1. Vitamin D Related/Nuclear Receptor Neuronal Signaling Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  2. LXR iGluR Endogenous Metabolite
  3. 24(S)-Hydroxycholesterol

24(S)-Hydroxycholesterol  (Synonyms: 24S-OHC; 24S-HC; Cerebrosterol)

Cat. No.: HY-16940 Purity: 99.55%
COA Handling Instructions

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.

For research use only. We do not sell to patients.

24(S)-Hydroxycholesterol Chemical Structure

24(S)-Hydroxycholesterol Chemical Structure

CAS No. : 474-73-7

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Based on 1 publication(s) in Google Scholar

Other Forms of 24(S)-Hydroxycholesterol:

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Description

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

IC50 & Target

NMDA Receptor

 

Human Endogenous Metabolite

 

In Vitro

24(S)-Hydroxycholesterol (1, 10, 30 μM) can protect isolated rat retina from damage caused by elevated hydrostatic pressure[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.65

Formula

C27H46O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CC[C@H](O)C(C)C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 20 mg/mL (49.67 mM; Need ultrasonic and warming)

DMSO : 0.1 mg/mL (0.25 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4835 mL 12.4177 mL 24.8355 mL
5 mM 0.4967 mL 2.4835 mL 4.9671 mL
10 mM 0.2484 mL 1.2418 mL 2.4835 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.55%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
24(S)-Hydroxycholesterol
Cat. No.:
HY-16940
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