1. Neuronal Signaling
    Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. LXR
    iGluR
    Endogenous Metabolite
  3. 24(S)-Hydroxycholesterol

24(S)-Hydroxycholesterol (Synonyms: 24S-OHC; 24S-HC; Cerebrosterol)

Cat. No.: HY-16940
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24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.

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24(S)-Hydroxycholesterol Chemical Structure

24(S)-Hydroxycholesterol Chemical Structure

CAS No. : 474-73-7

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Description

24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

400.68

Formula

C₂₈H₄₈O

CAS No.

474-73-7

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Keywords:

24(S)-Hydroxycholesterol24S-OHC24S-HCCerebrosterolLXRiGluREndogenous MetaboliteLiver X receptorIonotropic glutamate receptorsLTPbrainNMDARInhibitorinhibitorinhibit

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24(S)-Hydroxycholesterol
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HY-16940
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