β-Glycerophosphate disodium salt hydrate
Based on 35 publication(s) in Google Scholar
β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells.
For research use only. We do not sell to patients.
- Purity : 99.92%
- CAS No.: 154804-51-0
- Formula: C3H7O6PNa2.xH2O
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications Citing Use of MedChemExpress (MCE) β-Glycerophosphate disodium salt hydrate
More- Adv Mater. 2026 Apr;38(19):e23197. [Abstract]
- Adv Mater. 2025 Feb;37(7):e2415543. [Abstract]
- Bone Res. 2025 Mar 3;13(1):30. [Abstract]
- Autophagy. 2026 Jul 24:1-20.
- J Adv Res. 2026 Feb 11:S2090-1232(26)00141-4. [Abstract]
- Biomaterials. 2025 Feb:313:122756. [Abstract]
- Chem Eng J. 2026 Jun 8;543:178189.
- J Pharm Anal. 2025 Mar;15(3):101118. [Abstract]
- Mater Today Bio. 2025 Jun 21:33:102009. [Abstract]
- Mater Today Bio. 2023 May 18:20:100667. [Abstract]
- Virtual Phys Prototyp. 2026 Mar 1;21.
- Mater Today Adv. 2026 Feb 10.
- Free Radic Biol Med. 2025 Nov 23:243:351-366. [Abstract]
- Fundam Res. 2025 Jul 17.
- Redox Rep. 2024 Dec;29(1):2428147. [Abstract]
- J Ethnopharmacol. 2025 Jan 31:340:119128. [Abstract]
- Biochem Pharmacol. 2026 Oct:252:118244.
- Biochem Pharmacol. 2026 Feb:244:117586. [Abstract]
- Biomolecules. 2025 Nov 19;15(11):1623. [Abstract]
- Sci Rep. 2025 Mar 15;15(1):8950. [Abstract]
- Food Nutr Res. 2026 May 21:70.
- Ann N Y Acad Sci. 2026 Mar;1557(1):e70228. [Abstract]
- J Biomed Mater Res A. 2026 Feb;114(2):e70031. [Abstract]
- Cell Transplant. 2025 Jan-Dec:34:9636897251376125. [Abstract]
- J Dent Sci. 2022 Jul;17(3):1281-1291. [Abstract]
- IUBMB Life. 2024 Oct;76(10):832-844. [Abstract]
- J Mol Histol. 2024 Aug;55(4):503-512. [Abstract]
- J Mol Histol. 2021 Oct;52(5):1067-1080. [Abstract]
- Arch Oral Biol. 2025 Aug 13:179:106374. [Abstract]
- Biol Pharm Bull. 2025;48(6):895-907. [Abstract]
- bioRxiv. 2026 Jul 21.
- SSRN. 2026 Mar 20.
- Res Sq. 2025 Oct 27.
- Res Sq. 2025 Jul 21.
- Research Square Print. 2022 Aug.
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Cell Imaging/Staining
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Cell Imaging/Staining
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IF
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Cell Imaging/Staining
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WB
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
IC50 & Target
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ERK1 |
ERK2 |
In Vitro
β-Glycerophosphate disodium salt pentahydrate, as a phosphate source of the bone mineral hydroxyapatite, can promote osteogenic differentiation and further induce osteogenic gene expression through phosphorylation of the cytokinase-associated kinase ERK1/2[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 154804-51-0
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Appearance Solid
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Formula C3H7O6PNa2.xH2O
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Color White to off-white
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SMILES
OCC(OP(O[Na])(O[Na])=O)CO.[H]O[H].[x]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (35)
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Journal Impact Factor
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Most Recent
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Adv Mater
A Biologically Lubricating Allicin-Based Nanoplatform for Remodeling the Inflammation-Senescence Axis in the Treatment of Periodontitis. [Abstract]2026 Apr;38(19):e23197. PMID: 41787647 -
Adv Mater
Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis. [Abstract]2025 Feb;37(7):e2415543. PMID: 39726077 -
Bone Res
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus. [Abstract]2025 Mar 3;13(1):30. PMID: 40025004 -
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J Adv Res
2026 Feb 11:S2090-1232(26)00141-4. PMID: 41687771 -
Biomaterials
Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study. [Abstract]2025 Feb:313:122756. PMID: 39182327
β-Glycerophosphate disodium salt hydrate purchased from MedChemExpress. Usage Cited in: Biomaterials. 2025 Feb:313:122756. [Abstract]
Representative images of Alizarin Red staining on 14 and 21 days of BMSCs seeded on porous tantalum scaffolds and cultured in osteogenic induction medium containing 1 M β-glycerophosphate (β-Glycerophosphate disodium salt pentahydrate) and 10 mM ascorbic acid ( L-Ascorbic acid).
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J Pharm Anal
Elemene as a binding stabilizer of microRNA-145-5p suppresses the growth of non-small cell lung cancer. [Abstract]2025 Mar;15(3):101118. PMID: 40161444 -
Mater Today Bio
A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis. [Abstract]2025 Jun 21:33:102009. PMID: 40673132
β-Glycerophosphate disodium salt hydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Jun 21:33:102009. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 1 week). DPA@NM@CTZE boosts the mineralization and differentiation capabilities of osteoblasts in a palmitic acid (Pa) environment.
