1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. iGluR
    LXR
  3. 24-Hydroxycholesterol

24-Hydroxycholesterol 

Cat. No.: HY-N2370 Purity: >98.0%
Handling Instructions

24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

For research use only. We do not sell to patients.

24-Hydroxycholesterol Chemical Structure

24-Hydroxycholesterol Chemical Structure

CAS No. : 30271-38-6

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2 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Description

24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

In Vitro

24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation[1].

In Vivo

Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1+ islets[1]. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

402.65

Formula

C₂₇H₄₆O₂

CAS No.

30271-38-6

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Product Name:
24-Hydroxycholesterol
Cat. No.:
HY-N2370
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24-Hydroxycholesterol

Cat. No.: HY-N2370