Transcription Factors

Human MYC mRNA encodes the human MYC proto-oncogene, bHLH transcription factor (MYC) protein, a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.

Human ASCL1 mRNA encodes the human achaete-scute family bHLH transcription factor 1 (ASCL1) protein, a member of the basic helix-loop-helix (BHLH) family. ASCL1 plays a role in the neuronal commitment and differentiation, and in the generation of olfactory and autonomic neurons.

Human ETS variant transcription factor 2 (ETV2) mRNA encodes a protein that can binds to DNA sequences containing the consensus pentanucleotide 5''-CGGA[AT]-3''.

Human FLI1 mRNA encodes a transcription factor containing an ETS DNA-binding domain. FLI1 is a sequence-specific transcriptional activator that can recognize the DNA sequence 5''-C[CA]GGAAGT-3''.

Human GATA2 mRNA encodes the human GATA binding protein 2 (GATA2) protein, a member of the GATA family of zinc-finger transcription factors. GATA2 plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages.

Human GATA4 mRNA encodes the human GATA binding protein 4 (GATA4) protein, a member of the GATA family of zinc-finger transcription factors. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. It is also necessary for normal testicular development.

Human HNF1A mRNA encodes the human HNF1 homeobox A (HNF1A) protein, a transcription factor that required for the expression of several liver-specific genes. HNF1A functions as a homodimer and binds to the inverted palindrome 5''-GTTAATNATTAAC-3''.

Human HNF1B mRNA encodes the human HNF1 homeobox B (HNF1B) protein, a member of the homeodomain-containing superfamily of transcription factors. HNF1B has been shown to function in nephron development, and regulates development of the embryonic pancreas.

Human ISL1 mRNA encodes the human ISL LIM homeobox 1 (ISL1) protein, a member of the LIM/homeodomain family of transcription factors. ISL1 is central to the development of pancreatic cell lineages and may also be required for motor neuron generation.

Human kruppel like factor 4 (KLF4) mRNA encodes a protein that belongs to the Kruppel family of transcription factors. KLF4 protein is thought to regulate the expression of key transcription factors during embryonic development and play an important role in maintaining embryonic stem cells, and in preventing their differentiation. In addition it is also required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface.

Human LHX3 mRNA encodes the human LIM homeobox 3 (LHX3) protein, a member of a large proteins family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. LHX3 is a transcription factor that is required for pituitary development and motor neuron specification.

Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.

Human LMX1A mRNA encodes the human LIM homeobox transcription factor 1 alpha (LMX1A) protein, a homeodomain and LIM-domain containing protein. LMX1A is a transcription factor that acts as a positive regulator of insulin gene transcription. It also plays a role in the development of dopamine producing neurons during embryogenesis.

Human MAFA mRNA encodes the human MAF bZIP transcription factor A (MAFA) protein, a transcription factor that regulates pancreatic beta cell-specific expression of the insulin gene.

Human MEF2A mRNA encodes the human myocyte enhancer factor 2A (MEF2A) protein, a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. MEF2A is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis.

Human MEF2C mRNA encodes the human myocyte enhancer factor 2C (MEF2C) protein, a member of the MADS box transcription enhancer factor 2 (MEF2) family. MEF2C has both trans-activating and DNA binding activities and may play a role in maintaining the differentiated state of muscle cells.

Human MESP1 mRNA encodes the human Mesoderm posterior bHLH transcription factor 1 (MESP1) protein, a member of transcription factor which plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.

Human MITF mRNA encodes the human melanocyte inducing transcription factor (MITF) protein, a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. MITF could regulate melanocyte development and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes.

Human MNX1 mRNA encodes the human motor neuron and pancreas homeobox 1 (MNX1) protein, a putative transcription factor involved in pancreas development and function.

Human MYB mRNA encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. MYB plays an essential role in the regulation of hematopoiesis.