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Mater Today Bio
The design of strut/TPMS-based pore geometries in bioceramic scaffolds guiding osteogenesis and angiogenesis in bone regeneration. [Abstract]2023 May 18:20:100667. PMID: 37273795
β-Glycerophosphate disodium salt hydrate purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2023 May 18:20:100667. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 7 days). Representative ALP staining image of BMSCs cultured on Gyroid, Cylindrical, Cubic pore scaffolds and Control in the osteogenic medium after culturing for 7 days.
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Free Radic Biol Med
Gut microbial metabolite alleviates osteoporosis by attenuating AKT-NFATc1 signaling pathway and ROS production. [Abstract]2025 Nov 23:243:351-366. PMID: 41290102 -
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Redox Rep
Inhibition of SLC40A1 represses osteoblast formation via inducing iron accumulation and activating the PERK/ATF4/CHOP pathway mediated oxidative stress. [Abstract]2024 Dec;29(1):2428147. PMID: 39607819 -
J Ethnopharmacol
Serum metabolomics and 16S rRNA amplicon sequencing reveal the role of puerarin in alleviating bone loss aggravated by antidiabetic agent pioglitazone in type 2 diabetic mice. [Abstract]2025 Jan 31:340:119128. PMID: 39617084 -
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Biochem Pharmacol
Glucocorticoid impairs angiogenesis-dependent osteogenesis by downregulating EphB4 in endothelial cells. [Abstract]2026 Feb:244:117586. PMID: 41344513 -
Biomolecules
Mitochondrial Imaging and Transcriptome Analysis of Bone Mesenchymal Stem Cells During Osteogenesis Under Different Culture Conditions. [Abstract]2025 Nov 19;15(11):1623. PMID: 41301543 -
Sci Rep
Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis. [Abstract]2025 Mar 15;15(1):8950. PMID: 40089548 -
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Ann N Y Acad Sci
Differential Effects of DLX3 Mutations Drive Phenotypic Variability in Tricho-Dento-Osseous Syndrome via Direct Activation of WNT10A. [Abstract]2026 Mar;1557(1):e70228. PMID: 41774401 -
J Biomed Mater Res A
Injectable Butyl Glycidyl Ether-Modified Methylcellulose Thermosensitive Hydrogel for Topical Delivery of Vancomycin Hydrochloride in the Treatment of Osteomyelitis. [Abstract]2026 Feb;114(2):e70031. PMID: 41586469 -
Cell Transplant
Adipose-derived stem cells inhibit dendritic cell migration by secreting tumor necrosis factor-α-stimulated gene 6 to improve the allogeneic skin transplantation survival rate in mice. [Abstract]2025 Jan-Dec:34:9636897251376125. PMID: 41108126 -
J Dent Sci
MicroRNA-34a and microRNA-146a target CELF3 and suppress the osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch. [Abstract]2022 Jul;17(3):1281-1291. PMID: 35784124 -
IUBMB Life
Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice. [Abstract]2024 Oct;76(10):832-844. PMID: 39012196 -
J Mol Histol
2024 Aug;55(4):503-512. PMID: 38801643
β-Glycerophosphate disodium salt hydrate purchased from MedChemExpress. Usage Cited in: J Mol Histol. 2024 Aug;55(4):503-512. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 7-21 days). The expression levels of KLF9 (shown by immunofluorescence staining) under different induction conditions.
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J Mol Histol
Globular adiponectin inhibits osteoblastic differentiation of vascular smooth muscle cells through the PI3K/AKT and Wnt/β-catenin pathway. [Abstract]2021 Oct;52(5):1067-1080. PMID: 34398360
β-Glycerophosphate disodium salt hydrate purchased from MedChemExpress. Usage Cited in: J Mol Histol. 2021 Oct;52(5):1067-1080. [Abstract]
β-Glycerophosphate disodium salt pentahydrate (10 mM; 48 h). Western blot showed that the expression of ALP, BMP2, phosphorylation-STAT3 and STAT3 protein in VSMCs treated by different chemical compound.
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Arch Oral Biol
GDC-0449 suppresses odontogenic keratocyst aggressiveness in fibroblasts by upregulating SPARC via Hedgehog pathway inhibition. [Abstract]2025 Aug 13:179:106374. PMID: 40840062 -
Biol Pharm Bull
Anti-osteoporosis Activity of Sodium Glucuronate in Preosteo-blast MC3T3-E1 Cells and an Ovariectomized Rat Model. [Abstract]2025;48(6):895-907. PMID: 40571633 -
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Solvent & Solubility
In Vitro:
H2O : 175 mg/mL (Need ultrasonic)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL; Clear solution; Need ultrasonic and warming
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Belfield A, et al. Inhibition of the nucleotidase effect of alkaline phosphatase by beta-glycerophosphate. Nature. 1968 Jul 6;219(5149):73-5. [Content Brief]
[2]. Shioi A, et al. Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1995 Nov;15(11):2003-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)