1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. Sodium orthovanadate

Sodium orthovanadate 

Cat. No.: HY-D0852 Purity: ≥95.0%
Handling Instructions

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

For research use only. We do not sell to patients.

Sodium orthovanadate Chemical Structure

Sodium orthovanadate Chemical Structure

CAS No. : 13721-39-6

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Description

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

IC50 & Target

PPTPase[1].

In Vitro

In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO42- or H2VO4-) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process[1]. Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

183.91

Formula

Na₃O₄V

CAS No.

13721-39-6

SMILES

O=[V](=O)(=O)([Na])([Na])([Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (45.29 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.44 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4374 mL 27.1872 mL 54.3744 mL
5 mM 1.0875 mL 5.4374 mL 10.8749 mL
10 mM 0.5437 mL 2.7187 mL 5.4374 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥95.0%

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Keywords:

Sodium orthovanadatePhosphataseInhibitorinhibitorinhibit

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Sodium orthovanadate
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