 mL | |
| 30 mM | 0.1089 mL | 0.5445 mL | 1.0889 mL | 2.7223 mL | |
| 40 mM | 0.0817 mL | 0.4083 mL | 0.8167 mL | 2.0417 mL | |
| 50 mM | 0.0653 mL | 0.3267 mL | 0.6534 mL | 1.6334 mL | |
| 60 mM | 0.0544 mL | 0.2722 mL | 0.5445 mL | 1.3612 mL | |
| 80 mM | 0.0408 mL | 0.2042 mL | 0.4083 mL | 1.0209 mL | |
| 100 mM | 0.0327 mL | 0.1633 mL | 0.3267 mL | 0.8167 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
β-Glycerophosphate disodium salt pentahydrate Related Classifications
HY-D0886 Related Classifications
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